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Items: 1 to 50 of 84

1.

Defective interplay between mTORC1 activity and endoplasmic reticulum stress-unfolded protein response in uremic vascular calcification.

Panda DK, Bai X, Sabbagh Y, Zhang Y, Zaun HC, Karellis A, Koromilas AE, Lipman ML, Karaplis AC.

Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1046-F1061. doi: 10.1152/ajprenal.00350.2017. Epub 2018 Jan 10.

2.

The parathyroid hormone regulates skin tumour susceptibility in mice.

Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I, Wakana S, Yamaguchi M, Shitara H, Taya C, Karaplis AC, Kominami R, Wakabayashi Y.

Sci Rep. 2017 Sep 11;7(1):11208. doi: 10.1038/s41598-017-11561-x.

3.

Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis.

Saag KG, Petersen J, Brandi ML, Karaplis AC, Lorentzon M, Thomas T, Maddox J, Fan M, Meisner PD, Grauer A.

N Engl J Med. 2017 Oct 12;377(15):1417-1427. doi: 10.1056/NEJMoa1708322. Epub 2017 Sep 11.

4.

A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures.

Radi S, Karaplis AC.

Case Rep Endocrinol. 2017;2017:6328524. doi: 10.1155/2017/6328524. Epub 2017 Jul 16.

5.

FGF23 Is Not Required to Regulate Fetal Phosphorus Metabolism but Exerts Effects Within 12 Hours After Birth.

Ma Y, Kirby BJ, Fairbridge NA, Karaplis AC, Lanske B, Kovacs CS.

Endocrinology. 2017 Feb 1;158(2):252-263. doi: 10.1210/en.2016-1369.

6.

Fibroblast Growth Factor 23 Regulation by Systemic and Local Osteoblast-Synthesized 1,25-Dihydroxyvitamin D.

Nguyen-Yamamoto L, Karaplis AC, St-Arnaud R, Goltzman D.

J Am Soc Nephrol. 2017 Feb;28(2):586-597. doi: 10.1681/ASN.2016010066. Epub 2016 Aug 17.

7.

CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders.

Bai X, Miao D, Xiao S, Qiu D, St-Arnaud R, Petkovich M, Gupta A, Goltzman D, Karaplis AC.

J Clin Invest. 2016 Feb;126(2):667-80. doi: 10.1172/JCI81928. Epub 2016 Jan 19.

8.

Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis.

Hirai T, Kobayashi T, Nishimori S, Karaplis AC, Goltzman D, Kronenberg HM.

Endocrinology. 2015 Aug;156(8):2774-80. doi: 10.1210/en.2014-1835. Epub 2015 Jun 8.

9.

Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization.

Ma Y, Samaraweera M, Cooke-Hubley S, Kirby BJ, Karaplis AC, Lanske B, Kovacs CS.

Endocrinology. 2014 May;155(5):1596-605. doi: 10.1210/en.2013-2061. Epub 2014 Mar 6.

10.

Knockdown of parathyroid hormone related protein in smooth muscle cells alters renal hemodynamics but not blood pressure.

Raison D, Coquard C, Hochane M, Steger J, Massfelder T, Moulin B, Karaplis AC, Metzger D, Chambon P, Helwig JJ, Barthelmebs M.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F333-42. doi: 10.1152/ajprenal.00503.2012. Epub 2013 May 29.

11.

Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone.

Kirby BJ, Ma Y, Martin HM, Buckle Favaro KL, Karaplis AC, Kovacs CS.

J Bone Miner Res. 2013 Sep;28(9):1987-2000. doi: 10.1002/jbmr.1925.

12.

Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor.

Panda DK, Goltzman D, Karaplis AC.

Am J Physiol Endocrinol Metab. 2012 Dec 15;303(12):E1489-501. doi: 10.1152/ajpendo.00254.2012. Epub 2012 Oct 23.

13.

Mineralizing enthesopathy is a common feature of renal phosphate-wasting disorders attributed to FGF23 and is exacerbated by standard therapy in hyp mice.

Karaplis AC, Bai X, Falet JP, Macica CM.

Endocrinology. 2012 Dec;153(12):5906-17. doi: 10.1210/en.2012-1551. Epub 2012 Oct 4.

14.

The calcium-sensing receptor complements parathyroid hormone-induced bone turnover in discrete skeletal compartments in mice.

Xue Y, Xiao Y, Liu J, Karaplis AC, Pollak MR, Brown EM, Miao D, Goltzman D.

Am J Physiol Endocrinol Metab. 2012 Apr 1;302(7):E841-51. doi: 10.1152/ajpendo.00599.2011. Epub 2012 Jan 24.

15.

PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target.

Li J, Karaplis AC, Huang DC, Siegel PM, Camirand A, Yang XF, Muller WJ, Kremer R.

J Clin Invest. 2011 Dec;121(12):4655-69. doi: 10.1172/JCI46134. Epub 2011 Nov 7.

16.

Parathyroid hormone related protein (PTHrP) in tumor progression.

Kremer R, Li J, Camirand A, Karaplis AC.

Adv Exp Med Biol. 2011;720:145-60. doi: 10.1007/978-1-4614-0254-1_12. Review.

PMID:
21901625
17.

Vitamin D status and response to daily 400 IU vitamin D3 and weekly alendronate 70 mg in men and women with osteoporosis.

Karaplis AC, Chouha F, Djandji M, Sampalis JS, Hanley DA.

Ann Pharmacother. 2011 May;45(5):561-8. doi: 10.1345/aph.1P439. Epub 2011 Apr 26.

PMID:
21521859
18.

Fibroblast growth factor 23 overexpression impacts negatively on dentin mineralization and dentinogenesis in mice.

Chen L, Liu H, Sun W, Bai X, Karaplis AC, Goltzman D, Miao D.

Clin Exp Pharmacol Physiol. 2011 Jun;38(6):395-402. doi: 10.1111/j.1440-1681.2011.05526.x.

PMID:
21488937
19.

Skeletal recovery after weaning does not require PTHrP.

Kirby BJ, Ardeshirpour L, Woodrow JP, Wysolmerski JJ, Sims NA, Karaplis AC, Kovacs CS.

J Bone Miner Res. 2011 Jun;26(6):1242-51. doi: 10.1002/jbmr.339.

20.

Parathyroid hormone regulates fetal-placental mineral homeostasis.

Simmonds CS, Karsenty G, Karaplis AC, Kovacs CS.

J Bone Miner Res. 2010 Mar;25(3):594-605. doi: 10.1359/jbmr.090825.

21.

TIP39/parathyroid hormone type 2 receptor signaling is a potent inhibitor of chondrocyte proliferation and differentiation.

Panda D, Goltzman D, Jüppner H, Karaplis AC.

Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1125-36. doi: 10.1152/ajpendo.00254.2009. Epub 2009 Aug 25.

22.

Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein.

Miao D, Su H, He B, Gao J, Xia Q, Zhu M, Gu Z, Goltzman D, Karaplis AC.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20309-14. doi: 10.1073/pnas.0805690105. Epub 2008 Dec 17.

23.

Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype.

Bai X, Dinghong Q, Miao D, Goltzman D, Karaplis AC.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E79-88. doi: 10.1152/ajpendo.90539.2008. Epub 2008 Nov 4.

24.

Variable number of tandem repeats polymorphism in parathyroid hormone-related protein as predictor of peak bone mass in young healthy Finnish males.

Gupta A, Välimäki VV, J Välimäki M, Löyttyniemi E, Richard M, L Bukka P, Goltzman D, Karaplis AC.

Eur J Endocrinol. 2008 May;158(5):755-64. doi: 10.1530/EJE-07-0886.

PMID:
18426836
25.

Early lethality in Hyp mice with targeted deletion of Pth gene.

Bai X, Miao D, Goltzman D, Karaplis AC.

Endocrinology. 2007 Oct;148(10):4974-83. Epub 2007 Jul 5.

PMID:
17615144
26.

Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone.

Gao J, Tiwari-Pandey R, Samadfam R, Yang Y, Miao D, Karaplis AC, Sairam MR, Goltzman D.

Endocrinology. 2007 Jun;148(6):2613-21. Epub 2007 Mar 1.

PMID:
17332067
27.
28.

Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins.

Hendy GN, Li T, Girard M, Feldstein RC, Mulay S, Desjardins R, Day R, Karaplis AC, Tremblay ML, Canaff L.

Mol Endocrinol. 2006 Aug;20(8):1935-47. Epub 2006 Mar 23.

PMID:
16556729
29.

Exogenous PTH-related protein and PTH improve mineral and skeletal status in 25-hydroxyvitamin D-1alpha-hydroxylase and PTH double knockout mice.

Xue Y, Zhang Z, Karaplis AC, Hendy GN, Goltzman D, Miao D.

J Bone Miner Res. 2005 Oct;20(10):1766-77. Epub 2005 Jun 20.

30.

Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34.

Miao D, He B, Jiang Y, Kobayashi T, Sorocéanu MA, Zhao J, Su H, Tong X, Amizuka N, Gupta A, Genant HK, Kronenberg HM, Goltzman D, Karaplis AC.

J Clin Invest. 2005 Sep;115(9):2402-11.

31.
32.

Rosiglitazone impacts negatively on bone by promoting osteoblast/osteocyte apoptosis.

Sorocéanu MA, Miao D, Bai XY, Su H, Goltzman D, Karaplis AC.

J Endocrinol. 2004 Oct;183(1):203-16.

PMID:
15525588
33.

Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders.

Bai X, Miao D, Li J, Goltzman D, Karaplis AC.

Endocrinology. 2004 Nov;145(11):5269-79. Epub 2004 Jul 29.

PMID:
15284207
34.

Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice.

Miao D, Li J, Xue Y, Su H, Karaplis AC, Goltzman D.

Endocrinology. 2004 Aug;145(8):3554-62. Epub 2004 Apr 16.

PMID:
15090463
35.

Cartilage abnormalities are associated with abnormal Phex expression and with altered matrix protein and MMP-9 localization in Hyp mice.

Miao D, Bai X, Panda DK, Karaplis AC, Goltzman D, McKee MD.

Bone. 2004 Apr;34(4):638-47.

PMID:
15050894
36.

Skeletal abnormalities in Pth-null mice are influenced by dietary calcium.

Miao D, He B, Lanske B, Bai XY, Tong XK, Hendy GN, Goltzman D, Karaplis AC.

Endocrinology. 2004 Apr;145(4):2046-53. Epub 2003 Dec 30.

PMID:
14701672
37.

Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro.

Shin HI, Divieti P, Sims NA, Kobayashi T, Miao D, Karaplis AC, Baron R, Bringhurst R, Kronenberg HM.

Endocrinology. 2004 Mar;145(3):1376-85. Epub 2003 Nov 14.

PMID:
14617570
38.

Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation.

VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ.

J Clin Invest. 2003 Nov;112(9):1429-36.

39.

The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone.

Kos CH, Karaplis AC, Peng JB, Hediger MA, Goltzman D, Mohammad KS, Guise TA, Pollak MR.

J Clin Invest. 2003 Apr;111(7):1021-8.

40.
41.

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.

Bai X, Miao D, Panda D, Grady S, McKee MD, Goltzman D, Karaplis AC.

Mol Endocrinol. 2002 Dec;16(12):2913-25.

PMID:
12456809
42.

The murine gene encoding parathyroid hormone: genomic organization, nucleotide sequence and transcriptional regulation.

He B, Tong TK, Hiou-Tim FF, Al-Akad B, Kronenberg HM, Karaplis AC.

J Mol Endocrinol. 2002 Oct;29(2):193-203.

PMID:
12370121
43.

Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP-mediated activation of PKA.

Deckelbaum RA, Chan G, Miao D, Goltzman D, Karaplis AC.

J Cell Sci. 2002 Jul 15;115(Pt 14):3015-25.

44.

Parathyroid hormone is essential for normal fetal bone formation.

Miao D, He B, Karaplis AC, Goltzman D.

J Clin Invest. 2002 May;109(9):1173-82.

45.

PTH and PTHrP effects on the skeleton.

Karaplis AC, Goltzman D.

Rev Endocr Metab Disord. 2000 Nov;1(4):331-41. Review. No abstract available.

PMID:
11706747
46.

Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets.

Clemens TL, Cormier S, Eichinger A, Endlich K, Fiaschi-Taesch N, Fischer E, Friedman PA, Karaplis AC, Massfelder T, Rossert J, Schlüter KD, Silve C, Stewart AF, Takane K, Helwig JJ.

Br J Pharmacol. 2001 Nov;134(6):1113-36. Review.

47.

PTHrP inhibits adipocyte differentiation by down-regulating PPAR gamma activity via a MAPK-dependent pathway.

Chan GK, Deckelbaum RA, Bolivar I, Goltzman D, Karaplis AC.

Endocrinology. 2001 Nov;142(11):4900-9.

PMID:
11606458
48.

Genetics and animal models of hypoparathyroidism.

Garfield N, Karaplis AC.

Trends Endocrinol Metab. 2001 Sep;12(7):288-94. Review.

PMID:
11504667
49.

PTHrP: novel roles in skeletal biology.

Karaplis AC.

Curr Pharm Des. 2001 May;7(8):655-70. Review.

PMID:
11375774
50.

Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles.

He B, Deckelbaum RA, Miao D, Lipman ML, Pollak M, Goltzman D, Karaplis AC.

Endocrinology. 2001 May;142(5):2070-7.

PMID:
11316774

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