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J Asthma. 2018 Apr;55(4):437-442. doi: 10.1080/02770903.2017.1336243. Epub 2017 Jul 31.

A "real-life" study on height in prepubertal asthmatic children receiving inhaled steroids.

Author information

1
a Paediatric Endocrinology Unit, 3rd Paediatric Dept, Hippokration Hospital , Aristotle University of Thessaloniki , Greece, Thessaloniki , Greece.
2
b Harokopio University, School of Health Science and Education , Athens , Greece.

Abstract

INTRODUCTION:

Asthma is the most common chronic respiratory disease in children and inhaled corticosteroids (ICS) constitute the first line of treatment for these patients. However, the potential growth-inhibiting effect of ICS has often been a cause of concern for both caregivers as well as physicians, and there still remains conflict regarding their safety profile.

OBJECTIVE:

To assess whether the administration of ICS in low or medium doses is associated with height reduction in prepubertal children.

METHODS:

We performed a retrospective study to examine the association between ICS treatment and growth deceleration in children with mild persistent asthma. The comparison of height measurements every 6 months from 3 to 8 years of age was conducted among three groups of patients: patients not receiving ICS, patients being treated with low dose of ICS and patients being treated with medium dose of ICS (GINA Guidelines 2015).

RESULTS:

This study included 284 patients (198 male, 86 female) aged 3-8 years; 75 patients were not receiving ICS, 63 patients were on low-dose ICS and 146 patients were on medium-dose ICS. The measured height every 6 months did not differ significantly (p > 0.05) among the three groups while the difference remained stable (p > 0.05), even when we evaluated males and females separately.

CONCLUSIONS:

In this "real-life" study we found that long-term treatment with ICS in low or medium doses is not associated with height reduction in prepubertal children with asthma.

KEYWORDS:

Asthma; children; growth; height; steroids

PMID:
28708950
DOI:
10.1080/02770903.2017.1336243
[Indexed for MEDLINE]

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