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SCINA: A Semi-Supervised Subtyping Algorithm of Single Cells and Bulk Samples.

Zhang Z, Luo D, Zhong X, Choi JH, Ma Y, Wang S, Mahrt E, Guo W, Stawiski EW, Modrusan Z, Seshagiri S, Kapur P, Hon GC, Brugarolas J, Wang T.

Genes (Basel). 2019 Jul 12;10(7). pii: E531. doi: 10.3390/genes10070531.


Correlating Anticancer Drug Delivery Efficiency with Vascular Permeability of Renal Clearable Versus Non-renal Clearable Nanocarriers.

Peng C, Yu M, Hsieh JT, Kapur P, Zheng J.

Angew Chem Int Ed Engl. 2019 Aug 26;58(35):12076-12080. doi: 10.1002/anie.201905738. Epub 2019 Jul 24.


Current Challenges in Diagnosis and Assessment of the Response of Locally Advanced and Metastatic Renal Cell Carcinoma.

Diaz de Leon A, Pirasteh A, Costa DN, Kapur P, Hammers H, Brugarolas J, Pedrosa I.

Radiographics. 2019 Jul-Aug;39(4):998-1016. doi: 10.1148/rg.2019180178. Epub 2019 Jun 14.


PD-L1 detection using 89Zr-atezolizumab immuno-PET in renal cell carcinoma tumorgrafts from a patient with favorable nivolumab response.

Vento J, Mulgaonkar A, Woolford L, Nham K, Christie A, Bagrodia A, de Leon AD, Hannan R, Bowman I, McKay RM, Kapur P, Hao G, Sun X, Brugarolas J.

J Immunother Cancer. 2019 Jun 3;7(1):144. doi: 10.1186/s40425-019-0607-z.


Activation of sphingosine kinase by lipopolysaccharide promotes prostate cancer cell invasion and metastasis via SphK1/S1PR4/matriptase.

Lee CF, Dang A, Hernandez E, Pong RC, Chen B, Sonavane R, Raj G, Kapur P, Lin HY, Wu SR, Ko CJ, Lo UG, Lee HY, Hsieh JT, Lee MS.

Oncogene. 2019 Jul;38(28):5580-5598. doi: 10.1038/s41388-019-0833-3. Epub 2019 May 31.


Tuning the In Vivo Transport of Anticancer Drugs Using Renal-Clearable Gold Nanoparticles.

Peng C, Xu J, Yu M, Ning X, Huang Y, Du B, Hernandez E, Kapur P, Hsieh JT, Zheng J.

Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8479-8483. doi: 10.1002/anie.201903256. Epub 2019 May 14.


Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation.

Yun EJ, Lin CJ, Dang A, Hernandez E, Guo J, Chen WM, Allison J, Kim N, Kapur P, Brugarolas J, Wu K, He D, Lai CH, Lin H, Saha D, Baek ST, Chen BPC, Hsieh JT.

Clin Cancer Res. 2019 Jul 15;25(14):4542-4551. doi: 10.1158/1078-0432.CCR-18-3004. Epub 2019 Apr 18.


Expression and prognostic utility of PD-L1 in patients with squamous cell carcinoma of the bladder.

Owyong M, Lotan Y, Kapur P, Panwar V, McKenzie T, Lee TK, Zi X, Martin JW, Mosbah A, Abol-Enein H, Ghoneim M, Youssef RF.

Urol Oncol. 2019 Jul;37(7):478-484. doi: 10.1016/j.urolonc.2019.02.017. Epub 2019 Mar 23.


Does proximity of positive prostate biopsy core to capsular margin help predict side-specific extracapsular extension at prostatectomy?

Singla N, Walker JT, Woldu SL, De La Fuente K, Araj E, Swartz B, Kapur P, Roehrborn CG.

Can J Urol. 2019 Feb;26(1):9634-9643.


Prognostic significance of BAP1 expression in high-grade upper tract urothelial carcinoma: a multi-institutional study.

Aydin AM, Singla N, Panwar V, Woldu SL, Freifeld Y, Wood CG, Karam JA, Weizer AZ, Raman JD, Remzi M, Rioux-Leclercq N, Haitel A, Roscigno M, Bolenz C, Bensalah K, Westerman ME, Sagalowsky AI, Shariat SF, Lotan Y, Bagrodia A, Kapur P, Margulis V, Krabbe LM.

World J Urol. 2019 Feb 13. doi: 10.1007/s00345-019-02678-x. [Epub ahead of print]


IFNγ-Induced IFIT5 Promotes Epithelial-to-Mesenchymal Transition in Prostate Cancer via miRNA Processing.

Lo UG, Pong RC, Yang D, Gandee L, Hernandez E, Dang A, Lin CJ, Santoyo J, Ma S, Sonavane R, Huang J, Tseng SF, Moro L, Arbini AA, Kapur P, Raj GV, He D, Lai CH, Lin H, Hsieh JT.

Cancer Res. 2019 Mar 15;79(6):1098-1112. doi: 10.1158/0008-5472.CAN-18-2207. Epub 2018 Nov 30.


Radiomics in Kidney Cancer: MR Imaging.

de Leon AD, Kapur P, Pedrosa I.

Magn Reson Imaging Clin N Am. 2019 Feb;27(1):1-13. doi: 10.1016/j.mric.2018.08.005. Review.


Reliable gene mutation prediction in clear cell renal cell carcinoma through multi-classifier multi-objective radiogenomics model.

Chen X, Zhou Z, Hannan R, Thomas K, Pedrosa I, Kapur P, Brugarolas J, Mou X, Wang J.

Phys Med Biol. 2018 Oct 24;63(21):215008. doi: 10.1088/1361-6560/aae5cd.


Novel MEIS1-NCOA2 Gene Fusions Define a Distinct Primitive Spindle Cell Sarcoma of the Kidney.

Argani P, Reuter VE, Kapur P, Brown JE, Sung YS, Zhang L, Williamson R, Francis G, Sommerville S, Swanson D, Dickson BC, Antonescu CR.

Am J Surg Pathol. 2018 Nov;42(11):1562-1570. doi: 10.1097/PAS.0000000000001140.


Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo.

Courtney KD, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk AM, Wimberly J, McNeil SS, Kapur P, Lotan Y, Margulis V, Cadeddu JA, Pedrosa I, DeBerardinis RJ, Malloy CR, Bachoo RM, Maher EA.

Cell Metab. 2018 Nov 6;28(5):793-800.e2. doi: 10.1016/j.cmet.2018.07.020. Epub 2018 Aug 23.


A patient-derived explant (PDE) model of hormone-dependent cancer.

Centenera MM, Hickey TE, Jindal S, Ryan NK, Ravindranathan P, Mohammed H, Robinson JL, Schiewer MJ, Ma S, Kapur P, Sutherland PD, Hoffmann CE, Roehrborn CG, Gomella LG, Carroll JS, Birrell SN, Knudsen KE, Raj GV, Butler LM, Tilley WD.

Mol Oncol. 2018 Sep;12(9):1608-1622. doi: 10.1002/1878-0261.12354. Epub 2018 Aug 16.


Renal Cell Carcinoma Pseudoprogression with Clinical Deterioration: To Hospice and Back.

Elias R, Kapur P, Pedrosa I, Brugarolas J.

Clin Genitourin Cancer. 2018 Dec;16(6):485-488. doi: 10.1016/j.clgc.2018.07.015. Epub 2018 Jul 20. No abstract available.


The Social Media Index as an Indicator of Quality for Emergency Medicine Blogs: A METRIQ Study.

Thoma B, Chan TM, Kapur P, Sifford D, Siemens M, Paddock M, Ankel F, Grock A, Lin M; METRIQ Study Collaborators.

Ann Emerg Med. 2018 Dec;72(6):696-702. doi: 10.1016/j.annemergmed.2018.05.003. Epub 2018 Jul 3.


An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors.

Wang T, Lu R, Kapur P, Jaiswal BS, Hannan R, Zhang Z, Pedrosa I, Luke JJ, Zhang H, Goldstein LD, Yousuf Q, Gu YF, McKenzie T, Joyce A, Kim MS, Wang X, Luo D, Onabolu O, Stevens C, Xie Z, Chen M, Filatenkov A, Torrealba J, Luo X, Guo W, He J, Stawiski E, Modrusan Z, Durinck S, Seshagiri S, Brugarolas J.

Cancer Discov. 2018 Sep;8(9):1142-1155. doi: 10.1158/2159-8290.CD-17-1246. Epub 2018 Jun 8.


What is the role of nephrectomy following complete response to checkpoint inhibitors?

Woldu SL, Brugarolas J, Kapur P, Margulis V.

Urol Case Rep. 2018 Mar 14;18:60-63. doi: 10.1016/j.eucr.2018.02.016. eCollection 2018 May. No abstract available.


Multi-institutional evaluation of the prognostic significance of EZH2 expression in high-grade upper tract urothelial carcinoma.

Singla N, Krabbe LM, Aydin AM, Panwar V, Woldu SL, Freifeld Y, Wood CG, Karam JA, Weizer AZ, Raman JD, Remzi M, Rioux-Leclercq N, Haitel A, Roscigno M, Bolenz C, Bensalah K, Sagalowsky AI, Shariat SF, Lotan Y, Bagrodia A, Kapur P, Margulis V.

Urol Oncol. 2018 Jul;36(7):343.e1-343.e8. doi: 10.1016/j.urolonc.2018.04.004. Epub 2018 May 7.


Left ventricular outflow tract pseudoaneurysm diagnosed with point-of-care ultrasound in the emergency department.

Kapur P, Baimel M, Chenkin J.

CJEM. 2018 Sep;20(5):798-801. doi: 10.1017/cem.2018.20. Epub 2018 Mar 16.


Grade progression in urothelial carcinoma can occur with high or low mutational homology: a first-step toward tumor-specific care in initial low-grade bladder cancer.

Kittler R, Shiang C, Hutchinson R, Kollipara RK, Kapur P, Franto F, Lotan Y.

Oncotarget. 2018 Jan 6;9(10):9415-9424. doi: 10.18632/oncotarget.24072. eCollection 2018 Feb 6.


EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors.

Chen KS, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LHJ, Laetsch TW, Rakheja D, Amatruda JF.

Mol Cancer Ther. 2018 May;17(5):1079-1089. doi: 10.1158/1535-7163.MCT-17-0137. Epub 2018 Feb 26.


Metastatic "Burned Out" Seminoma Causing Neurological Paraneoplastic Syndrome-Not Quite "Burned Out".

Freifeld Y, Kapur P, Chitkara R, Lee F, Khemani P, Bagrodia A.

Front Neurol. 2018 Jan 30;9:20. doi: 10.3389/fneur.2018.00020. eCollection 2018.


Dose Dependencies and Biocompatibility of Renal Clearable Gold Nanoparticles: From Mice to Non-human Primates.

Xu J, Yu M, Peng C, Carter P, Tian J, Ning X, Zhou Q, Tu Q, Zhang G, Dao A, Jiang X, Kapur P, Hsieh JT, Zhao X, Liu P, Zheng J.

Angew Chem Int Ed Engl. 2018 Jan 2;57(1):266-271. doi: 10.1002/anie.201710584. Epub 2017 Dec 5.


Development of a Patient-specific Tumor Mold Using Magnetic Resonance Imaging and 3-Dimensional Printing Technology for Targeted Tissue Procurement and Radiomics Analysis of Renal Masses.

Dwivedi DK, Chatzinoff Y, Zhang Y, Yuan Q, Fulkerson M, Chopra R, Brugarolas J, Cadeddu JA, Kapur P, Pedrosa I.

Urology. 2018 Feb;112:209-214. doi: 10.1016/j.urology.2017.08.056. Epub 2017 Oct 19.


Oncometabolites: A New Paradigm for Oncology, Metabolism, and the Clinical Laboratory.

Collins RRJ, Patel K, Putnam WC, Kapur P, Rakheja D.

Clin Chem. 2017 Dec;63(12):1812-1820. doi: 10.1373/clinchem.2016.267666. Epub 2017 Oct 16. Review.


Multicenter Validation of Enhancer of Zeste Homolog 2 Expression as an Independent Prognostic Marker in Localized Clear Cell Renal Cell Carcinoma.

Ho TH, Kapur P, Eckel-Passow JE, Christie A, Joseph RW, Serie DJ, Cheville JC, Thompson RH, Homayoun F, Panwar V, Brugarolas J, Parker AS.

J Clin Oncol. 2017 Nov 10;35(32):3706-3713. doi: 10.1200/JCO.2017.73.3238. Epub 2017 Oct 4.


In Vivo X-ray Imaging of Transport of Renal Clearable Gold Nanoparticles in the Kidneys.

Xu J, Yu M, Carter P, Hernandez E, Dang A, Kapur P, Hsieh JT, Zheng J.

Angew Chem Int Ed Engl. 2017 Oct 16;56(43):13356-13360. doi: 10.1002/anie.201707819. Epub 2017 Sep 25.


Adverse drug reaction monitoring during antimicrobial therapy for septicemia patients at a university hospital in New Delhi.

Alam MS, Pillai KK, Abdi SAH, Kapur P, Pillai PK, Nagarajan K.

Korean J Intern Med. 2018 Nov;33(6):1203-1209. doi: 10.3904/kjim.2016.001. Epub 2017 Sep 6.


Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI.

Zhang Y, Udayakumar D, Cai L, Hu Z, Kapur P, Kho EY, Pavía-Jiménez A, Fulkerson M, de Leon AD, Yuan Q, Dimitrov IE, Yokoo T, Ye J, Mitsche MA, Kim H, McDonald JG, Xi Y, Madhuranthakam AJ, Dwivedi DK, Lenkinski RE, Cadeddu JA, Margulis V, Brugarolas J, DeBerardinis RJ, Pedrosa I.

JCI Insight. 2017 Aug 3;2(15). pii: 94278. doi: 10.1172/jci.insight.94278. eCollection 2017 Aug 3.


Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer.

Wang B, Lo UG, Wu K, Kapur P, Liu X, Huang J, Chen W, Hernandez E, Santoyo J, Ma SH, Pong RC, He D, Cheng YQ, Hsieh JT.

Int J Cancer. 2017 Nov 15;141(10):2121-2130. doi: 10.1002/ijc.30893. Epub 2017 Jul 31.


Splenic Involvement in Disseminated Mycobacterium avium-intracellulare Infection: Magnetic Resonance Imaging Findings.

Clark H, Khatri G, Kapur P, Pedrosa I.

J Comput Assist Tomogr. 2018 Jan/Feb;42(1):151-154. doi: 10.1097/RCT.0000000000000639.


Statistical clustering of parametric maps from dynamic contrast enhanced MRI and an associated decision tree model for non-invasive tumour grading of T1b solid clear cell renal cell carcinoma.

Xi Y, Yuan Q, Zhang Y, Madhuranthakam AJ, Fulkerson M, Margulis V, Brugarolas J, Kapur P, Cadeddu JA, Pedrosa I.

Eur Radiol. 2018 Jan;28(1):124-132. doi: 10.1007/s00330-017-4925-6. Epub 2017 Jul 5.


Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.

Gu YF, Cohn S, Christie A, McKenzie T, Wolff N, Do QN, Madhuranthakam AJ, Pedrosa I, Wang T, Dey A, Busslinger M, Xie XJ, Hammer RE, McKay RM, Kapur P, Brugarolas J.

Cancer Discov. 2017 Aug;7(8):900-917. doi: 10.1158/2159-8290.CD-17-0292. Epub 2017 May 4.


PBRM1 loss is a late event during the development of cholangiocarcinoma.

Luchini C, Robertson SA, Hong SM, Felsenstein M, Anders RA, Pea A, Nottegar A, Veronese N, He J, Weiss MJ, Capelli P, Scarpa A, Argani P, Kapur P, Wood LD.

Histopathology. 2017 Sep;71(3):375-382. doi: 10.1111/his.13234. Epub 2017 Jun 22.


Improved Magnetic Resonance Imaging-Pathology Correlation With Imaging-Derived, 3D-Printed, Patient-Specific Whole-Mount Molds of the Prostate.

Costa DN, Chatzinoff Y, Passoni NM, Kapur P, Roehrborn CG, Xi Y, Rofsky NM, Torrealba J, Francis F, Futch C, Hagens P, Notgrass H, Otero-Muinelo S, Pedrosa I, Chopra R.

Invest Radiol. 2017 Sep;52(9):507-513. doi: 10.1097/RLI.0000000000000372.


BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor.

Eckel-Passow JE, Serie DJ, Cheville JC, Ho TH, Kapur P, Brugarolas J, Thompson RH, Leibovich BC, Kwon ED, Joseph RW, Parker AS.

BMC Urol. 2017 Mar 21;17(1):19. doi: 10.1186/s12894-017-0209-3.


Low Testosterone Levels Result in Decreased Periurethral Vascularity via an Androgen Receptor-mediated Process: Pilot Study in Urethral Stricture Tissue.

Hofer MD, Kapur P, Cordon BH, Hamoun F, Russell D, Scott JM, Roehrborn CG, Morey AF.

Urology. 2017 Jul;105:175-180. doi: 10.1016/j.urology.2017.02.037. Epub 2017 Mar 2.


Effect of orlistat on periostin, adiponectin, inflammatory markers and ultrasound grades of fatty liver in obese NAFLD patients.

Ali Khan R, Kapur P, Jain A, Farah F, Bhandari U.

Ther Clin Risk Manag. 2017 Feb 20;13:139-149. doi: 10.2147/TCRM.S124621. eCollection 2017.


Renal Cell Carcinoma With Pulmonary Metastasis and Metachronous Non-Small Cell Lung Cancer.

Bowman IA, Pedrosa I, Kapur P, Brugarolas J.

Clin Genitourin Cancer. 2017 Aug;15(4):e675-e680. doi: 10.1016/j.clgc.2017.01.026. Epub 2017 Feb 6.


Unusual skull tumors with psammomatoid bodies: a diagnostic challenge.

Richardson TE, Georgescu MM, Kapur P, Hwang H, Barnett SL, Raisanen JM, Cai C, Hatanpaa KJ.

Clin Neuropathol. 2017 May/Jun;36 (2017)(3):114-120. doi: 10.5414/NP300997. Review.


Prognostic value of tissue-based biomarker signature in clear cell renal cell carcinoma.

Haddad AQ, Luo JH, Krabbe LM, Darwish O, Gayed B, Youssef R, Kapur P, Rakheja D, Lotan Y, Sagalowsky A, Margulis V.

BJU Int. 2017 May;119(5):741-747. doi: 10.1111/bju.13776. Epub 2017 Feb 9.


Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer.

Mani RS, Amin MA, Li X, Kalyana-Sundaram S, Veeneman BA, Wang L, Ghosh A, Aslam A, Ramanand SG, Rabquer BJ, Kimura W, Tran M, Cao X, Roychowdhury S, Dhanasekaran SM, Palanisamy N, Sadek HA, Kapur P, Koch AE, Chinnaiyan AM.

Cell Rep. 2016 Dec 6;17(10):2620-2631. doi: 10.1016/j.celrep.2016.11.019.


Targeting renal cell carcinoma with a HIF-2 antagonist.

Chen W, Hill H, Christie A, Kim MS, Holloman E, Pavia-Jimenez A, Homayoun F, Ma Y, Patel N, Yell P, Hao G, Yousuf Q, Joyce A, Pedrosa I, Geiger H, Zhang H, Chang J, Gardner KH, Bruick RK, Reeves C, Hwang TH, Courtney K, Frenkel E, Sun X, Zojwalla N, Wong T, Rizzi JP, Wallace EM, Josey JA, Xie Y, Xie XJ, Kapur P, McKay RM, Brugarolas J.

Nature. 2016 Nov 3;539(7627):112-117. doi: 10.1038/nature19796. Epub 2016 Sep 5.


Cell-cycle markers do not improve discrimination of EORTC and CUETO risk models in predicting recurrence and progression of non-muscle-invasive high-grade bladder cancer.

Passoni N, Gayed B, Kapur P, Sagalowsky AI, Shariat SF, Lotan Y.

Urol Oncol. 2016 Nov;34(11):485.e7-485.e14. doi: 10.1016/j.urolonc.2016.05.014. Epub 2016 Sep 13.


Zinc-sensitive MRI contrast agent detects differential release of Zn(II) ions from the healthy vs. malignant mouse prostate.

Clavijo Jordan MV, Lo ST, Chen S, Preihs C, Chirayil S, Zhang S, Kapur P, Li WH, De Leon-Rodriguez LM, Lubag AJ, Rofsky NM, Sherry AD.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5464-71. doi: 10.1073/pnas.1609450113. Epub 2016 Aug 25.


Multi-disciplinary surgical approach to the management of patients with renal cell carcinoma with venous tumor thrombus: 15 year experience and lessons learned.

Gayed BA, Youssef R, Darwish O, Kapur P, Bagrodia A, Brugarolas J, Raj G, DiMaio JM, Sagalowsky A, Margulis V.

BMC Urol. 2016 Jul 19;16(1):43. doi: 10.1186/s12894-016-0157-3.


Concordance in Biomarker Status Between Bladder Tumors at Time of Transurethral Resection and Subsequent Radical Cystectomy: Results of a 5-year Prospective Study.

Passoni NM, Shariat SF, Bagrodia A, Francis F, Rachakonda V, Xylinas E, Kapur P, Sagalowsky AI, Lotan Y.

Bladder Cancer. 2016 Jan 7;2(1):91-99.

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