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Mediated nuclear import and export of TAZ and the underlying molecular requirements.

Kofler M, Speight P, Little D, Di Ciano-Oliveira C, Szászi K, Kapus A.

Nat Commun. 2018 Nov 23;9(1):4966. doi: 10.1038/s41467-018-07450-0.


Nrf2 Regulates the Hepatoprotective Effects of Remote Ischemic Conditioning in Hemorrhagic Shock.

Leung CH, Caldarone CA, Guan R, Wen XY, Ailenberg M, Kapus A, Szaszi K, Rotstein OD.

Antioxid Redox Signal. 2018 Nov 7. doi: 10.1089/ars.2018.7541. [Epub ahead of print]


Sunitinib induces early histomolecular changes in a subset of renal cancer cells that contribute to resistance.

Lichner Z, Saleeb R, Butz H, Ding Q, Nofech-Mozes R, Riad S, Farag M, Varkouhi AK, Dos Santos CC, Kapus A, Yousef GM.

FASEB J. 2018 Aug 27:fj201800596R. doi: 10.1096/fj.201800596R. [Epub ahead of print]


Cell membrane-bound CD200 signals both via an extracellular domain and following nuclear translocation of a cytoplasmic fragment.

Chen Z, Kapus A, Khatri I, Kos O, Zhu F, Gorczynski RM.

Leuk Res. 2018 Jun;69:72-80. doi: 10.1016/j.leukres.2018.04.007. Epub 2018 Apr 19.


Hemorrhagic Shock/Resuscitation Reduces the M2 Phenotype of Alveolar Macrophages: A Potential Mechanism Contributing to Increased LPS-Induced Lung Injury.

Safavian D, Leung CH, Kapus A, Ailenberg M, Szaszi K, Shani R, Di Ciano-Oliveira C, Ghazerian M, Rotstein O.

Shock. 2018 Feb 27. doi: 10.1097/SHK.0000000000001135. [Epub ahead of print]


Should basic science matter to clinicians?

Filewod NC, Batt J, Kapus A, Szaszi K, Fairn GD, Slutsky AS, Lee WL.

Lancet. 2018 Feb 3;391(10119):410-412. doi: 10.1016/S0140-6736(18)30199-5. No abstract available.


Cell confluence regulates claudin-2 expression: possible role for ZO-1 and Rac.

Amoozadeh Y, Anwer S, Dan Q, Venugopal S, Shi Y, Branchard E, Liedtke E, Ailenberg M, Rotstein OD, Kapus A, Szászi K.

Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C366-C378. doi: 10.1152/ajpcell.00234.2017. Epub 2017 Nov 29.


Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.

Zabini D, Granton E, Hu Y, Miranda MZ, Weichelt U, Breuils Bonnet S, Bonnet S, Morrell NW, Connelly KA, Provencher S, Ghanim B, Klepetko W, Olschewski A, Kapus A, Kuebler WM.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):244-260. doi: 10.1164/rccm.201702-0386OC.


TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism.

Miranda MZ, Bialik JF, Speight P, Dan Q, Yeung T, Szászi K, Pedersen SF, Kapus A.

J Biol Chem. 2017 Sep 8;292(36):14902-14920. doi: 10.1074/jbc.M117.780502. Epub 2017 Jul 24.


Role of integrins in mediating cardiac fibroblast-cardiomyocyte cross talk: a dynamic relationship in cardiac biology and pathophysiology.

Civitarese RA, Kapus A, McCulloch CA, Connelly KA.

Basic Res Cardiol. 2017 Jan;112(1):6. doi: 10.1007/s00395-016-0598-6. Epub 2016 Dec 20. Review.


Sirtuin 1 Activation Reduces Transforming Growth Factor-β1-Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease.

Zhang Y, Connelly KA, Thai K, Wu X, Kapus A, Kepecs D, Gilbert RE.

Am J Pathol. 2017 Jan;187(1):80-90. doi: 10.1016/j.ajpath.2016.09.016.


Stimulus-dependent dissociation between XB130 and Tks5 scaffold proteins promotes airway epithelial cell migration.

Moodley S, Derouet M, Bai XH, Xu F, Kapus A, Yang BB, Liu M.

Oncotarget. 2016 Nov 22;7(47):76437-76452. doi: 10.18632/oncotarget.13261.


MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells.

Li CX, Talele NP, Boo S, Koehler A, Knee-Walden E, Balestrini JL, Speight P, Kapus A, Hinz B.

Nat Mater. 2017 Mar;16(3):379-389. doi: 10.1038/nmat4780. Epub 2016 Oct 31.


Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): a cohort study.

Goldenberg NM, Steinberg BE, Rutka JT, Chen R, Cabral V, Rosenblum ND, Kapus A, Lee WL.

CMAJ Open. 2016 Aug 22;4(3):E444-E447. eCollection 2016 Jul-Sep.


The α11 integrin mediates fibroblast-extracellular matrix-cardiomyocyte interactions in health and disease.

Civitarese RA, Talior-Volodarsky I, Desjardins JF, Kabir G, Switzer J, Mitchell M, Kapus A, McCulloch CA, Gullberg D, Connelly KA.

Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H96-H106. doi: 10.1152/ajpheart.00918.2015. Epub 2016 May 13.


Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src.

Tsang JL, Jia SH, Parodo J, Plant P, Lodyga M, Charbonney E, Szaszi K, Kapus A, Marshall JC.

PLoS One. 2016 Apr 21;11(4):e0153946. doi: 10.1371/journal.pone.0153946. eCollection 2016.


YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis.

Szeto SG, Narimatsu M, Lu M, He X, Sidiqi AM, Tolosa MF, Chan L, De Freitas K, Bialik JF, Majumder S, Boo S, Hinz B, Dan Q, Advani A, John R, Wrana JL, Kapus A, Yuen DA.

J Am Soc Nephrol. 2016 Oct;27(10):3117-3128. doi: 10.1681/ASN.2015050499. Epub 2016 Mar 9.


A little (up)SET THEORY: a philosophical and psychological pondering of a scientist on the state of our art.

Kapus A.

Can J Kidney Health Dis. 2015 Dec 1;2:48. doi: 10.1186/s40697-015-0084-3. eCollection 2015. No abstract available.


Myocardin-related Transcription Factor Regulates Nox4 Protein Expression: LINKING CYTOSKELETAL ORGANIZATION TO REDOX STATE.

Rozycki M, Bialik JF, Speight P, Dan Q, Knudsen TE, Szeto SG, Yuen DA, Szászi K, Pedersen SF, Kapus A.

J Biol Chem. 2016 Jan 1;291(1):227-43. doi: 10.1074/jbc.M115.674606. Epub 2015 Nov 10.


XB130/Tks5 scaffold protein interaction regulates Src-mediated cell proliferation and survival.

Moodley S, Hui Bai X, Kapus A, Yang B, Liu M.

Mol Biol Cell. 2015 Dec 1;26(24):4492-502. doi: 10.1091/mbc.E15-07-0483. Epub 2015 Oct 7.


Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury.

Yin J, Michalick L, Tang C, Tabuchi A, Goldenberg N, Dan Q, Awwad K, Wang L, Erfinanda L, Nouailles G, Witzenrath M, Vogelzang A, Lv L, Lee WL, Zhang H, Rotstein O, Kapus A, Szaszi K, Fleming I, Liedtke WB, Kuppe H, Kuebler WM.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):370-83. doi: 10.1165/rcmb.2014-0225OC.


Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells.

Talele NP, Fradette J, Davies JE, Kapus A, Hinz B.

Stem Cell Reports. 2015 Jun 9;4(6):1016-30. doi: 10.1016/j.stemcr.2015.05.004. Epub 2015 May 28.


Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation.

Tawadros PS, Powers KA, Ailenberg M, Birch SE, Marshall JC, Szaszi K, Kapus A, Rotstein OD.

Shock. 2015 Aug;44(2):157-65. doi: 10.1097/SHK.0000000000000392.


Dynasore enhances the formation of mitochondrial antiviral signalling aggregates and endocytosis-independent NF-κB activation.

Ailenberg M, Di Ciano-Oliveira C, Szaszi K, Dan Q, Rozycki M, Kapus A, Rotstein OD.

Br J Pharmacol. 2015 Aug;172(15):3748-63. doi: 10.1111/bph.13162. Epub 2015 May 15.


Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness.

Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP.

Am J Pathol. 2014 May;184(5):1489-502. doi: 10.1016/j.ajpath.2014.01.016. Epub 2014 Mar 17.


Activated neutrophils induce epithelial cell apoptosis through oxidant-dependent tyrosine dephosphorylation of caspase-8.

Jia SH, Parodo J, Charbonney E, Tsang JLY, Jia SY, Rotstein OD, Kapus A, Marshall JC.

Am J Pathol. 2014 Apr;184(4):1030-1040. doi: 10.1016/j.ajpath.2013.12.031. Epub 2014 Feb 28.


The fate of the primary cilium during myofibroblast transition.

Rozycki M, Lodyga M, Lam J, Miranda MZ, Fátyol K, Speight P, Kapus A.

Mol Biol Cell. 2014 Mar;25(5):643-57. doi: 10.1091/mbc.E13-07-0429. Epub 2014 Jan 8.


Differential topical susceptibility to TGFβ in intact and injured regions of the epithelium: key role in myofibroblast transition.

Speight P, Nakano H, Kelley TJ, Hinz B, Kapus A.

Mol Biol Cell. 2013 Nov;24(21):3326-36. doi: 10.1091/mbc.E13-04-0220. Epub 2013 Sep 4.


Plasma membrane--cortical cytoskeleton interactions: a cell biology approach with biophysical considerations.

Kapus A, Janmey P.

Compr Physiol. 2013 Jul;3(3):1231-81. doi: 10.1002/cphy.c120015. Review.


Chloride transport-driven alveolar fluid secretion is a major contributor to cardiogenic lung edema.

Solymosi EA, Kaestle-Gembardt SM, Vadász I, Wang L, Neye N, Chupin CJ, Rozowsky S, Ruehl R, Tabuchi A, Schulz H, Kapus A, Morty RE, Kuebler WM.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2308-16. doi: 10.1073/pnas.1216382110. Epub 2013 May 3.


Central role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.

Waheed F, Dan Q, Amoozadeh Y, Zhang Y, Tanimura S, Speight P, Kapus A, Szászi K.

Mol Biol Cell. 2013 Apr;24(7):1068-82. doi: 10.1091/mbc.E12-09-0661. Epub 2013 Feb 6.


How do your contacts (or their absence) shape your fate?

Charbonney E, Speight P, Kapus A.

Tissue Barriers. 2013 Jan 1;1(1):e23699. doi: 10.4161/tisb.23699.


Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton.

Ly DL, Waheed F, Lodyga M, Speight P, Masszi A, Nakano H, Hersom M, Pedersen SF, Szászi K, Kapus A.

Am J Physiol Cell Physiol. 2013 Jan 15;304(2):C115-27. doi: 10.1152/ajpcell.00290.2012. Epub 2012 Oct 10.


β-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition.

Charbonney E, Speight P, Masszi A, Nakano H, Kapus A.

Mol Biol Cell. 2011 Dec;22(23):4472-85. doi: 10.1091/mbc.E11-04-0335. Epub 2011 Sep 30.


Osmosensory mechanisms in cellular and systemic volume regulation.

Pedersen SF, Kapus A, Hoffmann EK.

J Am Soc Nephrol. 2011 Sep;22(9):1587-97. doi: 10.1681/ASN.2010121284. Epub 2011 Aug 18. Review.


Pre-B cell colony-enhancing factor (PBEF/Nampt/visfatin) primes neutrophils for augmented respiratory burst activity through partial assembly of the NADPH oxidase.

Malam Z, Parodo J, Waheed F, Szaszi K, Kapus A, Marshall JC.

J Immunol. 2011 Jun 1;186(11):6474-84. doi: 10.4049/jimmunol.1003706. Epub 2011 Apr 25.


Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition.

Quaggin SE, Kapus A.

Kidney Int. 2011 Jul;80(1):41-50. doi: 10.1038/ki.2011.77. Epub 2011 Mar 23. Review.


Hyperosmotic stress strongly potentiates serum response factor (SRF)-dependent transcriptional activity in Ehrlich Lettré Ascites cells through a mechanism involving p38 mitogen-activated protein kinase.

Gorbatenko A, Wiwel M, Klingberg H, Nielsen AB, Kapus A, Pedersen SF.

J Cell Physiol. 2011 Nov;226(11):2857-68. doi: 10.1002/jcp.22628.


Adaptor protein XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion.

Lodyga M, Bai XH, Kapus A, Liu M.

J Cell Sci. 2010 Dec 1;123(Pt 23):4156-69. doi: 10.1242/jcs.071050.


Smaddening complexity: the role of Smad3 in epithelial-myofibroblast transition.

Masszi A, Kapus A.

Cells Tissues Organs. 2011;193(1-2):41-52. doi: 10.1159/000320180. Epub 2010 Nov 3. Review.


The protein kinase C cascade regulates recruitment of matrix metalloprotease 9 to podosomes and its release and activation.

Xiao H, Bai XH, Kapus A, Lu WY, Mak AS, Liu M.

Mol Cell Biol. 2010 Dec;30(23):5545-61. doi: 10.1128/MCB.00382-10. Epub 2010 Oct 11.


Altered inhibitory κBα expression in LPS-stimulated alveolar macrophages following resuscitated hemorrhagic shock.

Papia G, Fan J, Kapus A, Szaszi K, Marshall JC, Tawadros P, Ailenberg M, Rotstein OD.

Shock. 2011 Feb;35(2):171-7. doi: 10.1097/SHK.0b013e3181f21d2d.


Organ fibrosis: when epithelia are muscled to change.

Masszi A, Kapus A.

Cell Cycle. 2010 Jun 15;9(12):2263-4. Epub 2010 Jun 15. No abstract available.


Mechanotransduction by endothelial cells is locally generated, direction-dependent, and ligand-specific.

Chrétien ML, Zhang M, Jackson MR, Kapus A, Langille BL.

J Cell Physiol. 2010 Aug;224(2):352-61. doi: 10.1002/jcp.22125.


Epidermal growth factor receptor signalling contributes to house dust mite-induced epithelial barrier dysfunction.

Heijink IH, van Oosterhout A, Kapus A.

Eur Respir J. 2010 Nov;36(5):1016-26. doi: 10.1183/09031936.00125809. Epub 2010 Mar 29.


Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase.

Waheed F, Speight P, Kawai G, Dan Q, Kapus A, Szászi K.

Am J Physiol Cell Physiol. 2010 Jun;298(6):C1376-87. doi: 10.1152/ajpcell.00408.2009. Epub 2010 Mar 17.


Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3.

Masszi A, Speight P, Charbonney E, Lodyga M, Nakano H, Szászi K, Kapus A.

J Cell Biol. 2010 Feb 8;188(3):383-99. doi: 10.1083/jcb.200906155. Epub 2010 Feb 1.


Remote ischemic preconditioning by hindlimb occlusion prevents liver ischemic/reperfusion injury: the role of High Mobility Group-Box 1.

Wang F, Birch SE, He R, Tawadros P, Szaszi K, Kapus A, Rotstein OD.

Ann Surg. 2010 Feb;251(2):292-9. doi: 10.1097/SLA.0b013e3181bfda8c.


A switchable light-input, light-output system modelled and constructed in yeast.

Sorokina O, Kapus A, Terecskei K, Dixon LE, Kozma-Bognar L, Nagy F, Millar AJ.

J Biol Eng. 2009 Sep 17;3:15. doi: 10.1186/1754-1611-3-15.

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