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Items: 1 to 50 of 199

1.

Intermittent Occlusion of the Superior Vena Cava Reduces Cardiac Filling Pressures in Preclinical Models of Heart Failure.

Kapur NK, Reyelt L, Crowley P, Richey L, McCarthy J, Annamalai S, Newman S, Jorde L, Forotuanjazi S, Razavi A, Lenihan T, Burkhoff D, Karas RH.

J Cardiovasc Transl Res. 2019 Nov 26. doi: 10.1007/s12265-019-09916-y. [Epub ahead of print]

PMID:
31773461
2.

First-in-human experience with occlusion of the superior vena cava to reduce cardiac filling pressures in congestive heart failure.

Kapur NK, Karas RH, Newman S, Jorde L, Chabrashvili T, Annamalai S, Esposito M, Kimmelstiel CD, Lenihan T, Burkhoff D.

Catheter Cardiovasc Interv. 2019 Jun 1;93(7):1205-1210. doi: 10.1002/ccd.28326. Epub 2019 May 21.

PMID:
31112633
3.

Androgens Ameliorate Impaired Ischemia-Induced Neovascularization Due to Aging in Male Mice.

Lam YT, Lecce L, Yuen SC, Wise SG, Handelsman DJ, Karas RH, Ng MKC.

Endocrinology. 2019 May 1;160(5):1137-1149. doi: 10.1210/en.2018-00951.

PMID:
30830222
4.

Unloading the Left Ventricle Before Reperfusion in Patients With Anterior ST-Segment-Elevation Myocardial Infarction.

Kapur NK, Alkhouli MA, DeMartini TJ, Faraz H, George ZH, Goodwin MJ, Hernandez-Montfort JA, Iyer VS, Josephy N, Kalra S, Kaki A, Karas RH, Kimmelstiel CD, Koenig GC, Lau E, Lotun K, Madder RD, Mannino SF, Meraj PM, Moreland JA, Moses JW, Kim RL, Schreiber TL, Udelson JE, Witzke C, Wohns DHW, O'Neill WW.

Circulation. 2019 Jan 15;139(3):337-346. doi: 10.1161/CIRCULATIONAHA.118.038269.

PMID:
30586728
5.

Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload.

Calamaras TD, Baumgartner RA, Aronovitz MJ, McLaughlin AL, Tam K, Richards DA, Cooper CW, Li N, Baur WE, Qiao X, Wang GR, Davis RJ, Kapur NK, Karas RH, Blanton RM.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H145-H159. doi: 10.1152/ajpheart.00029.2018. Epub 2018 Oct 26.

6.

Abdominal Positioning of the Next-Generation Intra-Aortic Fluid Entrainment Pump (Aortix) Improves Cardiac Output in a Swine Model of Heart Failure.

Annamalai SK, Esposito ML, Reyelt LA, Natov P, Jorde LE, Karas RH, Kapur NK.

Circ Heart Fail. 2018 Aug;11(8):e005115. doi: 10.1161/CIRCHEARTFAILURE.118.005115.

7.

Left Ventricular Unloading Before Reperfusion Promotes Functional Recovery After Acute Myocardial Infarction.

Esposito ML, Zhang Y, Qiao X, Reyelt L, Paruchuri V, Schnitzler GR, Morine KJ, Annamalai SK, Bogins C, Natov PS, Pedicini R, Breton C, Mullin A, Mackey EE, Patel A, Rowin E, Jaffe IZ, Karas RH, Kapur NK.

J Am Coll Cardiol. 2018 Jul 31;72(5):501-514. doi: 10.1016/j.jacc.2018.05.034.

8.

Selected Phytoestrogens Distinguish Roles of ERα Transactivation and Ligand Binding for Anti-Inflammatory Activity.

Liu H, He S, Wang T, Orang-Ojong B, Lu Q, Zhang Z, Pan L, Chai X, Wu H, Fan G, Zhang P, Feng Y, Song YS, Gao X, Karas RH, Zhu Y.

Endocrinology. 2018 Sep 1;159(9):3351-3364. doi: 10.1210/en.2018-00275.

PMID:
30010822
9.

Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A.

Ueda K, Takimoto E, Lu Q, Liu P, Fukuma N, Adachi Y, Suzuki R, Chou S, Baur W, Aronovitz MJ, Greenberg AS, Komuro I, Karas RH.

Diabetes. 2018 Aug;67(8):1524-1537. doi: 10.2337/db17-1342. Epub 2018 May 15.

10.

Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II.

Shukri MZ, Tan JW, Manosroi W, Pojoga LH, Rivera A, Williams JS, Seely EW, Adler GK, Jaffe IZ, Karas RH, Williams GH, Romero JR.

Hypertension. 2018 Jun;71(6):1083-1090. doi: 10.1161/HYPERTENSIONAHA.117.11087. Epub 2018 Apr 23.

11.

Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure.

Morine KJ, Qiao X, York S, Natov PS, Paruchuri V, Zhang Y, Aronovitz MJ, Karas RH, Kapur NK.

Circulation. 2018 Jul 31;138(5):513-526. doi: 10.1161/CIRCULATIONAHA.117.031635.

12.

Reduced activin receptor-like kinase 1 activity promotes cardiac fibrosis in heart failure.

Morine KJ, Qiao X, Paruchuri V, Aronovitz MJ, Mackey EE, Buiten L, Levine J, Ughreja K, Nepali P, Blanton RM, Oh SP, Karas RH, Kapur NK.

Cardiovasc Pathol. 2017 Nov - Dec;31:26-33. doi: 10.1016/j.carpath.2017.07.004. Epub 2017 Jul 18.

13.

Acute Hemodynamic Effects of Intra-aortic Balloon Counterpulsation Pumps in Advanced Heart Failure.

Annamalai SK, Buiten L, Esposito ML, Paruchuri V, Mullin A, Breton C, Pedicini R, O'Kelly R, Morine K, Wessler B, Patel AR, Kiernan MS, Karas RH, Kapur NK.

J Card Fail. 2017 Aug;23(8):606-614. doi: 10.1016/j.cardfail.2017.05.015. Epub 2017 May 26.

PMID:
28554716
14.

Conditional knockout of activin like kinase-1 (ALK-1) leads to heart failure without maladaptive remodeling.

Morine KJ, Qiao X, Paruchuri V, Aronovitz MJ, Mackey EE, Buiten L, Levine J, Ughreja K, Nepali P, Blanton RM, Karas RH, Oh SP, Kapur NK.

Heart Vessels. 2017 May;32(5):628-636. doi: 10.1007/s00380-017-0955-x. Epub 2017 Feb 17.

15.

Unliganded estrogen receptor alpha regulates vascular cell function and gene expression.

Lu Q, Schnitzler GR, Vallaster CS, Ueda K, Erdkamp S, Briggs CE, Iyer LK, Jaffe IZ, Karas RH.

Mol Cell Endocrinol. 2017 Feb 15;442:12-23. doi: 10.1016/j.mce.2016.11.019. Epub 2016 Nov 22.

PMID:
27888004
16.

Distinct Effects of Left or Right Atrial Cannulation on Left Ventricular Hemodynamics in a Swine Model of Acute Myocardial Injury.

Esposito ML, Shah N, Dow S, Kang S, Paruchuri V, Karas RH, Kapur NK.

ASAIO J. 2016 Nov/Dec;62(6):671-676.

PMID:
27442859
17.

Endoglin selectively modulates transient receptor potential channel expression in left and right heart failure.

Morine KJ, Paruchuri V, Qiao X, Aronovitz M, Huggins GS, DeNofrio D, Kiernan MS, Karas RH, Kapur NK.

Cardiovasc Pathol. 2016 Nov - Dec;25(6):478-482. doi: 10.1016/j.carpath.2016.08.004. Epub 2016 Aug 21.

18.

MicroRNA-Offset RNA Alters Gene Expression and Cell Proliferation.

Zhao J, Schnitzler GR, Iyer LK, Aronovitz MJ, Baur WE, Karas RH.

PLoS One. 2016 Jun 8;11(6):e0156772. doi: 10.1371/journal.pone.0156772. eCollection 2016.

19.

Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks.

Liu HX, Wang Y, Lu Q, Yang MZ, Fan GW, Karas RH, Gao XM, Zhu Y.

Chin J Nat Med. 2016 Apr;14(4):241-254. doi: 10.1016/S1875-5364(16)30024-3. Review.

PMID:
27114311
20.

Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload-Induced Heart Failure.

Salvador AM, Nevers T, Velázquez F, Aronovitz M, Wang B, Abadía Molina A, Jaffe IZ, Karas RH, Blanton RM, Alcaide P.

J Am Heart Assoc. 2016 Mar 15;5(3):e003126. doi: 10.1161/JAHA.115.003126.

21.

ER Alpha Rapid Signaling Is Required for Estrogen Induced Proliferation and Migration of Vascular Endothelial Cells.

Lu Q, Schnitzler GR, Ueda K, Iyer LK, Diomede OI, Andrade T, Karas RH.

PLoS One. 2016 Apr 1;11(4):e0152807. doi: 10.1371/journal.pone.0152807. eCollection 2016.

22.

Mechanical Pre-Conditioning With Acute Circulatory Support Before Reperfusion Limits Infarct Size in Acute Myocardial Infarction.

Kapur NK, Qiao X, Paruchuri V, Morine KJ, Syed W, Dow S, Shah N, Pandian N, Karas RH.

JACC Heart Fail. 2015 Nov;3(11):873-82. doi: 10.1016/j.jchf.2015.06.010.

23.

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.

Thoonen R, Cauwels A, Decaluwe K, Geschka S, Tainsh RE, Delanghe J, Hochepied T, De Cauwer L, Rogge E, Voet S, Sips P, Karas RH, Bloch KD, Vuylsteke M, Stasch JP, Van de Voorde J, Buys ES, Brouckaert P.

Nat Commun. 2015 Oct 7;6:8482. doi: 10.1038/ncomms9482.

24.

A new shield from the double-edged sword of reperfusion in STEMI.

Kapur NK, Karas RH.

Eur Heart J. 2015 Nov 21;36(44):3058-60. doi: 10.1093/eurheartj/ehv438. Epub 2015 Sep 8. No abstract available.

PMID:
26351396
25.

Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure.

Nevers T, Salvador AM, Grodecki-Pena A, Knapp A, Velázquez F, Aronovitz M, Kapur NK, Karas RH, Blanton RM, Alcaide P.

Circ Heart Fail. 2015 Jul;8(4):776-87. doi: 10.1161/CIRCHEARTFAILURE.115.002225. Epub 2015 May 28.

26.

Hemodynamic effects of left atrial or left ventricular cannulation for acute circulatory support in a bovine model of left heart injury.

Kapur NK, Paruchuri V, Pham DT, Reyelt L, Murphy B, Beale C, Bogins C, Wiener D, Nilson J, Esposito M, Perkins S, Perides G, Karas RH.

ASAIO J. 2015 May-Jun;61(3):301-6. doi: 10.1097/MAT.0000000000000195.

PMID:
25485565
27.

γδT cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice.

Vu DM, Tai A, Tatro JB, Karas RH, Huber BT, Beasley D.

PLoS One. 2014 Oct 14;9(10):e109416. doi: 10.1371/journal.pone.0109416. eCollection 2014.

28.

Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function.

Barrett Mueller K, Lu Q, Mohammad NN, Luu V, McCurley A, Williams GH, Adler GK, Karas RH, Jaffe IZ.

Endocrinology. 2014 Nov;155(11):4461-72. doi: 10.1210/en.2014-1270. Epub 2014 Jul 22.

29.

Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload.

Kapur NK, Qiao X, Paruchuri V, Mackey EE, Daly GH, Ughreja K, Morine KJ, Levine J, Aronovitz MJ, Hill NS, Jaffe IZ, Letarte M, Karas RH.

J Am Heart Assoc. 2014 Jul 11;3(4). pii: e000965. doi: 10.1161/JAHA.114.000965. Erratum in: J Am Heart Assoc. 2014 Aug;3(4):e000419. Ughreja, Kesahn [Corrected to Ughreja, Kishan].

30.

PDE5 inhibitor efficacy is estrogen dependent in female heart disease.

Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E.

J Clin Invest. 2014 Jun;124(6):2464-71. doi: 10.1172/JCI70731. Epub 2014 May 16.

31.

The time-to-integrate-to-nest test as an indicator of wellbeing in laboratory mice.

Rock ML, Karas AZ, Rodriguez KB, Gallo MS, Pritchett-Corning K, Karas RH, Aronovitz M, Gaskill BN.

J Am Assoc Lab Anim Sci. 2014 Jan;53(1):24-8.

32.

Lipoprotein-associated phospholipase A2, a novel cardiovascular inflammatory marker, in HIV-infected patients.

Mangili A, Ahmad R, Wolfert RL, Kuvin J, Polak JF, Karas RH, Wanke CA.

Clin Infect Dis. 2014 Mar;58(6):893-900. doi: 10.1093/cid/cit815. Epub 2013 Dec 11.

33.

High-density lipoproteins: a consensus statement from the National Lipid Association.

Toth PP, Barter PJ, Rosenson RS, Boden WE, Chapman MJ, Cuchel M, D'Agostino RB Sr, Davidson MH, Davidson WS, Heinecke JW, Karas RH, Kontush A, Krauss RM, Miller M, Rader DJ.

J Clin Lipidol. 2013 Sep-Oct;7(5):484-525. doi: 10.1016/j.jacl.2013.08.001. Epub 2013 Aug 11. Review.

PMID:
24079290
34.

Biventricular remodeling in murine models of right ventricular pressure overload.

Kapur NK, Paruchuri V, Aronovitz MJ, Qiao X, Mackey EE, Daly GH, Ughreja K, Levine J, Blanton R, Hill NS, Karas RH.

PLoS One. 2013 Jul 30;8(7):e70802. doi: 10.1371/journal.pone.0070802. Print 2013.

35.

Vascular reactivity screen of Chinese medicine danhong injection identifies Danshensu as a NO-independent but PGI2-mediated relaxation factor.

Wang D, Fan G, Wang Y, Liu H, Wang B, Dong J, Zhang P, Zhang B, Karas RH, Gao X, Zhu Y.

J Cardiovasc Pharmacol. 2013 Nov;62(5):457-65. doi: 10.1097/FJC.0b013e3182a29657.

PMID:
23921303
36.

Mechanically unloading the left ventricle before coronary reperfusion reduces left ventricular wall stress and myocardial infarct size.

Kapur NK, Paruchuri V, Urbano-Morales JA, Mackey EE, Daly GH, Qiao X, Pandian N, Perides G, Karas RH.

Circulation. 2013 Jul 23;128(4):328-36. doi: 10.1161/CIRCULATIONAHA.112.000029. Epub 2013 Jun 13.

PMID:
23766351
37.

Rapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation.

Ueda K, Lu Q, Baur W, Aronovitz MJ, Karas RH.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1837-43. doi: 10.1161/ATVBAHA.112.300752. Epub 2013 Jun 6.

38.

Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease.

Blanton RM, Takimoto E, Aronovitz M, Thoonen R, Kass DA, Karas RH, Mendelsohn ME.

J Gerontol A Biol Sci Med Sci. 2013 Nov;68(11):1351-5. doi: 10.1093/gerona/glt042. Epub 2013 May 8.

39.

Racial differences in central hemodynamic burden in men with HIV: preliminary findings.

Heffernan KS, Wanke CA, Dong K, Warner PJ, Anskat PE, Karas RH, Kuvin JT.

Ethn Dis. 2013 Spring;23(2):217-22.

PMID:
23530304
40.

Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo.

Blanton RM, Takimoto E, Lane AM, Aronovitz M, Piotrowski R, Karas RH, Kass DA, Mendelsohn ME.

J Am Heart Assoc. 2012 Oct;1(5):e003731. doi: 10.1161/JAHA.112.003731. Epub 2012 Oct 25.

41.

Emerging evidence of the importance of rapid, non-nuclear estrogen receptor signaling in the cardiovascular system.

Ueda K, Karas RH.

Steroids. 2013 Jun;78(6):589-96. doi: 10.1016/j.steroids.2012.12.006. Epub 2012 Dec 29. Review.

PMID:
23276634
42.

The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.

Lavigne PM, Karas RH.

J Am Coll Cardiol. 2013 Jan 29;61(4):440-446. doi: 10.1016/j.jacc.2012.10.030. Epub 2012 Dec 19.

43.

Estrogen receptor-mediated regulation of microRNA inhibits proliferation of vascular smooth muscle cells.

Zhao J, Imbrie GA, Baur WE, Iyer LK, Aronovitz MJ, Kershaw TB, Haselmann GM, Lu Q, Karas RH.

Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):257-65. doi: 10.1161/ATVBAHA.112.300200. Epub 2012 Nov 21.

44.

Direct binding and regulation of RhoA protein by cyclic GMP-dependent protein kinase Iα.

Kato M, Blanton R, Wang GR, Judson TJ, Abe Y, Myoishi M, Karas RH, Mendelsohn ME.

J Biol Chem. 2012 Nov 30;287(49):41342-51. doi: 10.1074/jbc.M112.421040. Epub 2012 Oct 12.

45.

Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury.

Bernelot Moens SJ, Schnitzler GR, Nickerson M, Guo H, Ueda K, Lu Q, Aronovitz MJ, Nickerson H, Baur WE, Hansen U, Iyer LK, Karas RH.

Circulation. 2012 Oct 16;126(16):1993-2004. doi: 10.1161/CIRCULATIONAHA.112.124529. Epub 2012 Sep 20.

46.

Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice.

Ehsan A, McGraw AP, Aronovitz MJ, Galayda C, Conte MS, Karas RH, Jaffe IZ.

J Thorac Cardiovasc Surg. 2013 Jun;145(6):1642-9, 1649.e1. doi: 10.1016/j.jtcvs.2012.08.007. Epub 2012 Sep 13.

47.

Cell surface estrogen receptor alpha is upregulated during subchronic metabolic stress and inhibits neuronal cell degeneration.

Barbati C, Pierdominici M, Gambardella L, Malchiodi Albedi F, Karas RH, Rosano G, Malorni W, Ortona E.

PLoS One. 2012;7(7):e42339. doi: 10.1371/journal.pone.0042339. Epub 2012 Jul 31.

48.

Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure.

Kapur NK, Wilson S, Yunis AA, Qiao X, Mackey E, Paruchuri V, Baker C, Aronovitz MJ, Karumanchi SA, Letarte M, Kass DA, Mendelsohn ME, Karas RH.

Circulation. 2012 Jun 5;125(22):2728-38. doi: 10.1161/CIRCULATIONAHA.111.080002. Epub 2012 May 16.

49.

Distinct effects of unfractionated heparin versus bivalirudin on circulating angiogenic peptides.

Kapur NK, Shenoy C, Yunis AA, Mohammad NN, Wilson S, Paruchuri V, Mackey EE, Qiao X, Shah A, Esposito ML, Karas RH, Jaffe IZ.

PLoS One. 2012;7(4):e34344. doi: 10.1371/journal.pone.0034344. Epub 2012 Apr 11.

50.

A call to action: women and peripheral artery disease: a scientific statement from the American Heart Association.

Hirsch AT, Allison MA, Gomes AS, Corriere MA, Duval S, Ershow AG, Hiatt WR, Karas RH, Lovell MB, McDermott MM, Mendes DM, Nussmeier NA, Treat-Jacobson D; American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular Nursing; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia; Council on Clinical Cardiology; Council on Epidemiology and Prevention.

Circulation. 2012 Mar 20;125(11):1449-72. doi: 10.1161/CIR.0b013e31824c39ba. Epub 2012 Feb 15. No abstract available.

PMID:
22343782

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