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Items: 1 to 50 of 277

1.

Role of TLR5 in inflammation and tissue damage after intestinal ischemia-reperfusion injury.

Ito H, Sadatomo A, Inoue Y, Yamada N, Aizawa E, Hishida E, Kamata R, Karasawa T, Kimura H, Watanabe S, Komada T, Horie H, Kitayama J, Sata N, Takahashi M.

Biochem Biophys Res Commun. 2019 Aug 28. pii: S0006-291X(19)31606-7. doi: 10.1016/j.bbrc.2019.08.083. [Epub ahead of print]

PMID:
31472954
2.

Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss.

Jiang M, Li H, Johnson A, Karasawa T, Zhang Y, Meier WB, Taghizadeh F, Kachelmeier A, Steyger PS.

Sci Adv. 2019 Jul 17;5(7):eaaw1836. doi: 10.1126/sciadv.aaw1836. eCollection 2019 Jul.

3.

Crucial Role of NLRP3 Inflammasome in the Development of Peritoneal Dialysis-related Peritoneal Fibrosis.

Hishida E, Ito H, Komada T, Karasawa T, Kimura H, Watanabe S, Kamata R, Aizawa E, Kasahara T, Morishita Y, Akimoto T, Nagata D, Takahashi M.

Sci Rep. 2019 Jul 17;9(1):10363. doi: 10.1038/s41598-019-46504-1.

4.

Inflammasome-Independent and Atypical Processing of IL-1β Contributes to Acid Aspiration-Induced Acute Lung Injury.

Mizushina Y, Karasawa T, Aizawa K, Kimura H, Watanabe S, Kamata R, Komada T, Mato N, Kasahara T, Koyama S, Bando M, Hagiwara K, Takahashi M.

J Immunol. 2019 Jul 1;203(1):236-246. doi: 10.4049/jimmunol.1900168. Epub 2019 May 20.

PMID:
31109954
5.

Solvent-Dependent Enantiodivergence in anti-Selective Catalytic Asymmetric Nitroaldol Reactions.

Karasawa T, Saito A, Kumagai N, Shibasaki M.

Org Lett. 2019 May 17;21(10):3581-3583. doi: 10.1021/acs.orglett.9b00982. Epub 2019 Apr 17.

PMID:
30995054
6.

Saturated fatty acid-crystals activate NLRP3 inflammasome.

Karasawa T, Takahashi M.

Aging (Albany NY). 2019 Mar 26;11(6):1613-1614. doi: 10.18632/aging.101892. No abstract available.

7.

Exogenous nanoparticles and endogenous crystalline molecules as danger signals for the NLRP3 inflammasomes.

Shirasuna K, Karasawa T, Takahashi M.

J Cell Physiol. 2019 May;234(5):5436-5450. doi: 10.1002/jcp.27475. Epub 2018 Oct 28. Review.

PMID:
30370619
8.

Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages.

Sakai K, Nagashima S, Wakabayashi T, Tumenbayar B, Hayakawa H, Hayakawa M, Karasawa T, Ohashi K, Yamazaki H, Takei A, Takei S, Yamamuro D, Takahashi M, Yagyu H, Osuga JI, Takahashi M, Tominaga SI, Ishibashi S.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2590-2600. doi: 10.1161/ATVBAHA.118.311664.

PMID:
30354246
9.

Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow.

Wakabayashi T, Takahashi M, Yamamuro D, Karasawa T, Takei A, Takei S, Yamazaki H, Nagashima S, Ebihara K, Takahashi M, Ishibashi S.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2576-2589. doi: 10.1161/ATVBAHA.118.311648.

PMID:
30354239
10.

anti-Selective Catalytic Asymmetric Nitroaldol Reaction of α-Keto Esters: Intriguing Solvent Effect, Flow Reaction, and Synthesis of Active Pharmaceutical Ingredients.

Karasawa T, Oriez R, Kumagai N, Shibasaki M.

J Am Chem Soc. 2018 Sep 26;140(38):12290-12295. doi: 10.1021/jacs.8b08236. Epub 2018 Sep 17.

PMID:
30176214
11.

Serum Mac-2 binding protein glycosylation isomer predicts the activation of hepatic stellate cells after liver transplantation.

Yamada N, Katano T, Hirata Y, Okada N, Sanada Y, Ihara Y, Urahashi T, Ushijima K, Karasawa T, Takahashi M, Mizuta K.

J Gastroenterol Hepatol. 2019 Feb;34(2):418-424. doi: 10.1111/jgh.14438. Epub 2018 Sep 9.

PMID:
30101431
12.

Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.

Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, Ohno N, Kasahara T, Minota S, Takahashi M.

Sci Rep. 2018 May 15;8(1):7601. doi: 10.1038/s41598-018-25856-0.

13.

The Second Candida auris Isolate from Aural Discharge in Japan.

Iguchi S, Mizushima R, Kamada K, Itakura Y, Yoshida A, Uzawa Y, Arai Y, Takaoka M, Sato S, Goto A, Karasawa T, Tsuruoka N, Totsuka D, Ono E, Nonaka M, Makimura K, Kikuchi K.

Jpn J Infect Dis. 2018 Mar 22;71(2):174-175. doi: 10.7883/yoken.JJID.2017.466. Epub 2018 Feb 28. No abstract available.

14.

Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.

Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R, Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama N, Shimano H, Kasahara T, Takahashi M.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):744-756. doi: 10.1161/ATVBAHA.117.310581. Epub 2018 Feb 8.

PMID:
29437575
15.

Heterogeneous Heterobimetallic Catalysis Enabling Expeditious Access to CF3-Containing vic-Amino Alcohols.

Karasawa T, Kumagai N, Shibasaki M.

Org Lett. 2018 Jan 5;20(1):308-311. doi: 10.1021/acs.orglett.7b03767. Epub 2017 Dec 26.

PMID:
29278337
16.

The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis.

Karasawa T, Takahashi M.

Inflamm Regen. 2017 Sep 11;37:18. doi: 10.1186/s41232-017-0050-9. eCollection 2017. Review.

17.

A Series of Lithium Pyridyl Phenolate Complexes with a Pendant Pyridyl Group for Electron-Injection Layers in Organic Light-Emitting Devices.

Ohisa S, Karasawa T, Watanabe Y, Ohsawa T, Pu YJ, Koganezawa T, Sasabe H, Kido J.

ACS Appl Mater Interfaces. 2017 Nov 22;9(46):40541-40548. doi: 10.1021/acsami.7b13550. Epub 2017 Nov 13.

PMID:
29111651
18.

Aminoglycoside-Induced Cochleotoxicity: A Review.

Jiang M, Karasawa T, Steyger PS.

Front Cell Neurosci. 2017 Oct 9;11:308. doi: 10.3389/fncel.2017.00308. eCollection 2017. Review.

19.

ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.

Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M.

J Immunol. 2017 Nov 15;199(10):3614-3622. doi: 10.4049/jimmunol.1700184. Epub 2017 Oct 11.

20.

Interaction of Neutrophils with Macrophages Promotes IL-1β Maturation and Contributes to Hepatic Ischemia-Reperfusion Injury.

Sadatomo A, Inoue Y, Ito H, Karasawa T, Kimura H, Watanabe S, Mizushina Y, Nakamura J, Kamata R, Kasahara T, Horie H, Sata N, Takahashi M.

J Immunol. 2017 Nov 1;199(9):3306-3315. doi: 10.4049/jimmunol.1700717. Epub 2017 Oct 2.

21.

The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction.

Kobayashi M, Usui-Kawanishi F, Karasawa T, Kimura H, Watanabe S, Mise N, Kayama F, Kasahara T, Hasebe N, Takahashi M.

PLoS One. 2017 May 11;12(5):e0176676. doi: 10.1371/journal.pone.0176676. eCollection 2017.

22.

Community network for deaf scientists.

Adler HJ, Anbuhl KL, Atcherson SR, Barlow N, Brennan MA, Brigande JV, Buran BN, Fraenzer JT, Gale JE, Gallun FJ, Gluck SD, Goldsworthy RL, Heng J, Hight AE, Huyck JJ, Jacobson BD, Karasawa T, Kovačić D, Lim SR, Malone AK, Nolan LS, Pisano DV, Rao VRM, Raphael RM, Ratnanather JT, Reiss LAJ, Ruffin CV, Schwalje AT, Sinan M, Stahn P, Steyger PS, Tang SJ, Tejani VD, Wong V.

Science. 2017 Apr 28;356(6336):386-387. doi: 10.1126/science.aan2330. Epub 2017 Apr 27. No abstract available.

23.

High-accuracy current generation in the nanoampere regime from a silicon single-trap electron pump.

Yamahata G, Giblin SP, Kataoka M, Karasawa T, Fujiwara A.

Sci Rep. 2017 Mar 21;7:45137. doi: 10.1038/srep45137.

24.

Role of NLRP3 Inflammasomes in Atherosclerosis.

Karasawa T, Takahashi M.

J Atheroscler Thromb. 2017 May 1;24(5):443-451. doi: 10.5551/jat.RV17001. Epub 2017 Mar 4. Review.

25.

Controlled Secretion of the Anticancer Protein MDA-7 from Engineered Mesenchymal Stem Cells.

Sagara A, Karasawa T, Igarashi K, Otsuka M, Sugiura R, Kodama A, Yamashita M, Narita M, Kato Y.

Biol Pharm Bull. 2017;40(1):113-117. doi: 10.1248/bpb.b16-00658.

26.

Endocan as a prognostic biomarker of triple-negative breast cancer.

Sagara A, Igarashi K, Otsuka M, Kodama A, Yamashita M, Sugiura R, Karasawa T, Arakawa K, Narita M, Kuzumaki N, Narita M, Kato Y.

Breast Cancer Res Treat. 2017 Jan;161(2):269-278. doi: 10.1007/s10549-016-4057-8. Epub 2016 Nov 25.

27.

Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.

Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M.

Am J Physiol Endocrinol Metab. 2016 Nov 1;311(5):E881-E890. doi: 10.1152/ajpendo.00174.2016. Epub 2016 Oct 4.

28.

Intrinsic Resistance to 5-Fluorouracil in a Brain Metastatic Variant of Human Breast Cancer Cell Line, MDA-MB-231BR.

Sagara A, Igarashi K, Otsuka M, Karasawa T, Gotoh N, Narita M, Kuzumaki N, Narita M, Kato Y.

PLoS One. 2016 Oct 10;11(10):e0164250. doi: 10.1371/journal.pone.0164250. eCollection 2016.

29.

Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells.

Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T.

J Reprod Immunol. 2016 Aug;116:104-12. doi: 10.1016/j.jri.2016.06.001. Epub 2016 Jun 6.

PMID:
27300134
30.

NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity.

Kobayashi M, Usui F, Karasawa T, Kawashima A, Kimura H, Mizushina Y, Shirasuna K, Mizukami H, Kasahara T, Hasebe N, Takahashi M.

Sci Rep. 2016 May 26;6:26489. doi: 10.1038/srep26489.

31.

Letter by Karasawa and Takahashi Regarding Article, "Anti-inflammatory and Antiatherogenic Effects of the Inflammasome NLRP3 Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet".

Karasawa T, Takahashi M.

Circulation. 2015 Nov 24;132(21):e249. doi: 10.1161/CIRCULATIONAHA.115.016070. No abstract available.

PMID:
26596982
32.

Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders.

Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M.

Sci Rep. 2015 Oct 30;5:15883. doi: 10.1038/srep15883.

33.

NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy.

Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M.

Endocrinology. 2015 Nov;156(11):4281-92. doi: 10.1210/en.2015-1408. Epub 2015 Sep 10.

PMID:
26360504
34.

An integrated view of cisplatin-induced nephrotoxicity and ototoxicity.

Karasawa T, Steyger PS.

Toxicol Lett. 2015 Sep 17;237(3):219-27. doi: 10.1016/j.toxlet.2015.06.012. Epub 2015 Jun 20. Review.

35.

Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury.

Komada T, Usui F, Kawashima A, Kimura H, Karasawa T, Inoue Y, Kobayashi M, Mizushina Y, Kasahara T, Taniguchi S, Muto S, Nagata D, Takahashi M.

Sci Rep. 2015 Jun 5;5:10901. doi: 10.1038/srep10901.

36.

Asymmetric Total Synthesis of ent-Pyripyropene A.

Fuse S, Ikebe A, Oosumi K, Karasawa T, Matsumura K, Izumikawa M, Johmoto K, Uekusa H, Shin-ya K, Doi T, Takahashi T.

Chemistry. 2015 Jun 22;21(26):9454-60. doi: 10.1002/chem.201500703. Epub 2015 May 26.

PMID:
26014374
37.

Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing.

Karasawa T, Kawashima A, Usui F, Kimura H, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Sagara J, Takahashi M.

FEBS Open Bio. 2015 Apr 23;5:348-56. doi: 10.1016/j.fob.2015.04.011. eCollection 2015.

38.

Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles.

Yang Y, Chen F, Karasawa T, Ma KT, Guan BC, Shi XR, Li H, Steyger PS, Nuttall AL, Jiang ZG.

PLoS One. 2015 May 4;10(5):e0125266. doi: 10.1371/journal.pone.0125266. eCollection 2015.

39.

RIP140 as a novel therapeutic target in the treatment of atherosclerosis.

Karasawa T, Takahashi M.

J Mol Cell Cardiol. 2015 Apr;81:136-8. doi: 10.1016/j.yjmcc.2015.02.009. Epub 2015 Feb 18. No abstract available.

PMID:
25701715
40.

NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β.

Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M.

J Biol Chem. 2015 Feb 20;290(8):5065-77. doi: 10.1074/jbc.M114.603217. Epub 2014 Dec 29.

41.

Interferon-tau attenuates uptake of nanoparticles and secretion of interleukin-1β in macrophages.

Hara K, Shirasuna K, Usui F, Karasawa T, Mizushina Y, Kimura H, Kawashima A, Ohkuchi A, Matsuyama S, Kimura K, Takahashi M.

PLoS One. 2014 Dec 8;9(12):e113974. doi: 10.1371/journal.pone.0113974. eCollection 2014.

42.

Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.

Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):127-36. doi: 10.1161/ATVBAHA.114.303763. Epub 2014 Nov 6.

PMID:
25378412
43.

Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides.

Jiang M, Wang Q, Karasawa T, Koo JW, Li H, Steyger PS.

PLoS One. 2014 Sep 30;9(9):e108941. doi: 10.1371/journal.pone.0108941. eCollection 2014.

44.

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H.

Endocrinology. 2014 Dec;155(12):4706-19. doi: 10.1210/en.2014-1113. Epub 2014 Sep 18.

PMID:
25233440
45.

Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders.

Karasawa T, Lombroso PJ.

Neurosci Res. 2014 Dec;89:1-9. doi: 10.1016/j.neures.2014.08.018. Epub 2014 Sep 10. Review.

46.

Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.

Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M.

Nanotoxicology. 2015;9(5):554-67. doi: 10.3109/17435390.2014.956156. Epub 2014 Sep 11.

PMID:
25211550
47.

Glomerular epithelial cell phenotype in diffuse mesangial sclerosis: a report of 2 cases with markedly increased urinary podocyte excretion.

Ikezumi Y, Suzuki T, Karasawa T, Kaneko U, Yamada T, Hasegawa H, Nagata M, Saitoh A.

Hum Pathol. 2014 Aug;45(8):1778-83. doi: 10.1016/j.humpath.2014.03.017. Epub 2014 Apr 18.

PMID:
24856573
48.

NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.

Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M.

J Immunol. 2014 May 1;192(9):4342-51. doi: 10.4049/jimmunol.1302039. Epub 2014 Apr 2.

49.

ASC in renal collecting duct epithelial cells contributes to inflammation and injury after unilateral ureteral obstruction.

Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M.

Am J Pathol. 2014 May;184(5):1287-98. doi: 10.1016/j.ajpath.2014.01.014. Epub 2014 Mar 5.

PMID:
24606883
50.

Spindle cell angiosarcoma almost exclusively made up of spindle cells.

Makita S, Kono M, Yamada M, Suzuki N, Karasawa T, Tanahashi C, Akiyama M.

Eur J Dermatol. 2014 Jan-Feb;24(1):106-7. doi: 10.1684/ejd.2013.2224. No abstract available.

PMID:
24491268

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