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Items: 1 to 50 of 58

1.

Renal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System.

Sharp TE 3rd, Polhemus DJ, Li Z, Spaletra P, Jenkins JS, Reilly JP, White CJ, Kapusta DR, Lefer DJ, Goodchild TT.

J Am Coll Cardiol. 2018 Nov 27;72(21):2609-2621. doi: 10.1016/j.jacc.2018.08.2186.

PMID:
30466519
2.

Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney.

Polhemus DJ, Trivedi RK, Gao J, Li Z, Scarborough AL, Goodchild TT, Varner KJ, Xia H, Smart FW, Kapusta DR, Lefer DJ.

J Am Coll Cardiol. 2017 Oct 24;70(17):2139-2153. doi: 10.1016/j.jacc.2017.08.056.

3.

Sympathoinhibitory Effect of Radiofrequency Renal Denervation in Spontaneously Hypertensive Rats With Established Hypertension.

Gao J, Kerut EK, Smart F, Katsurada A, Seth D, Navar LG, Kapusta DR.

Am J Hypertens. 2016 Dec 1;29(12):1394-1401. doi: 10.1093/ajh/hpw089.

4.

Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling.

Polhemus DJ, Gao J, Scarborough AL, Trivedi R, McDonough KH, Goodchild TT, Smart F, Kapusta DR, Lefer DJ.

Circ Res. 2016 Jul 22;119(3):470-80. doi: 10.1161/CIRCRESAHA.115.308278. Epub 2016 Jun 13.

5.

Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal?

Soltani Z, Rasheed K, Kapusta DR, Reisin E.

Curr Hypertens Rep. 2013 Jun;15(3):175-81. doi: 10.1007/s11906-013-0344-5. Review.

6.

Central nervous system Gαi2-subunit proteins maintain salt resistance via a renal nerve-dependent sympathoinhibitory pathway.

Kapusta DR, Pascale CL, Kuwabara JT, Wainford RD.

Hypertension. 2013 Feb;61(2):368-75. doi: 10.1161/HYPERTENSIONAHA.111.00014. Epub 2012 Dec 3.

7.

Brain heterotrimeric Gαi₂-subunit protein-gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress.

Kapusta DR, Pascale CL, Wainford RD.

FASEB J. 2012 Jul;26(7):2776-87. doi: 10.1096/fj.11-196550. Epub 2012 Mar 29.

8.

Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus.

Yoshida T, Semprun-Prieto L, Wainford RD, Sukhanov S, Kapusta DR, Delafontaine P.

Endocrinology. 2012 Mar;153(3):1411-20. doi: 10.1210/en.2011-1764. Epub 2012 Jan 10.

9.

Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception.

Toll L, Khroyan TV, Sonmez K, Ozawa A, Lindberg I, McLaughlin JP, Eans SO, Shahien AA, Kapusta DR.

FASEB J. 2012 Feb;26(2):947-54. doi: 10.1096/fj.11-192831. Epub 2011 Oct 28.

10.
11.

Microinjection of glycine into the hypothalamic paraventricular nucleus produces diuresis, natriuresis, and inhibition of central sympathetic outflow.

Krowicki ZK, Kapusta DR.

J Pharmacol Exp Ther. 2011 Apr;337(1):247-55. doi: 10.1124/jpet.110.175398. Epub 2011 Jan 13.

12.

Modulation of α(2C) adrenergic receptor temperature-sensitive trafficking by HSP90.

Filipeanu CM, de Vries R, Danser AH, Kapusta DR.

Biochim Biophys Acta. 2011 Feb;1813(2):346-57. doi: 10.1016/j.bbamcr.2010.11.020. Epub 2010 Dec 9.

13.

Hypothalamic paraventricular nucleus G alpha q subunit protein pathways mediate vasopressin dysregulation and fluid retention in salt-sensitive rats.

Wainford RD, Kapusta DR.

Endocrinology. 2010 Nov;151(11):5403-14. doi: 10.1210/en.2010-0345. Epub 2010 Sep 22.

14.

Chronic high-NaCl intake prolongs the cardiorenal responses to central N/OFQ and produces regional changes in the endogenous brain NOP receptor system.

Wainford RD, Kapusta DR.

Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R280-8. doi: 10.1152/ajpregu.00096.2008. Epub 2008 Nov 5.

15.

Cytokine blockade attenuates sympathoexcitation in heart failure: cross-talk between nNOS, AT-1R and cytokines in the hypothalamic paraventricular nucleus.

Guggilam A, Patel KP, Haque M, Ebenezer PJ, Kapusta DR, Francis J.

Eur J Heart Fail. 2008 Jul;10(7):625-34. doi: 10.1016/j.ejheart.2008.05.004. Epub 2008 Jun 11.

16.

Nociceptin/orphanin FQ (N/OFQ)-evoked bradycardia, hypotension, and diuresis are absent in N/OFQ peptide (NOP) receptor knockout mice.

Burmeister MA, Ansonoff MA, Pintar JE, Kapusta DR.

J Pharmacol Exp Ther. 2008 Sep;326(3):897-904. doi: 10.1124/jpet.107.135905. Epub 2008 Jun 6.

PMID:
18539652
17.

Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats.

Wainford RD, Kurtz K, Kapusta DR.

Am J Physiol Regul Integr Comp Physiol. 2008 Aug;295(2):R535-42. doi: 10.1152/ajpregu.00043.2008. Epub 2008 Jun 4.

18.

In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor.

Rizzi A, Spagnolo B, Wainford RD, Fischetti C, Guerrini R, Marzola G, Baldisserotto A, Salvadori S, Regoli D, Kapusta DR, Calo G.

Peptides. 2007 Jun;28(6):1240-51. Epub 2007 May 6.

19.
21.

UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor.

Calo G, Guerrini R, Rizzi A, Salvadori S, Burmeister M, Kapusta DR, Lambert DG, Regoli D.

CNS Drug Rev. 2005 Summer;11(2):97-112. Review.

22.
23.

Functional selectivity of nociceptin/orphanin FQ peptide receptor partial agonists on cardiovascular and renal function.

Kapusta DR, Burmeister MA, Calo' G, Guerrini R, Gottlieb HB, Kenigs VA.

J Pharmacol Exp Ther. 2005 Aug;314(2):643-51. Epub 2005 Apr 26.

PMID:
15855356
24.

Pharmacodynamic characterization of ZP120 (Ac-RYYRWKKKKKKK-NH2), a novel, functionally selective nociceptin/orphanin FQ peptide receptor partial agonist with sodium-potassium-sparing aquaretic activity.

Kapusta DR, Thorkildsen C, Kenigs VA, Meier E, Vinge MM, Quist C, Petersen JS.

J Pharmacol Exp Ther. 2005 Aug;314(2):652-60. Epub 2005 Apr 26.

PMID:
15855355
25.

Mechanisms underlying the sympathomimetic cardiovascular responses elicited by gamma-hydroxybutyrate.

Hicks AR, Kapusta DR, Varner KJ.

J Cardiovasc Pharmacol. 2004 Dec;44(6):631-8.

PMID:
15550780
26.

[(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor.

Carrà G, Rizzi A, Guerrini R, Barnes TA, McDonald J, Hebbes CP, Mela F, Kenigs VA, Marzola G, Rizzi D, Gavioli E, Zucchini S, Regoli D, Morari M, Salvadori S, Rowbotham DJ, Lambert DG, Kapusta DR, Calo' G.

J Pharmacol Exp Ther. 2005 Mar;312(3):1114-23. Epub 2004 Oct 27.

PMID:
15509719
28.

Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation.

Hadrup N, Petersen JS, Praetorius J, Meier E, Graebe M, Brønd L, Staahltoft D, Nielsen S, Christensen S, Kapusta DR, Jonassen TE.

Am J Physiol Renal Physiol. 2004 Jul;287(1):F160-8. Epub 2004 Mar 9.

29.

Nociceptin/orphanin FQ modulates the cardiovascular, but not renal, responses to stress in spontaneously hypertensive rats.

Kapusta DR, Dayan LA, Kenigs VA.

Clin Exp Pharmacol Physiol. 2002 Mar;29(3):254-9.

PMID:
11906494
30.

Activation of alpha(2)-receptors in the rostral ventrolateral medulla evokes natriuresis by a renal nerve mechanism.

Menegaz RG, Kapusta DR, Mauad H, de Melo Cabral A.

Am J Physiol Regul Integr Comp Physiol. 2001 Jul;281(1):R98-R107.

31.
32.
33.

Role of intrarenal alpha(2)-adrenoceptors in the renal responses to xylazine in rats.

Menegaz RG, Kapusta DR, Cabral AM.

Am J Physiol Regul Integr Comp Physiol. 2000 Apr;278(4):R1074-81.

34.

Cardiovascular and renal responses produced by central orphanin FQ/nociceptin occur independent of renal nerves.

Kapusta DR, Kenigs VA.

Am J Physiol. 1999 Oct;277(4):R987-95. doi: 10.1152/ajpregu.1999.277.4.R987.

PMID:
10516236
36.

Central alpha2-receptor mechanisms contribute to enhanced renal responses during ketamine-xylazine anesthesia.

Cabral AD, Kapusta DR, Kenigs VA, Varner KJ.

Am J Physiol. 1998 Dec;275(6):R1867-74. doi: 10.1152/ajpregu.1998.275.6.R1867.

PMID:
9843875
37.

Renal excretory responses produced by the delta opioid agonist, BW373U86, in conscious rats.

Sezen SF, Kenigs VA, Kapusta DR.

J Pharmacol Exp Ther. 1998 Oct;287(1):238-45.

PMID:
9765343
38.

Effects of NO synthase inhibitors, arginine-deficient diet, and amiloride in pregnant rats.

Greenberg SS, Lancaster JR, Xie J, Sarphie TG, Zhao X, Hua L, Freeman T, Kapusta DR, Giles TD, Powers DR.

Am J Physiol. 1997 Sep;273(3 Pt 2):R1031-45.

PMID:
9321883
39.

Renal excretory responses produced by central administration of opioid agonists in ketamine and xylazine-anesthetized rats.

Cabral AM, Varner KJ, Kapusta DR.

J Pharmacol Exp Ther. 1997 Aug;282(2):609-16.

PMID:
9262322
40.

Metformin inhibits ganglionic neurotransmission in renal nerves.

Petersen JS, Liu W, Kapusta DR, Varner KJ.

Hypertension. 1997 May;29(5):1173-7.

PMID:
9149683
41.

Nociceptin: an endogenous agonist for central opioid like1 (ORL1) receptors possesses systemic vasorelaxant properties.

Gumusel B, Hao Q, Hyman A, Chang JK, Kapusta DR, Lippton H.

Life Sci. 1997;60(8):PL141-5.

PMID:
9042395
42.

Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ).

Kapusta DR, Sezen SF, Chang JK, Lippton H, Kenigs VA.

Life Sci. 1997;60(1):PL15-21.

PMID:
8995537
43.

Opioid mechanisms controlling renal function.

Kapusta DR.

Clin Exp Pharmacol Physiol. 1995 Dec;22(12):891-902. Review.

PMID:
8846510
44.

Effects of kappa-opioid receptor agonists on stimulated phosphoinositide hydrolysis in rat kidney.

Mosaddeghi M, Kapusta DR, Minor LD, Duan N, Paul D.

Eur J Pharmacol. 1995 May 26;289(3):411-7.

PMID:
7556409
45.

Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide.

Greenberg SS, Xie J, Zatarain JM, Kapusta DR, Miller MJ.

J Pharmacol Exp Ther. 1995 Apr;273(1):257-65.

PMID:
7714773
46.
47.

Role of endogenous central opioid mechanisms in maintenance of body sodium balance.

Kapusta DR, Obih JC.

Am J Physiol. 1995 Mar;268(3 Pt 2):R723-30.

PMID:
7900916
48.
49.
50.

Central mu opioid receptor-mediated changes in renal function in conscious rats.

Kapusta DR, Obih JC, Dibona GF.

J Pharmacol Exp Ther. 1993 Apr;265(1):134-43.

PMID:
8097241

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