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Items: 1 to 50 of 245

1.

Special issue: Translating extracellular matrix: From cancer progression to therapeutics.

Karamanos NK.

Semin Cancer Biol. 2019 Oct 23. pii: S1044-579X(19)30368-2. doi: 10.1016/j.semcancer.2019.10.014. [Epub ahead of print] No abstract available.

PMID:
31655117
2.

Extracellular matrix: key structural and functional meshwork in health and disease.

Karamanos NK.

FEBS J. 2019 Aug;286(15):2826-2829. doi: 10.1111/febs.14992.

PMID:
31379113
3.

Hyaluronan-CD44 axis orchestrates cancer stem cell functions.

Skandalis SS, Karalis TT, Chatzopoulos A, Karamanos NK.

Cell Signal. 2019 Nov;63:109377. doi: 10.1016/j.cellsig.2019.109377. Epub 2019 Jul 27. Review.

PMID:
31362044
4.

Estrogen receptor-mediated targeting of the extracellular matrix network in cancer.

Piperigkou Z, Karamanos NK.

Semin Cancer Biol. 2019 Jul 13. pii: S1044-579X(19)30088-4. doi: 10.1016/j.semcancer.2019.07.006. [Epub ahead of print] Review.

PMID:
31310807
5.

Dynamic Interplay between miRNAs and the Extracellular Matrix Influences the Tumor Microenvironment.

Piperigkou Z, Karamanos NK.

Trends Biochem Sci. 2019 Dec;44(12):1076-1088. doi: 10.1016/j.tibs.2019.06.007. Epub 2019 Jul 6. Review.

PMID:
31288968
6.

Tumorigenic functions of serglycin: Regulatory roles in epithelial to mesenchymal transition and oncogenic signaling.

Manou D, Karamanos NK, Theocharis AD.

Semin Cancer Biol. 2019 Jul 4. pii: S1044-579X(19)30040-9. doi: 10.1016/j.semcancer.2019.07.004. [Epub ahead of print] Review.

PMID:
31279836
7.

Expression and Localization of Glycosaminoglycans/Proteoglycan in Pterygium: An Immunohistochemical Study.

Georgakopoulos CD, Makri OE, Pagoulatos D, Karamanos NK.

Med Hypothesis Discov Innov Ophthalmol. 2019 Spring;8(1):39-43.

8.

The extracellular matrix as a multitasking player in disease.

Theocharis AD, Manou D, Karamanos NK.

FEBS J. 2019 Aug;286(15):2830-2869. doi: 10.1111/febs.14818. Epub 2019 Apr 11. Review.

PMID:
30908868
9.

The Complex Interplay Between Extracellular Matrix and Cells in Tissues.

Manou D, Caon I, Bouris P, Triantaphyllidou IE, Giaroni C, Passi A, Karamanos NK, Vigetti D, Theocharis AD.

Methods Mol Biol. 2019;1952:1-20. doi: 10.1007/978-1-4939-9133-4_1. Review.

PMID:
30825161
10.

Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer.

Tavianatou AG, Caon I, Franchi M, Piperigkou Z, Galesso D, Karamanos NK.

FEBS J. 2019 Aug;286(15):2883-2908. doi: 10.1111/febs.14777. Epub 2019 Feb 21. Review.

PMID:
30724463
11.

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.

Karamanos NK, Piperigkou Z, Theocharis AD, Watanabe H, Franchi M, Baud S, Brézillon S, Götte M, Passi A, Vigetti D, Ricard-Blum S, Sanderson RD, Neill T, Iozzo RV.

Chem Rev. 2018 Sep 26;118(18):9152-9232. doi: 10.1021/acs.chemrev.8b00354. Epub 2018 Sep 11. Review.

PMID:
30204432
12.

Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases.

Karamanos NK, Theocharis AD, Neill T, Iozzo RV.

Matrix Biol. 2019 Jan;75-76:1-11. doi: 10.1016/j.matbio.2018.08.007. Epub 2018 Aug 18. Review.

PMID:
30130584
13.

Advances in targeting epidermal growth factor receptor signaling pathway in mammary cancer.

Kyriakopoulou K, Kefali E, Piperigkou Z, Bassiony H, Karamanos NK.

Cell Signal. 2018 Nov;51:99-109. doi: 10.1016/j.cellsig.2018.07.010. Epub 2018 Jul 31. Review.

PMID:
30071291
14.

Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling.

Bouris P, Manou D, Sopaki-Valalaki A, Kolokotroni A, Moustakas A, Kapoor A, Iozzo RV, Karamanos NK, Theocharis AD.

Matrix Biol. 2018 Dec;74:35-51. doi: 10.1016/j.matbio.2018.05.011. Epub 2018 May 26.

PMID:
29842969
15.

Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors.

Karalis TT, Heldin P, Vynios DH, Neill T, Buraschi S, Iozzo RV, Karamanos NK, Skandalis SS.

Matrix Biol. 2019 May;78-79:118-138. doi: 10.1016/j.matbio.2018.04.007. Epub 2018 Apr 16.

PMID:
29673760
16.

The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery.

Afratis NA, Klepfish M, Karamanos NK, Sagi I.

Adv Drug Deliv Rev. 2018 Apr;129:4-15. doi: 10.1016/j.addr.2018.03.004. Epub 2018 Apr 5. Review.

PMID:
29627371
17.

Proteoglycans remodeling in cancer: Underlying molecular mechanisms.

Theocharis AD, Karamanos NK.

Matrix Biol. 2019 Jan;75-76:220-259. doi: 10.1016/j.matbio.2017.10.008. Epub 2017 Nov 8. Review.

PMID:
29128506
18.

Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing.

Piperigkou Z, Götte M, Theocharis AD, Karamanos NK.

Adv Drug Deliv Rev. 2018 Apr;129:16-36. doi: 10.1016/j.addr.2017.10.008. Epub 2017 Oct 24. Review.

PMID:
29079535
19.

Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis.

Mavrogonatou E, Pratsinis H, Papadopoulou A, Karamanos NK, Kletsas D.

Matrix Biol. 2019 Jan;75-76:27-42. doi: 10.1016/j.matbio.2017.10.004. Epub 2017 Oct 21. Review.

PMID:
29066153
20.

Estrogen receptor beta as epigenetic mediator of miR-10b and miR-145 in mammary cancer.

Piperigkou Z, Franchi M, Götte M, Karamanos NK.

Matrix Biol. 2017 Dec;64:94-111. doi: 10.1016/j.matbio.2017.08.002. Epub 2017 Aug 8.

PMID:
28797712
21.

IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules.

Afratis NA, Bouris P, Skandalis SS, Multhaupt HA, Couchman JR, Theocharis AD, Karamanos NK.

Sci Rep. 2017 Jan 12;7:40138. doi: 10.1038/srep40138.

22.

Matrix pathobiology-central roles for proteoglycans and heparanase in health and disease.

Karamanos NK.

FEBS J. 2017 Jan;284(1):7-9. doi: 10.1111/febs.13945.

23.

Syndecans - key regulators of cell signaling and biological functions.

Afratis NA, Nikitovic D, Multhaupt HA, Theocharis AD, Couchman JR, Karamanos NK.

FEBS J. 2017 Jan;284(1):27-41. doi: 10.1111/febs.13940. Epub 2016 Nov 18. Review.

24.

Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer.

Karousou E, Misra S, Ghatak S, Dobra K, Götte M, Vigetti D, Passi A, Karamanos NK, Skandalis SS.

Matrix Biol. 2017 May;59:3-22. doi: 10.1016/j.matbio.2016.10.001. Epub 2016 Oct 13. Review.

PMID:
27746219
25.

Data on the putative role of p53 in breast cancer cell adhesion: Technical information for adhesion assay.

Voudouri K, Nikitovic D, Berdiaki A, Tsiaoussis J, Kletsas D, Karamanos NK, Tzanakakis GN.

Data Brief. 2016 Sep 30;9:568-572. eCollection 2016 Dec.

26.

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β.

Liakou E, Mavrogonatou E, Pratsinis H, Rizou S, Evangelou K, Panagiotou PN, Karamanos NK, Gorgoulis VG, Kletsas D.

Aging (Albany NY). 2016 Aug;8(8):1650-69. doi: 10.18632/aging.100989.

27.

IGF-I/EGF and E2 signaling crosstalk through IGF-IR conduit point affects breast cancer cell adhesion.

Voudouri K, Nikitovic D, Berdiaki A, Kletsas D, Karamanos NK, Tzanakakis GN.

Matrix Biol. 2016 Dec;56:95-113. doi: 10.1016/j.matbio.2016.06.005. Epub 2016 Jun 25.

PMID:
27353258
28.

Estrogen receptor beta modulates breast cancer cells functional properties, signaling and expression of matrix molecules.

Piperigkou Z, Bouris P, Onisto M, Franchi M, Kletsas D, Theocharis AD, Karamanos NK.

Matrix Biol. 2016 Dec;56:4-23. doi: 10.1016/j.matbio.2016.05.003. Epub 2016 May 11.

PMID:
27179695
29.

Synthesis and antiproliferative activity of two diastereomeric lignan amides serving as dimeric caffeic acid-l-DOPA hybrids.

Magoulas GE, Rigopoulos A, Piperigkou Z, Gialeli C, Karamanos NK, Takis PG, Troganis AN, Chrissanthopoulos A, Maroulis G, Papaioannou D.

Bioorg Chem. 2016 Jun;66:132-44. doi: 10.1016/j.bioorg.2016.04.003. Epub 2016 Apr 23.

PMID:
27155809
30.

Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties.

Petridis T, Giannakopoulou D, Stamatopoulou V, Grafanaki K, Kostopoulos CG, Papadaki H, Malavaki CJ, Karamanos NK, Douroumi S, Papachristou D, Magoulas GE, Papaioannou D, Drainas D.

Birth Defects Res B Dev Reprod Toxicol. 2016 Feb;107(1):32-44. doi: 10.1002/bdrb.21170. Epub 2016 Jan 13.

PMID:
26762583
31.

Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines.

Korpetinou A, Papachristou DJ, Lampropoulou A, Bouris P, Labropoulou VT, Noulas A, Karamanos NK, Theocharis AD.

Biomed Res Int. 2015;2015:690721. doi: 10.1155/2015/690721. Epub 2015 Oct 25.

32.

Extracellular matrix structure.

Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK.

Adv Drug Deliv Rev. 2016 Feb 1;97:4-27. doi: 10.1016/j.addr.2015.11.001. Epub 2015 Nov 10. Review.

PMID:
26562801
33.

Syndecan-1 alters heparan sulfate composition and signaling pathways in malignant mesothelioma.

Heidari-Hamedani G, Vivès RR, Seffouh A, Afratis NA, Oosterhof A, van Kuppevelt TH, Karamanos NK, Metintas M, Hjerpe A, Dobra K, Szatmári T.

Cell Signal. 2015 Oct;27(10):2054-67. doi: 10.1016/j.cellsig.2015.07.017. Epub 2015 Jul 23. Erratum in: Cell Signal. 2015 Dec;27(12):2599-601.

34.

Increased β-glucuronidase activity in bronchoalveolar lavage fluid of children with bacterial lung infection: A case-control study.

Panagiotopoulou EC, Fouzas S, Douros K, Triantaphyllidou IE, Malavaki C, Priftis KN, Karamanos NK, Anthracopoulos MB.

Respirology. 2015 Nov;20(8):1248-54. doi: 10.1111/resp.12596. Epub 2015 Jul 14.

35.

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine.

Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Sanderson RD, Schaefer L, Iozzo RV, Karamanos NK.

Biochim Biophys Acta. 2015 Apr;1855(2):276-300. doi: 10.1016/j.bbcan.2015.03.006. Epub 2015 Mar 28. Review.

36.

Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells.

Bouris P, Skandalis SS, Piperigkou Z, Afratis N, Karamanou K, Aletras AJ, Moustakas A, Theocharis AD, Karamanos NK.

Matrix Biol. 2015 Apr;43:42-60. doi: 10.1016/j.matbio.2015.02.008. Epub 2015 Feb 27.

37.

Anti-TNFα treatment decreases the previously increased serum Indian Hedgehog levels in patients with ankylosing spondylitis and affects the expression of functional Hedgehog pathway target genes.

Daoussis D, Filippopoulou A, Liossis SN, Sirinian C, Klavdianou K, Bouris P, Karamanos NK, Andonopoulos AP.

Semin Arthritis Rheum. 2015 Jun;44(6):646-51. doi: 10.1016/j.semarthrit.2015.01.004. Epub 2015 Jan 23.

PMID:
25701499
38.

Synthesis and evaluation of anticancer activity in cells of novel stoichiometric pegylated fullerene-doxorubicin conjugates.

Magoulas GE, Bantzi M, Messari D, Voulgari E, Gialeli C, Barbouri D, Giannis A, Karamanos NK, Papaioannou D, Avgoustakis K.

Pharm Res. 2015 May;32(5):1676-93. doi: 10.1007/s11095-014-1566-1. Epub 2014 Nov 8.

PMID:
25380982
39.

Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer.

Theocharis AD, Gialeli C, Bouris P, Giannopoulou E, Skandalis SS, Aletras AJ, Iozzo RV, Karamanos NK.

FEBS J. 2014 Nov;281(22):5023-42. doi: 10.1111/febs.12927. Epub 2014 Nov 6. Review.

40.

Validated capillary electrophoretic assays for disaccharide composition analysis of galactosaminoglycans in biologic samples and drugs/nutraceuticals.

Asimakopoulou AP, Malavaki C, Afratis NA, Theocharis AD, Lamari FN, Karamanos NK.

Methods Mol Biol. 2015;1229:129-41. doi: 10.1007/978-1-4939-1714-3_13.

PMID:
25325950
41.

Novel insights into matrix pathobiology regulatory mechanisms in health and disease.

Karamanos NK, Passi A.

FEBS J. 2014 Nov;281(22):4978-9. doi: 10.1111/febs.13106. Epub 2014 Nov 6. No abstract available.

42.

Preparation and toxicological assessment of functionalized carbon nanotube-polymer hybrids.

Koromilas ND, Lainioti GCh, Gialeli C, Barbouri D, Kouravelou KB, Karamanos NK, Voyiatzis GA, Kallitsis JK.

PLoS One. 2014 Sep 17;9(9):e107029. doi: 10.1371/journal.pone.0107029. eCollection 2014.

43.

Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer.

Skandalis SS, Gialeli C, Theocharis AD, Karamanos NK.

Adv Cancer Res. 2014;123:277-317. doi: 10.1016/B978-0-12-800092-2.00011-3. Review.

PMID:
25081534
44.

Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer.

Misra S, Ghatak S, Vyas A, O'Brien P, Markwald RR, Khetmalas M, Hascall VC, McCarthy JB, Karamanos NK, Tammi MI, Tammi RH, Prestwitch GD, Padhye S.

Med Chem Res. 2014 Aug 1;23(8):3836-3851.

45.

Matrix-mediated cell behaviour and properties.

Karamanos NK.

Biochim Biophys Acta. 2014 Aug;1840(8):2385. doi: 10.1016/j.bbagen.2014.05.015. No abstract available.

PMID:
24974091
46.

FACE analysis as a fast and reliable methodology to monitor the sulfation and total amount of chondroitin sulfate in biological samples of clinical importance.

Karousou E, Asimakopoulou A, Monti L, Zafeiropoulou V, Afratis N, Gartaganis P, Rossi A, Passi A, Karamanos NK.

Molecules. 2014 Jun 12;19(6):7959-80. doi: 10.3390/molecules19067959.

47.

EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules.

Ellina MI, Bouris P, Aletras AJ, Theocharis AD, Kletsas D, Karamanos NK.

Biochim Biophys Acta. 2014 Aug;1840(8):2651-61. doi: 10.1016/j.bbagen.2014.04.019. Epub 2014 May 2.

PMID:
24792576
48.

The differential proliferative response of fetal and adult human skin fibroblasts to TGF-β is retained when cultured in the presence of fibronectin or collagen.

Armatas AA, Pratsinis H, Mavrogonatou E, Angelopoulou MT, Kouroumalis A, Karamanos NK, Kletsas D.

Biochim Biophys Acta. 2014 Aug;1840(8):2635-42. doi: 10.1016/j.bbagen.2014.04.004. Epub 2014 Apr 13.

PMID:
24735795
49.

EMMPRIN/CD147-encriched membrane vesicles released from malignant human testicular germ cells increase MMP production through tumor-stroma interaction.

Milia-Argeiti E, Mourah S, Vallée B, Huet E, Karamanos NK, Theocharis AD, Menashi S.

Biochim Biophys Acta. 2014 Aug;1840(8):2581-8. doi: 10.1016/j.bbagen.2014.02.026. Epub 2014 Mar 6.

PMID:
24608032
50.

Dynamic interplay between breast cancer cells and normal endothelium mediates the expression of matrix macromolecules, proteasome activity and functional properties of endothelial cells.

Gialeli Ch, Viola M, Barbouri D, Kletsas D, Passi A, Karamanos NK.

Biochim Biophys Acta. 2014 Aug;1840(8):2549-59. doi: 10.1016/j.bbagen.2014.02.019. Epub 2014 Feb 26.

PMID:
24582970

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