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Items: 31

1.

Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands.

Szczepańska K, Karcz T, Siwek A, Kuder KJ, Latacz G, Bednarski M, Szafarz M, Hagenow S, Lubelska A, Olejarz-Maciej A, Sobolewski M, Mika K, Kotańska M, Stark H, Kieć-Kononowicz K.

Bioorg Chem. 2019 Oct;91:103071. doi: 10.1016/j.bioorg.2019.103071. Epub 2019 Jun 20.

PMID:
31362197
2.

Therapeutic suppression of pulmonary neutrophilia and allergic airway hyperresponsiveness by a RORγt inverse agonist.

Whitehead GS, Kang HS, Thomas SY, Medvedev A, Karcz TP, Izumi G, Nakano K, Makarov SS, Nakano H, Jetten AM, Cook DN.

JCI Insight. 2019 Jun 11;5. pii: 125528. doi: 10.1172/jci.insight.125528.

3.

Design, synthesis, and in vitro and in vivo characterization of 1-{4-[4-(substituted)piperazin-1-yl]butyl}guanidines and their piperidine analogues as histamine H3 receptor antagonists.

Staszewski M, Stasiak A, Karcz T, McNaught Flores D, Fogel WA, Kieć-Kononowicz K, Leurs R, Walczyński K.

Medchemcomm. 2019 Jan 11;10(2):234-251. doi: 10.1039/c8md00527c. eCollection 2019 Feb 1.

PMID:
30881612
4.

Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.

Załuski M, Schabikowski J, Schlenk M, Olejarz-Maciej A, Kubas B, Karcz T, Kuder K, Latacz G, Zygmunt M, Synak D, Hinz S, Müller CE, Kieć-Kononowicz K.

Bioorg Med Chem. 2019 Apr 1;27(7):1195-1210. doi: 10.1016/j.bmc.2019.02.004. Epub 2019 Feb 2.

PMID:
30808606
5.

Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies.

Kaproń B, Łuszczki JJ, Płazińska A, Siwek A, Karcz T, Gryboś A, Nowak G, Makuch-Kocka A, Walczak K, Langner E, Szalast K, Marciniak S, Paczkowska M, Cielecka-Piontek J, Ciesla LM, Plech T.

Eur J Pharm Sci. 2019 Mar 1;129:42-57. doi: 10.1016/j.ejps.2018.12.018. Epub 2018 Dec 28.

PMID:
30594731
6.

Optimization and preclinical evaluation of novel histamine H3receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives.

Szczepańska K, Karcz T, Kotańska M, Siwek A, Kuder KJ, Latacz G, Mogilski S, Hagenow S, Lubelska A, Sobolewski M, Stark H, Kieć-Kononowicz K.

Bioorg Med Chem. 2018 Dec 15;26(23-24):6056-6066. doi: 10.1016/j.bmc.2018.11.010. Epub 2018 Nov 10.

PMID:
30448256
7.

4-tert-Pentylphenoxyalkyl derivatives - Histamine H3 receptor ligands and monoamine oxidase B inhibitors.

Łażewska D, Olejarz-Maciej A, Kaleta M, Bajda M, Siwek A, Karcz T, Doroz-Płonka A, Cichoń U, Kuder K, Kieć-Kononowicz K.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3596-3600. doi: 10.1016/j.bmcl.2018.10.048. Epub 2018 Oct 31.

PMID:
30404719
8.

Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties.

Załuski M, Stanuch K, Karcz T, Hinz S, Latacz G, Szymańska E, Schabikowski J, Doroż-Płonka A, Handzlik J, Drabczyńska A, Müller CE, Kieć-Kononowicz K.

Medchemcomm. 2018 May 14;9(6):951-962. doi: 10.1039/c8md00070k. eCollection 2018 Jun 1.

9.

Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands.

Szczepańska K, Karcz T, Mogilski S, Siwek A, Kuder KJ, Latacz G, Kubacka M, Hagenow S, Lubelska A, Olejarz A, Kotańska M, Sadek B, Stark H, Kieć-Kononowicz K.

Eur J Med Chem. 2018 May 25;152:223-234. doi: 10.1016/j.ejmech.2018.04.043. Epub 2018 Apr 25.

PMID:
29723785
10.

Novel naphthyloxy derivatives - Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation.

Łażewska D, Kaleta M, Hagenow S, Mogilski S, Latacz G, Karcz T, Lubelska A, Honkisz E, Handzlik J, Reiner D, Satała G, Filipek B, Stark H, Kieć-Kononowicz K.

Bioorg Med Chem. 2018 May 15;26(9):2573-2585. doi: 10.1016/j.bmc.2018.04.023. Epub 2018 Apr 11.

PMID:
29681486
11.

Fluorescent-Labeled Selective Adenosine A2B Receptor Antagonist Enables Competition Binding Assay by Flow Cytometry.

Köse M, Gollos S, Karcz T, Fiene A, Heisig F, Behrenswerth A, Kieć-Kononowicz K, Namasivayam V, Müller CE.

J Med Chem. 2018 May 24;61(10):4301-4316. doi: 10.1021/acs.jmedchem.7b01627. Epub 2018 May 15.

PMID:
29681156
12.

Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione - a novel anticonvulsant drug candidate.

Kaproń B, Łuszczki J, Paneth A, Wujec M, Siwek A, Karcz T, Mordyl B, Głuch-Lutwin M, Gryboś A, Nowak G, Pająk K, Jóźwiak K, Tomczykowski A, Plech T.

Int J Med Sci. 2017 Jul 18;14(8):741-749. doi: 10.7150/ijms.20001. eCollection 2017.

13.

Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands.

Łażewska D, Kaleta M, Schwed JS, Karcz T, Mogilski S, Latacz G, Olejarz A, Siwek A, Kubacka M, Lubelska A, Honkisz E, Handzlik J, Filipek B, Stark H, Kieć-Kononowicz K.

Bioorg Med Chem. 2017 Oct 15;25(20):5341-5354. doi: 10.1016/j.bmc.2017.07.058. Epub 2017 Jul 29.

PMID:
28797771
14.

On the efficiency of instruction-based rule encoding.

Ruge H, Karcz T, Mark T, Martin V, Zwosta K, Wolfensteller U.

Acta Psychol (Amst). 2018 Mar;184:4-19. doi: 10.1016/j.actpsy.2017.04.005. Epub 2017 Apr 18.

PMID:
28427713
15.

Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands.

Kuder KJ, Łażewska D, Kaleta M, Latacz G, Kottke T, Olejarz A, Karcz T, Fruziński A, Szczepańska K, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K.

Bioorg Med Chem. 2017 May 15;25(10):2701-2712. doi: 10.1016/j.bmc.2017.03.031. Epub 2017 Mar 21.

PMID:
28372935
16.

3-Aminomethyl Derivatives of 2-Phenylimidazo[1,2-a]-pyridine as Positive Allosteric Modulators of GABAA Receptor with Potential Antipsychotic Activity.

Marcinkowska M, Kołaczkowski M, Kamiński K, Bucki A, Pawłowski M, Siwek A, Karcz T, Starowicz G, Słoczyńska K, Pękala E, Wesołowska A, Samochowiec J, Mierzejewski P, Bienkowski P.

ACS Chem Neurosci. 2017 Jun 21;8(6):1291-1298. doi: 10.1021/acschemneuro.6b00432. Epub 2017 Mar 1.

PMID:
28211669
17.

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats.

Sadek B, Saad A, Latacz G, Kuder K, Olejarz A, Karcz T, Stark H, Kieć-Kononowicz K.

Drug Des Devel Ther. 2016 Nov 25;10:3879-3898. eCollection 2016.

18.

Design, synthesis, and biological evaluation of fluorinated imidazo[1,2-a]pyridine derivatives with potential antipsychotic activity.

Marcinkowska M, Kołaczkowski M, Kamiński K, Bucki A, Pawłowski M, Siwek A, Karcz T, Mordyl B, Starowicz G, Kubowicz P, Pękala E, Wesołowska A, Samochowiec J, Mierzejewski P, Bienkowski P.

Eur J Med Chem. 2016 Nov 29;124:456-467. doi: 10.1016/j.ejmech.2016.08.059. Epub 2016 Aug 26.

PMID:
27598234
19.

Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.

Szymańska E, Drabczyńska A, Karcz T, Müller CE, Köse M, Karolak-Wojciechowska J, Fruziński A, Schabikowski J, Doroz-Płonka A, Handzlik J, Kieć-Kononowicz K.

Bioorg Med Chem. 2016 Sep 15;24(18):4347-4362. doi: 10.1016/j.bmc.2016.07.028. Epub 2016 Jul 18.

PMID:
27485602
20.

The Synthesis of 1,3,5-triazine Derivatives and JNJ7777120 Analogues with Histamine H4 Receptor Affinity and Their Interaction with PTEN Promoter.

Latacz G, Kechagioglou P, Papi R, Łażewska D, Więcek M, Kamińska K, Wencel P, Karcz T, Schwed JS, Stark H, Kyriakidis DA, Kieć-Kononowicz K.

Chem Biol Drug Des. 2016 Aug;88(2):254-63. doi: 10.1111/cbdd.12752. Epub 2016 Mar 31.

PMID:
26931395
21.

Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay.

Bohnert JA, Schuster S, Kern WV, Karcz T, Olejarz A, Kaczor A, Handzlik J, Kieć-Kononowicz K.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):1974-83. doi: 10.1128/AAC.01995-15. Print 2016 Apr.

22.

Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.

Kuder K, Łażewska D, Latacz G, Schwed JS, Karcz T, Stark H, Karolak-Wojciechowska J, Kieć-Kononowicz K.

Bioorg Med Chem. 2016 Jan 15;24(2):53-72. doi: 10.1016/j.bmc.2015.11.021. Epub 2015 Dec 2.

PMID:
26690914
23.

(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands.

Kamińska K, Ziemba J, Ner J, Schwed JS, Łażewska D, Więcek M, Karcz T, Olejarz A, Latacz G, Kuder K, Kottke T, Zygmunt M, Sapa J, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K.

Eur J Med Chem. 2015 Oct 20;103:238-51. doi: 10.1016/j.ejmech.2015.08.014. Epub 2015 Aug 10.

PMID:
26360048
24.

Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents.

Zygmunt M, Sapa J, Drabczyńska A, Karcz T, Müller C, Köse M, Latacz G, Schabikowski J, Bednarski M, Kieć-Kononowicz K.

Arch Pharm (Weinheim). 2015 Oct;348(10):704-14. doi: 10.1002/ardp.201500169. Epub 2015 Aug 6.

PMID:
26248713
25.

Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.

Łażewska D, Więcek M, Ner J, Kamińska K, Kottke T, Schwed JS, Zygmunt M, Karcz T, Olejarz A, Kuder K, Latacz G, Grosicki M, Sapa J, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K.

Eur J Med Chem. 2014 Aug 18;83:534-46. doi: 10.1016/j.ejmech.2014.06.032. Epub 2014 Jun 17.

PMID:
24996140
26.
27.

Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones.

Drabczyńska A, Karcz T, Szymańska E, Köse M, Müller CE, Paskaleva M, Karolak-Wojciechowska J, Handzlik J, Yuzlenko O, Kieć-Kononowicz K.

Purinergic Signal. 2013 Sep;9(3):395-414. doi: 10.1007/s11302-013-9358-3. Epub 2013 Apr 2.

28.

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55.

Rempel V, Fuchs A, Hinz S, Karcz T, Lehr M, Koetter U, Müller CE.

ACS Med Chem Lett. 2012 Nov 14;4(1):41-5. doi: 10.1021/ml300235q. eCollection 2013 Jan 10.

29.

7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists.

Rempel V, Volz N, Hinz S, Karcz T, Meliciani I, Nieger M, Wenzel W, Bräse S, Müller CE.

J Med Chem. 2012 Sep 27;55(18):7967-77. Epub 2012 Sep 11.

PMID:
22916707
30.

Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.

Drabczyńska A, Yuzlenko O, Köse M, Paskaleva M, Schiedel AC, Karolak-Wojciechowska J, Handzlik J, Karcz T, Kuder K, Müller CE, Kieć-Kononowicz K.

Eur J Med Chem. 2011 Sep;46(9):3590-607. doi: 10.1016/j.ejmech.2011.05.023. Epub 2011 May 23.

PMID:
21664729
31.

Search for histamine H4 receptor ligands in the group of 4-methylpiperazino amide derivatives.

Karcz T, Handzlik J, Łażewska D, Kottke T, Seifert R, Kieć-Kononowicz K.

Inflamm Res. 2010 Mar;59 Suppl 2:S243-5. doi: 10.1007/s00011-009-0141-4. No abstract available.

PMID:
20058181

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