Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 82

1.

MGMT Promoter Methylation and Parathyroid Carcinoma.

Storvall S, Ryhänen E, Heiskanen I, Vesterinen T, Bensch FV, Schildt J, Kytölä S, Karhu A, Arola J, Schalin-Jäntti C.

J Endocr Soc. 2019 Jul 23;3(11):2114-2122. doi: 10.1210/js.2019-00175. eCollection 2019 Nov 1.

2.

Genetic and Epigenetic Characterization of Growth Hormone-Secreting Pituitary Tumors.

Välimäki N, Schalin-Jäntti C, Karppinen A, Paetau A, Kivipelto L, Aaltonen LA, Karhu A.

Mol Cancer Res. 2019 Dec;17(12):2432-2443. doi: 10.1158/1541-7786.MCR-19-0434. Epub 2019 Oct 2.

PMID:
31578227
3.

Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans.

Kaasinen E, Kuismin O, Rajamäki K, Ristolainen H, Aavikko M, Kondelin J, Saarinen S, Berta DG, Katainen R, Hirvonen EAM, Karhu A, Taira A, Tanskanen T, Alkodsi A, Taipale M, Morgunova E, Franssila K, Lehtonen R, Mäkinen M, Aittomäki K, Palotie A, Kurki MI, Pietiläinen O, Hilpert M, Saarentaus E, Niinimäki J, Junttila J, Kaikkonen K, Vahteristo P, Skoda RC, Seppänen MRJ, Eklund KK, Taipale J, Kilpivaara O, Aaltonen LA.

Nat Commun. 2019 Mar 19;10(1):1252. doi: 10.1038/s41467-019-09198-7.

4.

Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer.

Kondelin J, Salokas K, Saarinen L, Ovaska K, Rauanheimo H, Plaketti RM, Hamberg J, Liu X, Yadav L, Gylfe AE, Cajuso T, Hänninen UA, Palin K, Ristolainen H, Katainen R, Kaasinen E, Tanskanen T, Aavikko M, Taipale M, Taipale J, Renkonen-Sinisalo L, Lepistö A, Koskensalo S, Böhm J, Mecklin JP, Ongen H, Dermitzakis ET, Kilpivaara O, Vahteristo P, Turunen M, Hautaniemi S, Tuupanen S, Karhu A, Välimäki N, Varjosalo M, Pitkänen E, Aaltonen LA.

EMBO Mol Med. 2018 Sep;10(9). pii: e8552. doi: 10.15252/emmm.201708552.

5.

Screening for germline KCNQ1 and KCNE2 mutations in a set of somatotropinoma patients.

Iivonen AP, Känsäkoski J, Karppinen A, Kivipelto L, Schalin-Jäntti C, Karhu A, Raivio T.

Endocr Connect. 2018 May;7(5):645-652. doi: 10.1530/EC-18-0123.

6.

Global metabolomic profiling of uterine leiomyomas.

Heinonen HR, Mehine M, Mäkinen N, Pasanen A, Pitkänen E, Karhu A, Sarvilinna NS, Sjöberg J, Heikinheimo O, Bützow R, Aaltonen LA, Kaasinen E.

Br J Cancer. 2017 Dec 5;117(12):1855-1864. doi: 10.1038/bjc.2017.361. Epub 2017 Oct 26.

7.

Impact of AIP and inhibitory G protein alpha 2 proteins on clinical features of sporadic GH-secreting pituitary adenomas.

Ritvonen E, Pitkänen E, Karppinen A, Vehkavaara S, Demir H, Paetau A, Schalin-Jäntti C, Karhu A.

Eur J Endocrinol. 2017 Feb;176(2):243-252. doi: 10.1530/EJE-16-0620.

PMID:
27998919
8.

Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice.

Lecoq AL, Zizzari P, Hage M, Decourtye L, Adam C, Viengchareun S, Veldhuis JD, Geoffroy V, Lombès M, Tolle V, Guillou A, Karhu A, Kappeler L, Chanson P, Kamenický P.

J Endocrinol. 2016 Oct;231(1):59-69. doi: 10.1530/JOE-16-0190.

PMID:
27621108
9.

The role of imidoselenium(II) chlorides in the formation of cyclic selenium imides via cyclocondensation.

Karhu AJ, Pakkanen OJ, Rautiainen JM, Oilunkaniemi R, Chivers T, Laitinen RS.

Dalton Trans. 2016 Apr 14;45(14):6210-21. doi: 10.1039/c5dt04236d.

PMID:
26629863
10.

Mercury- and cadmium-assisted [2 + 2] cyclodimerization of tert-butylselenium diimide.

Karhu AJ, Rautiainen JM, Oilunkaniemi R, Chivers T, Laitinen RS.

Inorg Chem. 2015 Oct 5;54(19):9499-508. doi: 10.1021/acs.inorgchem.5b01434. Epub 2015 Sep 17.

PMID:
26379047
11.

Whole-Genome Sequencing of Growth Hormone (GH)-Secreting Pituitary Adenomas.

Välimäki N, Demir H, Pitkänen E, Kaasinen E, Karppinen A, Kivipelto L, Schalin-Jäntti C, Aaltonen LA, Karhu A.

J Clin Endocrinol Metab. 2015 Oct;100(10):3918-27. doi: 10.1210/jc.2015-3129. Epub 2015 Aug 17.

PMID:
26280510
12.

Experimental and Computational (77)Se NMR Investigations of the Cyclic Eight-Membered Selenium Imides 1,3,5,7-Se4(NR)4 (R = Me, (t)Bu) and 1,5-Se6(NMe)2.

Karhu AJ, Pakkanen OJ, Rautiainen JM, Oilunkaniemi R, Chivers T, Laitinen RS.

Inorg Chem. 2015 May 18;54(10):4990-7. doi: 10.1021/acs.inorgchem.5b00582. Epub 2015 May 1.

PMID:
25932943
13.

Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas.

Demir H, Donner I, Kivipelto L, Kuismin O, Schalin-Jäntti C, De Menis E, Karhu A.

PLoS One. 2014 Oct 7;9(10):e109897. doi: 10.1371/journal.pone.0109897. eCollection 2014.

14.

Clinical characterization, genetic mapping and whole-genome sequence analysis of a novel autosomal recessive intellectual disability syndrome.

Kaasinen E, Rahikkala E, Koivunen P, Miettinen S, Wamelink MM, Aavikko M, Palin K, Myllyharju J, Moilanen JS, Pajunen L, Karhu A, Aaltonen LA.

Eur J Med Genet. 2014 Oct;57(10):543-51. doi: 10.1016/j.ejmg.2014.07.002. Epub 2014 Jul 29.

PMID:
25078763
15.

AIP inactivation leads to pituitary tumorigenesis through defective Gαi-cAMP signaling.

Tuominen I, Heliövaara E, Raitila A, Rautiainen MR, Mehine M, Katainen R, Donner I, Aittomäki V, Lehtonen HJ, Ahlsten M, Kivipelto L, Schalin-Jäntti C, Arola J, Hautaniemi S, Karhu A.

Oncogene. 2015 Feb 26;34(9):1174-84. doi: 10.1038/onc.2014.50. Epub 2014 Mar 24.

PMID:
24662816
16.

Eleven candidate susceptibility genes for common familial colorectal cancer.

Gylfe AE, Katainen R, Kondelin J, Tanskanen T, Cajuso T, Hänninen U, Taipale J, Taipale M, Renkonen-Sinisalo L, Järvinen H, Mecklin JP, Kilpivaara O, Pitkänen E, Vahteristo P, Tuupanen S, Karhu A, Aaltonen LA.

PLoS Genet. 2013;9(10):e1003876. doi: 10.1371/journal.pgen.1003876. Epub 2013 Oct 17.

17.

Identification of candidate oncogenes in human colorectal cancers with microsatellite instability.

Gylfe AE, Kondelin J, Turunen M, Ristolainen H, Katainen R, Pitkänen E, Kaasinen E, Rantanen V, Tanskanen T, Varjosalo M, Lehtonen H, Palin K, Taipale M, Taipale J, Renkonen-Sinisalo L, Järvinen H, Böhm J, Mecklin JP, Ristimäki A, Kilpivaara O, Tuupanen S, Karhu A, Vahteristo P, Aaltonen LA.

Gastroenterology. 2013 Sep;145(3):540-3.e22. doi: 10.1053/j.gastro.2013.05.015. Epub 2013 May 16.

PMID:
23684749
18.

Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.

Beckers A, Aaltonen LA, Daly AF, Karhu A.

Endocr Rev. 2013 Apr;34(2):239-77. doi: 10.1210/er.2012-1013. Epub 2013 Jan 31. Review.

19.

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

Sur IK, Hallikas O, Vähärautio A, Yan J, Turunen M, Enge M, Taipale M, Karhu A, Aaltonen LA, Taipale J.

Science. 2012 Dec 7;338(6112):1360-3. doi: 10.1126/science.1228606. Epub 2012 Nov 1.

20.

Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42,103 individuals.

Dunlop MG, Tenesa A, Farrington SM, Ballereau S, Brewster DH, Koessler T, Pharoah P, Schafmayer C, Hampe J, Völzke H, Chang-Claude J, Hoffmeister M, Brenner H, von Holst S, Picelli S, Lindblom A, Jenkins MA, Hopper JL, Casey G, Duggan D, Newcomb PA, Abulí A, Bessa X, Ruiz-Ponte C, Castellví-Bel S, Niittymäki I, Tuupanen S, Karhu A, Aaltonen L, Zanke B, Hudson T, Gallinger S, Barclay E, Martin L, Gorman M, Carvajal-Carmona L, Walther A, Kerr D, Lubbe S, Broderick P, Chandler I, Pittman A, Penegar S, Campbell H, Tomlinson I, Houlston RS.

Gut. 2013 Jun;62(6):871-81. doi: 10.1136/gutjnl-2011-300537. Epub 2012 Apr 5.

21.

Candidate driver genes in microsatellite-unstable colorectal cancer.

Alhopuro P, Sammalkorpi H, Niittymäki I, Biström M, Raitila A, Saharinen J, Nousiainen K, Lehtonen HJ, Heliövaara E, Puhakka J, Tuupanen S, Sousa S, Seruca R, Ferreira AM, Hofstra RM, Mecklin JP, Järvinen H, Ristimäki A, Orntoft TF, Hautaniemi S, Arango D, Karhu A, Aaltonen LA.

Int J Cancer. 2012 Apr 1;130(7):1558-66. doi: 10.1002/ijc.26167. Epub 2011 Aug 3.

22.

Somatic mutations and germline sequence variants in patients with familial colorectal cancer.

Gylfe AE, Sirkiä J, Ahlsten M, Järvinen H, Mecklin JP, Karhu A, Aaltonen LA.

Int J Cancer. 2010 Dec 15;127(12):2974-80. doi: 10.1002/ijc.25529.

23.

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

Niittymäki I, Tuupanen S, Li Y, Järvinen H, Mecklin JP, Tomlinson IP, Houlston RS, Karhu A, Aaltonen LA.

BMC Med Genet. 2011 Feb 14;12:23. doi: 10.1186/1471-2350-12-23.

24.

Downregulation of the hedgehog receptor PTCH1 in colorectal serrated adenocarcinomas is not caused by PTCH1 mutations.

Stefanius K, Kantola T, Tuomisto A, Vahteristo P, Karttunen TJ, Aaltonen LA, Mäkinen MJ, Karhu A.

Virchows Arch. 2011 Feb;458(2):213-9. doi: 10.1007/s00428-010-1031-4. Epub 2011 Jan 14.

PMID:
21234763
25.

High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint.

Niittymäki I, Gylfe A, Laine L, Laakso M, Lehtonen HJ, Kondelin J, Tolvanen J, Nousiainen K, Pouwels J, Järvinen H, Nuorva K, Mecklin JP, Mäkinen M, Ristimäki A, Ørntoft TF, Hautaniemi S, Karhu A, Kallio MJ, Aaltonen LA.

Carcinogenesis. 2011 Mar;32(3):305-11. doi: 10.1093/carcin/bgq272. Epub 2010 Dec 16.

PMID:
21163887
26.

No evidence of RET germline mutations in familial pituitary adenoma.

Heliövaara E, Tuupanen S, Ahlsten M, Hodgson S, de Menis E, Kuismin O, Izatt L, McKinlay Gardner RJ, Gundogdu S, Lucassen A, Arola J, Tuomisto A, Mäkinen M, Karhu A, Aaltonen LA.

J Mol Endocrinol. 2010 Dec 21;46(1):1-8. doi: 10.1677/JME-10-0052. Print 2011 Feb.

PMID:
20956458
27.

Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression.

Raitila A, Lehtonen HJ, Arola J, Heliövaara E, Ahlsten M, Georgitsi M, Jalanko A, Paetau A, Aaltonen LA, Karhu A.

Am J Pathol. 2010 Oct;177(4):1969-76. doi: 10.2353/ajpath.2010.100138. Epub 2010 Aug 13.

28.

Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study.

Daly AF, Tichomirowa MA, Petrossians P, Heliövaara E, Jaffrain-Rea ML, Barlier A, Naves LA, Ebeling T, Karhu A, Raappana A, Cazabat L, De Menis E, Montañana CF, Raverot G, Weil RJ, Sane T, Maiter D, Neggers S, Yaneva M, Tabarin A, Verrua E, Eloranta E, Murat A, Vierimaa O, Salmela PI, Emy P, Toledo RA, Sabaté MI, Villa C, Popelier M, Salvatori R, Jennings J, Longás AF, Labarta Aizpún JI, Georgitsi M, Paschke R, Ronchi C, Valimaki M, Saloranta C, De Herder W, Cozzi R, Guitelman M, Magri F, Lagonigro MS, Halaby G, Corman V, Hagelstein MT, Vanbellinghen JF, Barra GB, Gimenez-Roqueplo AP, Cameron FJ, Borson-Chazot F, Holdaway I, Toledo SP, Stalla GK, Spada A, Zacharieva S, Bertherat J, Brue T, Bours V, Chanson P, Aaltonen LA, Beckers A.

J Clin Endocrinol Metab. 2010 Nov;95(11):E373-83. doi: 10.1210/jc.2009-2556. Epub 2010 Aug 4.

29.

Mutations in the circadian gene CLOCK in colorectal cancer.

Alhopuro P, Björklund M, Sammalkorpi H, Turunen M, Tuupanen S, Biström M, Niittymäki I, Lehtonen HJ, Kivioja T, Launonen V, Saharinen J, Nousiainen K, Hautaniemi S, Nuorva K, Mecklin JP, Järvinen H, Orntoft T, Arango D, Lehtonen R, Karhu A, Taipale J, Aaltonen LA.

Mol Cancer Res. 2010 Jul;8(7):952-60. doi: 10.1158/1541-7786.MCR-10-0086. Epub 2010 Jun 15.

30.

Low-penetrance susceptibility variants in familial colorectal cancer.

Niittymäki I, Kaasinen E, Tuupanen S, Karhu A, Järvinen H, Mecklin JP, Tomlinson IP, Di Bernardo MC, Houlston RS, Aaltonen LA.

Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1478-83. doi: 10.1158/1055-9965.EPI-09-1320. Epub 2010 May 25.

31.

Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1).

Kaasinen E, Aittomäki K, Eronen M, Vahteristo P, Karhu A, Mecklin JP, Kajantie E, Aaltonen LA, Lehtonen R.

Hum Mol Genet. 2010 Jul 15;19(14):2747-53. doi: 10.1093/hmg/ddq164. Epub 2010 Apr 22.

PMID:
20413652
32.

No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome.

Vahteristo P, Koski TA, Näätsaari L, Kiuru M, Karhu A, Herva R, Sallinen SL, Vierimaa O, Björck E, Richard S, Gardie B, Bessis D, Van Glabeke E, Blanco I, Houlston R, Senter L, Hietala M, Aittomäki K, Aaltonen LA, Launonen V, Lehtonen R.

Fam Cancer. 2010 Jun;9(2):245-51. doi: 10.1007/s10689-009-9312-2.

PMID:
20091131
33.

Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours.

Velho S, Oliveira C, Paredes J, Sousa S, Leite M, Matos P, Milanezi F, Ribeiro AS, Mendes N, Licastro D, Karhu A, Oliveira MJ, Ligtenberg M, Hamelin R, Carneiro F, Lindblom A, Peltomaki P, Castedo S, Schwartz S Jr, Jordan P, Aaltonen LA, Hofstra RM, Suriano G, Stupka E, Fialho AM, Seruca R.

Hum Mol Genet. 2010 Feb 15;19(4):697-706. doi: 10.1093/hmg/ddp536. Epub 2009 Dec 2.

34.

The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas.

Heliövaara E, Raitila A, Launonen V, Paetau A, Arola J, Lehtonen H, Sane T, Weil RJ, Vierimaa O, Salmela P, Tuppurainen K, Mäkinen M, Aaltonen LA, Karhu A.

Am J Pathol. 2009 Dec;175(6):2501-7. doi: 10.2353/ajpath.2009.081131. Epub 2009 Oct 22.

35.

Aryl hydrocarbon receptor interacting protein mutations seem not to associate with familial non-medullary thyroid cancer.

Raitila A, Georgitsi M, Bonora E, Vargiolu M, Tuppurainen K, Mäkinen MJ, Vierimaa O, Salmela PI, Launonen V, Vahteristo P, Aaltonen LA, Romeo G, Karhu A.

J Endocrinol Invest. 2009 May;32(5):426-9.

PMID:
19794292
36.

Aggressive pituitary adenomas occurring in young patients in a large Polynesian kindred with a germline R271W mutation in the AIP gene.

Jennings JE, Georgitsi M, Holdaway I, Daly AF, Tichomirowa M, Beckers A, Aaltonen LA, Karhu A, Cameron FJ.

Eur J Endocrinol. 2009 Nov;161(5):799-804. doi: 10.1530/EJE-09-0406. Epub 2009 Aug 14.

37.

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

Tuupanen S, Turunen M, Lehtonen R, Hallikas O, Vanharanta S, Kivioja T, Björklund M, Wei G, Yan J, Niittymäki I, Mecklin JP, Järvinen H, Ristimäki A, Di-Bernardo M, East P, Carvajal-Carmona L, Houlston RS, Tomlinson I, Palin K, Ukkonen E, Karhu A, Taipale J, Aaltonen LA.

Nat Genet. 2009 Aug;41(8):885-90. doi: 10.1038/ng.406. Epub 2009 Jun 28.

PMID:
19561604
38.

Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer.

Koski TA, Lehtonen HJ, Jee KJ, Ninomiya S, Joosse SA, Vahteristo P, Kiuru M, Karhu A, Sammalkorpi H, Vanharanta S, Lehtonen R, Edgren H, Nederlof PM, Hietala M, Aittomäki K, Herva R, Knuutila S, Aaltonen LA, Launonen V.

Genes Chromosomes Cancer. 2009 Jul;48(7):544-51. doi: 10.1002/gcc.20663.

PMID:
19373782
39.

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.

COGENT Study, Houlston RS, Webb E, Broderick P, Pittman AM, Di Bernardo MC, Lubbe S, Chandler I, Vijayakrishnan J, Sullivan K, Penegar S; Colorectal Cancer Association Study Consortium, Carvajal-Carmona L, Howarth K, Jaeger E, Spain SL, Walther A, Barclay E, Martin L, Gorman M, Domingo E, Teixeira AS; CoRGI Consortium, Kerr D, Cazier JB, Niittymäki I, Tuupanen S, Karhu A, Aaltonen LA, Tomlinson IP, Farrington SM, Tenesa A, Prendergast JG, Barnetson RA, Cetnarskyj R, Porteous ME, Pharoah PD, Koessler T, Hampe J, Buch S, Schafmayer C, Tepel J, Schreiber S, Völzke H, Chang-Claude J, Hoffmeister M, Brenner H, Zanke BW, Montpetit A, Hudson TJ, Gallinger S, Campbell H, Dunlop MG.

Nat Genet. 2008 Dec;40(12):1426-35. doi: 10.1038/ng.262. Epub 2008 Nov 16.

40.

Mutation analysis of MYH11 in acute myeloid leukemia.

Sammalkorpi H, Alhopuro P, Niittymäki I, Orntoft TF, Hokland P, Karhu A, Aaltonen LA.

Leuk Lymphoma. 2008 Sep;49(9):1829-31. doi: 10.1080/10428190802203796. No abstract available.

PMID:
18798114
41.

Somatic mutation analysis of MYH11 in breast and prostate cancer.

Alhopuro P, Karhu A, Winqvist R, Waltering K, Visakorpi T, Aaltonen LA.

BMC Cancer. 2008 Sep 17;8:263. doi: 10.1186/1471-2407-8-263.

42.

Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer.

Pittman AM, Webb E, Carvajal-Carmona L, Howarth K, Di Bernardo MC, Broderick P, Spain S, Walther A, Price A, Sullivan K, Twiss P, Fielding S, Rowan A, Jaeger E, Vijayakrishnan J, Chandler I, Penegar S, Qureshi M, Lubbe S, Domingo E, Kemp Z, Barclay E, Wood W, Martin L, Gorman M, Thomas H, Peto J, Bishop T, Gray R, Maher ER, Lucassen A, Kerr D, Evans GR; CORGI Consortium, van Wezel T, Morreau H, Wijnen JT, Hopper JL, Southey MC, Giles GG, Severi G, Castellví-Bel S, Ruiz-Ponte C, Carracedo A, Castells A; EPICOLON Consortium, Försti A, Hemminki K, Vodicka P, Naccarati A, Lipton L, Ho JW, Cheng KK, Sham PC, Luk J, Agúndez JA, Ladero JM, de la Hoya M, Caldés T, Niittymäki I, Tuupanen S, Karhu A, Aaltonen LA, Cazier JB, Tomlinson IP, Houlston RS.

Hum Mol Genet. 2008 Dec 1;17(23):3720-7. doi: 10.1093/hmg/ddn267. Epub 2008 Aug 27.

PMID:
18753146
43.

Large genomic deletions in AIP in pituitary adenoma predisposition.

Georgitsi M, Heliövaara E, Paschke R, Kumar AV, Tischkowitz M, Vierimaa O, Salmela P, Sane T, De Menis E, Cannavò S, Gündogdu S, Lucassen A, Izatt L, Aylwin S, Bano G, Hodgson S, Koch CA, Karhu A, Aaltonen LA.

J Clin Endocrinol Metab. 2008 Oct;93(10):4146-51. doi: 10.1210/jc.2008-1003. Epub 2008 Jul 15.

PMID:
18628514
44.

Aryl hydrocarbon receptor interacting protein (AIP) gene mutation analysis in children and adolescents with sporadic pituitary adenomas.

Georgitsi M, De Menis E, Cannavò S, Mäkinen MJ, Tuppurainen K, Pauletto P, Curtò L, Weil RJ, Paschke R, Zielinski G, Wasik A, Lubinski J, Vahteristo P, Karhu A, Aaltonen LA.

Clin Endocrinol (Oxf). 2008 Oct;69(4):621-7. doi: 10.1111/j.1365-2265.2008.03266.x. Epub 2008 Apr 10.

PMID:
18410548
45.

Unregulated smooth-muscle myosin in human intestinal neoplasia.

Alhopuro P, Phichith D, Tuupanen S, Sammalkorpi H, Nybondas M, Saharinen J, Robinson JP, Yang Z, Chen LQ, Orntoft T, Mecklin JP, Järvinen H, Eng C, Moeslein G, Shibata D, Houlston RS, Lucassen A, Tomlinson IP, Launonen V, Ristimäki A, Arango D, Karhu A, Sweeney HL, Aaltonen LA.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5513-8. doi: 10.1073/pnas.0801213105. Epub 2008 Apr 7.

46.

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

Tomlinson IP, Webb E, Carvajal-Carmona L, Broderick P, Howarth K, Pittman AM, Spain S, Lubbe S, Walther A, Sullivan K, Jaeger E, Fielding S, Rowan A, Vijayakrishnan J, Domingo E, Chandler I, Kemp Z, Qureshi M, Farrington SM, Tenesa A, Prendergast JG, Barnetson RA, Penegar S, Barclay E, Wood W, Martin L, Gorman M, Thomas H, Peto J, Bishop DT, Gray R, Maher ER, Lucassen A, Kerr D, Evans DG; CORGI Consortium, Schafmayer C, Buch S, Völzke H, Hampe J, Schreiber S, John U, Koessler T, Pharoah P, van Wezel T, Morreau H, Wijnen JT, Hopper JL, Southey MC, Giles GG, Severi G, Castellví-Bel S, Ruiz-Ponte C, Carracedo A, Castells A; EPICOLON Consortium, Försti A, Hemminki K, Vodicka P, Naccarati A, Lipton L, Ho JW, Cheng KK, Sham PC, Luk J, Agúndez JA, Ladero JM, de la Hoya M, Caldés T, Niittymäki I, Tuupanen S, Karhu A, Aaltonen L, Cazier JB, Campbell H, Dunlop MG, Houlston RS.

Nat Genet. 2008 May;40(5):623-30. doi: 10.1038/ng.111. Epub 2008 Mar 30.

PMID:
18372905
47.

Stress-induced expression of a novel variant of human fumarate hydratase (FH).

Lehtonen HJ, Ylisaukko-Oja SK, Kiuru M, Karhu A, Lehtonen R, Vanharanta S, Jalanko A, Aaltonen LA, Launonen V.

Gene Expr. 2007;14(2):59-69.

48.

Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.

Tuupanen S, Niittymäki I, Nousiainen K, Vanharanta S, Mecklin JP, Nuorva K, Järvinen H, Hautaniemi S, Karhu A, Aaltonen LA.

Cancer Res. 2008 Jan 1;68(1):14-7. doi: 10.1158/0008-5472.CAN-07-5766.

49.

No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.

Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Mäkinen MJ, Birkenkamp-Demtröder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA.

Endocr Relat Cancer. 2007 Sep;14(3):901-6.

PMID:
17914118
50.

Susceptibility to pituitary neoplasia related to MEN-1, CDKN1B and AIP mutations: an update.

Karhu A, Aaltonen LA.

Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R73-9. Review.

PMID:
17613551

Supplemental Content

Support Center