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Items: 1 to 50 of 64

1.

Dynamics of the mitochondrial permeability transition pore: Transient and permanent opening events.

Boyman L, Coleman AK, Zhao G, Wescott AP, Joca HC, Greiser BM, Karbowski M, Ward CW, Lederer WJ.

Arch Biochem Biophys. 2019 May 15;666:31-39. doi: 10.1016/j.abb.2019.03.016. Epub 2019 Mar 28.

PMID:
30930285
2.

The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species.

Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V, Cherok E, Khalil A, Yadava N, Ge SX, Francis TC, Kennedy NW, Picton LK, Kumar T, Uppuluri S, Miller AM, Itoh K, Karbowski M, Sesaki H, Hill RB, Polster BM.

Dev Cell. 2017 Mar 27;40(6):583-594.e6. doi: 10.1016/j.devcel.2017.02.020.

3.

Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics.

Cherok E, Xu S, Li S, Das S, Meltzer WA, Zalzman M, Wang C, Karbowski M.

Mol Biol Cell. 2017 Feb 1;28(3):396-410. doi: 10.1091/mbc.E16-04-0208. Epub 2016 Dec 8.

4.

Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein.

Xu S, Cherok E, Das S, Li S, Roelofs BA, Ge SX, Polster BM, Boyman L, Lederer WJ, Wang C, Karbowski M.

Mol Biol Cell. 2016 Jan 15;27(2):349-59. doi: 10.1091/mbc.E15-09-0678. Epub 2015 Nov 12.

5.

Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission.

Li S, Xu S, Roelofs BA, Boyman L, Lederer WJ, Sesaki H, Karbowski M.

J Cell Biol. 2015 Jan 5;208(1):109-23. doi: 10.1083/jcb.201404050. Epub 2014 Dec 29.

6.
7.

[Fournier's gangrene--a case report].

Mazur A, Karbowski M.

Wiad Lek. 2013;66(3):260-1. Polish.

PMID:
24483035
8.

Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changes.

Clerc P, Ge SX, Hwang H, Waddell J, Roelofs BA, Karbowski M, Sesaki H, Polster BM.

Br J Pharmacol. 2014 Apr;171(8):1988-99. doi: 10.1111/bph.12515.

9.

Ubiquitination-induced fluorescence complementation (UiFC) for detection of K48 ubiquitin chains in vitro and in live cells.

Chen Z, Zhong Y, Wang Y, Xu S, Liu Z, Baskakov IV, Monteiro MJ, Karbowski M, Shen Y, Fang S.

PLoS One. 2013 Sep 5;8(9):e73482. doi: 10.1371/journal.pone.0073482. eCollection 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/65881dc3-5bce-4f0b-9060-7079e16b1877.

10.

Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.

Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M, Youle RJ, Nicoll RA, Roche KW.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19426-31. doi: 10.1073/pnas.1217477109. Epub 2012 Nov 5.

11.

The ubiquitin/proteasome system-dependent control of mitochondrial steps in apoptosis.

Neutzner A, Li S, Xu S, Karbowski M.

Semin Cell Dev Biol. 2012 Jul;23(5):499-508. doi: 10.1016/j.semcdb.2012.03.019. Epub 2012 Apr 11. Review.

PMID:
22516642
12.

Neurodegeneration as a consequence of failed mitochondrial maintenance.

Karbowski M, Neutzner A.

Acta Neuropathol. 2012 Feb;123(2):157-71. doi: 10.1007/s00401-011-0921-0. Epub 2011 Dec 7. Review.

PMID:
22143516
13.

Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation.

Karbowski M, Youle RJ.

Curr Opin Cell Biol. 2011 Aug;23(4):476-82. doi: 10.1016/j.ceb.2011.05.007. Epub 2011 Jun 24. Review.

14.

A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis.

Neutzner A, Neutzner M, Benischke AS, Ryu SW, Frank S, Youle RJ, Karbowski M.

J Biol Chem. 2011 Mar 11;286(10):8633-43. doi: 10.1074/jbc.M110.197459. Epub 2011 Jan 4.

15.

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin.

Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ.

J Cell Biol. 2010 Dec 27;191(7):1367-80. doi: 10.1083/jcb.201007013. Epub 2010 Dec 20.

16.

The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover.

Xu S, Peng G, Wang Y, Fang S, Karbowski M.

Mol Biol Cell. 2011 Feb 1;22(3):291-300. doi: 10.1091/mbc.E10-09-0748. Epub 2010 Nov 30.

17.
18.

Bcl-2 family interaction with the mitochondrial morphogenesis machinery.

Cleland MM, Norris KL, Karbowski M, Wang C, Suen DF, Jiao S, George NM, Luo X, Li Z, Youle RJ.

Cell Death Differ. 2011 Feb;18(2):235-47. doi: 10.1038/cdd.2010.89. Epub 2010 Jul 30.

19.

Optic atrophy 3 as a protein of the mitochondrial outer membrane induces mitochondrial fragmentation.

Ryu SW, Jeong HJ, Choi M, Karbowski M, Choi C.

Cell Mol Life Sci. 2010 Aug;67(16):2839-50. doi: 10.1007/s00018-010-0365-z. Epub 2010 Apr 8.

PMID:
20372962
20.

IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation.

Benard G, Neutzner A, Peng G, Wang C, Livak F, Youle RJ, Karbowski M.

EMBO J. 2010 Apr 21;29(8):1458-71. doi: 10.1038/emboj.2010.39. Epub 2010 Mar 18.

21.

Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1.

Park YY, Lee S, Karbowski M, Neutzner A, Youle RJ, Cho H.

J Cell Sci. 2010 Feb 15;123(Pt 4):619-26. doi: 10.1242/jcs.061481. Epub 2010 Jan 26.

22.

Mitochondrial fusion and division: Regulation and role in cell viability.

Benard G, Karbowski M.

Semin Cell Dev Biol. 2009 May;20(3):365-74. Review.

23.

Editorial of the directed issue on mitochondrial dynamics in biology and medicine.

Rossignol R, Karbowski M.

Int J Biochem Cell Biol. 2009 Oct;41(10):1748-9. doi: 10.1016/j.biocel.2009.05.019. Epub 2009 Jun 6. No abstract available.

PMID:
19501184
24.

SLP-2 is required for stress-induced mitochondrial hyperfusion.

Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC, Alexander C, Bauer C, Youle R, Langer T, Martinou JC.

EMBO J. 2009 Jun 3;28(11):1589-600. doi: 10.1038/emboj.2009.89. Epub 2009 Apr 9.

25.

Role of the ubiquitin conjugation system in the maintenance of mitochondrial homeostasis.

Neutzner A, Benard G, Youle RJ, Karbowski M.

Ann N Y Acad Sci. 2008 Dec;1147:242-53. doi: 10.1196/annals.1427.012. Review.

PMID:
19076446
26.

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

Wang H, Lim PJ, Karbowski M, Monteiro MJ.

Hum Mol Genet. 2009 Feb 15;18(4):737-52. doi: 10.1093/hmg/ddn404. Epub 2008 Nov 27.

27.

OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion.

Zanna C, Ghelli A, Porcelli AM, Karbowski M, Youle RJ, Schimpf S, Wissinger B, Pinti M, Cossarizza A, Vidoni S, Valentino ML, Rugolo M, Carelli V.

Brain. 2008 Feb;131(Pt 2):352-67. doi: 10.1093/brain/awm335.

PMID:
18222991
28.

Outer mitochondrial membrane protein degradation by the proteasome.

Neutzner A, Youle RJ, Karbowski M.

Novartis Found Symp. 2007;287:4-14; discussion 14-20. Review.

PMID:
18074628
29.

Polyflex self-expanding, removable plastic stents: assessment of treatment efficacy and safety in a variety of benign and malignant conditions of the esophagus.

Karbowski M, Schembre D, Kozarek R, Ayub K, Low D.

Surg Endosc. 2008 May;22(5):1326-33. Epub 2007 Nov 20.

PMID:
18027044
30.
31.

Role of Bax and Bak in mitochondrial morphogenesis.

Karbowski M, Norris KL, Cleland MM, Jeong SY, Youle RJ.

Nature. 2006 Oct 12;443(7112):658-62. Epub 2006 Oct 1.

PMID:
17035996
32.

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis.

Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang HG.

Mol Cell Biol. 2005 Nov;25(21):9369-82.

33.

Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells.

Spodnik JH, Wozniak M, Budzko D, Teranishi MA, Karbowski M, Nishizawa Y, Usukura J, Wakabayashi T.

Mitochondrion. 2002 Dec;2(3):163-79.

PMID:
16120318
34.

Mitochondrial fission in apoptosis.

Youle RJ, Karbowski M.

Nat Rev Mol Cell Biol. 2005 Aug;6(8):657-63. Review.

PMID:
16025099
35.

Modification of physicochemical properties of actin filaments suppresses cell fragmentation in the execution phase of staurosporine-induced apoptotic processes.

Majczak A, Karbowski M, Kamiński M, Masaoka M, Kurono C, Niemczyk E, Kedzior J, Soji T, Knap D, Hallmann A, Wakabayashi T.

J Electron Microsc (Tokyo). 2004;53(6):635-47.

PMID:
15582977
36.

The switch mechanism of the cell death mode from apoptosis to necrosis in menadione-treated human osteosarcoma cell line 143B cells.

Kamiński M, Niemczyk E, Masaoka M, Karbowski M, Hallmann A, Kedzior J, Majczak A, Knap D, Nishizawa Y, Usukura J, Woźniak M, Klimek J, Wakabayashi T.

Microsc Res Tech. 2004 Jun 15;64(3):255-8.

PMID:
15452893
37.

Endophilin B1 is required for the maintenance of mitochondrial morphology.

Karbowski M, Jeong SY, Youle RJ.

J Cell Biol. 2004 Sep 27;166(7):1027-39.

38.

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis.

Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ.

Mol Biol Cell. 2004 Nov;15(11):5001-11. Epub 2004 Sep 8.

39.
40.

The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle.

Suzuki M, Jeong SY, Karbowski M, Youle RJ, Tjandra N.

J Mol Biol. 2003 Nov 28;334(3):445-58.

PMID:
14623186
41.

Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization.

Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F, Youle RJ.

EMBO J. 2003 Sep 1;22(17):4385-99.

42.

Ultrastructural basis for the transition of cell death mode from apoptosis to necrosis in menadione-treated osteosarcoma 143B cells.

Kamiński M, Masaoka M, Karbowski M, Kedzior J, Nishizawa Y, Usukura J, Wakabayashi T.

J Electron Microsc (Tokyo). 2003;52(3):313-25.

PMID:
12892222
43.

Dynamics of mitochondrial morphology in healthy cells and during apoptosis.

Karbowski M, Youle RJ.

Cell Death Differ. 2003 Aug;10(8):870-80. Review.

44.

Caspase inhibition prevents the mitochondrial release of apoptosis-inducing factor.

Arnoult D, Karbowski M, Youle RJ.

Cell Death Differ. 2003 Jul;10(7):845-9. No abstract available.

45.

Co-existence of apoptotic and necrotic features within one single cell as a result of menadione treatment.

Kamiński M, Karbowski M, Miyazaki Y, Kedzior J, Spodnik JH, Gil A, Woźniak M, Wakabayashi T.

Folia Morphol (Warsz). 2002;61(4):217-20.

PMID:
12725487
46.

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis.

Karbowski M, Lee YJ, Gaume B, Jeong SY, Frank S, Nechushtan A, Santel A, Fuller M, Smith CL, Youle RJ.

J Cell Biol. 2002 Dec 23;159(6):931-8. Epub 2002 Dec 23.

47.

Structural changes of mitochondria related to apoptosis.

Wakabayashi T, Karbowski M.

Biol Signals Recept. 2001 Jan-Apr;10(1-2):26-56. Review.

PMID:
11223639
48.

Opposite effects of microtubule-stabilizing and microtubule-destabilizing drugs on biogenesis of mitochondria in mammalian cells.

Karbowski M, Spodnik JH, Teranishi M, Wozniak M, Nishizawa Y, Usukura J, Wakabayashi T.

J Cell Sci. 2001 Jan;114(Pt 2):281-91.

49.

Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain.

Petronzelli F, Riccio A, Markham GD, Seeholzer SH, Genuardi M, Karbowski M, Yeung AT, Matsumoto Y, Bellacosa A.

J Cell Physiol. 2000 Dec;185(3):473-80.

PMID:
11056019
50.

Swelling of free-radical-induced megamitochondria causes apoptosis.

Teranishi M, Spodonik JH, Karbowski M, Kurono C, Soji T, Wakabayashi T.

Exp Mol Pathol. 2000 Apr;68(2):104-23.

PMID:
10716914

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