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Disease site as a prognostic factor for mycosis fungoides: an analysis of 2428 cases from the US National Cancer Database.

Su C, Tang R, Bai HX, Girardi M, Karakousis G, Zhang PJ, Xiao R, Zhang G.

Br J Haematol. 2018 Sep 14. doi: 10.1111/bjh.15570. [Epub ahead of print] No abstract available.


Response: "Does Surgeon Sex Matter? Practice Patterns and Outcomes of Female and Male Surgeons".

Sharoky CE, Karakousis GC, Kelz RR.

Ann Surg. 2018 Sep 13. doi: 10.1097/SLA.0000000000003047. [Epub ahead of print] No abstract available.


Relationship between Age and Likelihood of Lymph Node Metastases in Patients with Intermediate Thickness Melanoma (1.01 - 4.00 mm): A National Cancer Database Study.

Hanna AN, Sinnamon AJ, Roses RE, Kelz RR, Elder DE, Xu X, Pockaj BA, Zager JS, Fraker DL, Karakousis GC.

J Am Acad Dermatol. 2018 Aug 27. pii: S0190-9622(18)32476-9. doi: 10.1016/j.jaad.2018.08.022. [Epub ahead of print]


Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response.

Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W.

Nature. 2018 Aug;560(7718):382-386. doi: 10.1038/s41586-018-0392-8. Epub 2018 Aug 8.


Letter: Craniotomy and Survival for Primary Central Nervous System Lymphoma.

Su C, Karakousis G, Zhang PJ, Bai HX.

Neurosurgery. 2018 Oct 1;83(4):E190-E191. doi: 10.1093/neuros/nyy326. No abstract available.


Comparison of Radiofrequency Ablation and Hepatic Resection for the Treatment of Hepatocellular Carcinoma 2 cm or Less.

Huang Y, Shen Q, Bai HX, Wu J, Ma C, Shang Q, Hunt SJ, Karakousis G, Zhang PJ, Zhang Z.

J Vasc Interv Radiol. 2018 Sep;29(9):1218-1225.e2. doi: 10.1016/j.jvir.2018.04.023. Epub 2018 Jul 31.


Prediction of Residual Nodal Disease at Completion Dissection Following Positive Sentinel Lymph Node Biopsy for Melanoma.

Sinnamon AJ, Song Y, Sharon CE, Yang YX, Elder DE, Zhang PJ, Xu X, Roses RE, Kelz RR, Fraker DL, Karakousis GC.

Ann Surg Oncol. 2018 Jul 24. doi: 10.1245/s10434-018-6647-7. [Epub ahead of print]


Assessment of care pattern and outcome in hemangioblastoma.

Huang Y, Chan L, Bai HX, Li X, Zhang Z, Wang Y, Cao Y, Karakousis G, Huang R, Xiao B, Zhang PJ, Yang L.

Sci Rep. 2018 Jul 24;8(1):11144. doi: 10.1038/s41598-018-29047-9.


Relative survival of patients with central neurocytoma.

Su C, Karakousis G, Zhang PJ, Bai HX.

J Clin Neurosci. 2018 Jul 21. pii: S0967-5868(18)30742-2. doi: 10.1016/j.jocn.2018.07.020. [Epub ahead of print]


Interpreting the Association of First-in-Class Immune Checkpoint Inhibition and Targeted Therapy With Survival in Patients With Stage IV Melanoma-Reply.

Sinnamon AJ, Gimotty PA, Karakousis GC.

JAMA Oncol. 2018 Aug 1;4(8):1136-1137. doi: 10.1001/jamaoncol.2018.0898. No abstract available.


Association of Marital Status With T Stage at Presentation and Management of Early-Stage Melanoma.

Sharon CE, Sinnamon AJ, Ming ME, Chu EY, Fraker DL, Karakousis GC.

JAMA Dermatol. 2018 May 1;154(5):574-580. doi: 10.1001/jamadermatol.2018.0233.


Ethnic disparity in primary cutaneous CD30+ T-cell lymphoproliferative disorders: an analysis of 1496 cases from the US National Cancer Database.

Su C, Nguyen KA, Bai HX, Zogg CK, Cao Y, Karakousis G, Zhang PJ, Zhang G, Xiao R.

Br J Haematol. 2018 Jun;181(6):752-759. doi: 10.1111/bjh.15222. Epub 2018 Apr 20.


Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.

EchevarrĂ­a-Vargas IM, Reyes-Uribe PI, Guterres AN, Yin X, Kossenkov AV, Liu Q, Zhang G, Krepler C, Cheng C, Wei Z, Somasundaram R, Karakousis G, Xu W, Morrissette JJ, Lu Y, Mills GB, Sullivan RJ, Benchun M, Frederick DT, Boland G, Flaherty KT, Weeraratna AT, Herlyn M, Amaravadi R, Schuchter LM, Burd CE, Aplin AE, Xu X, Villanueva J.

EMBO Mol Med. 2018 May;10(5). pii: e8446. doi: 10.15252/emmm.201708446.


Disease site as a determinant of survival outcome in patients with systemic anaplastic lymphoma kinase positive anaplastic large cell lymphoma with extranodal involvement: an analysis of 1306 cases from the US National Cancer Database.

Nguyen KA, Su C, Bai HX, Zhang Z, Xiao R, Karakousis G, Zhang PJ, Zhang G.

Br J Haematol. 2018 Apr;181(2):196-204. doi: 10.1111/bjh.15145. Epub 2018 Mar 30.


Disparities in resection of hepatic metastases in colon cancer.

Neuwirth MG, Epstein AJ, Karakousis GC, Mamtani R, Paulson EC.

J Gastrointest Oncol. 2018 Feb;9(1):126-134. doi: 10.21037/jgo.2017.11.03.


Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma.

Zhang G, Wu LW, Mender I, Barzily-Rokni M, Hammond MR, Ope O, Cheng C, Vasilopoulos T, Randell S, Sadek N, Beroard A, Xiao M, Tian T, Tan J, Saeed U, Sugarman E, Krepler C, Brafford P, Sproesser K, Murugan S, Somasundaram R, Garman B, Wubbenhorst B, Woo J, Yin X, Liu Q, Frederick DT, Miao B, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Kwong LN, Amaravadi RK, Lu Y, Boland GM, Wei Z, Nathanson K, Herbig U, Mills GB, Flaherty KT, Herlyn M, Shay JW.

Clin Cancer Res. 2018 Mar 21. doi: 10.1158/1078-0432.CCR-17-2773. [Epub ahead of print]


The prognostic significance of tumor-infiltrating lymphocytes for primary melanoma varies by sex.

Sinnamon AJ, Sharon CE, Song Y, Neuwirth MG, Elder DE, Xu X, Chu EY, Ming ME, Fraker DL, Gimotty PA, Karakousis GC.

J Am Acad Dermatol. 2018 Aug;79(2):245-251. doi: 10.1016/j.jaad.2018.02.066. Epub 2018 Mar 5.


Publication trend, resource utilization, and impact of the US National Cancer Database: A systematic review.

Su C, Peng C, Agbodza E, Bai HX, Huang Y, Karakousis G, Zhang PJ, Zhang Z.

Medicine (Baltimore). 2018 Mar;97(9):e9823. doi: 10.1097/MD.0000000000009823. Review.


Histological immune response patterns in sentinel lymph nodes involved by metastatic melanoma and prognostic significance.

Abbott J, Buckley M, Taylor LA, Xu G, Karakousis G, Czerniecki BJ, Gimotty PA, Zhang PJ.

J Cutan Pathol. 2018 Jun;45(6):377-386. doi: 10.1111/cup.13127. Epub 2018 Mar 23.


Comparison of Adjuvant Radiation Therapy Alone and Chemotherapy Alone in Surgically Resected Low-Grade Gliomas: Survival Analyses of 2253 Cases from the National Cancer Data Base.

Wu J, Neale N, Huang Y, Bai HX, Li X, Zhang Z, Karakousis G, Huang R, Zhang PJ, Tang L, Xiao B, Yang L.

World Neurosurg. 2018 Apr;112:e812-e822. doi: 10.1016/j.wneu.2018.01.163. Epub 2018 Jan 31.


Disease site as a determinant of survival outcome in patients with primary cutaneous peripheral T-cell lymphoma, unspecified: an analysis of 4057 cases from the US National Cancer Database.

Su C, Nguyen KA, Bai HX, Cao Y, Tao Y, Karakousis G, Zhang PJ, Zhang G, Xiao R.

Leuk Lymphoma. 2018 Sep;59(9):2105-2112. doi: 10.1080/10428194.2017.1410886. Epub 2017 Dec 7.


Transected thin melanoma: Implications for sentinel lymph node staging.

Herbert G, Karakousis GC, Bartlett EK, Zaheer S, Graham D, Czerniecki BJ, Fraker DL, Ariyan C, Coit DG, Brady MS.

J Surg Oncol. 2018 Mar;117(4):567-571. doi: 10.1002/jso.24930. Epub 2017 Nov 30.


Surgical Management of Early-Stage Esophageal Adenocarcinoma Based on Lymph Node Metastasis Risk.

Newton AD, Predina JD, Xia L, Roses RE, Karakousis GC, Dempsey DT, Williams NN, Kucharczuk JC, Singhal S.

Ann Surg Oncol. 2018 Jan;25(1):318-325. doi: 10.1245/s10434-017-6238-z. Epub 2017 Nov 16.


Association of First-in-Class Immune Checkpoint Inhibition and Targeted Therapy With Survival in Patients With Stage IV Melanoma.

Sinnamon AJ, Neuwirth MG, Gimotty PA, Gangadhar TC, Amaravadi RK, Schuchter LM, Karakousis GC.

JAMA Oncol. 2018 Jan 1;4(1):126-128. doi: 10.1001/jamaoncol.2017.3462. No abstract available.


A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma.

Krepler C, Sproesser K, Brafford P, Beqiri M, Garman B, Xiao M, Shannan B, Watters A, Perego M, Zhang G, Vultur A, Yin X, Liu Q, Anastopoulos IN, Wubbenhorst B, Wilson MA, Xu W, Karakousis G, Feldman M, Xu X, Amaravadi R, Gangadhar TC, Elder DE, Haydu LE, Wargo JA, Davies MA, Lu Y, Mills GB, Frederick DT, Barzily-Rokni M, Flaherty KT, Hoon DS, Guarino M, Bennett JJ, Ryan RW, Petrelli NJ, Shields CL, Terai M, Sato T, Aplin AE, Roesch A, Darr D, Angus S, Kumar R, Halilovic E, Caponigro G, Jeay S, Wuerthner J, Walter A, Ocker M, Boxer MB, Schuchter L, Nathanson KL, Herlyn M.

Cell Rep. 2017 Nov 14;21(7):1953-1967. doi: 10.1016/j.celrep.2017.10.021.


Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines.

Garman B, Anastopoulos IN, Krepler C, Brafford P, Sproesser K, Jiang Y, Wubbenhorst B, Amaravadi R, Bennett J, Beqiri M, Elder D, Flaherty KT, Frederick DT, Gangadhar TC, Guarino M, Hoon D, Karakousis G, Liu Q, Mitra N, Petrelli NJ, Schuchter L, Shannan B, Shields CL, Wargo J, Wenz B, Wilson MA, Xiao M, Xu W, Xu X, Yin X, Zhang NR, Davies MA, Herlyn M, Nathanson KL.

Cell Rep. 2017 Nov 14;21(7):1936-1952. doi: 10.1016/j.celrep.2017.10.052.


Prophylactic Cholecystectomy at Time of Surgery for Small Bowel Neuroendocrine Tumor Does Not Increase Postoperative Morbidity.

Sinnamon AJ, Neuwirth MG, Vining CC, Sharoky CE, Yang YX, Kelz RR, Fraker DL, Roses RE, Karakousis GC.

Ann Surg Oncol. 2018 Jan;25(1):239-245. doi: 10.1245/s10434-017-6093-y. Epub 2017 Oct 24.


A Multicenter Phase I Study Evaluating Dual PI3K and BRAF Inhibition with PX-866 and Vemurafenib in Patients with Advanced BRAF V600-Mutant Solid Tumors.

Yam C, Xu X, Davies MA, Gimotty PA, Morrissette JJD, Tetzlaff MT, Wani KM, Liu S, Deng W, Buckley M, Zhao J, Amaravadi RK, Haas NB, Kudchadkar RR, Pavlick AC, Sosman JA, Tawbi H, Walker L, Schuchter LM, Karakousis GC, Gangadhar TC.

Clin Cancer Res. 2018 Jan 1;24(1):22-32. doi: 10.1158/1078-0432.CCR-17-1807. Epub 2017 Oct 19.


Isolated Limb Perfusion and Infusion for Extremity Soft Tissue Sarcoma: A Contemporary Systematic Review and Meta-Analysis.

Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC.

Ann Surg Oncol. 2017 Dec;24(13):3803-3810. doi: 10.1245/s10434-017-6109-7. Epub 2017 Oct 11. Review.


Comparison of chemoradiotherapy with radiotherapy alone for early-stage extranodal natural killer/T-cell lymphoma, nasal type in elderly patients.

Su C, Nguyen KA, Bai HX, Balaji D, Cao Y, Karakousis G, Zhang PJ, Zhang G, Xiao R.

Leuk Lymphoma. 2018 Jun;59(6):1406-1412. doi: 10.1080/10428194.2017.1379078. Epub 2017 Oct 5.


Comparison of chemoradiotherapy with radiotherapy alone for "biopsy only" anaplastic astrocytoma.

Wu J, Zou T, Bai HX, Li X, Zhang Z, Xiao B, Nasrallah M, Karakousis G, Cao Y, Zhang PJ, Yang L.

Oncotarget. 2017 Apr 26;8(40):69038-69046. doi: 10.18632/oncotarget.17441. eCollection 2017 Sep 15.


PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas.

Lu H, Liu S, Zhang G, Bin Wu, Zhu Y, Frederick DT, Hu Y, Zhong W, Randell S, Sadek N, Zhang W, Chen G, Cheng C, Zeng J, Wu LW, Zhang J, Liu X, Xu W, Krepler C, Sproesser K, Xiao M, Miao B, Liu J, Song CD, Liu JY, Karakousis GC, Schuchter LM, Lu Y, Mills G, Cong Y, Chernoff J, Guo J, Boland GM, Sullivan RJ, Wei Z, Field J, Amaravadi RK, Flaherty KT, Herlyn M, Xu X, Guo W.

Nature. 2017 Oct 5;550(7674):133-136. doi: 10.1038/nature24040. Epub 2017 Sep 27.


An Update on Randomized Clinical Trials in Melanoma.

Karakousis G, Ariyan C.

Surg Oncol Clin N Am. 2017 Oct;26(4):559-586. doi: 10.1016/j.soc.2017.05.002. Review.


Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.

Zhang Y, Kurupati R, Liu L, Zhou XY, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis GC, Schuchter LM, Xu W, Amaravadi R, Xiao M, Sadek N, Krepler C, Herlyn M, Freeman GJ, Rabinowitz JD, Ertl HCJ.

Cancer Cell. 2017 Sep 11;32(3):377-391.e9. doi: 10.1016/j.ccell.2017.08.004.


Trends in major upper abdominal surgery for cancer in octogenarians: Has there been a change in patient selection?

Neuwirth MG, Bierema C, Sinnamon AJ, Fraker DL, Kelz RR, Roses RE, Karakousis GC.

Cancer. 2018 Jan 1;124(1):125-135. doi: 10.1002/cncr.30977. Epub 2017 Sep 7.


Understanding readmissions following operations of the thyroid and parathyroid glands.

Collier K, Sataloff J, Wirtalla C, Kuo L, Karakousis GC, Kelz RR.

Am J Surg. 2017 Sep;214(3):501-508. doi: 10.1016/j.amjsurg.2017.01.008. Epub 2017 Jan 10.


Hospitalization in the Year Preceding Major Oncologic Surgery Increases Risk for Adverse Postoperative Events.

Sharoky CE, Collier KT, Wirtalla CJ, Sinnamon AJ, Neuwirth MG, Kuo LE, Roses RE, Fraker DL, Karakousis GC, Kelz RR.

Ann Surg Oncol. 2017 Nov;24(12):3477-3485. doi: 10.1245/s10434-017-6032-y. Epub 2017 Aug 14.


Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma.

Gangadhar TC, Savitch SL, Yee SS, Xu W, Huang AC, Harmon S, Lieberman DB, Soucier D, Fan R, Black TA, Morrissette JJD, Salathia N, Waters J, Zhang S, Toung J, van Hummelen P, Fan JB, Xu X, Amaravadi RK, Schuchter LM, Karakousis GC, Hwang WT, Carpenter EL.

Pigment Cell Melanoma Res. 2018 Jan;31(1):73-81. doi: 10.1111/pcmr.12623. Epub 2017 Oct 23.


Does Surgeon Sex Matter?: Practice Patterns and Outcomes of Female and Male Surgeons.

Sharoky CE, Sellers MM, Keele LJ, Wirtalla CJ, Karakousis GC, Morris JB, Kelz RR.

Ann Surg. 2018 Jun;267(6):1069-1076. doi: 10.1097/SLA.0000000000002460.


Association Between Patient Age and Lymph Node Positivity in Thin Melanoma.

Sinnamon AJ, Neuwirth MG, Yalamanchi P, Gimotty P, Elder DE, Xu X, Kelz RR, Roses RE, Chu EY, Ming ME, Fraker DL, Karakousis GC.

JAMA Dermatol. 2017 Sep 1;153(9):866-873. doi: 10.1001/jamadermatol.2017.2497.


Predictors of false negative sentinel lymph node biopsy in trunk and extremity melanoma.

Sinnamon AJ, Neuwirth MG, Bartlett EK, Zaheer S, Etherington MS, Xu X, Elder DE, Czerniecki BJ, Fraker DL, Karakousis GC.

J Surg Oncol. 2017 Dec;116(7):848-855. doi: 10.1002/jso.24743. Epub 2017 Jun 26.


Racial disparity in mycosis fungoides: An analysis of 4495 cases from the US National Cancer Database.

Su C, Nguyen KA, Bai HX, Cao Y, Tao Y, Xiao R, Karakousis G, Zhang PJ, Zhang G.

J Am Acad Dermatol. 2017 Sep;77(3):497-502.e2. doi: 10.1016/j.jaad.2017.04.1137. Epub 2017 Jun 20.


Adjuvant chemotherapy in resectable synovial sarcoma.

Vining CC, Sinnamon AJ, Ecker BL, Kelz RR, Fraker DL, Roses RE, Karakousis GC.

J Surg Oncol. 2017 Sep;116(4):550-558. doi: 10.1002/jso.24688. Epub 2017 Jun 5.


Contemporary reappraisal of the efficacy of adjuvant chemotherapy in resected retroperitoneal sarcoma: Evidence from a nationwide clinical oncology database and review of the literature.

Datta J, Ecker BL, Neuwirth MG, Geha RC, Fraker DL, Roses RE, Karakousis GC.

Surg Oncol. 2017 Jun;26(2):117-124. doi: 10.1016/j.suronc.2017.01.008. Epub 2017 Feb 2. Review.


T-cell invigoration to tumour burden ratio associated with anti-PD-1 response.

Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, Adamow M, Kuk D, Panageas KS, Carrera C, Wong P, Quagliarello F, Wubbenhorst B, D'Andrea K, Pauken KE, Herati RS, Staupe RP, Schenkel JM, McGettigan S, Kothari S, George SM, Vonderheide RH, Amaravadi RK, Karakousis GC, Schuchter LM, Xu X, Nathanson KL, Wolchok JD, Gangadhar TC, Wherry EJ.

Nature. 2017 May 4;545(7652):60-65. doi: 10.1038/nature22079. Epub 2017 Apr 10.


Adjuvant chemotherapy versus chemoradiotherapy in the management of patients with surgically resected duodenal adenocarcinoma: A propensity score-matched analysis of a nationwide clinical oncology database.

Ecker BL, McMillan MT, Datta J, Lee MK, Karakousis GC, Vollmer CM Jr, Drebin JA, Fraker DL, Roses RE.

Cancer. 2017 May 15;123(6):967-976. doi: 10.1002/cncr.30439. Epub 2016 Nov 7.


Lymph node dissection for melanoma: where do we stand?

Neuwirth MG, Bartlett EK, Karakousis GC.

Melanoma Manag. 2017 Mar;4(1):49-59. doi: 10.2217/mmt-2016-0023. Epub 2017 Mar 3. Review.


Development and validation of a prediction model for patients discharged to post-acute care after colorectal cancer surgery.

Bailey EA, Hoffman RL, Wirtalla C, Karakousis G, Kelz RR.

Surgery. 2017 Apr;161(4):1049-1057. doi: 10.1016/j.surg.2016.10.015. Epub 2016 Dec 3.


Lymph node evaluation and survival after curative-intent resection of duodenal adenocarcinoma: A matched cohort study.

Ecker BL, McMillan MT, Datta J, Dempsey DT, Karakousis GC, Fraker DL, Drebin JA, Mamtani R, Giantonio BJ, Roses RE.

Eur J Cancer. 2016 Dec;69:135-141. doi: 10.1016/j.ejca.2016.09.027. Epub 2016 Nov 4.


Thin Melanoma with Nodal Involvement: Analysis of Demographic, Pathologic, and Treatment Factors with Regard to Prognosis.

Karakousis G, Gimotty PA, Bartlett EK, Sim MS, Neuwirth MG, Fraker D, Czerniecki BJ, Faries MB.

Ann Surg Oncol. 2017 Apr;24(4):952-959. doi: 10.1245/s10434-016-5646-9. Epub 2016 Nov 2.

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