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Symptom perception, placebo effects and the Bayesian brain.

Ongaro G, Kaptchuk TJ.

Pain. 2018 Aug 6. doi: 10.1097/j.pain.0000000000001367. [Epub ahead of print] No abstract available.


Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus.

Evers AWM, Colloca L, Blease C, Annoni M, Atlas LY, Benedetti F, Bingel U, Büchel C, Carvalho C, Colagiuri B, Crum AJ, Enck P, Gaab J, Geers AL, Howick J, Jensen KB, Kirsch I, Meissner K, Napadow V, Peerdeman KJ, Raz A, Rief W, Vase L, Wager TD, Wampold BE, Weimer K, Wiech K, Kaptchuk TJ, Klinger R, Kelley JM.

Psychother Psychosom. 2018;87(4):204-210. doi: 10.1159/000490354. Epub 2018 Jun 12.


Enhancing treatment of osteoarthritis knee pain by boosting expectancy: A functional neuroimaging study.

Kong J, Wang Z, Leiser J, Minicucci D, Edwards R, Kirsch I, Wasan AD, Lang C, Gerber J, Yu S, Napadow V, Kaptchuk TJ, Gollub RL.

Neuroimage Clin. 2018 Feb 28;18:325-334. doi: 10.1016/j.nicl.2018.01.021. eCollection 2018.


Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition.

Crum AJ, Akinola M, Turnwald BP, Kaptchuk TJ, Hall KT.

PLoS One. 2018 Apr 20;13(4):e0195883. doi: 10.1371/journal.pone.0195883. eCollection 2018.


Factors Associated With Response to Placebo in Patients With Irritable Bowel Syndrome and Constipation.

Ballou S, Beath A, Kaptchuk TJ, Hirsch W, Sommers T, Nee J, Iturrino J, Rangan V, Singh P, Jones M, Lembo A.

Clin Gastroenterol Hepatol. 2018 Apr 12. pii: S1542-3565(18)30345-8. doi: 10.1016/j.cgh.2018.04.009. [Epub ahead of print]


Learned immunosuppressive placebo responses in renal transplant patients.

Kirchhof J, Petrakova L, Brinkhoff A, Benson S, Schmidt J, Unteroberdörster M, Wilde B, Kaptchuk TJ, Witzke O, Schedlowski M.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4223-4227. doi: 10.1073/pnas.1720548115. Epub 2018 Apr 2.


Open-Label Placebo Treatment for Cancer-Related Fatigue: A Randomized-Controlled Clinical Trial.

Hoenemeyer TW, Kaptchuk TJ, Mehta TS, Fontaine KR.

Sci Rep. 2018 Feb 9;8(1):2784. doi: 10.1038/s41598-018-20993-y.


Placebo Effects in Traumatic Brain Injury.

Polich G, Iaccarino MA, Kaptchuk TJ, Morales-Quezada L, Zafonte R.

J Neurotrauma. 2018 Jun 1;35(11):1205-1212. doi: 10.1089/neu.2017.5506. Epub 2018 Apr 5.


A Functional Neuroimaging Study of Expectancy Effects on Pain Response in Patients With Knee Osteoarthritis.

Gollub RL, Kirsch I, Maleki N, Wasan AD, Edwards RR, Tu Y, Kaptchuk TJ, Kong J.

J Pain. 2018 May;19(5):515-527. doi: 10.1016/j.jpain.2017.12.260. Epub 2018 Jan 8.


The National Cancer Institute's Conference on Acupuncture for Symptom Management in Oncology: State of the Science, Evidence, and Research Gaps.

Zia FZ, Olaku O, Bao T, Berger A, Deng G, Fan AY, Garcia MK, Herman PM, Kaptchuk TJ, Ladas EJ, Langevin HM, Lao L, Lu W, Napadow V, Niemtzow RC, Vickers AJ, Shelley Wang X, Witt CM, Mao JJ.

J Natl Cancer Inst Monogr. 2017 Nov 1;2017(52). doi: 10.1093/jncimonographs/lgx005.


Dopaminergic tone does not influence pain levels during placebo interventions in patients with chronic neuropathic pain.

Skyt I, Moslemi K, Baastrup C, Grosen K, Benedetti F, Petersen GL, Price DD, Hall KT, Kaptchuk TJ, Svensson P, Jensen TS, Vase L.

Pain. 2018 Feb;159(2):261-272. doi: 10.1097/j.pain.0000000000001089.


Influence of the patient-practitioner interaction context on acupuncture outcomes in functional dyspepsia: study protocol for a multicenter randomized controlled trial.

Ko SJ, Park JW, Leem J, Kaptchuk TJ, Napadow V, Kuo B, Gerber J, Dimisko L, Yeo I, Lee J, Kim J.

BMC Complement Altern Med. 2017 Jul 14;17(1):363. doi: 10.1186/s12906-017-1869-y.


Network analysis of the genomic basis of the placebo effect.

Wang RS, Hall KT, Giulianini F, Passow D, Kaptchuk TJ, Loscalzo J.

JCI Insight. 2017 Jun 2;2(11). pii: 93911. doi: 10.1172/jci.insight.93911. [Epub ahead of print]


Open-label versus double-blind placebo treatment in irritable bowel syndrome: study protocol for a randomized controlled trial.

Ballou S, Kaptchuk TJ, Hirsch W, Nee J, Iturrino J, Hall KT, Kelley JM, Cheng V, Kirsch I, Jacobson E, Conboy L, Lembo A, Davis RB.

Trials. 2017 May 25;18(1):234. doi: 10.1186/s13063-017-1964-x.


Certainty of genuine treatment increases drug responses among intellectually disabled patients.

Jensen KB, Kirsch I, Pontén M, Rosén A, Yang K, Gollub RL, des Portes V, Kaptchuk TJ, Curie A.

Neurology. 2017 May 16;88(20):1912-1918. doi: 10.1212/WNL.0000000000003934. Epub 2017 Apr 19.


Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture.

Maeda Y, Kim H, Kettner N, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Ong-Sutherland R, Mezzacappa P, Libby A, Mawla I, Morse LR, Kaptchuk TJ, Audette J, Napadow V.

Brain. 2017 Apr 1;140(4):914-927. doi: 10.1093/brain/awx015.



Carvalho C, Kirsch I, Kaptchuk TJ.

Pain. 2017 Mar;158(3):536-537. doi: 10.1097/j.pain.0000000000000795. No abstract available.


Side effects can enhance treatment response through expectancy effects: an experimental analgesic randomized controlled trial.

Berna C, Kirsch I, Zion SR, Lee YC, Jensen KB, Sadler P, Kaptchuk TJ, Edwards RR.

Pain. 2017 Jun;158(6):1014-1020. doi: 10.1097/j.pain.0000000000000870.


Parental Attitudes About Placebo Use in Children.

Faria V, Kossowsky J, Petkov MP, Kaptchuk TJ, Kirsch I, Lebel A, Borsook D.

J Pediatr. 2017 Feb;181:272-278.e10. doi: 10.1016/j.jpeds.2016.10.018. Epub 2016 Nov 15.


Open-label placebo treatment in chronic low back pain: a randomized controlled trial.

Carvalho C, Caetano JM, Cunha L, Rebouta P, Kaptchuk TJ, Kirsch I.

Pain. 2016 Dec;157(12):2766-2772. Erratum in: Pain. 2017 Feb;158(2):365.


Effect of EphB4/EphrinB2 reverse signal on angiogenesis induced by Xuefu Zhuyu Capsule () containing serum in human microvascular endothelial cell 1.

Zhang JS, Wang YZ, Hu YQ, Lin F, Gao D, Song J, Kaptchuk TJ, Chen KJ.

Chin J Integr Med. 2016 Aug;22(8):605-10. doi: 10.1007/s11655-016-2470-9. Epub 2016 Jun 14.


Catechol-O-methyltransferase association with hemoglobin A1c.

Hall KT, Jablonski KA, Chen L, Harden M, Tolkin BR, Kaptchuk TJ, Bray GA, Ridker PM, Florez JC; Diabetes Prevention Program Research Group, Mukamal KJ, Chasman DI.

Metabolism. 2016 Jul;65(7):961-967. doi: 10.1016/j.metabol.2016.04.001. Epub 2016 Apr 14.


Placebo effects in obesity research.

Fontaine KR, Williams MS, Hoenemeyer TW, Kaptchuk TJ, Dutton GR.

Obesity (Silver Spring). 2016 Apr;24(4):769-71. doi: 10.1002/oby.21456. No abstract available.


Establishing an Integrative Medicine Program Within an Academic Health Center: Essential Considerations.

Eisenberg DM, Kaptchuk TJ, Post DE, Hrbek AL, O'Connor BB, Osypiuk K, Wayne PM, Buring JE, Levy DB.

Acad Med. 2016 Sep;91(9):1223-30. doi: 10.1097/ACM.0000000000001173.


Homeopathy Use by US Adults: Results of a National Survey.

Dossett ML, Davis RB, Kaptchuk TJ, Yeh GY.

Am J Public Health. 2016 Apr;106(4):743-5. doi: 10.2105/AJPH.2015.303025. Epub 2016 Feb 18.


Are open-Label Placebos Ethical? Informed Consent and Ethical Equivocations.

Blease C, Colloca L, Kaptchuk TJ.

Bioethics. 2016 Jul;30(6):407-14. doi: 10.1111/bioe.12245. Epub 2016 Feb 3.


To what extent are surgery and invasive procedures effective beyond a placebo response? A systematic review with meta-analysis of randomised, sham controlled trials.

Jonas WB, Crawford C, Colloca L, Kaptchuk TJ, Moseley B, Miller FG, Kriston L, Linde K, Meissner K.

BMJ Open. 2015 Dec 11;5(12):e009655. doi: 10.1136/bmjopen-2015-009655. Review.


Psychiatrists' Attitudes Toward Non-Pharmacologic Factors Within the Context of Antidepressant Pharmacotherapy.

Vijapura S, Laferton JA, Mintz D, Kaptchuk TJ, Wolfe D.

Acad Psychiatry. 2016 Oct;40(5):783-9. doi: 10.1007/s40596-015-0470-2. Epub 2015 Dec 8.


The Use of Traditional Vietnamese Medicine Among Vietnamese Immigrants Attending an Urban Community Health Center in the United States.

Nguyen LT, Kaptchuk TJ, Davis RB, Nguyen G, Pham V, Tringale SM, Loh YL, Gardiner P.

J Altern Complement Med. 2016 Feb;22(2):145-53. doi: 10.1089/acm.2014.0209. Epub 2015 Dec 2.


Patient-Provider Interactions Affect Symptoms in Gastroesophageal Reflux Disease: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial.

Dossett ML, Mu L, Davis RB, Bell IR, Lembo AJ, Kaptchuk TJ, Yeh GY.

PLoS One. 2015 Sep 30;10(9):e0136855. doi: 10.1371/journal.pone.0136855. eCollection 2015.


Online Education for Improving Communication and Documentation of Dietary Supplements Among Health Professionals Practicing in a Hospital Setting.

Gardiner P, Filippelli AC, Kabbara K, Lin SC, Sadikova E, Kaptchuk TJ, Kemper K.

J Altern Complement Med. 2015 Oct;21(10):638-44. doi: 10.1089/acm.2015.0156. Epub 2015 Aug 13.


Placebo Responses in Genetically Determined Intellectual Disability: A Meta-Analysis.

Curie A, Yang K, Kirsch I, Gollub RL, des Portes V, Kaptchuk TJ, Jensen KB.

PLoS One. 2015 Jul 30;10(7):e0133316. doi: 10.1371/journal.pone.0133316. eCollection 2015.


Placebo Effects in Medicine.

Kaptchuk TJ, Miller FG.

N Engl J Med. 2015 Jul 2;373(1):8-9. doi: 10.1056/NEJMp1504023. No abstract available.


Stress Management and Relaxation Techniques use among underserved inpatients in an inner city hospital.

Gardiner P, Sadikova E, Filippelli AC, Mitchell S, White LF, Saper R, Kaptchuk TJ, Jack BW, Fredman L.

Complement Ther Med. 2015 Jun;23(3):405-12. doi: 10.1016/j.ctim.2015.03.006. Epub 2015 Mar 20.


Classical conditioning of analgesic and hyperalgesic pain responses without conscious awareness.

Jensen K, Kirsch I, Odmalm S, Kaptchuk TJ, Ingvar M.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7863-7. doi: 10.1073/pnas.1504567112. Epub 2015 May 15.


Structural integration as an adjunct to outpatient rehabilitation for chronic nonspecific low back pain: a randomized pilot clinical trial.

Jacobson EE, Meleger AL, Bonato P, Wayne PM, Langevin HM, Kaptchuk TJ, Davis RB.

Evid Based Complement Alternat Med. 2015;2015:813418. doi: 10.1155/2015/813418. Epub 2015 Apr 7.


Placebo effects in infants, toddlers, and parents.

Kossowsky J, Kaptchuk TJ.

JAMA Pediatr. 2015 May;169(5):505. doi: 10.1001/jamapediatrics.2014.3798. No abstract available.


Placebo-induced somatic sensations: a multi-modal study of three different placebo interventions.

Beissner F, Brünner F, Fink M, Meissner K, Kaptchuk TJ, Napadow V.

PLoS One. 2015 Apr 22;10(4):e0124808. doi: 10.1371/journal.pone.0124808. eCollection 2015.


Genetics and the placebo effect: the placebome.

Hall KT, Loscalzo J, Kaptchuk TJ.

Trends Mol Med. 2015 May;21(5):285-94. doi: 10.1016/j.molmed.2015.02.009. Epub 2015 Apr 14. Review.


Distinct neural representations of placebo and nocebo effects.

Freeman S, Yu R, Egorova N, Chen X, Kirsch I, Claggett B, Kaptchuk TJ, Gollub RL, Kong J.

Neuroimage. 2015 May 15;112:197-207. doi: 10.1016/j.neuroimage.2015.03.015. Epub 2015 Mar 14.


Can acupuncture treatment be double-blinded? An evaluation of double-blind acupuncture treatment of postoperative pain.

Vase L, Baram S, Takakura N, Takayama M, Yajima H, Kawase A, Schuster L, Kaptchuk TJ, Schou S, Jensen TS, Zachariae R, Svensson P.

PLoS One. 2015 Mar 6;10(3):e0119612. doi: 10.1371/journal.pone.0119612. eCollection 2015.


Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients.

Hall KT, Tolkin BR, Chinn GM, Kirsch I, Kelley JM, Lembo AJ, Kaptchuk TJ, Kokkotou E, Davis RB, Conboy LA.

Brain Behav. 2015 Jan;5(1):39-44. doi: 10.1002/brb3.294. Epub 2014 Nov 13.


Evoked itch perception is associated with changes in functional brain connectivity.

Desbordes G, Li A, Loggia ML, Kim J, Schalock PC, Lerner E, Tran TN, Ring J, Rosen BR, Kaptchuk TJ, Pfab F, Napadow V.

Neuroimage Clin. 2014 Dec 3;7:213-21. doi: 10.1016/j.nicl.2014.12.002. eCollection 2015.


A Neural Mechanism for Nonconscious Activation of Conditioned Placebo and Nocebo Responses.

Jensen KB, Kaptchuk TJ, Chen X, Kirsch I, Ingvar M, Gollub RL, Kong J.

Cereb Cortex. 2015 Oct;25(10):3903-10. doi: 10.1093/cercor/bhu275. Epub 2014 Dec 1.


Well-loved music robustly relieves pain: a randomized, controlled trial.

Hsieh C, Kong J, Kirsch I, Edwards RR, Jensen KB, Kaptchuk TJ, Gollub RL.

PLoS One. 2014 Sep 11;9(9):e107390. doi: 10.1371/journal.pone.0107390. eCollection 2014.


Phantom acupuncture: dissociating somatosensory and cognitive/affective components of acupuncture stimulation with a novel form of placebo acupuncture.

Lee J, Napadow V, Kim J, Lee S, Choi W, Kaptchuk TJ, Park K.

PLoS One. 2014 Aug 7;9(8):e104582. doi: 10.1371/journal.pone.0104582. eCollection 2014.


Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease.

Hall KT, Nelson CP, Davis RB, Buring JE, Kirsch I, Mittleman MA, Loscalzo J, Samani NJ, Ridker PM, Kaptchuk TJ, Chasman DI.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2160-7. doi: 10.1161/ATVBAHA.114.303845. Epub 2014 Jul 17.


Design of a randomised acupuncture trial on functional neck/shoulder stiffness with two placebo controls.

Takakura N, Takayama M, Kawase A, Kaptchuk TJ, Kong J, Yajima H.

BMC Complement Altern Med. 2014 Jul 16;14:246. doi: 10.1186/1472-6882-14-246.


The placebo effect in asthma.

Dutile S, Kaptchuk TJ, Wechsler ME.

Curr Allergy Asthma Rep. 2014 Aug;14(8):456. doi: 10.1007/s11882-014-0456-2. Review.


Functional network architecture predicts psychologically mediated analgesia related to treatment in chronic knee pain patients.

Hashmi JA, Kong J, Spaeth R, Khan S, Kaptchuk TJ, Gollub RL.

J Neurosci. 2014 Mar 12;34(11):3924-36. doi: 10.1523/JNEUROSCI.3155-13.2014.

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