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Items: 17


Hydrogen-Deuterium Exchange Coupled to Top- and Middle-Down Mass Spectrometry Reveals Histone Tail Dynamics before and after Nucleosome Assembly.

Karch KR, Coradin M, Zandarashvili L, Kan ZY, Gerace M, Englander SW, Black BE, Garcia BA.

Structure. 2018 Dec 4;26(12):1651-1663.e3. doi: 10.1016/j.str.2018.08.006. Epub 2018 Oct 4.


The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage.

Karch KR, Langelier MF, Pascal JM, Garcia BA.

Mol Biosyst. 2017 Nov 21;13(12):2660-2671. doi: 10.1039/c7mb00498b.


Metabolic labeling in middle-down proteomics allows for investigation of the dynamics of the histone code.

Sidoli S, Lu C, Coradin M, Wang X, Karch KR, Ruminowicz C, Garcia BA.

Epigenetics Chromatin. 2017 Jul 6;10(1):34. doi: 10.1186/s13072-017-0139-z.


Monitoring proteolytic processing events by quantitative mass spectrometry.

Coradin M, Karch KR, Garcia BA.

Expert Rev Proteomics. 2017 May;14(5):409-418. doi: 10.1080/14789450.2017.1316977. Epub 2017 Apr 17. Review.


Identification and Quantification of Histone PTMs Using High-Resolution Mass Spectrometry.

Karch KR, Sidoli S, Garcia BA.

Methods Enzymol. 2016;574:3-29. doi: 10.1016/bs.mie.2015.12.007. Epub 2016 Feb 1.


Rapid proteomic responses to a near-lethal heat stress in the salt marsh mussel Geukensia demissa.

Fields PA, Burmester EM, Cox KM, Karch KR.

J Exp Biol. 2016 Sep 1;219(Pt 17):2673-86. doi: 10.1242/jeb.141176. Epub 2016 Jun 22.


A Novel Quantitative Mass Spectrometry Platform for Determining Protein O-GlcNAcylation Dynamics.

Wang X, Yuan ZF, Fan J, Karch KR, Ball LE, Denu JM, Garcia BA.

Mol Cell Proteomics. 2016 Jul;15(7):2462-75. doi: 10.1074/mcp.O115.049627. Epub 2016 Apr 25.


Analyses of Histone Proteoforms Using Front-end Electron Transfer Dissociation-enabled Orbitrap Instruments.

Anderson LC, Karch KR, Ugrin SA, Coradin M, English AM, Sidoli S, Shabanowitz J, Garcia BA, Hunt DF.

Mol Cell Proteomics. 2016 Mar;15(3):975-88. doi: 10.1074/mcp.O115.053843. Epub 2016 Jan 19.


Permuting the PGF Signature Motif Blocks both Archaeosortase-Dependent C-Terminal Cleavage and Prenyl Lipid Attachment for the Haloferax volcanii S-Layer Glycoprotein.

Abdul Halim MF, Karch KR, Zhou Y, Haft DH, Garcia BA, Pohlschroder M.

J Bacteriol. 2015 Dec 28;198(5):808-15. doi: 10.1128/JB.00849-15.


PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.

Dawicki-McKenna JM, Langelier MF, DeNizio JE, Riccio AA, Cao CD, Karch KR, McCauley M, Steffen JD, Black BE, Pascal JM.

Mol Cell. 2015 Dec 3;60(5):755-768. doi: 10.1016/j.molcel.2015.10.013. Epub 2015 Nov 25.


Low Resolution Data-Independent Acquisition in an LTQ-Orbitrap Allows for Simplified and Fully Untargeted Analysis of Histone Modifications.

Sidoli S, Simithy J, Karch KR, Kulej K, Garcia BA.

Anal Chem. 2015 Nov 17;87(22):11448-54. doi: 10.1021/acs.analchem.5b03009. Epub 2015 Nov 5.


Bottom-up and middle-down proteomics have comparable accuracies in defining histone post-translational modification relative abundance and stoichiometry.

Sidoli S, Lin S, Karch KR, Garcia BA.

Anal Chem. 2015 Mar 17;87(6):3129-33. doi: 10.1021/acs.analchem.5b00072. Epub 2015 Mar 3.


Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH) Analysis for Characterization and Quantification of Histone Post-translational Modifications.

Sidoli S, Lin S, Xiong L, Bhanu NV, Karch KR, Johansen E, Hunter C, Mollah S, Garcia BA.

Mol Cell Proteomics. 2015 Sep;14(9):2420-8. doi: 10.1074/mcp.O114.046102. Epub 2015 Jan 30.


High resolution is not a strict requirement for characterization and quantification of histone post-translational modifications.

Karch KR, Zee BM, Garcia BA.

J Proteome Res. 2014 Dec 5;13(12):6152-9. doi: 10.1021/pr500902f. Epub 2014 Oct 30.


Identification and interrogation of combinatorial histone modifications.

Karch KR, Denizio JE, Black BE, Garcia BA.

Front Genet. 2013 Dec 20;4:264. doi: 10.3389/fgene.2013.00264. Review.


Latitudinal variation in protein expression after heat stress in the salt marsh mussel Geukensia demissa.

Fields PA, Cox KM, Karch KR.

Integr Comp Biol. 2012 Nov;52(5):636-47. doi: 10.1093/icb/ics086. Epub 2012 May 28.


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