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Body weight-dependent and independent improvement in lipid metabolism after Roux-en-Y gastric bypass in ApoE*3Leiden.CETP mice.

Tarasco E, Boyle CN, Pellegrini G, Arnold M, Steiner R, Hornemann T, Nasias D, Kardassis D, Whiting L, Lutz TA.

Int J Obes (Lond). 2019 Dec;43(12):2394-2406. doi: 10.1038/s41366-019-0408-y. Epub 2019 Jul 3.


LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation.

Morén A, Bellomo C, Tsubakihara Y, Kardassis D, Mikulits W, Heldin CH, Moustakas A.

Oncogenesis. 2019 May 16;8(6):36. doi: 10.1038/s41389-019-0140-4.


Significant changes in hepatic transcriptome and circulating miRNAs are associated with diet-induced metabolic syndrome in apoE3L.CETP mice.

Nasias D, Evangelakos I, Nidris V, Vassou D, Tarasco E, Lutz TA, Kardassis D.

J Cell Physiol. 2019 Nov;234(11):20485-20500. doi: 10.1002/jcp.28649. Epub 2019 Apr 23.


Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129.

Gomes CPC, Ágg B, Andova A, Arslan S, Baker A, Barteková M, Beis D, Betsou F, Wettinger SB, Bugarski B, Condorelli G, Silva GJJD, Danilin S, de Gonzalo-Calvo D, Buil A, Carmo-Fonseca M, Enguita FJ, Felekkis K, Ferdinandy P, Gyöngyösi M, Hackl M, Karaduzovic-Hadziabdic K, Hellemans J, Heymans S, Hlavackova M, Hoydal MA, Jankovic A, Jusic A, Kardassis D, Kerkelä R, Kuster GM, Lakkisto P, Leszek P, Lustrek M, Maegdefessel L, Martelli F, Novella S, O'Brien T, Papaneophytou C, Pedrazzini T, Pinet F, Popescu O, Potočnjak I, Robinson E, Sasson S, Scholz M, Simionescu M, Stoll M, Varga ZV, Vinciguerra M, Xuereb A, Yilmaz MB, Emanueli C, Devaux Y, on behalf of the EU-CardioRNA COST Action (CA17129).

Noncoding RNA. 2019 Mar 29;5(2). pii: E31. doi: 10.3390/ncrna5020031.


The Opposite Effect of c-Jun Transcription Factor on Apolipoprotein E Gene Regulation in Hepatocytes and Macrophages.

Trusca VG, Fuior EV, Kardassis D, Simionescu M, Gafencu AV.

Int J Mol Sci. 2019 Mar 23;20(6). pii: E1471. doi: 10.3390/ijms20061471.


Ex vivo liver resection coupled with associated liver partition and portal vein ligation: Combining existing techniques to achieve surgical resectability.

Baimas-George MR, Levi DM, Eskind LB, Kirks RC, Passeri M, Lessne M, Kardassis D, Salmon S, Iannitti DA, Vrochides D.

J Surg Oncol. 2019 May;119(6):771-776. doi: 10.1002/jso.25375. Epub 2019 Jan 15.


Circulating microRNAs -192 and -194 are associated with the presence and incidence of diabetes mellitus.

Jaeger A, Zollinger L, Saely CH, Muendlein A, Evangelakos I, Nasias D, Charizopoulou N, Schofield JD, Othman A, Soran H, Kardassis D, Drexel H, Eckardstein AV.

Sci Rep. 2018 Sep 24;8(1):14274. doi: 10.1038/s41598-018-32274-9.


HDL-apoA-I induces the expression of angiopoietin like 4 (ANGPTL4) in endothelial cells via a PI3K/AKT/FOXO1 signaling pathway.

Theofilatos D, Fotakis P, Valanti E, Sanoudou D, Zannis V, Kardassis D.

Metabolism. 2018 Oct;87:36-47. doi: 10.1016/j.metabol.2018.06.002. Epub 2018 Jun 18.


Modulation of TGFβ/Smad signaling by the small GTPase RhoB.

Livitsanou M, Vasilaki E, Stournaras C, Kardassis D.

Cell Signal. 2018 Aug;48:54-63. doi: 10.1016/j.cellsig.2018.04.007. Epub 2018 Apr 26.


HDL Dysfunction Caused by Mutations in apoA-I and Other Genes that are Critical for HDL Biogenesis and Remodeling.

Chroni A, Kardassis D.

Curr Med Chem. 2019;26(9):1544-1575. doi: 10.2174/0929867325666180313114950. Review.


Transcriptional and post-transcriptional regulation of the genes encoding the small GTPases RhoA, RhoB, and RhoC: implications for the pathogenesis of human diseases.

Nomikou E, Livitsanou M, Stournaras C, Kardassis D.

Cell Mol Life Sci. 2018 Jun;75(12):2111-2124. doi: 10.1007/s00018-018-2787-y. Epub 2018 Mar 2. Review.


Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma.

Bellomo C, Caja L, Fabregat I, Mikulits W, Kardassis D, Heldin CH, Moustakas A.

Cell Death Differ. 2018 May;25(5):885-903. doi: 10.1038/s41418-017-0021-3. Epub 2017 Dec 11.


Functional analysis of the promoters of the small GTPases RhoA and RhoB in embryonic stem cells.

Nomikou E, Stournaras C, Kardassis D.

Biochem Biophys Res Commun. 2017 Sep 23;491(3):754-759. doi: 10.1016/j.bbrc.2017.07.114. Epub 2017 Jul 21.


Physical and functional interactions between nuclear receptor LXRα and the forkhead box transcription factor FOXA2 regulate the response of the human lipoprotein lipase gene to oxysterols in hepatic cells.

Kanaki M, Tiniakou I, Thymiakou E, Kardassis D.

Biochim Biophys Acta Gene Regul Mech. 2017 Aug;1860(8):848-860. doi: 10.1016/j.bbagrm.2017.05.007. Epub 2017 May 31.


Differential action of glucocorticoids on apolipoprotein E gene expression in macrophages and hepatocytes.

Trusca VG, Fuior EV, Fenyo IM, Kardassis D, Simionescu M, Gafencu AV.

PLoS One. 2017 Mar 29;12(3):e0174078. doi: 10.1371/journal.pone.0174078. eCollection 2017.


Regulation of the human lipoprotein lipase gene by the forkhead box transcription factor FOXA2/HNF-3β in hepatic cells.

Kanaki M, Kardassis D.

Biochim Biophys Acta Gene Regul Mech. 2017 Mar;1860(3):327-336. doi: 10.1016/j.bbagrm.2017.01.007. Epub 2017 Jan 23.


Differential Expression of miR-4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF).

Latsoudis H, Mashreghi MF, Grün JR, Chang HD, Stuhlmüller B, Repa A, Gergiannaki I, Kabouraki E, Vlachos GS, Häupl T, Radbruch A, Sidiropoulos P, Doukoumetzidis K, Kardassis D, Niewold TB, Boumpas DT, Goulielmos GN.

J Cell Physiol. 2017 Jun;232(6):1326-1336. doi: 10.1002/jcp.25602. Epub 2016 Dec 20.


Investigation of the genetic overlap between rheumatoid arthritis and psoriatic arthritis in a Greek population.

Myrthianou E, Zervou MI, Budu-Aggrey A, Eliopoulos E, Kardassis D, Boumpas DT, Kougkas N, Barton A, Sidiropoulos P, Goulielmos GN.

Scand J Rheumatol. 2017 May;46(3):180-186. doi: 10.1080/03009742.2016.1199734. Epub 2016 Jul 20.


Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation.

Carthy JM, Stöter M, Bellomo C, Vanlandewijck M, Heldin A, Morén A, Kardassis D, Gahman TC, Shiau AK, Bickle M, Zerial M, Heldin CH, Moustakas A.

Sci Rep. 2016 Jul 19;6:29868. doi: 10.1038/srep29868.


Transcriptional regulation of the human Liver X Receptor α gene by Hepatocyte Nuclear Factor 4α.

Theofilatos D, Anestis A, Hashimoto K, Kardassis D.

Biochem Biophys Res Commun. 2016 Jan 15;469(3):573-9. doi: 10.1016/j.bbrc.2015.12.031. Epub 2015 Dec 12.


Krüppel-like factor 4 synergizes with CREB to increase the activity of apolipoprotein E gene promoter in macrophages.

Stavri S, Simionescu M, Kardassis D, Gafencu AV.

Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):66-72. doi: 10.1016/j.bbrc.2015.10.163. Epub 2015 Nov 4.


Thyroid hormones upregulate apolipoprotein E gene expression in astrocytes.

Roman C, Fuior EV, Trusca VG, Kardassis D, Simionescu M, Gafencu AV.

Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):190-5. doi: 10.1016/j.bbrc.2015.10.132. Epub 2015 Oct 29.


Palliation With Endoscopic Metal Stents May Be Preferable to Surgical Intervention for Patients With Obstructive Pancreatic Head Adenocarcinoma.

Kofokotsios A, Papazisis K, Andronikidis I, Ntinas A, Kardassis D, Vrochides D.

Int Surg. 2015 Jun;100(6):1104-10. doi: 10.9738/INTSURG-D-14-00274.1.


Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice.

Tiniakou I, Kanaki Z, Georgopoulos S, Chroni A, Van Eck M, Fotakis P, Zannis VI, Kardassis D.

Atherosclerosis. 2015 Nov;243(1):77-85. doi: 10.1016/j.atherosclerosis.2015.08.028. Epub 2015 Aug 24.


Apolipoprotein A-I inhibits experimental colitis and colitis-propelled carcinogenesis.

Gkouskou KK, Ioannou M, Pavlopoulos GA, Georgila K, Siganou A, Nikolaidis G, Kanellis DC, Moore S, Papadakis KA, Kardassis D, Iliopoulos I, McDyer FA, Drakos E, Eliopoulos AG.

Oncogene. 2016 May 12;35(19):2496-505. doi: 10.1038/onc.2015.307. Epub 2015 Aug 17.


Impaired Antiatherogenic Functions of High-density Lipoprotein in Patients with Ankylosing Spondylitis.

Gkolfinopoulou C, Stratikos E, Theofilatos D, Kardassis D, Voulgari PV, Drosos AA, Chroni A.

J Rheumatol. 2015 Sep;42(9):1652-60. doi: 10.3899/jrheum.141532. Epub 2015 Aug 1.


The Effect of Natural LCAT Mutations on the Biogenesis of HDL.

Fotakis P, Kuivenhoven JA, Dafnis E, Kardassis D, Zannis VI.

Biochemistry. 2015 Jun 2;54(21):3348-59. doi: 10.1021/acs.biochem.5b00180. Epub 2015 May 22.


High-density lipoprotein attenuates Th1 and th17 autoimmune responses by modulating dendritic cell maturation and function.

Tiniakou I, Drakos E, Sinatkas V, Van Eck M, Zannis VI, Boumpas D, Verginis P, Kardassis D.

J Immunol. 2015 May 15;194(10):4676-87. doi: 10.4049/jimmunol.1402870. Epub 2015 Apr 13.


Regulation of HDL genes: transcriptional, posttranscriptional, and posttranslational.

Kardassis D, Gafencu A, Zannis VI, Davalos A.

Handb Exp Pharmacol. 2015;224:113-79. doi: 10.1007/978-3-319-09665-0_3. Review.


HDL biogenesis, remodeling, and catabolism.

Zannis VI, Fotakis P, Koukos G, Kardassis D, Ehnholm C, Jauhiainen M, Chroni A.

Handb Exp Pharmacol. 2015;224:53-111. doi: 10.1007/978-3-319-09665-0_2. Review.


Patients with multiple synchronous colonic cancer hepatic metastases benefit from enrolment in a "liver first" approach protocol.

Kardassis D, Ntinas A, Miliaras D, Kofokotsios A, Papazisis K, Vrochides D.

World J Hepatol. 2014 Jul 27;6(7):513-9. doi: 10.4254/wjh.v6.i7.513.


Novel mechanism of transcriptional repression of the human ATP binding cassette transporter A1 gene in hepatic cells by the winged helix/forkhead box transcription factor A2.

Thymiakou E, Kardassis D.

Biochim Biophys Acta. 2014 Jun;1839(6):526-36. doi: 10.1016/j.bbagrm.2014.04.021. Epub 2014 May 5.


apoE3[K146N/R147W] acts as a dominant negative apoE form that prevents remnant clearance and inhibits the biogenesis of HDL.

Fotakis P, Vezeridis A, Dafnis I, Chroni A, Kardassis D, Zannis VI.

J Lipid Res. 2014 Jul;55(7):1310-23. doi: 10.1194/jlr.M048348. Epub 2014 Apr 28.


Metabolism of HDL and its regulation.

Kardassis D, Mosialou I, Kanaki M, Tiniakou I, Thymiakou E.

Curr Med Chem. 2014;21(25):2864-80. Review.


Carotid artery remodelling in relation to body fat distribution, inflammation and sustained weight loss in obesity.

Kardassis D, Schönander M, Sjöström L, Karason K.

J Intern Med. 2014 May;275(5):534-43. doi: 10.1111/joim.12171. Epub 2014 Apr 7.


Significance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL.

Fotakis P, Tiniakou I, Kateifides AK, Gkolfinopoulou C, Chroni A, Stratikos E, Zannis VI, Kardassis D.

J Lipid Res. 2013 Dec;54(12):3293-302. doi: 10.1194/jlr.M043489. Epub 2013 Oct 12.


A novel liver parenchyma transection technique using locking straight rigid ties. An experimental study in pigs.

Vrochides D, Kardassis D, Ntinas A, Miliaras D, Papalois A, Magnissalis E, Metrakos P.

J Invest Surg. 2014 Apr;27(2):106-13. doi: 10.3109/08941939.2013.832825. Epub 2013 Sep 24.


Role of the hydrophobic and charged residues in the 218-226 region of apoA-I in the biogenesis of HDL.

Fotakis P, Kateifides AK, Gkolfinopoulou C, Georgiadou D, Beck M, Gründler K, Chroni A, Stratikos E, Kardassis D, Zannis VI.

J Lipid Res. 2013 Dec;54(12):3281-92. doi: 10.1194/jlr.M038356. Epub 2013 Aug 29. Erratum in: J Lipid Res. 2014 Jan;55(1):163.


Duration of the thoracic epidural catheter in a fast-track recovery protocol may decrease the length of stay after a major hepatectomy: a case control study.

Ntinas A, Kardassis D, Konstantinopoulos I, Kottos P, Manias A, Kyritsi M, Zilianiaki D, Vrochides D.

Int J Surg. 2013;11(9):882-5. doi: 10.1016/j.ijsu.2013.07.014. Epub 2013 Aug 4.


Acoustic detection of DNA conformation in genetic assays combined with PCR.

Papadakis G, Tsortos A, Kordas A, Tiniakou I, Morou E, Vontas J, Kardassis D, Gizeli E.

Sci Rep. 2013;3:2033. doi: 10.1038/srep02033.


Investigation of juvenile idiopathic arthritis susceptibility loci: results from a Greek population.

Dimopoulou DG, Zervou MI, Trachana M, Myrthianou E, Pratsidou-Gertsi P, Kardassis D, Garyfallos A, Goulielmos GN.

Hum Immunol. 2013 Sep;74(9):1194-8. doi: 10.1016/j.humimm.2013.06.018. Epub 2013 Jun 15.


Sleep apnea modifies the long-term impact of surgically induced weight loss on cardiac function and inflammation.

Kardassis D, Grote L, Sjöström L, Hedner J, Karason K.

Obesity (Silver Spring). 2013 Apr;21(4):698-704. doi: 10.1002/oby.20115.


European lipoprotein club: report of the 35th ELC annual conference (Tutzing, 10th-13th September 2012).

Costet P, Ehrenborg E, Fisher R, Fielding B, Groen A, Kardassis D, Malle E, Mulder M, Niemeier A, Norata GD, Hansen AT, Eckardstein Av.

Atherosclerosis. 2013 Feb;226(2):510-6. doi: 10.1016/j.atherosclerosis.2012.11.030. Epub 2012 Dec 5. No abstract available.


ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT.

Duka A, Fotakis P, Georgiadou D, Kateifides A, Tzavlaki K, von Eckardstein L, Stratikos E, Kardassis D, Zannis VI.

J Lipid Res. 2013 Jan;54(1):107-15. doi: 10.1194/jlr.M030114. Epub 2012 Nov 6.


Nimesulide may be more efficient than allopurinol in protecting pancreas from acute ischemia/reperfusion injury in an animal model.

Apostolidis D, Ntinas A, Kardassis D, Koulouris N, Thomareis O, Karayannopoulou G, Vrochides D.

Vasc Endovascular Surg. 2012 Nov;46(8):654-63. doi: 10.1177/1538574412465478.


Single-stitch telescopic bilioenterostomy in an animal model.

Vrochides D, Ntinas A, Kardassis D, Miliaras D, Metrakos P, Papalois A.

J Invest Surg. 2012 Oct;25(5):317-25.


STAT1 interacts with RXRα to upregulate ApoCII gene expression in macrophages.

Trusca VG, Florea IC, Kardassis D, Gafencu AV.

PLoS One. 2012;7(7):e40463. doi: 10.1371/journal.pone.0040463. Epub 2012 Jul 12.


Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance.

Stagakis I, Bertsias G, Karvounaris S, Kavousanaki M, Virla D, Raptopoulou A, Kardassis D, Boumpas DT, Sidiropoulos PI.

Arthritis Res Ther. 2012 Jun 12;14(3):R141. doi: 10.1186/ar3874.


Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia.

Wojciak-Stothard B, Zhao L, Oliver E, Dubois O, Wu Y, Kardassis D, Vasilaki E, Huang M, Mitchell JA, Harrington LS, Prendergast GC, Wilkins MR.

Circ Res. 2012 May 25;110(11):1423-34. doi: 10.1161/CIRCRESAHA.112.264473. Epub 2012 Apr 26. Erratum in: Circ Res. 2012 Aug 17;111(5):e163. Louise, Harrington [corrected to Harrington, Louise S].


Genetic variation in ABCG1 and risk of myocardial infarction and ischemic heart disease.

Schou J, Frikke-Schmidt R, Kardassis D, Thymiakou E, Nordestgaard BG, Jensen G, Grande P, Tybjærg-Hansen A.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):506-15. doi: 10.1161/ATVBAHA.111.234872. Epub 2011 Dec 8.


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