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Items: 26


The Codon 72 TP53 Polymorphism Contributes to TSC Tumorigenesis through the Notch-Nodal Axis.

Cho JH, Patel B, Bonala S, Mansouri H, Manne S, Vadrevu SK, Ghouse S, Kung CP, Murphy ME, Astrinidis A, Henske EP, Kwiatkowski DJ, Markiewski MM, Karbowniczek M.

Mol Cancer Res. 2019 Aug;17(8):1639-1651. doi: 10.1158/1541-7786.MCR-18-1292. Epub 2019 May 14.


Complementing Cancer Metastasis.

Kochanek DM, Ghouse SM, Karbowniczek MM, Markiewski MM.

Front Immunol. 2018 Jul 16;9:1629. doi: 10.3389/fimmu.2018.01629. eCollection 2018. Review.


Notch transactivates Rheb to maintain the multipotency of TSC-null cells.

Cho JH, Patel B, Bonala S, Manne S, Zhou Y, Vadrevu SK, Patel J, Peronaci M, Ghouse S, Henske EP, Roegiers F, Giannikou K, Kwiatkowski DJ, Mansouri H, Markiewski MM, White B, Karbowniczek M.

Nat Commun. 2017 Nov 29;8(1):1848. doi: 10.1038/s41467-017-01845-1.


The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1.

Markiewski MM, Vadrevu SK, Sharma SK, Chintala NK, Ghouse S, Cho JH, Fairlie DP, Paterson Y, Astrinidis A, Karbowniczek M.

J Immunol. 2017 Apr 1;198(7):2989-2999. doi: 10.4049/jimmunol.1602057. Epub 2017 Feb 22.


Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis.

Vadrevu SK, Sharma S, Chintala N, Patel J, Karbowniczek M, Markiewski M.

J Vis Exp. 2016 Jun 26;(112). doi: 10.3791/54306.


Exosomes mediate the acquisition of the disease phenotypes by cells with normal genome in tuberous sclerosis complex.

Patel B, Patel J, Cho JH, Manne S, Bonala S, Henske E, Roegiers F, Markiewski M, Karbowniczek M.

Oncogene. 2016 Jun 9;35(23):3027-36. doi: 10.1038/onc.2015.358. Epub 2015 Oct 5.


Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs.

Sharma SK, Chintala NK, Vadrevu SK, Patel J, Karbowniczek M, Markiewski MM.

J Immunol. 2015 Jun 1;194(11):5529-38. doi: 10.4049/jimmunol.1403215. Epub 2015 Apr 24.


Quantifying autophagosomes and autolysosomes in cells using imaging flow cytometry.

Rajan R, Karbowniczek M, Pugsley HR, Sabnani MK, Astrinidis A, La-Beck NM.

Cytometry A. 2015 May;87(5):451-8. doi: 10.1002/cyto.a.22652. Epub 2015 Feb 27.


Complement c5a receptor facilitates cancer metastasis by altering T-cell responses in the metastatic niche.

Vadrevu SK, Chintala NK, Sharma SK, Sharma P, Cleveland C, Riediger L, Manne S, Fairlie DP, Gorczyca W, Almanza O, Karbowniczek M, Markiewski MM.

Cancer Res. 2014 Jul 1;74(13):3454-65. doi: 10.1158/0008-5472.CAN-14-0157. Epub 2014 May 1.


The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis.

Zitserman D, Gupta S, Kruger WD, Karbowniczek M, Roegiers F.

PLoS One. 2012;7(11):e48720. doi: 10.1371/journal.pone.0048720. Epub 2012 Nov 7.


Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.

Parkhitko A, Myachina F, Morrison TA, Hindi KM, Auricchio N, Karbowniczek M, Wu JJ, Finkel T, Kwiatkowski DJ, Yu JJ, Henske EP.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12455-60. doi: 10.1073/pnas.1104361108. Epub 2011 Jul 11.


Microstructure evolution in hot worked steel after heating to semi-solid state.

Sołek K, Mitura Z, Karbowniczek M, Dutkiewicz J, Faryna M, Rogal Ł.

J Microsc. 2010 Mar;237(3):469-74. doi: 10.1111/j.1365-2818.2009.03296.x.


The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development.

Karbowniczek M, Zitserman D, Khabibullin D, Hartman T, Yu J, Morrison T, Nicolas E, Squillace R, Roegiers F, Henske EP.

J Clin Invest. 2010 Jan;120(1):93-102. doi: 10.1172/JCI40221. Epub 2009 Dec 28.


Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells.

Yu JJ, Robb VA, Morrison TA, Ariazi EA, Karbowniczek M, Astrinidis A, Wang C, Hernandez-Cuebas L, Seeholzer LF, Nicolas E, Hensley H, Jordan VC, Walker CL, Henske EP.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2635-40. doi: 10.1073/pnas.0810790106. Epub 2009 Feb 6.


Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.

Lee CH, Inoki K, Karbowniczek M, Petroulakis E, Sonenberg N, Henske EP, Guan KL.

EMBO J. 2007 Nov 28;26(23):4812-23. Epub 2007 Oct 25.


mTOR is activated in the majority of malignant melanomas.

Karbowniczek M, Spittle CS, Morrison T, Wu H, Henske EP.

J Invest Dermatol. 2008 Apr;128(4):980-7. Epub 2007 Oct 4.


Activation of the mTOR signaling pathway in renal clear cell carcinoma.

Robb VA, Karbowniczek M, Klein-Szanto AJ, Henske EP.

J Urol. 2007 Jan;177(1):346-52.


Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.

Karbowniczek M, Robertson GP, Henske EP.

J Biol Chem. 2006 Sep 1;281(35):25447-56. Epub 2006 Jun 27.


The role of tuberin in cellular differentiation: are B-Raf and MAPK involved?

Karbowniczek M, Henske EP.

Ann N Y Acad Sci. 2005 Nov;1059:168-73. Review.


Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.

Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP.

J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.


Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism.

Karbowniczek M, Astrinidis A, Balsara BR, Testa JR, Lium JH, Colby TV, McCormack FX, Henske EP.

Am J Respir Crit Care Med. 2003 Apr 1;167(7):976-82. Epub 2002 Oct 31.


Mutational analysis of the von hippel lindau gene in clear cell renal carcinomas from tuberous sclerosis complex patients.

Duffy K, Al-Saleem T, Karbowniczek M, Ewalt D, Prowse AH, Henske EP.

Mod Pathol. 2002 Mar;15(3):205-10.


p21/WAF1/Cip1 expression in invasive ductal breast carcinoma: relationship to p53, proliferation rate, and survival at 5 years.

Domagala W, Welcker M, Chosia M, Karbowniczek M, Harezga B, Bartkova J, Bartek J, Osborn M.

Virchows Arch. 2001 Aug;439(2):132-40.


Clinico-pathological characteristics of colorectal cancer and serum anti-p53 antibodies.

Bielicki D, Karbowniczek M, Sulzyc-Bielicka V, Kładny J, Boer C, Marlicz K, Domagała W.

Pol J Pathol. 1999;50(2):77-81.


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