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Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles.

Detzner J, Gloerfeld C, Pohlentz G, Legros N, Humpf HU, Mellmann A, Karch H, Müthing J.

Microorganisms. 2019 Nov 19;7(11). pii: E582. doi: 10.3390/microorganisms7110582.


Real-time interaction analysis of Shiga toxins and membrane microdomains of primary human brain microvascular endothelial cells.

Detzner J, Steil D, Pohlentz G, Legros N, Humpf HU, Mellmann A, Karch H, Müthing J.

Glycobiology. 2020 Feb 19;30(3):174-185. doi: 10.1093/glycob/cwz091.


Metabolomic analysis of Shiga toxin 2a-induced injury in conditionally immortalized glomerular endothelial cells.

Patry C, Plotnicki K, Betzen C, Ortiz AP, Pappan KL, Satchell SC, Mathieson PW, Bielaszewska M, Karch H, Tönshoff B, Rafat N.

Metabolomics. 2019 Oct 1;15(10):131. doi: 10.1007/s11306-019-1594-2.


PapG subtype-specific binding characteristics of Escherichia coli towards globo-series glycosphingolipids of human kidney and bladder uroepithelial cells.

Legros N, Ptascheck S, Pohlentz G, Karch H, Dobrindt U, Müthing J.

Glycobiology. 2019 Oct 21;29(11):789-802. doi: 10.1093/glycob/cwz059.


Pectin-derived neoglycolipids: Tools for differentiation of Shiga toxin subtypes and inhibitors of Shiga toxin-mediated cellular injury.

Pohlentz G, Steil D, Rubin D, Mellmann A, Karch H, Müthing J.

Carbohydr Polym. 2019 May 15;212:323-333. doi: 10.1016/j.carbpol.2019.02.039. Epub 2019 Feb 15.


Attack of the clones: whole genome-based characterization of two closely related enterohemorrhagic Escherichia coli O26 epidemic lineages.

Karnisova L, Marejkova M, Hrbackova H, Mellmann A, Karch H, Fruth A, Drevinek P, Blahova K, Bielaszewska M, Nunvar J.

BMC Genomics. 2018 Aug 31;19(1):647. doi: 10.1186/s12864-018-5045-7.


Microevolution of epidemiological highly relevant non-O157 enterohemorrhagic Escherichia coli of serogroups O26 and O111.

Eichhorn I, Semmler T, Mellmann A, Pickard D, Anjum MF, Fruth A, Karch H, Wieler LH.

Int J Med Microbiol. 2018 Dec;308(8):1085-1095. doi: 10.1016/j.ijmm.2018.08.003. Epub 2018 Aug 10.


The 2011 German Enterohemorrhagic Escherichia Coli O104:H4 Outbreak-The Danger Is Still Out There.

Kampmeier S, Berger M, Mellmann A, Karch H, Berger P.

Curr Top Microbiol Immunol. 2018;416:117-148. doi: 10.1007/82_2018_107. Review.


Combining Mass Spectrometry, Surface Acoustic Wave Interaction Analysis, and Cell Viability Assays for Characterization of Shiga Toxin Subtypes of Pathogenic Escherichia coli Bacteria.

Steil D, Pohlentz G, Legros N, Mormann M, Mellmann A, Karch H, Müthing J.

Anal Chem. 2018 Aug 7;90(15):8989-8997. doi: 10.1021/acs.analchem.8b01189. Epub 2018 Jul 9.


Lysogenic conversion of atypical enteropathogenic Escherichia coli (aEPEC) from human, murine, and bovine origin with bacteriophage Φ3538 Δstx2::cat proves their enterohemorrhagic E. coli (EHEC) progeny.

Eichhorn I, Heidemanns K, Ulrich RG, Schmidt H, Semmler T, Fruth A, Bethe A, Goulding D, Pickard D, Karch H, Wieler LH.

Int J Med Microbiol. 2018 Oct;308(7):890-898. doi: 10.1016/j.ijmm.2018.06.005. Epub 2018 Jun 19.


Enterohemorrhagic Escherichia coli O157 outer membrane vesicles induce interleukin 8 production in human intestinal epithelial cells by signaling via Toll-like receptors TLR4 and TLR5 and activation of the nuclear factor NF-κB.

Bielaszewska M, Marejková M, Bauwens A, Kunsmann-Prokscha L, Mellmann A, Karch H.

Int J Med Microbiol. 2018 Oct;308(7):882-889. doi: 10.1016/j.ijmm.2018.06.004. Epub 2018 Jun 19.


Membrane assembly of Shiga toxin glycosphingolipid receptors and toxin refractiveness of MDCK II epithelial cells.

Legros N, Pohlentz G, Steil D, Kouzel IU, Liashkovich I, Mellmann A, Karch H, Müthing J.

J Lipid Res. 2018 Aug;59(8):1383-1401. doi: 10.1194/jlr.M083048. Epub 2018 Jun 4.


Endothelial progenitor cells accelerate endothelial regeneration in an in vitro model of Shigatoxin-2a-induced injury via soluble growth factors.

Patry C, Betzen C, Fathalizadeh F, Fichtner A, Westhoff JH, Fleming T, Eckstein V, Bruckner T, Bielaszewska M, Karch H, Hoffmann GF, Tönshoff B, Rafat N.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F861-F869. doi: 10.1152/ajprenal.00633.2017. Epub 2018 Mar 7.


Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome.

Dammermann W, Mihajlov V, Middendorf B, Mellmann A, Karch H, Lüth S, Ullrich S.

J Gastroenterol Hepatol. 2018 Jul;33(7):1353-1356. doi: 10.1111/jgh.14082. Epub 2018 Mar 12.


Shiga Toxin Glycosphingolipid Receptors in Human Caco-2 and HCT-8 Colon Epithelial Cell Lines.

Kouzel IU, Pohlentz G, Schmitz JS, Steil D, Humpf HU, Karch H, Müthing J.

Toxins (Basel). 2017 Oct 25;9(11). pii: E338. doi: 10.3390/toxins9110338.


Sorbitol-Fermenting Enterohemorrhagic Escherichia coli O157:H- Isolates from Czech Patients with Novel Plasmid Composition Not Previously Seen in German Isolates.

Bauwens A, Marejková M, Middendorf-Bauchart B, Prager R, Kossow A, Zhang W, Karch H, Mellmann A, Bielaszewska M.

Appl Environ Microbiol. 2017 Nov 16;83(23). pii: e01454-17. doi: 10.1128/AEM.01454-17. Print 2017 Dec 1.


Intrahost milieu modulates production of outer membrane vesicles, vesicle-associated Shiga toxin 2a and cytotoxicity in Escherichia coli O157:H7 and O104:H4.

Bauwens A, Kunsmann L, Marejková M, Zhang W, Karch H, Bielaszewska M, Mellmann A.

Environ Microbiol Rep. 2017 Oct;9(5):626-634. doi: 10.1111/1758-2229.12562. Epub 2017 Jul 21.


Antibiotic-Mediated Modulations of Outer Membrane Vesicles in Enterohemorrhagic Escherichia coli O104:H4 and O157:H7.

Bauwens A, Kunsmann L, Karch H, Mellmann A, Bielaszewska M.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00937-17. doi: 10.1128/AAC.00937-17. Print 2017 Sep.


Colocalization of receptors for Shiga toxins with lipid rafts in primary human renal glomerular endothelial cells and influence of D-PDMP on synthesis and distribution of glycosphingolipid receptors.

Legros N, Pohlentz G, Runde J, Dusny S, Humpf HU, Karch H, Müthing J.

Glycobiology. 2017 Oct 1;27(10):947-965. doi: 10.1093/glycob/cwx048.


Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury.

Bielaszewska M, Rüter C, Bauwens A, Greune L, Jarosch KA, Steil D, Zhang W, He X, Lloubes R, Fruth A, Kim KS, Schmidt MA, Dobrindt U, Mellmann A, Karch H.

PLoS Pathog. 2017 Feb 3;13(2):e1006159. doi: 10.1371/journal.ppat.1006159. eCollection 2017 Feb.


A Topographical Atlas of Shiga Toxin 2e Receptor Distribution in the Tissues of Weaned Piglets.

Steil D, Bonse R, Meisen I, Pohlentz G, Vallejo G, Karch H, Müthing J.

Toxins (Basel). 2016 Nov 30;8(12). pii: E357.


The primary transcriptome of the Escherichia coli O104:H4 pAA plasmid and novel insights into its virulence gene expression and regulation.

Berger P, Knödler M, Förstner KU, Berger M, Bertling C, Sharma CM, Vogel J, Karch H, Dobrindt U, Mellmann A.

Sci Rep. 2016 Oct 17;6:35307. doi: 10.1038/srep35307.


Experimental Infection of Calves with Escherichia coli O104:H4 outbreak strain.

Hamm K, Barth SA, Stalb S, Geue L, Liebler-Tenorio E, Teifke JP, Lange E, Tauscher K, Kotterba G, Bielaszewska M, Karch H, Menge C.

Sci Rep. 2016 Sep 7;6:32812. doi: 10.1038/srep32812.


Shiga toxin glycosphingolipid receptors and their lipid membrane ensemble in primary human blood-brain barrier endothelial cells.

Legros N, Dusny S, Humpf HU, Pohlentz G, Karch H, Müthing J.

Glycobiology. 2017 Jan;27(1):99-109. doi: 10.1093/glycob/cww090. Epub 2016 Aug 24.


Ciprofloxacin versus colistin prophylaxis during neutropenia in acute myeloid leukemia: two parallel patient cohorts treated in a single center.

Pohlen M, Marx J, Mellmann A, Becker K, Mesters RM, Mikesch JH, Schliemann C, Lenz G, Müller-Tidow C, Büchner T, Krug U, Stelljes M, Karch H, Peters G, Gerth HU, Görlich D, Berdel WE.

Haematologica. 2016 Oct;101(10):1208-1215. Epub 2016 Jul 28.


Shiga toxin of enterohaemorrhagic Escherichia coli directly injures developing human erythrocytes.

Betz J, Dorn I, Kouzel IU, Bauwens A, Meisen I, Kemper B, Bielaszewska M, Mormann M, Weymann L, Sibrowski W, Karch H, Schlenke P, Müthing J.

Cell Microbiol. 2016 Oct;18(10):1339-48. doi: 10.1111/cmi.12592. Epub 2016 Apr 29.


Molecular Characterization of Human Atypical Sorbitol-Fermenting Enteropathogenic Escherichia coli O157 Reveals High Diversity.

Kossow A, Zhang W, Bielaszewska M, Rhode S, Hansen K, Fruth A, Rüter C, Karch H, Mellmann A.

J Clin Microbiol. 2016 May;54(5):1357-63. doi: 10.1128/JCM.02897-15. Epub 2016 Mar 16.


Shiga Toxin 2a-Induced Endothelial Injury in Hemolytic Uremic Syndrome: A Metabolomic Analysis.

Betzen C, Plotnicki K, Fathalizadeh F, Pappan K, Fleming T, Bielaszewska M, Karch H, Tönshoff B, Rafat N.

J Infect Dis. 2016 Mar 15;213(6):1031-40. doi: 10.1093/infdis/jiv540. Epub 2015 Nov 17.


Shiga toxin glycosphingolipid receptors of Vero-B4 kidney epithelial cells and their membrane microdomain lipid environment.

Steil D, Schepers CL, Pohlentz G, Legros N, Runde J, Humpf HU, Karch H, Müthing J.

J Lipid Res. 2015 Dec;56(12):2322-36. doi: 10.1194/jlr.M063040. Epub 2015 Oct 13.


Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma.

Becker J, May A, Gerges C, Anders M, Veits L, Weise K, Czamara D, Lyros O, Manner H, Terheggen G, Venerito M, Noder T, Mayershofer R, Hofer JH, Karch HW, Ahlbrand CJ, Arras M, Hofer S, Mangold E, Heilmann-Heimbach S, Heinrichs SK, Hess T, Kiesslich R, Izbicki JR, Hölscher AH, Bollschweiler E, Malfertheiner P, Lang H, Moehler M, Lorenz D, Müller-Myhsok B, Ott K, Schmidt T, Whiteman DC, Vaughan TL, Nöthen MM, Hackelsberger A, Schumacher B, Pech O, Vashist Y, Vieth M, Weismüller J, Neuhaus H, Rösch T, Ell C, Gockel I, Schumacher J.

Cancer Med. 2015 Nov;4(11):1700-4. doi: 10.1002/cam4.500. Epub 2015 Aug 15.


Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain.

Kunsmann L, Rüter C, Bauwens A, Greune L, Glüder M, Kemper B, Fruth A, Wai SN, He X, Lloubes R, Schmidt MA, Dobrindt U, Mellmann A, Karch H, Bielaszewska M.

Sci Rep. 2015 Aug 18;5:13252. doi: 10.1038/srep13252.


Highly Virulent Non-O157 Enterohemorrhagic Escherichia coli (EHEC) Serotypes Reflect Similar Phylogenetic Lineages, Providing New Insights into the Evolution of EHEC.

Eichhorn I, Heidemanns K, Semmler T, Kinnemann B, Mellmann A, Harmsen D, Anjum MF, Schmidt H, Fruth A, Valentin-Weigand P, Heesemann J, Suerbaum S, Karch H, Wieler LH.

Appl Environ Microbiol. 2015 Oct;81(20):7041-7. doi: 10.1128/AEM.01921-15. Epub 2015 Jul 31.


Analysis of bile colonization and intestinal flora may improve management in liver transplant recipients undergoing ERCP.

Kabar I, Hüsing A, Cicinnati VR, Heitschmidt L, Beckebaum S, Thölking G, Schmidt HH, Karch H, Kipp F.

Ann Transplant. 2015 May 4;20:249-55. doi: 10.12659/AOT.893549.


Agitation down-regulates immunoglobulin binding protein EibG expression in Shiga toxin-producing Escherichia coli (STEC).

Kuczius T, Zhang W, Merkel V, Mellmann A, Tarr PI, Karch H.

PLoS One. 2015 Mar 6;10(3):e0119583. doi: 10.1371/journal.pone.0119583. eCollection 2015.


Characterization of urinary tract infection-associated Shiga toxin-producing Escherichia coli.

Toval F, Schiller R, Meisen I, Putze J, Kouzel IU, Zhang W, Karch H, Bielaszewska M, Mormann M, Müthing J, Dobrindt U.

Infect Immun. 2014 Nov;82(11):4631-42. doi: 10.1128/IAI.01701-14. Epub 2014 Aug 25.


Hemolysin of enterohemorrhagic Escherichia coli: structure, transport, biological activity and putative role in virulence.

Bielaszewska M, Aldick T, Bauwens A, Karch H.

Int J Med Microbiol. 2014 Jul;304(5-6):521-9. doi: 10.1016/j.ijmm.2014.05.005. Epub 2014 May 15. Review.


Characterization of Escherichia coli isolates from hospital inpatients or outpatients with urinary tract infection.

Toval F, Köhler CD, Vogel U, Wagenlehner F, Mellmann A, Fruth A, Schmidt MA, Karch H, Bielaszewska M, Dobrindt U.

J Clin Microbiol. 2014 Feb;52(2):407-18. doi: 10.1128/JCM.02069-13. Epub 2013 Nov 13.


Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6.

Bielaszewska M, Schiller R, Lammers L, Bauwens A, Fruth A, Middendorf B, Schmidt MA, Tarr PI, Dobrindt U, Karch H, Mellmann A.

EMBO Mol Med. 2014 Mar;6(3):347-57. doi: 10.1002/emmm.201303133. Epub 2014 Jan 10.


Progress in detection and structural characterization of glycosphingolipids in crude lipid extracts by enzymatic phospholipid disintegration combined with thin-layer chromatography immunodetection and IR-MALDI mass spectrometry.

Kouzel IU, Pirkl A, Pohlentz G, Soltwisch J, Dreisewerd K, Karch H, Müthing J.

Anal Chem. 2014 Jan 21;86(2):1215-22. doi: 10.1021/ac4035696. Epub 2014 Jan 3.


Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis.

Bielaszewska M, Rüter C, Kunsmann L, Greune L, Bauwens A, Zhang W, Kuczius T, Kim KS, Mellmann A, Schmidt MA, Karch H.

PLoS Pathog. 2013;9(12):e1003797. doi: 10.1371/journal.ppat.1003797. Epub 2013 Dec 12.


Evolution of enterohemorrhagic escherichia coli O26 based on single-nucleotide polymorphisms.

Bletz S, Bielaszewska M, Leopold SR, Köck R, Witten A, Schuldes J, Zhang W, Karch H, Mellmann A.

Genome Biol Evol. 2013;5(10):1807-16. doi: 10.1093/gbe/evt136.


Phylogeny and phenotypes of clinical and environmental Shiga toxin-producing Escherichia coli O174.

Zhang W, Nadirk J, Kossow A, Bielaszewska M, Leopold SR, Witten A, Fruth A, Karch H, Ammon A, Mellmann A.

Environ Microbiol. 2014 Apr;16(4):963-76. doi: 10.1111/1462-2920.12234. Epub 2013 Aug 27.


Lability of the pAA Virulence Plasmid in Escherichia coli O104:H4: Implications for Virulence in Humans.

Zhang W, Bielaszewska M, Kunsmann L, Mellmann A, Bauwens A, Köck R, Kossow A, Anders A, Gatermann S, Karch H.

PLoS One. 2013 Jun 21;8(6):e66717. doi: 10.1371/journal.pone.0066717. Print 2013.


Shiga toxin 2 reduces complement inhibitor CD59 expression on human renal tubular epithelial and glomerular endothelial cells.

Ehrlenbach S, Rosales A, Posch W, Wilflingseder D, Hermann M, Brockmeyer J, Karch H, Satchell SC, Würzner R, Orth-Höller D.

Infect Immun. 2013 Aug;81(8):2678-85. doi: 10.1128/IAI.01079-12. Epub 2013 May 20.


Expression of Shiga toxin 2e glycosphingolipid receptors of primary porcine brain endothelial cells and toxin-mediated breakdown of the blood-brain barrier.

Meisen I, Rosenbrück R, Galla HJ, Hüwel S, Kouzel IU, Mormann M, Karch H, Müthing J.

Glycobiology. 2013 Jun;23(6):745-59. doi: 10.1093/glycob/cwt013. Epub 2013 Feb 21.


Thalamic involvement in patients with neurologic impairment due to Shiga toxin 2.

Meuth SG, Göbel K, Kanyshkova T, Ehling P, Ritter MA, Schwindt W, Bielaszewska M, Lebiedz P, Coulon P, Herrmann AM, Storck W, Kohmann D, Müthing J, Pavenstädt H, Kuhlmann T, Karch H, Peters G, Budde T, Wiendl H, Pape HC.

Ann Neurol. 2013 Mar;73(3):419-29. doi: 10.1002/ana.23814. Epub 2013 Feb 19.


Phylogenetic and molecular analysis of food-borne shiga toxin-producing Escherichia coli.

Hauser E, Mellmann A, Semmler T, Stoeber H, Wieler LH, Karch H, Kuebler N, Fruth A, Harmsen D, Weniger T, Tietze E, Schmidt H.

Appl Environ Microbiol. 2013 Apr;79(8):2731-40. doi: 10.1128/AEM.03552-12. Epub 2013 Feb 15.


Enterohemorrhagic Escherichia coli O26:H11/H-: a new virulent clone emerges in Europe.

Bielaszewska M, Mellmann A, Bletz S, Zhang W, Köck R, Kossow A, Prager R, Fruth A, Orth-Höller D, Marejková M, Morabito S, Caprioli A, Piérard D, Smith G, Jenkins C, Curová K, Karch H.

Clin Infect Dis. 2013 May;56(10):1373-81. doi: 10.1093/cid/cit055. Epub 2013 Feb 1.


Duration of fecal shedding of Shiga toxin-producing Escherichia coli O104:H4 in patients infected during the 2011 outbreak in Germany: a multicenter study.

Vonberg RP, Höhle M, Aepfelbacher M, Bange FC, Belmar Campos C, Claussen K, Christner M, Cramer JP, Haller H, Hornef M, Fickenscher H, Fraedrich K, Knobloch JK, Kühbacher T, Manns MP, Nitschke M, Peters G, Pulz M, Rohde H, Roseland RT, Sayk F, Schaumburg F, Schöcklmann HO, Schubert S, Solbach W, Karch H, Suerbaum S.

Clin Infect Dis. 2013 Apr;56(8):1132-40. doi: 10.1093/cid/cis1218. Epub 2013 Jan 8.


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