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1.
2.

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Febbraio MA, Reibe S, Shalapour S, Ooi GJ, Watt MJ, Karin M.

Cell Metab. 2019 Jan 8;29(1):18-26. doi: 10.1016/j.cmet.2018.10.012. Epub 2018 Nov 15. Review.

PMID:
30449681
3.

NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.

Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA.

Gastroenterology. 2018 Nov 13. pii: S0016-5085(18)35261-2. doi: 10.1053/j.gastro.2018.11.019. [Epub ahead of print]

PMID:
30445007
4.

Integrative genomic analysis of mouse and human hepatocellular carcinoma.

Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9879-E9888. doi: 10.1073/pnas.1811029115. Epub 2018 Oct 4.

PMID:
30287485
5.

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.

Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M.

Cell. 2018 Sep 20;175(1):133-145.e15. doi: 10.1016/j.cell.2018.08.020. Epub 2018 Sep 13.

PMID:
30220454
6.

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.

Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9192-E9200. doi: 10.1073/pnas.1810584115. Epub 2018 Sep 12.

PMID:
30209212
7.

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.

Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M.

Nature. 2018 Aug;560(7717):198-203. doi: 10.1038/s41586-018-0372-z. Epub 2018 Jul 25.

8.

Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.

Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M.

Nature. 2018 Sep;561(7721):E1. doi: 10.1038/s41586-018-0304-y.

PMID:
29973714
9.

Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling.

Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M.

Cancer Cell. 2018 Jun 11;33(6):1061-1077.e6. doi: 10.1016/j.ccell.2018.05.003.

PMID:
29894692
10.

Publisher Correction: The gut-liver axis and the intersection with the microbiome.

Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R.

Nat Rev Gastroenterol Hepatol. 2018 Dec;15(12):785. doi: 10.1038/s41575-018-0031-8.

PMID:
29785003
11.

The gut-liver axis and the intersection with the microbiome.

Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R.

Nat Rev Gastroenterol Hepatol. 2018 Jul;15(7):397-411. doi: 10.1038/s41575-018-0011-z. Review. Erratum in: Nat Rev Gastroenterol Hepatol. 2018 May 21;:.

12.

Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET.

Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS.

J Hepatol. 2018 Jul;69(1):79-88. doi: 10.1016/j.jhep.2018.02.014. Epub 2018 Mar 2.

PMID:
29505847
13.

NF-κB, inflammation, immunity and cancer: coming of age.

Taniguchi K, Karin M.

Nat Rev Immunol. 2018 May;18(5):309-324. doi: 10.1038/nri.2017.142. Epub 2018 Jan 22. Review.

PMID:
29379212
14.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

15.

IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways.

Song NY, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Wu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E812-E821. doi: 10.1073/pnas.1717520115. Epub 2018 Jan 8.

16.

Influence of the Type of Plateletpheresis on the Value of Corpuscular Elements in the Blood Donors.

Landžo E, Petrović J, Karin M, Tomić I, Pravdić D.

Psychiatr Danub. 2017 Dec;29 Suppl 4(Suppl 4):835-840.

PMID:
29278632
17.

Allergic reactions and anesthesia.

Bevanda DG, Čačić M, Mihaljević S, Bevanda M, Bogut A, Karin M.

Psychiatr Danub. 2017 Dec;29 Suppl 4(Suppl 4):778-786. Review.

PMID:
29278624
18.

Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.

Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M.

Nature. 2017 Dec 21;552(7685):430. doi: 10.1038/nature25028. Epub 2017 Nov 22.

PMID:
29168501
19.

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.

Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M.

Cancer Cell. 2017 Dec 11;32(6):824-839.e8. doi: 10.1016/j.ccell.2017.10.011. Epub 2017 Nov 16.

20.

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.

Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M.

Nature. 2017 Nov 16;551(7680):340-345. doi: 10.1038/nature24302. Epub 2017 Nov 8. Erratum in: Nature. 2017 Nov 22;:. Nature. 2018 Sep;561(7721):E1.

21.

Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1.

Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H.

PLoS One. 2017 Aug 10;12(8):e0181052. doi: 10.1371/journal.pone.0181052. eCollection 2017.

22.

IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents.

Ivovic A, Oprescu AI, Koulajian K, Mori Y, Eversley JA, Zhang L, Nino-Fong R, Lewis GF, Donath MY, Karin M, Wheeler MB, Ehses J, Volchuk A, Chan CB, Giacca A.

Diabetologia. 2017 Oct;60(10):2021-2032. doi: 10.1007/s00125-017-4345-9. Epub 2017 Jul 20.

PMID:
28725915
23.

Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome.

Afonina IS, Zhong Z, Karin M, Beyaert R.

Nat Immunol. 2017 Jul 19;18(8):861-869. doi: 10.1038/ni.3772. Review.

PMID:
28722711
24.

DNA methylation markers for diagnosis and prognosis of common cancers.

Hao X, Luo H, Krawczyk M, Wei W, Wang W, Wang J, Flagg K, Hou J, Zhang H, Yi S, Jafari M, Lin D, Chung C, Caughey BA, Li G, Dhar D, Shi W, Zheng L, Hou R, Zhu J, Zhao L, Fu X, Zhang E, Zhang C, Zhu JK, Karin M, Xu RH, Zhang K.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7414-7419. doi: 10.1073/pnas.1703577114. Epub 2017 Jun 26.

25.

GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer.

Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, Lopez ES, Wong J, Ju H, Tian L, Zhang F, Xu H, Wang SD, Li X, Karin M, Ren H.

Cell Death Differ. 2017 May;24(5):929-943. doi: 10.1038/cdd.2017.50. Epub 2017 Apr 7.

26.

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.

Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1432-E1440. doi: 10.1073/pnas.1700232114. Epub 2017 Feb 6. Erratum in: Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4115. Paszek, Miles [added].

27.

YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.

Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27.

28.

A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging.

Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN.

Nat Immunol. 2017 Mar;18(3):354-363. doi: 10.1038/ni.3665. Epub 2017 Jan 23.

29.

Correlation of clinical and endoscopic indices in IBD patients in University Clinical Hospital Mostar.

Babić E, Bevanda M, Karin M, Volarić M, Bevanda D, Glibo DB, Bogut A.

Psychiatr Danub. 2016 Dec;28 Suppl 2:242-246.

PMID:
28035129
30.

Corrigendum: PI3Kγ is a molecular switch that controls immune suppression.

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA.

Nature. 2017 Feb 2;542(7639):124. doi: 10.1038/nature21026. Epub 2016 Dec 14. No abstract available.

PMID:
27974794
31.

Targeting Inflammation in Cancer Prevention and Therapy.

Todoric J, Antonucci L, Karin M.

Cancer Prev Res (Phila). 2016 Dec;9(12):895-905. Epub 2016 Nov 10. Review.

32.

Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction.

Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U.

Cell. 2016 Nov 3;167(4):1052-1066.e18. doi: 10.1016/j.cell.2016.10.015.

33.

PI3Kγ is a molecular switch that controls immune suppression.

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA.

Nature. 2016 Nov 17;539(7629):437-442. doi: 10.1038/nature19834. Epub 2016 Sep 19. Erratum in: Nature. 2017 Feb 2;542(7639):124.

34.

p62 in Cancer: Signaling Adaptor Beyond Autophagy.

Moscat J, Karin M, Diaz-Meco MT.

Cell. 2016 Oct 20;167(3):606-609. doi: 10.1016/j.cell.2016.09.030. Review.

35.

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.

Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J.

Cancer Cell. 2016 Oct 10;30(4):595-609. doi: 10.1016/j.ccell.2016.09.004.

36.

Prevalence of amebiasis in inflammatory bowel disease in University Clinical Hospital Mostar.

Babić E, Bevanda M, Mimica M, Karin M, Volarić M, Bogut A, Barišić T, Pravdić D, Šutalo N.

Springerplus. 2016 Sep 15;5(1):1586. doi: 10.1186/s40064-016-3261-7. eCollection 2016.

37.

Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases.

Zhong Z, Sanchez-Lopez E, Karin M.

Clin Exp Rheumatol. 2016 Jul-Aug;34(4 Suppl 98):12-6. Epub 2016 Jul 21. Review.

38.

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment.

Zhong Z, Sanchez-Lopez E, Karin M.

Cell. 2016 Jul 14;166(2):288-298. doi: 10.1016/j.cell.2016.05.051. Review.

39.

p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.

Taniguchi K, Yamachika S, He F, Karin M.

FEBS Lett. 2016 Aug;590(15):2375-97. doi: 10.1002/1873-3468.12301. Epub 2016 Aug 6. Review.

40.

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.

Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T.

Hepatology. 2016 Oct;64(4):1217-31. doi: 10.1002/hep.28723. Epub 2016 Aug 11.

PMID:
27396433
41.

Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer.

McLoed AG, Sherrill TP, Cheng DS, Han W, Saxon JA, Gleaves LA, Wu P, Polosukhin VV, Karin M, Yull FE, Stathopoulos GT, Georgoulias V, Zaynagetdinov R, Blackwell TS.

Cell Rep. 2016 Jun 28;16(1):120-132. doi: 10.1016/j.celrep.2016.05.085. Epub 2016 Jun 16.

42.

Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

Lee JH, Cho US, Karin M.

Sci Signal. 2016 Jun 7;9(431):re5. doi: 10.1126/scisignal.aaf2885. Review.

43.

The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease.

Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T.

Curr Pathobiol Rep. 2016 Mar;4(1):27-35. Epub 2016 Feb 19.

44.

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.

Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M.

Cancer Cell. 2016 Jun 13;29(6):935-948. doi: 10.1016/j.ccell.2016.04.006. Epub 2016 May 19.

45.

Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2.

Karin M, Dhar D.

Carcinogenesis. 2016 Jun;37(6):541-6. doi: 10.1093/carcin/bgw060. Epub 2016 May 4. Review.

46.

ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation.

de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E.

Nat Commun. 2016 May 17;7:11551. doi: 10.1038/ncomms11551.

47.

Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis.

Shalapour S, Karin M.

Cell Metab. 2016 May 10;23(5):759-61. doi: 10.1016/j.cmet.2016.04.018.

48.

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M.

Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057.

49.

Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38α-Dependent Restraint of NF-κB Signaling.

Caballero-Franco C, Guma M, Choo MK, Sano Y, Enzler T, Karin M, Mizoguchi A, Park JM.

J Immunol. 2016 Mar 1;196(5):2368-76. doi: 10.4049/jimmunol.1501724. Epub 2016 Jan 20.

50.

Reparative inflammation takes charge of tissue regeneration.

Karin M, Clevers H.

Nature. 2016 Jan 21;529(7586):307-15. doi: 10.1038/nature17039. Review.

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