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Paul Vouros and northeastern university/barnett institute.

Karger BL.

Mass Spectrom Rev. 2019 Mar 7. doi: 10.1002/mas.21593. [Epub ahead of print] Review. No abstract available.


Multi-Omics Study on the Impact of Cysteine Feed Level on Cell Viability and mAb Production in a CHO Bioprocess.

Ali AS, Raju R, Kshirsagar R, Ivanov AR, Gilbert A, Zang L, Karger BL.

Biotechnol J. 2019 Apr;14(4):e1800352. doi: 10.1002/biot.201800352. Epub 2018 Dec 14.


Complementary middle-down and intact monoclonal antibody proteoform characterization by capillary zone electrophoresis - mass spectrometry.

Belov AM, Zang L, Sebastiano R, Santos MR, Bush DR, Karger BL, Ivanov AR.

Electrophoresis. 2018 Aug;39(16):2069-2082. doi: 10.1002/elps.201800067. Epub 2018 Jun 5.


Lipidomics of CHO Cell Bioprocessing: Relation to Cell Growth and Specific Productivity of a Monoclonal Antibody.

Ali AS, Raju R, Ray S, Kshirsagar R, Gilbert A, Zang L, Karger BL.

Biotechnol J. 2018 Oct;13(10):e1700745. doi: 10.1002/biot.201700745. Epub 2018 Mar 26.


Analysis of Proteins, Protein Complexes, and Organellar Proteomes Using Sheathless Capillary Zone Electrophoresis - Native Mass Spectrometry.

Belov AM, Viner R, Santos MR, Horn DM, Bern M, Karger BL, Ivanov AR.

J Am Soc Mass Spectrom. 2017 Dec;28(12):2614-2634. doi: 10.1007/s13361-017-1781-1. Epub 2017 Sep 5.


Host Cell Protein Profiling by Targeted and Untargeted Analysis of Data Independent Acquisition Mass Spectrometry Data with Parallel Reaction Monitoring Verification.

Kreimer S, Gao Y, Ray S, Jin M, Tan Z, Mussa NA, Tao L, Li Z, Ivanov AR, Karger BL.

Anal Chem. 2017 May 16;89(10):5294-5302. doi: 10.1021/acs.analchem.6b04892. Epub 2017 Apr 26.


Binding Site Characterization of AM1336, a Novel Covalent Inverse Agonist at Human Cannabinoid 2 Receptor, Using Mass Spectrometric Analysis.

Mallipeddi S, Kreimer S, Zvonok N, Vemuri K, Karger BL, Ivanov AR, Makriyannis A.

J Proteome Res. 2017 Jul 7;16(7):2419-2428. doi: 10.1021/acs.jproteome.7b00023. Epub 2017 Jun 19.


Advanced Precursor Ion Selection Algorithms for Increased Depth of Bottom-Up Proteomic Profiling.

Kreimer S, Belov ME, Danielson WF, Levitsky LI, Gorshkov MV, Karger BL, Ivanov AR.

J Proteome Res. 2016 Oct 7;15(10):3563-3573. Epub 2016 Sep 7.


Combined metabolomics and proteomics reveals hypoxia as a cause of lower productivity on scale-up to a 5000-liter CHO bioprocess.

Gao Y, Ray S, Dai S, Ivanov AR, Abu-Absi NR, Lewis AM, Huang Z, Xing Z, Borys MC, Li ZJ, Karger BL.

Biotechnol J. 2016 Sep;11(9):1190-200. doi: 10.1002/biot.201600030. Epub 2016 Jun 29.


High Resolution CZE-MS Quantitative Characterization of Intact Biopharmaceutical Proteins: Proteoforms of Interferon-β1.

Bush DR, Zang L, Belov AM, Ivanov AR, Karger BL.

Anal Chem. 2016 Jan 19;88(2):1138-46. doi: 10.1021/acs.analchem.5b03218. Epub 2015 Dec 24.


A quantitative proteomic analysis of cellular responses to high glucose media in Chinese hamster ovary cells.

Liu Z, Dai S, Bones J, Ray S, Cha S, Karger BL, Li JJ, Wilson L, Hinckle G, Rossomando A.

Biotechnol Prog. 2015 Jul-Aug;31(4):1026-38. doi: 10.1002/btpr.2090. Epub 2015 Apr 29.


Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity.

Keskin DB, Reinhold BR, Zhang GL, Ivanov AR, Karger BL, Reinherz EL.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2418. doi: 10.1073/pnas.1503931112. Epub 2015 Apr 6. No abstract available. Erratum in: Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2845.


An Integrated Platform for Isolation, Processing, and Mass Spectrometry-based Proteomic Profiling of Rare Cells in Whole Blood.

Li S, Plouffe BD, Belov AM, Ray S, Wang X, Murthy SK, Karger BL, Ivanov AR.

Mol Cell Proteomics. 2015 Jun;14(6):1672-83. doi: 10.1074/mcp.M114.045724. Epub 2015 Mar 9.


Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity.

Keskin DB, Reinhold BB, Zhang GL, Ivanov AR, Karger BL, Reinherz EL.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2151-6. doi: 10.1073/pnas.1423482112. Epub 2015 Feb 2.


Tumor antigens as proteogenomic biomarkers in invasive ductal carcinomas.

Olsen L, Campos B, Winther O, Sgroi DC, Karger BL, Brusic V.

BMC Med Genomics. 2014;7 Suppl 3:S2. doi: 10.1186/1755-8794-7-S3-S2. Epub 2014 Dec 8.


Pathway analysis and transcriptomics improve protein identification by shotgun proteomics from samples comprising small number of cells--a benchmarking study.

Sun J, Zhang GL, Li S, Ivanov AR, Fenyo D, Lisacek F, Murthy SK, Karger BL, Brusic V.

BMC Genomics. 2014;15 Suppl 9:S1. doi: 10.1186/1471-2164-15-S9-S1. Epub 2014 Dec 8.


Development of LC-MS methods for quantitation of hepcidin and demonstration of siRNA-mediated hepcidin suppression in serum.

Li S, Nakayama T, Akinc A, Wu SL, Karger BL.

J Pharmacol Toxicol Methods. 2015 Jan-Feb;71:110-9. doi: 10.1016/j.vascn.2014.09.008. Epub 2014 Oct 2.


Near-zero growth kinetics of Pseudomonas putida deduced from proteomic analysis.

Panikov NS, Mandalakis M, Dai S, Mulcahy LR, Fowle W, Garrett WS, Karger BL.

Environ Microbiol. 2015 Jan;17(1):215-28. doi: 10.1111/1462-2920.12584. Epub 2014 Aug 27.


Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.

Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL.

J Biol Chem. 2014 Jul 4;289(27):18880-92. doi: 10.1074/jbc.M114.574996. Epub 2014 May 21. Erratum in: J Biol Chem. 2015 Jan 2;290(1):239.


Comparative proteomic analysis reveals mechanistic insights into Pseudomonas putida F1 growth on benzoate and citrate.

Mandalakis M, Panikov N, Dai S, Ray S, Karger BL.

AMB Express. 2013 Oct 25;3(1):64. doi: 10.1186/2191-0855-3-64.


Comparability analysis of anti-CD20 commercial (rituximab) and RNAi-mediated fucosylated antibodies by two LC-MS approaches.

Li C, Rossomando A, Wu SL, Karger BL.

MAbs. 2013 Jul-Aug;5(4):565-75. doi: 10.4161/mabs.24814. Epub 2013 Apr 25.


In-depth characterization of N-linked oligosaccharides using fluoride-mediated negative ion microfluidic chip LC-MS.

Ni W, Bones J, Karger BL.

Anal Chem. 2013 Mar 19;85(6):3127-35. doi: 10.1021/ac3031898. Epub 2013 Feb 27.


Integrated proteomic analysis of major isoaspartyl-containing proteins in the urine of wild type and protein L-isoaspartate O-methyltransferase-deficient mice.

Dai S, Ni W, Patananan AN, Clarke SG, Karger BL, Zhou ZS.

Anal Chem. 2013 Feb 19;85(4):2423-30. doi: 10.1021/ac303428h. Epub 2013 Feb 6.


Complete mapping of a cystine knot and nested disulfides of recombinant human arylsulfatase A by multi-enzyme digestion and LC-MS analysis using CID and ETD.

Ni W, Lin M, Salinas P, Savickas P, Wu SL, Karger BL.

J Am Soc Mass Spectrom. 2013 Jan;24(1):125-33. doi: 10.1007/s13361-012-0510-z. Epub 2012 Dec 4.


Evaluation of exogenous siRNA addition as a metabolic engineering tool for modifying biopharmaceuticals.

Tummala S, Titus M, Wilson L, Wang C, Ciatto C, Thill G, Foster D, Li C, Szabo Z, Guttman A, Bettencourt B, Jayaraman M, Deroot J, Kocisko D, Pollard S, Charisse K, Kuchimanchi S, Hinkle G, Milstein S, Meyers R, Wu SL, Karger BL, Rossomando A.

Biotechnol Prog. 2013 Mar-Apr;29(2):415-24. doi: 10.1002/btpr.1667. Epub 2013 Feb 13.


Reversion of the ErbB malignant phenotype and the DNA damage response.

Runkle EA, Zhang H, Cai Z, Zhu Z, Karger BL, Wu SL, O'Rourke DM, Zhou Z, Wang Q, Greene MI.

Exp Mol Pathol. 2012 Dec;93(3):324-33. doi: 10.1016/j.yexmp.2012.09.007. Epub 2012 Sep 27. Review.


Sialic acid speciation using capillary electrophoresis: optimization of analyte derivatization and separation.

Szabo Z, Bones J, Guttman A, Glick J, Karger BL.

Anal Chem. 2012 Sep 18;84(18):7638-42. doi: 10.1021/ac301840f. Epub 2012 Aug 29.


Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.

Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z, Wu SL, Cai Z, Zhang H, Karger BL, Hancock WW, Wells AD, Zhou Z, Greene MI.

Cell Rep. 2012 Jun 28;1(6):665-75. doi: 10.1016/j.celrep.2012.04.012. Epub 2012 Jun 15.


Ultrasensitive capillary electrophoretic analysis of potentially immunogenic carbohydrate residues in biologics: galactose-α-1,3-galactose containing oligosaccharides.

Szabo Z, Guttman A, Bones J, Shand RL, Meh D, Karger BL.

Mol Pharm. 2012 Jun 4;9(6):1612-9. doi: 10.1021/mp200612n. Epub 2012 May 15.


Integrated proteomic, transcriptomic, and biological network analysis of breast carcinoma reveals molecular features of tumorigenesis and clinical relapse.

Imielinski M, Cha S, Rejtar T, Richardson EA, Karger BL, Sgroi DC.

Mol Cell Proteomics. 2012 Jun;11(6):M111.014910. doi: 10.1074/mcp.M111.014910. Epub 2012 Jan 12.


Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope.

Zhou Z, Du X, Cai Z, Song X, Zhang H, Mizuno T, Suzuki E, Yee MR, Berezov A, Murali R, Wu SL, Karger BL, Greene MI, Wang Q.

J Biol Chem. 2012 Feb 17;287(8):5317-26. doi: 10.1074/jbc.M111.304543. Epub 2011 Dec 14.


Microproteomic analysis of 10,000 laser captured microdissected breast tumor cells using short-range sodium dodecyl sulfate-polyacrylamide gel electrophoresis and porous layer open tubular liquid chromatography tandem mass spectrometry.

Thakur D, Rejtar T, Wang D, Bones J, Cha S, Clodfelder-Miller B, Richardson E, Binns S, Dahiya S, Sgroi D, Karger BL.

J Chromatogr A. 2011 Nov 11;1218(45):8168-74. doi: 10.1016/j.chroma.2011.09.022. Epub 2011 Sep 14.


Discovery of lung cancer biomarkers by profiling the plasma proteome with monoclonal antibody libraries.

Guergova-Kuras M, Kurucz I, Hempel W, Tardieu N, Kádas J, Malderez-Bloes C, Jullien A, Kieffer Y, Hincapie M, Guttman A, Csánky E, Dezso B, Karger BL, Takács L.

Mol Cell Proteomics. 2011 Dec;10(12):M111.010298. doi: 10.1074/mcp.M111.010298. Epub 2011 Sep 26.


Histone deacetylase activity is necessary for left-right patterning during vertebrate development.

Carneiro K, Donnet C, Rejtar T, Karger BL, Barisone GA, Díaz E, Kortagere S, Lemire JM, Levin M.

BMC Dev Biol. 2011 May 20;11:29. doi: 10.1186/1471-213X-11-29.


Rapid high-resolution characterization of functionally important monoclonal antibody N-glycans by capillary electrophoresis.

Szabo Z, Guttman A, Bones J, Karger BL.

Anal Chem. 2011 Jul 1;83(13):5329-36. doi: 10.1021/ac2007587. Epub 2011 Jun 2.


2D-LC analysis of BRP 3 erythropoietin N-glycosylation using anion exchange fractionation and hydrophilic interaction UPLC reveals long poly-N-acetyl lactosamine extensions.

Bones J, McLoughlin N, Hilliard M, Wynne K, Karger BL, Rudd PM.

Anal Chem. 2011 Jun 1;83(11):4154-62. doi: 10.1021/ac200406z. Epub 2011 May 2.


Characterization and comparison of disulfide linkages and scrambling patterns in therapeutic monoclonal antibodies: using LC-MS with electron transfer dissociation.

Wang Y, Lu Q, Wu SL, Karger BL, Hancock WS.

Anal Chem. 2011 Apr 15;83(8):3133-40. doi: 10.1021/ac200128d. Epub 2011 Mar 23.


In situ proteomic analysis of human breast cancer epithelial cells using laser capture microdissection: annotation by protein set enrichment analysis and gene ontology.

Cha S, Imielinski MB, Rejtar T, Richardson EA, Thakur D, Sgroi DC, Karger BL.

Mol Cell Proteomics. 2010 Nov;9(11):2529-44. doi: 10.1074/mcp.M110.000398. Epub 2010 Aug 25.


Analysis of isoaspartic Acid by selective proteolysis with Asp-N and electron transfer dissociation mass spectrometry.

Ni W, Dai S, Karger BL, Zhou ZS.

Anal Chem. 2010 Sep 1;82(17):7485-91. doi: 10.1021/ac101806e.


Characterization of the glycosylation occupancy and the active site in the follow-on protein therapeutic: TNK-tissue plasminogen activator.

Jiang H, Wu SL, Karger BL, Hancock WS.

Anal Chem. 2010 Jul 15;82(14):6154-62. doi: 10.1021/ac100956x.


Improved sample preparation method for glycan analysis of glycoproteins by CE-LIF and CE-MS.

Szabo Z, Guttman A, Rejtar T, Karger BL.

Electrophoresis. 2010 Apr;31(8):1389-95. doi: 10.1002/elps.201000037.


Rapid release of N-linked glycans from glycoproteins by pressure-cycling technology.

Szabo Z, Guttman A, Karger BL.

Anal Chem. 2010 Mar 15;82(6):2588-93. doi: 10.1021/ac100098e.


Antigen identification and characterization of lung cancer specific monoclonal antibodies produced by mAb proteomics.

Wang D, Hincapie M, Guergova-Kuras M, Kadas J, Takacs L, Karger BL.

J Proteome Res. 2010 Apr 5;9(4):1834-42. doi: 10.1021/pr900997z.


Desulfurization of cysteine-containing peptides resulting from sample preparation for protein characterization by mass spectrometry.

Wang Z, Rejtar T, Zhou ZS, Karger BL.

Rapid Commun Mass Spectrom. 2010 Feb;24(3):267-75. doi: 10.1002/rcm.4383.


Chemical methods for the detection of protein N-homocysteinylation via selective reactions with aldehydes.

Zang T, Dai S, Chen D, Lee BW, Liu S, Karger BL, Zhou ZS.

Anal Chem. 2009 Nov 1;81(21):9065-71. doi: 10.1021/ac9017132.


Profiling the glycoforms of the intact alpha subunit of recombinant human chorionic gonadotropin by high-resolution capillary electrophoresis-mass spectrometry.

Thakur D, Rejtar T, Karger BL, Washburn NJ, Bosques CJ, Gunay NS, Shriver Z, Venkataraman G.

Anal Chem. 2009 Nov 1;81(21):8900-7. doi: 10.1021/ac901506p.


Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton.

Jia Y, Wu SL, Isenberg JS, Dai S, Sipes JM, Field L, Zeng B, Bandle RW, Ridnour LA, Wink DA, Ramchandran R, Karger BL, Roberts DD.

Cell Stress Chaperones. 2010 Mar;15(2):165-81. doi: 10.1007/s12192-009-0130-0. Epub 2009 Jul 5.

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