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Genetic background influences hepcidin response to iron imbalance in a mouse model of hemolytic anemia (Congenital erythropoietic porphyria).

Lefebvre T, Millot S, Richard E, Blouin JM, Lalanne M, Lamrissi-Garcia I, Costet P, Lyoumi S, Gouya L, Puy H, Moreau-Gaudry F, de Verneuil H, Karim Z, Ged C.

Biochem Biophys Res Commun. 2019 Oct 7. pii: S0006-291X(19)31886-8. doi: 10.1016/j.bbrc.2019.09.141. [Epub ahead of print]


The effects of hookah/waterpipe smoking on general health and the cardiovascular system.

Qasim H, Alarabi AB, Alzoubi KH, Karim ZA, Alshbool FZ, Khasawneh FT.

Environ Health Prev Med. 2019 Sep 14;24(1):58. doi: 10.1186/s12199-019-0811-y.


Mouse transient receptor potential channel type 6 selectively regulates agonist-induced platelet function.

Paez Espinosa EV, Lin OA, Karim ZA, Alshbool FZ, Khasawneh FT.

Biochem Biophys Rep. 2019 Aug 31;20:100685. doi: 10.1016/j.bbrep.2019.100685. eCollection 2019 Dec.


Extrahepatic hepcidin production: The intriguing outcomes of recent years.

Daher R, Lefebvre T, Puy H, Karim Z.

World J Clin Cases. 2019 Aug 6;7(15):1926-1936. doi: 10.12998/wjcc.v7.i15.1926. Review.


Processing-Structure-Property Correlation Understanding of Microfibrillated Cellulose Based Dimensional Structures for Ferric Ions Removal.

Karim Z, Svedberg A, Lee KY, Khan MJ.

Sci Rep. 2019 Jul 16;9(1):10277. doi: 10.1038/s41598-019-46812-6.


A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome.

Bondu S, Alary AS, Lefèvre C, Houy A, Jung G, Lefebvre T, Rombaut D, Boussaid I, Bousta A, Guillonneau F, Perrier P, Alsafadi S, Wassef M, Margueron R, Rousseau A, Droin N, Cagnard N, Kaltenbach S, Winter S, Kubasch AS, Bouscary D, Santini V, Toma A, Hunault M, Stamatoullas A, Gyan E, Cluzeau T, Platzbecker U, Adès L, Puy H, Stern MH, Karim Z, Mayeux P, Nemeth E, Park S, Ganz T, Kautz L, Kosmider O, Fontenay M.

Sci Transl Med. 2019 Jul 10;11(500). pii: eaav5467. doi: 10.1126/scitranslmed.aav5467.


OMERACT agreement and reliability study of ultrasonographic elementary lesions in osteoarthritis of the foot.

Zabotti A, Filippou G, Canzoni M, Adinolfi A, Picerno V, Carrara G, Balint P, Bruyn G, D'Agostino MA, Damjanov N, Delle Sedie A, Filippucci E, Gonzalez Fernandez ML, Hammer HB, Karim Z, Mandl P, Moller I, Morales Lozano MR, Naredo E, Porta F, Sakellariou G, Terslev L, Scirè CA, Iagnocco A; OMERACT Ultrasound Task Force members .

RMD Open. 2019 Mar 8;5(1):e000795. doi: 10.1136/rmdopen-2018-000795. eCollection 2019.


Arhgef1 Plays a Vital Role in Platelet Function and Thrombogenesis.

Qasim H, Karim ZA, Hernandez KR, Lozano D, Khasawneh FT, Alshbool FZ.

J Am Heart Assoc. 2019 May 7;8(9):e011712. doi: 10.1161/JAHA.118.011712.


Regulator of G-Protein Signaling 16 Is a Negative Modulator of Platelet Function and Thrombosis.

Hernandez KR, Karim ZA, Qasim H, Druey KM, Alshbool FZ, Khasawneh FT.

J Am Heart Assoc. 2019 Mar 5;8(5):e011273. doi: 10.1161/JAHA.118.011273.


Acquired Protein S Deficiency in a Patient with Lupus Nephritis.

Meriam H, Soumaya B, Lamia R, Karim ZM.

Saudi J Med Med Sci. 2019 Jan-Apr;7(1):51-52. doi: 10.4103/sjmms.sjmms_22_17. Epub 2018 Dec 14. No abstract available.


Regulation and tissue-specific expression of δ-aminolevulinic acid synthases in non-syndromic sideroblastic anemias and porphyrias.

Peoc'h K, Nicolas G, Schmitt C, Mirmiran A, Daher R, Lefebvre T, Gouya L, Karim Z, Puy H.

Mol Genet Metab. 2019 Jan 23. pii: S1096-7192(18)30632-2. doi: 10.1016/j.ymgme.2019.01.015. [Epub ahead of print] Review.


Erythroid-Progenitor-Targeted Gene Therapy Using Bifunctional TFR1 Ligand-Peptides in Human Erythropoietic Protoporphyria.

Mirmiran A, Schmitt C, Lefebvre T, Manceau H, Daher R, Oustric V, Poli A, Lacapère JJ, Moulouel B, Puy H, Karim Z, Peoc'h K, Lenglet H, Simonin S, Deybach JC, Nicolas G, Gouya L.

Am J Hum Genet. 2019 Feb 7;104(2):341-347. doi: 10.1016/j.ajhg.2018.12.021. Epub 2019 Jan 31.


Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1.

Rio S, Gastou M, Karboul N, Derman R, Suriyun T, Manceau H, Leblanc T, El Benna J, Schmitt C, Azouzi S, Larghéro J, Karim Z, Macias-Garcia A, Chen JJ, Hermine O, Courtois G, Puy H, Gouya L, Mohandas N, Da Costa L.

Blood. 2019 Mar 21;133(12):1358-1370. doi: 10.1182/blood-2018-09-875674. Epub 2019 Jan 30.


The Relevancy of Data Regarding the Metabolism of Iron to Our Understanding of Deregulated Mechanisms in ALS; Hypotheses and Pitfalls.

Petillon C, Hergesheimer R, Puy H, Corcia P, Vourc'h P, Andres C, Karim Z, Blasco H.

Front Neurosci. 2019 Jan 15;12:1031. doi: 10.3389/fnins.2018.01031. eCollection 2018. Review.


GLRX5 mutations impair heme biosynthetic enzymes ALA synthase 2 and ferrochelatase in Human congenital sideroblastic anemia.

Daher R, Mansouri A, Martelli A, Bayart S, Manceau H, Callebaut I, Moulouel B, Gouya L, Puy H, Kannengiesser C, Karim Z.

Mol Genet Metab. 2019 Jan 7. pii: S1096-7192(18)30633-4. doi: 10.1016/j.ymgme.2018.12.012. [Epub ahead of print]


Hepatocellular carcinoma in acute hepatic porphyrias: A Damocles Sword.

Peoc'h K, Manceau H, Karim Z, Wahlin S, Gouya L, Puy H, Deybach JC.

Mol Genet Metab. 2018 Oct 9. pii: S1096-7192(18)30482-7. doi: 10.1016/j.ymgme.2018.10.001. [Epub ahead of print]


Author Correction: Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine.

Zhu Y, Romero EL, Ren X, Sanca AJ, Du C, Liu C, Karim ZA, Alshbool FZ, Khasawneh FT, Zhou J, Zhong D, Geng B.

Nat Commun. 2018 Oct 10;9(1):4278. doi: 10.1038/s41467-018-06832-8.


Dyserythropoiesis evaluated by the RED score and hepcidin:ferritin ratio predicts response to erythropoietin in lower-risk myelodysplastic syndromes.

Park S, Kosmider O, Maloisel F, Drenou B, Chapuis N, Lefebvre T, Karim Z, Puy H, Alary AS, Ducamp S, Verdier F, Bouilloux C, Rousseau A, Jacob MC, Debliquis A, Charpentier A, Gyan E, Anglaret B, Leyronnas C, Corm S, Slama B, Cheze S, Laribi K, Amé S, Rose C, Lachenal F, Toma A, Pica GM, Carre M, Garban F, Mariette C, Cahn JY, Meunier M, Herault O, Fenaux P, Wagner-Ballon O, Bardet V, Dreyfus F, Fontenay M.

Haematologica. 2019 Mar;104(3):497-504. doi: 10.3324/haematol.2018.203158. Epub 2018 Oct 4.


Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine.

Zhu Y, Romero EL, Ren X, Sanca AJ, Du C, Liu C, Karim ZA, Alshbool FZ, Khasawneh FT, Zhou J, Zhong D, Geng B.

Nat Commun. 2018 Sep 27;9(1):3952. doi: 10.1038/s41467-018-06373-0. Erratum in: Nat Commun. 2018 Oct 10;9(1):4278.


Thin Film Composite Membrane for Oily Waste Water Treatment: Recent Advances and Challenges.

Ahmad NA, Goh PS, Abdul Karim Z, Ismail AF.

Membranes (Basel). 2018 Sep 21;8(4). pii: E86. doi: 10.3390/membranes8040086. Review.


Functional erythropoietin-hepcidin axis in recombinant human erythropoietin independent haemodialysis patients.

Touzot M, Lefebvre T, Roux A, Maheas C, Ridel C, Puy H, Karim Z.

Nephrology (Carlton). 2019 Jul;24(7):751-757. doi: 10.1111/nep.13485. Epub 2019 Apr 25.


Short-Term E-Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice.

Qasim H, Karim ZA, Silva-Espinoza JC, Khasawneh FT, Rivera JO, Ellis CC, Bauer SL, Almeida IC, Alshbool FZ.

J Am Heart Assoc. 2018 Jul 18;7(15). pii: e009264. doi: 10.1161/JAHA.118.009264.


Investigation of a Thromboxane A2 Receptor-Based Vaccine for Managing Thrombogenesis.

Alshbool FZ, Karim ZA, Espinosa EVP, Lin OA, Khasawneh FT.

J Am Heart Assoc. 2018 Jun 23;7(13). pii: e009139. doi: 10.1161/JAHA.118.009139.


High urinary ferritin reflects myoglobin iron evacuation in DMD patients.

Rouillon J, Lefebvre T, Denard J, Puy V, Daher R, Ausseil J, Zocevic A, Fogel P, Peoc'h K, Wong B, Servais L, Voit T, Puy H, Karim Z, Svinartchouk F.

Neuromuscul Disord. 2018 Jul;28(7):564-571. doi: 10.1016/j.nmd.2018.03.008. Epub 2018 Mar 20.


Role of IκB kinase β in regulating the remodeling of the CARMA1-Bcl10-MALT1 complex.

Karim ZA, Hensch NR, Qasim H, Alshbool FZ, Khasawneh FT.

Biochem Biophys Res Commun. 2018 Jun 2;500(2):268-274. doi: 10.1016/j.bbrc.2018.04.057. Epub 2018 Apr 14.


Porphyria and kidney diseases.

Pallet N, Karras A, Thervet E, Gouya L, Karim Z, Puy H.

Clin Kidney J. 2018 Apr;11(2):191-197. doi: 10.1093/ckj/sfx146. Epub 2018 Jan 10.


Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease.

Puy V, Darwiche W, Trudel S, Gomila C, Lony C, Puy L, Lefebvre T, Vitry S, Boullier A, Karim Z, Ausseil J.

Glia. 2018 Aug;66(8):1709-1723. doi: 10.1002/glia.23335. Epub 2018 Apr 6.


Isolation and characterization of nanocrystalline cellulose from roselle-derived microcrystalline cellulose.

Kian LK, Jawaid M, Ariffin H, Karim Z.

Int J Biol Macromol. 2018 Jul 15;114:54-63. doi: 10.1016/j.ijbiomac.2018.03.065. Epub 2018 Mar 15.


Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver.

Schmitt C, Lenglet H, Yu A, Delaby C, Benecke A, Lefebvre T, Letteron P, Paradis V, Wahlin S, Sandberg S, Harper P, Sardh E, Sandvik AK, Hov JR, Aarsand AK, Chiche L, Bazille C, Scoazec JY, To-Figueras J, Carrascal M, Abian J, Mirmiran A, Karim Z, Deybach JC, Puy H, Peoc'h K, Manceau H, Gouya L.

J Intern Med. 2018 Jul;284(1):78-91. doi: 10.1111/joim.12750. Epub 2018 Mar 26.


From a dominant to an oligogenic model of inheritance with environmental modifiers in acute intermittent porphyria.

Lenglet H, Schmitt C, Grange T, Manceau H, Karboul N, Bouchet-Crivat F, Robreau AM, Nicolas G, Lamoril J, Simonin S, Mirmiran A, Karim Z, Casalino E, Deybach JC, Puy H, Peoc'h K, Gouya L.

Hum Mol Genet. 2018 Apr 1;27(7):1164-1173. doi: 10.1093/hmg/ddy030.


Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease.

Lefebvre T, Reihani N, Daher R, de Villemeur TB, Belmatoug N, Rose C, Colin-Aronovicz Y, Puy H, Le Van Kim C, Franco M, Karim Z.

Haematologica. 2018 Apr;103(4):587-596. doi: 10.3324/haematol.2017.177816. Epub 2018 Jan 5.


Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease.

Daher R, Manceau H, Karim Z.

Presse Med. 2017 Dec;46(12 Pt 2):e272-e278. doi: 10.1016/j.lpm.2017.10.006. Epub 2017 Nov 10. Review.


P2Y12 antibody inhibits platelet activity and protects against thrombogenesis.

Hensch NR, Karim ZA, Pineda J, Mercado N, Alshbool FZ, Khasawneh FT.

Biochem Biophys Res Commun. 2017 Nov 18;493(2):1069-1074. doi: 10.1016/j.bbrc.2017.09.083. Epub 2017 Sep 18.


Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria.

Yien YY, Ducamp S, van der Vorm LN, Kardon JR, Manceau H, Kannengiesser C, Bergonia HA, Kafina MD, Karim Z, Gouya L, Baker TA, Puy H, Phillips JD, Nicolas G, Paw BH.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8045-E8052. doi: 10.1073/pnas.1700632114. Epub 2017 Sep 5.


Impact of Electronic Cigarettes on the Cardiovascular System.

Qasim H, Karim ZA, Rivera JO, Khasawneh FT, Alshbool FZ.

J Am Heart Assoc. 2017 Aug 30;6(9). pii: e006353. doi: 10.1161/JAHA.117.006353. Review. No abstract available.


Iron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes.

Bakouh N, Bellanca S, Nyboer B, Moliner Cubel S, Karim Z, Sanchez CP, Stein WD, Planelles G, Lanzer M.

J Biol Chem. 2017 Sep 29;292(39):16109-16121. doi: 10.1074/jbc.M117.805200. Epub 2017 Aug 2.


Iron metabolism: State of the art.

Daher R, Karim Z.

Transfus Clin Biol. 2017 Sep;24(3):115-119. doi: 10.1016/j.tracli.2017.06.015. Epub 2017 Jul 8. Review.


Management of iron overload in hemoglobinopathies.

Allali S, de Montalembert M, Brousse V, Chalumeau M, Karim Z.

Transfus Clin Biol. 2017 Sep;24(3):223-226. doi: 10.1016/j.tracli.2017.06.008. Epub 2017 Jun 30. Review.


Iron status and inflammatory biomarkers in patients with acutely decompensated heart failure: early in-hospital phase and 30-day follow-up.

Van Aelst LNL, Abraham M, Sadoune M, Lefebvre T, Manivet P, Logeart D, Launay JM, Karim Z, Puy H, Cohen-Solal A.

Eur J Heart Fail. 2017 Aug;19(8):1075-1076. doi: 10.1002/ejhf.837. Epub 2017 May 17. No abstract available.


CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia.

Raballah E, Kempaiah P, Karim Z, Orinda GO, Otieno MF, Perkins DJ, Ong'echa JM.

PLoS One. 2017 Apr 20;12(4):e0175864. doi: 10.1371/journal.pone.0175864. eCollection 2017.


Cardiac iron overload in chronically transfused patients with thalassemia, sickle cell anemia, or myelodysplastic syndrome.

de Montalembert M, Ribeil JA, Brousse V, Guerci-Bresler A, Stamatoullas A, Vannier JP, Dumesnil C, Lahary A, Touati M, Bouabdallah K, Cavazzana M, Chauzit E, Baptiste A, Lefebvre T, Puy H, Elie C, Karim Z, Ernst O, Rose C.

PLoS One. 2017 Mar 3;12(3):e0172147. doi: 10.1371/journal.pone.0172147. eCollection 2017.


Hemolytic anemia repressed hepcidin level without hepatocyte iron overload: lesson from Günther disease model.

Millot S, Delaby C, Moulouel B, Lefebvre T, Pilard N, Ducrot N, Ged C, Lettéron P, de Franceschi L, Deybach JC, Beaumont C, Gouya L, De Verneuil H, Lyoumi S, Puy H, Karim Z.

Haematologica. 2017 Feb;102(2):260-270. doi: 10.3324/haematol.2016.151621. Epub 2016 Nov 10.


A Variant of Peptide Transporter 2 Predicts the Severity of Porphyria-Associated Kidney Disease.

Tchernitchko D, Tavernier Q, Lamoril J, Schmitt C, Talbi N, Lyoumi S, Robreau AM, Karim Z, Gouya L, Thervet E, Karras A, Puy H, Pallet N.

J Am Soc Nephrol. 2017 Jun;28(6):1924-1932. doi: 10.1681/ASN.2016080918. Epub 2016 Dec 28.


RGS10 Negatively Regulates Platelet Activation and Thrombogenesis.

Hensch NR, Karim ZA, Druey KM, Tansey MG, Khasawneh FT.

PLoS One. 2016 Nov 9;11(11):e0165984. doi: 10.1371/journal.pone.0165984. eCollection 2016.


Platelet Hyperactivity in TNFSF14/LIGHT Knockout Mouse Model of Impaired Healing.

Dhall S, Karim ZA, Khasawneh FT, Martins-Green M.

Adv Wound Care (New Rochelle). 2016 Oct 1;5(10):421-431.


Inhibitory effect of chlorogenic acid on digestion of potato starch.

Karim Z, Holmes M, Orfila C.

Food Chem. 2017 Feb 15;217:498-504. doi: 10.1016/j.foodchem.2016.08.058. Epub 2016 Aug 21.



Karim Z, Puy H, Beaumont C, Gouya L, Kannengiesser C.

Gastroenterology. 2016 Oct;151(4):771-2. doi: 10.1053/j.gastro.2016.09.002. Epub 2016 Sep 10. No abstract available.


Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp70 and NF-κB activation.

Kempaiah P, Dokladny K, Karim Z, Raballah E, Ong'echa JM, Moseley PL, Perkins DJ.

Mol Med. 2016 Oct;22:570-584. doi: 10.2119/molmed.2016.00130. Epub 2016 Aug 30.


Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation.

Davenport GC, Hittner JB, Otieno V, Karim Z, Mukundan H, Fenimore PW, Hengartner NW, McMahon BH, Kempaiah P, Ong'echa JM, Perkins DJ.

Mediators Inflamm. 2016;2016:4286576. doi: 10.1155/2016/4286576. Epub 2016 Jun 22.


Necessity of enzymatic hydrolysis for production and functionalization of nanocelluloses.

Karim Z, Afrin S, Husain Q, Danish R.

Crit Rev Biotechnol. 2017 May;37(3):355-370. doi: 10.3109/07388551.2016.1163322. Epub 2016 Apr 6. Review.


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