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Items: 34

1.

Sex-specific regulation of cardiac microRNAs targeting mitochondrial proteins in pressure overload.

Sanchez-Ruderisch H, Queirós AM, Fliegner D, Eschen C, Kararigas G, Regitz-Zagrosek V.

Biol Sex Differ. 2019 Feb 6;10(1):8. doi: 10.1186/s13293-019-0222-1.

2.

An integrative systems approach identifies novel candidates in Marfan syndrome-related pathophysiology.

Bhushan R, Altinbas L, Jäger M, Zaradzki M, Lehmann D, Timmermann B, Clayton NP, Zhu Y, Kallenbach K, Kararigas G, Robinson PN.

J Cell Mol Med. 2019 Apr;23(4):2526-2535. doi: 10.1111/jcmm.14137. Epub 2019 Jan 24.

3.

Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes.

Godoy JC, Niesman IR, Busija AR, Kassan A, Schilling JM, Schwarz A, Alvarez EA, Dalton ND, Drummond JC, Roth DM, Kararigas G, Patel HH, Zemljic-Harpf AE.

FASEB J. 2019 Jan;33(1):1209-1225. doi: 10.1096/fj.201800876R. Epub 2018 Aug 31.

PMID:
30169110
4.

Large-scale in silico identification of drugs exerting sex-specific effects in the heart.

Cui C, Huang C, Liu K, Xu G, Yang J, Zhou Y, Feng Y, Kararigas G, Geng B, Cui Q.

J Transl Med. 2018 Aug 29;16(1):236. doi: 10.1186/s12967-018-1612-6.

5.

The DrugPattern tool for drug set enrichment analysis and its prediction for beneficial effects of oxLDL on type 2 diabetes.

Huang C, Yang W, Wang J, Zhou Y, Geng B, Kararigas G, Yang J, Cui Q.

J Genet Genomics. 2018 Jul 20;45(7):389-397. doi: 10.1016/j.jgg.2018.07.002. Epub 2018 Jul 24.

PMID:
30054214
6.

Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide synthase.

Octavia Y, Kararigas G, de Boer M, Chrifi I, Kietadisorn R, Swinnen M, Duimel H, Verheyen FK, Brandt MM, Fliegner D, Cheng C, Janssens S, Duncker DJ, Moens AL.

J Cell Mol Med. 2017 Dec;21(12):3277-3287. doi: 10.1111/jcmm.13231. Epub 2017 Jun 13.

7.

Sex in basic research: concepts in the cardiovascular field.

Ventura-Clapier R, Dworatzek E, Seeland U, Kararigas G, Arnal JF, Brunelleschi S, Carpenter TC, Erdmann J, Franconi F, Giannetta E, Glezerman M, Hofmann SM, Junien C, Katai M, Kublickiene K, König IR, Majdic G, Malorni W, Mieth C, Miller VM, Reynolds RM, Shimokawa H, Tannenbaum C, D'Ursi AM, Regitz-Zagrosek V.

Cardiovasc Res. 2017 Jun 1;113(7):711-724. doi: 10.1093/cvr/cvx066. Review.

PMID:
28472454
8.

Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy.

Esslinger U, Garnier S, Korniat A, Proust C, Kararigas G, Müller-Nurasyid M, Empana JP, Morley MP, Perret C, Stark K, Bick AG, Prasad SK, Kriebel J, Li J, Tiret L, Strauch K, O'Regan DP, Marguiles KB, Seidman JG, Boutouyrie P, Lacolley P, Jouven X, Hengstenberg C, Komajda M, Hakonarson H, Isnard R, Arbustini E, Grallert H, Cook SA, Seidman CE, Regitz-Zagrosek V, Cappola TP, Charron P, Cambien F, Villard E.

PLoS One. 2017 Mar 15;12(3):e0172995. doi: 10.1371/journal.pone.0172995. eCollection 2017.

9.

En route to precision medicine through the integration of biological sex into pharmacogenomics.

Gaignebet L, Kararigas G.

Clin Sci (Lond). 2017 Feb 1;131(4):329-342. doi: 10.1042/CS20160379. Review.

PMID:
28159880
10.

Intralipid protects the heart in late pregnancy against ischemia/reperfusion injury via Caveolin2/STAT3/GSK-3β pathway.

Li J, Ruffenach G, Kararigas G, Cunningham CM, Motayagheni N, Barakai N, Umar S, Regitz-Zagrosek V, Eghbali M.

J Mol Cell Cardiol. 2017 Jan;102:108-116. doi: 10.1016/j.yjmcc.2016.11.006. Epub 2016 Nov 12.

11.

17β-Estradiol-induced interaction of estrogen receptor α and human atrial essential myosin light chain modulates cardiac contractile function.

Duft K, Schanz M, Pham H, Abdelwahab A, Schriever C, Kararigas G, Dworatzek E, Davidson MM, Regitz-Zagrosek V, Morano I, Mahmoodzadeh S.

Basic Res Cardiol. 2017 Jan;112(1):1. Epub 2016 Nov 11.

PMID:
27837311
12.

Mechanistic Pathways of Sex Differences in Cardiovascular Disease.

Regitz-Zagrosek V, Kararigas G.

Physiol Rev. 2017 Jan;97(1):1-37. Review.

13.

Integrating topics of sex and gender into medical curricula-lessons from the international community.

Miller VM, Kararigas G, Seeland U, Regitz-Zagrosek V, Kublickiene K, Einstein G, Casanova R, Legato MJ.

Biol Sex Differ. 2016 Oct 14;7(Suppl 1):44. eCollection 2016.

14.

eGender-from e-Learning to e-Research: a web-based interactive knowledge-sharing platform for sex- and gender-specific medical education.

Seeland U, Nauman AT, Cornelis A, Ludwig S, Dunkel M, Kararigas G, Regitz-Zagrosek V.

Biol Sex Differ. 2016 Oct 14;7(Suppl 1):39. eCollection 2016.

15.

Reduction of apoptosis and preservation of mitochondrial integrity under ischemia/reperfusion injury is mediated by estrogen receptor β.

Schubert C, Raparelli V, Westphal C, Dworatzek E, Petrov G, Kararigas G, Regitz-Zagrosek V.

Biol Sex Differ. 2016 Sep 23;7:53. doi: 10.1186/s13293-016-0104-8. eCollection 2016.

16.

Why the study of the effects of biological sex is important. Commentary.

Kararigas G, Seeland U, Barcena de Arellano ML, Dworatzek E, Regitz-Zagrosek V.

Ann Ist Super Sanita. 2016 Apr-Jun;52(2):149-50. doi: 10.4415/ANN_16_02_03.

17.

Estradiol modulates myosin regulatory light chain phosphorylation and contractility in skeletal muscle of female mice.

Lai S, Collins BC, Colson BA, Kararigas G, Lowe DA.

Am J Physiol Endocrinol Metab. 2016 May 1;310(9):E724-33. doi: 10.1152/ajpendo.00439.2015. Epub 2016 Mar 8.

18.

Effects of aging on cardiac extracellular matrix in men and women.

Dworatzek E, Baczko I, Kararigas G.

Proteomics Clin Appl. 2016 Jan;10(1):84-91. doi: 10.1002/prca.201500031. Epub 2015 Sep 25.

PMID:
26280680
19.

Comparative proteomic analysis reveals sex and estrogen receptor β effects in the pressure overloaded heart.

Kararigas G, Fliegner D, Forler S, Klein O, Schubert C, Gustafsson JÅ, Klose J, Regitz-Zagrosek V.

J Proteome Res. 2014 Dec 5;13(12):5829-36. doi: 10.1021/pr500749j. Epub 2014 Nov 19.

PMID:
25406860
20.

Maladaptive remodeling is associated with impaired survival in women but not in men after aortic valve replacement.

Petrov G, Dworatzek E, Schulze TM, Dandel M, Kararigas G, Mahmoodzadeh S, Knosalla C, Hetzer R, Regitz-Zagrosek V.

JACC Cardiovasc Imaging. 2014 Nov;7(11):1073-80. doi: 10.1016/j.jcmg.2014.06.017. Epub 2014 Oct 8.

21.

Sex-dependent regulation of fibrosis and inflammation in human left ventricular remodelling under pressure overload.

Kararigas G, Dworatzek E, Petrov G, Summer H, Schulze TM, Baczko I, Knosalla C, Golz S, Hetzer R, Regitz-Zagrosek V.

Eur J Heart Fail. 2014 Nov;16(11):1160-7. doi: 10.1002/ejhf.171. Epub 2014 Oct 7.

22.

Genetic background defines the regulation of postnatal cardiac growth by 17β-estradiol through a β-catenin mechanism.

Kararigas G, Nguyen BT, Zelarayan LC, Hassenpflug M, Toischer K, Sanchez-Ruderisch H, Hasenfuss G, Bergmann MW, Jarry H, Regitz-Zagrosek V.

Endocrinology. 2014 Jul;155(7):2667-76. doi: 10.1210/en.2013-2180. Epub 2014 Apr 14.

PMID:
24731099
23.

Sex differences in exercise-induced physiological myocardial hypertrophy are modulated by oestrogen receptor beta.

Dworatzek E, Mahmoodzadeh S, Schubert C, Westphal C, Leber J, Kusch A, Kararigas G, Fliegner D, Moulin M, Ventura-Clapier R, Gustafsson JA, Davidson MM, Dragun D, Regitz-Zagrosek V.

Cardiovasc Res. 2014 Jun 1;102(3):418-28. doi: 10.1093/cvr/cvu065. Epub 2014 Mar 19.

PMID:
24654233
24.

Estrogen modulates cardiac growth through an estrogen receptor α-dependent mechanism in healthy ovariectomized mice.

Kararigas G, Nguyen BT, Jarry H.

Mol Cell Endocrinol. 2014 Feb 15;382(2):909-14. doi: 10.1016/j.mce.2013.11.011. Epub 2013 Nov 22.

PMID:
24275180
25.

Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart.

Queirós AM, Eschen C, Fliegner D, Kararigas G, Dworatzek E, Westphal C, Sanchez Ruderisch H, Regitz-Zagrosek V.

Int J Cardiol. 2013 Nov 20;169(5):331-8. doi: 10.1016/j.ijcard.2013.09.002. Epub 2013 Oct 5.

PMID:
24157234
26.

Dose-dependent effects of a genistein-enriched diet in the heart of ovariectomized mice.

Nguyen BT, Kararigas G, Jarry H.

Genes Nutr. 2013 Jul;8(4):383-90. doi: 10.1007/s12263-012-0323-5. Epub 2012 Oct 30.

27.

17β-Estradiol-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes.

Mahmoodzadeh S, Pham TH, Kuehne A, Fielitz B, Dworatzek E, Kararigas G, Petrov G, Davidson MM, Regitz-Zagrosek V.

Cardiovasc Res. 2012 Dec 1;96(3):411-21. doi: 10.1093/cvr/cvs281. Epub 2012 Sep 7.

PMID:
22962310
28.

CardioNet: a human metabolic network suited for the study of cardiomyocyte metabolism.

Karlstädt A, Fliegner D, Kararigas G, Ruderisch HS, Regitz-Zagrosek V, Holzhütter HG.

BMC Syst Biol. 2012 Aug 29;6:114. doi: 10.1186/1752-0509-6-114.

29.

Transcriptome characterization of estrogen-treated human myocardium identifies myosin regulatory light chain interacting protein as a sex-specific element influencing contractile function.

Kararigas G, Bito V, Tinel H, Becher E, Baczko I, Knosalla C, Albrecht-Küpper B, Sipido KR, Regitz-Zagrosek V.

J Am Coll Cardiol. 2012 Jan 24;59(4):410-7. doi: 10.1016/j.jacc.2011.09.054.

30.

Long-term treatment of ovariectomized mice with estradiol or phytoestrogens as a new model to study the role of estrogenic substances in the heart.

Nguyen BT, Kararigas G, Wuttke W, Jarry H.

Planta Med. 2012 Jan;78(1):6-11. doi: 10.1055/s-0031-1280228. Epub 2011 Sep 16.

PMID:
21928168
31.

Role of the estrogen/estrogen-receptor-beta axis in the genomic response to pressure overload-induced hypertrophy.

Kararigas G, Fliegner D, Gustafsson JÅ, Regitz-Zagrosek V.

Physiol Genomics. 2011 Apr 27;43(8):438-46. doi: 10.1152/physiolgenomics.00199.2010. Epub 2011 Feb 15.

PMID:
21325064
32.

Sex-specific modification of progesterone receptor expression by 17β-oestradiol in human cardiac tissues.

Kararigas G, Becher E, Mahmoodzadeh S, Knosalla C, Hetzer R, Regitz-Zagrosek V.

Biol Sex Differ. 2010 Nov 4;1(1):2. doi: 10.1186/2042-6410-1-2.

33.

Differential cardiac remodeling in preload versus afterload.

Toischer K, Rokita AG, Unsöld B, Zhu W, Kararigas G, Sossalla S, Reuter SP, Becker A, Teucher N, Seidler T, Grebe C, Preuss L, Gupta SN, Schmidt K, Lehnart SE, Krüger M, Linke WA, Backs J, Regitz-Zagrosek V, Schäfer K, Field LJ, Maier LS, Hasenfuss G.

Circulation. 2010 Sep 7;122(10):993-1003. doi: 10.1161/CIRCULATIONAHA.110.943431. Epub 2010 Aug 23.

34.

Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload.

Fliegner D, Schubert C, Penkalla A, Witt H, Kararigas G, Dworatzek E, Staub E, Martus P, Ruiz Noppinger P, Kintscher U, Gustafsson JA, Regitz-Zagrosek V.

Am J Physiol Regul Integr Comp Physiol. 2010 Jun;298(6):R1597-606. doi: 10.1152/ajpregu.00825.2009. Epub 2010 Apr 7. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2010 Sep;299(3):R981. Kararigas, George [corrected to Kararigas, Georgios].

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