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Items: 1 to 50 of 52

1.

Telomere shortening is a hallmark of genetic cardiomyopathies.

Chang ACY, Chang ACH, Kirillova A, Sasagawa K, Su W, Weber G, Lin J, Termglinchan V, Karakikes I, Seeger T, Dainis AM, Hinson JT, Seidman J, Seidman CE, Day JW, Ashley E, Wu JC, Blau HM.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9276-9281. doi: 10.1073/pnas.1714538115. Epub 2018 Aug 27.

2.

Recent Progress in Genome Editing Approaches for Inherited Cardiovascular Diseases.

Kaur B, Perea-Gil I, Karakikes I.

Curr Cardiol Rep. 2018 Jun 2;20(7):58. doi: 10.1007/s11886-018-0998-3. Review.

PMID:
29860642
3.

SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation.

Lee J, Shao NY, Paik DT, Wu H, Guo H, Termglinchan V, Churko JM, Kim Y, Kitani T, Zhao MT, Zhang Y, Wilson KD, Karakikes I, Snyder MP, Wu JC.

Cell Stem Cell. 2018 Mar 1;22(3):428-444.e5. doi: 10.1016/j.stem.2018.02.005.

PMID:
29499155
4.

Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs.

Zhao MT, Chen H, Liu Q, Shao NY, Sayed N, Wo HT, Zhang JZ, Ong SG, Liu C, Kim Y, Yang H, Chour T, Ma H, Gutierrez NM, Karakikes I, Mitalipov S, Snyder MP, Wu JC.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11111-E11120. doi: 10.1073/pnas.1708991114. Epub 2017 Dec 4.

5.

Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling.

Abilez OJ, Tzatzalos E, Yang H, Zhao MT, Jung G, Zöllner AM, Tiburcy M, Riegler J, Matsa E, Shukla P, Zhuge Y, Chour T, Chen VC, Burridge PW, Karakikes I, Kuhl E, Bernstein D, Couture LA, Gold JD, Zimmermann WH, Wu JC.

Stem Cells. 2018 Feb;36(2):265-277. doi: 10.1002/stem.2732. Epub 2017 Nov 13.

PMID:
29086457
6.

A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases.

Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo N, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC.

Circ Res. 2017 May 12;120(10):1561-1571. doi: 10.1161/CIRCRESAHA.116.309948. Epub 2017 Feb 28. Review.

7.

Concise Review: Mending a Broken Heart: The Evolution of Biological Therapeutics.

Chen C, Termglinchan V, Karakikes I.

Stem Cells. 2017 May;35(5):1131-1140. doi: 10.1002/stem.2602. Epub 2017 Mar 16. Review.

8.

Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells.

Stillitano F, Hansen J, Kong CW, Karakikes I, Funck-Brentano C, Geng L, Scott S, Reynier S, Wu M, Valogne Y, Desseaux C, Salem JE, Jeziorowska D, Zahr N, Li R, Iyengar R, Hajjar RJ, Hulot JS.

Elife. 2017 Jan 30;6. pii: e19406. doi: 10.7554/eLife.19406.

9.

Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers.

Gu M, Shao NY, Sa S, Li D, Termglinchan V, Ameen M, Karakikes I, Sosa G, Grubert F, Lee J, Cao A, Taylor S, Ma Y, Zhao Z, Chappell J, Hamid R, Austin ED, Gold JD, Wu JC, Snyder MP, Rabinovitch M.

Cell Stem Cell. 2017 Apr 6;20(4):490-504.e5. doi: 10.1016/j.stem.2016.08.019. Epub 2016 Dec 22.

10.

Gene Transfer in Cardiomyocytes Derived from ES and iPS Cells.

Stillitano F, Karakikes I, Hajjar RJ.

Methods Mol Biol. 2017;1521:183-193.

PMID:
27910049
11.

Efficient Genome Editing in Induced Pluripotent Stem Cells with Engineered Nucleases In Vitro.

Termglinchan V, Seeger T, Chen C, Wu JC, Karakikes I.

Methods Mol Biol. 2017;1521:55-68.

PMID:
27910041
12.

iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy.

Kodo K, Ong SG, Jahanbani F, Termglinchan V, Hirono K, InanlooRahatloo K, Ebert AD, Shukla P, Abilez OJ, Churko JM, Karakikes I, Jung G, Ichida F, Wu SM, Snyder MP, Bernstein D, Wu JC.

Nat Cell Biol. 2016 Oct;18(10):1031-42. doi: 10.1038/ncb3411. Epub 2016 Sep 19.

13.

Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro.

Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, Snyder MP, Wu JC.

Cell Stem Cell. 2016 Sep 1;19(3):311-25. doi: 10.1016/j.stem.2016.07.006. Epub 2016 Aug 18.

14.

Genomic correction of familial cardiomyopathy in human engineered cardiac tissues.

Stillitano F, Turnbull IC, Karakikes I, Nonnenmacher M, Backeris P, Hulot JS, Kranias EG, Hajjar RJ, Costa KD.

Eur Heart J. 2016 Nov 14;37(43):3282-3284. Epub 2016 Jul 22.

PMID:
27450564
15.

Cytokines profile in hypertensive patients with left ventricular remodeling and dysfunction.

Kuznetsova T, Haddad F, Knez J, Rosenberg-Hasson Y, Sung J, Cauwenberghs N, Thijs L, Karakikes I, Maecker H, Mahaffey KW, Wu JC, Staessen JA.

J Am Soc Hypertens. 2015 Dec;9(12):975-84.e3. doi: 10.1016/j.jash.2015.10.003. Epub 2015 Oct 17.

PMID:
26565110
16.

A Rapid, High-Quality, Cost-Effective, Comprehensive and Expandable Targeted Next-Generation Sequencing Assay for Inherited Heart Diseases.

Wilson KD, Shen P, Fung E, Karakikes I, Zhang A, InanlooRahatloo K, Odegaard J, Sallam K, Davis RW, Lui GK, Ashley EA, Scharfe C, Wu JC.

Circ Res. 2015 Sep 11;117(7):603-11. doi: 10.1161/CIRCRESAHA.115.306723. Epub 2015 Aug 11.

17.

Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes.

Karakikes I, Ameen M, Termglinchan V, Wu JC.

Circ Res. 2015 Jun 19;117(1):80-8. doi: 10.1161/CIRCRESAHA.117.305365. Review.

18.

Effectiveness of gene delivery systems for pluripotent and differentiated cells.

Rapti K, Stillitano F, Karakikes I, Nonnenmacher M, Weber T, Hulot JS, Hajjar RJ.

Mol Ther Methods Clin Dev. 2015 Feb 18;2:14067. doi: 10.1038/mtm.2014.67. eCollection 2015.

19.

Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy.

Karakikes I, Stillitano F, Nonnenmacher M, Tzimas C, Sanoudou D, Termglinchan V, Kong CW, Rushing S, Hansen J, Ceholski D, Kolokathis F, Kremastinos D, Katoulis A, Ren L, Cohen N, Gho JM, Tsiapras D, Vink A, Wu JC, Asselbergs FW, Li RA, Hulot JS, Kranias EG, Hajjar RJ.

Nat Commun. 2015 Apr 29;6:6955. doi: 10.1038/ncomms7955.

20.

Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs.

Chen G, Li S, Karakikes I, Ren L, Chow MZ, Chopra A, Keung W, Yan B, Chan CW, Costa KD, Kong CW, Hajjar RJ, Chen CS, Li RA.

Circ Arrhythm Electrophysiol. 2015 Feb;8(1):193-202. doi: 10.1161/CIRCEP.114.002049. Epub 2014 Dec 10.

21.

Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure.

Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A, Karakikes I, Xie C, Akar FG, Shimada YJ, Gwathmey JK, Asokan A, McPhee S, Samulski J, Samulski RJ, Sigg DC, Weber T, Kranias EG, Hajjar RJ.

Mol Ther. 2014 Dec;22(12):2038-45. doi: 10.1038/mt.2014.127. Epub 2014 Jul 15.

22.

Rapid and efficient conversion of integration-free human induced pluripotent stem cells to GMP-grade culture conditions.

Durruthy-Durruthy J, Briggs SF, Awe J, Ramathal CY, Karumbayaram S, Lee PC, Heidmann JD, Clark A, Karakikes I, Loh KM, Wu JC, Hoffman AR, Byrne J, Reijo Pera RA, Sebastiano V.

PLoS One. 2014 Apr 9;9(4):e94231. doi: 10.1371/journal.pone.0094231. eCollection 2014.

23.

Human-induced pluripotent stem cell models of inherited cardiomyopathies.

Karakikes I, Termglinchan V, Wu JC.

Curr Opin Cardiol. 2014 May;29(3):214-9. doi: 10.1097/HCO.0000000000000049. Review.

24.

A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells.

Weng Z, Kong CW, Ren L, Karakikes I, Geng L, He J, Chow MZ, Mok CF, Chan HYS, Webb SE, Keung W, Chow H, Miller AL, Leung AY, Hajjar RJ, Li RA, Chan CW.

Stem Cells Dev. 2014 Jul 15;23(14):1704-16. doi: 10.1089/scd.2013.0509. Epub 2014 Apr 22. Erratum in: Stem Cells Dev. 2016 Jun 1;25(11):882.

25.

Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes.

Karakikes I, Senyei GD, Hansen J, Kong CW, Azeloglu EU, Stillitano F, Lieu DK, Wang J, Ren L, Hulot JS, Iyengar R, Li RA, Hajjar RJ.

Stem Cells Transl Med. 2014 Jan;3(1):18-31. doi: 10.5966/sctm.2013-0110. Epub 2013 Dec 9.

26.

Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts.

Pritchard TJ, Kawase Y, Haghighi K, Anjak A, Cai W, Jiang M, Nicolaou P, Pylar G, Karakikes I, Rapti K, Rubinstein J, Hajjar RJ, Kranias EG.

PLoS One. 2013 Dec 2;8(12):e80717. doi: 10.1371/journal.pone.0080717. eCollection 2013.

27.

Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+ -ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells.

Lipskaia L, Bobe R, Chen J, Turnbull IC, Lopez JJ, Merlet E, Jeong D, Karakikes I, Ross AS, Liang L, Mougenot N, Atassi F, Lompré AM, Tarzami ST, Kovacic JC, Kranias E, Hajjar RJ, Hadri L.

Circulation. 2014 Feb 18;129(7):773-85. doi: 10.1161/CIRCULATIONAHA.113.002565. Epub 2013 Nov 18.

28.

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium.

Turnbull IC, Karakikes I, Serrao GW, Backeris P, Lee JJ, Xie C, Senyei G, Gordon RE, Li RA, Akar FG, Hajjar RJ, Hulot JS, Costa KD.

FASEB J. 2014 Feb;28(2):644-54. doi: 10.1096/fj.13-228007. Epub 2013 Oct 30.

29.

Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias.

Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA.

Biomaterials. 2013 Nov;34(35):8878-86. doi: 10.1016/j.biomaterials.2013.07.039. Epub 2013 Aug 12.

PMID:
23942210
30.

Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling.

Karakikes I, Chaanine AH, Kang S, Mukete BN, Jeong D, Zhang S, Hajjar RJ, Lebeche D.

J Am Heart Assoc. 2013 Apr 23;2(2):e000078. doi: 10.1161/JAHA.113.000078.

31.

Efficient transduction of vascular smooth muscle cells with a translational AAV2.5 vector: a new perspective for in-stent restenosis gene therapy.

Lompré AM, Hadri L, Merlet E, Keuylian Z, Mougenot N, Karakikes I, Chen J, Atassi F, Marchand A, Blaise R, Limon I, McPhee SW, Samulski RJ, Hajjar RJ, Lipskaia L.

Gene Ther. 2013 Sep;20(9):901-12. doi: 10.1038/gt.2013.13. Epub 2013 Mar 28.

32.

AAV9.I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodeling.

Fish KM, Ladage D, Kawase Y, Karakikes I, Jeong D, Ly H, Ishikawa K, Hadri L, Tilemann L, Muller-Ehmsen J, Samulski RJ, Kranias EG, Hajjar RJ.

Circ Heart Fail. 2013 Mar;6(2):310-7. doi: 10.1161/CIRCHEARTFAILURE.112.971325. Epub 2012 Dec 27.

33.

Interaction of HLA-DR and CD74 at the cell surface of antigen-presenting cells by single particle image analysis.

Karakikes I, Morrison IE, O'Toole P, Metodieva G, Navarrete CV, Gomez J, Miranda-Sayago JM, Cherry RJ, Metodiev M, Fernandez N.

FASEB J. 2012 Dec;26(12):4886-96. doi: 10.1096/fj.12-211466. Epub 2012 Aug 13.

PMID:
22889831
34.

Concomitant intravenous nitroglycerin with intracoronary delivery of AAV1.SERCA2a enhances gene transfer in porcine hearts.

Karakikes I, Hadri L, Rapti K, Ladage D, Ishikawa K, Tilemann L, Yi GH, Morel C, Gwathmey JK, Zsebo K, Weber T, Kawase Y, Hajjar RJ.

Mol Ther. 2012 Mar;20(3):565-71. doi: 10.1038/mt.2011.268. Epub 2012 Jan 3.

35.

Fetal cells traffic to injured maternal myocardium and undergo cardiac differentiation.

Kara RJ, Bolli P, Karakikes I, Matsunaga I, Tripodi J, Tanweer O, Altman P, Shachter NS, Nakano A, Najfeld V, Chaudhry HW.

Circ Res. 2012 Jan 6;110(1):82-93. doi: 10.1161/CIRCRESAHA.111.249037. Epub 2011 Nov 14. Erratum in: Circ Res. 2015 Nov 6;117(11):e91.

36.

Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives.

Chen A, Lieu DK, Freschauf L, Lew V, Sharma H, Wang J, Nguyen D, Karakikes I, Hajjar RJ, Gopinathan A, Botvinick E, Fowlkes CC, Li RA, Khine M.

Adv Mater. 2011 Dec 22;23(48):5785-91. doi: 10.1002/adma.201103463. Epub 2011 Nov 8.

PMID:
22065428
37.

A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.

Borah JC, Mujtaba S, Karakikes I, Zeng L, Muller M, Patel J, Moshkina N, Morohashi K, Zhang W, Gerona-Navarro G, Hajjar RJ, Zhou MM.

Chem Biol. 2011 Apr 22;18(4):531-41. doi: 10.1016/j.chembiol.2010.12.021.

38.

Delivery of gelfoam-enabled cells and vectors into the pericardial space using a percutaneous approach in a porcine model.

Ladage D, Turnbull IC, Ishikawa K, Takewa Y, Rapti K, Morel C, Karakikes I, Hadri L, Müller-Ehmsen J, Costa KD, Hajjar RJ, Kawase Y.

Gene Ther. 2011 Oct;18(10):979-85. doi: 10.1038/gt.2011.52. Epub 2011 Apr 21.

39.

Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes.

Dhandapany PS, Fabris F, Tonk R, Illaste A, Karakikes I, Sorourian M, Sheng J, Hajjar RJ, Tartaglia M, Sobie EA, Lebeche D, Gelb BD.

J Mol Cell Cardiol. 2011 Jul;51(1):4-15. doi: 10.1016/j.yjmcc.2011.03.001. Epub 2011 Apr 8.

40.

SERCA2a controls the mode of agonist-induced intracellular Ca2+ signal, transcription factor NFAT and proliferation in human vascular smooth muscle cells.

Bobe R, Hadri L, Lopez JJ, Sassi Y, Atassi F, Karakikes I, Liang L, Limon I, Lompré AM, Hatem SN, Hajjar RJ, Lipskaia L.

J Mol Cell Cardiol. 2011 Apr;50(4):621-33. doi: 10.1016/j.yjmcc.2010.12.016. Epub 2010 Dec 29.

41.

Amniotic fluid cells are more efficiently reprogrammed to pluripotency than adult cells.

Galende E, Karakikes I, Edelmann L, Desnick RJ, Kerenyi T, Khoueiry G, Lafferty J, McGinn JT, Brodman M, Fuster V, Hajjar RJ, Polgar K.

Cell Reprogram. 2010 Apr;12(2):117-25. doi: 10.1089/cell.2009.0077.

42.

Gene delivery of sarcoplasmic reticulum calcium ATPase inhibits ventricular remodeling in ischemic mitral regurgitation.

Beeri R, Chaput M, Guerrero JL, Kawase Y, Yosefy C, Abedat S, Karakikes I, Morel C, Tisosky A, Sullivan S, Handschumacher MD, Gilon D, Vlahakes GJ, Hajjar RJ, Levine RA.

Circ Heart Fail. 2010 Sep;3(5):627-34. doi: 10.1161/CIRCHEARTFAILURE.109.891184. Epub 2010 Jul 15.

43.

KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling.

Jin H, Hadri L, Palomeque J, Morel C, Karakikes I, Kaprielian R, Hajjar R, Lebeche D.

J Mol Cell Cardiol. 2010 Jun;48(6):1169-79. doi: 10.1016/j.yjmcc.2009.12.019. Epub 2010 Jan 4.

44.

Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a.

Karakikes I, Kim M, Hadri L, Sakata S, Sun Y, Zhang W, Chemaly ER, Hajjar RJ, Lebeche D.

PLoS One. 2009 Jul 31;4(7):e6474. doi: 10.1371/journal.pone.0006474.

45.

Mechanical work and energetic analysis of eccentric cardiac remodeling in a volume overload heart failure in rats.

Takewa Y, Chemaly ER, Takaki M, Liang LF, Jin H, Karakikes I, Morel C, Taenaka Y, Tatsumi E, Hajjar RJ.

Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1117-24. doi: 10.1152/ajpheart.01120.2008. Epub 2009 Feb 6.

46.

Resident cardiac stem cells.

Torella D, Ellison GM, Karakikes I, Nadal-Ginard B.

Cell Mol Life Sci. 2007 Mar;64(6):661-73. Review.

PMID:
17380307
47.

Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells.

Ellison GM, Torella D, Karakikes I, Purushothaman S, Curcio A, Gasparri C, Indolfi C, Cable NT, Goldspink DF, Nadal-Ginard B.

J Biol Chem. 2007 Apr 13;282(15):11397-409. Epub 2007 Jan 19.

48.

Myocyte death and renewal: modern concepts of cardiac cellular homeostasis.

Ellison GM, Torella D, Karakikes I, Nadal-Ginard B.

Nat Clin Pract Cardiovasc Med. 2007 Feb;4 Suppl 1:S52-9.

PMID:
17230216
49.

Growth-factor-mediated cardiac stem cell activation in myocardial regeneration.

Torella D, Ellison GM, Karakikes I, Nadal-Ginard B.

Nat Clin Pract Cardiovasc Med. 2007 Feb;4 Suppl 1:S46-51.

PMID:
17230215
50.

Detecting and quantifying colocalization of cell surface molecules by single particle fluorescence imaging.

Morrison IE, Karakikes I, Barber RE, Fernández N, Cherry RJ.

Biophys J. 2003 Dec;85(6):4110-21.

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