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Neurofeedback impacts cognition and quality of life in pediatric focal epilepsy: An exploratory randomized double-blinded sham-controlled trial.

Morales-Quezada L, Martinez D, El-Hagrassy MM, Kaptchuk TJ, Sterman MB, Yeh GY.

Epilepsy Behav. 2019 Nov 7;101(Pt A):106570. doi: 10.1016/j.yebeh.2019.106570. [Epub ahead of print]


Leveraging the Shared Neurobiology of Placebo Effects and Functional Neurological Disorder: A Call for Research.

Burke MJ, Faria V, Cappon D, Pascual-Leone A, Kaptchuk TJ, Santarnecchi E.

J Neuropsychiatry Clin Neurosci. 2019 Oct 30:appineuropsych19030077. doi: 10.1176/appi.neuropsych.19030077. [Epub ahead of print] No abstract available.


Placebo Effects of Nurses' Communication alongside Standard Medical Care on Pain and Other Outcomes: A Randomized Controlled Trial in Clinical Tonsillectomy Care.

van Vliet LM, Godfried MB, van Deelen GW, Kaunang M, Kaptchuk TJ, van Dulmen S, Thiel B, Bensing JM.

Psychother Psychosom. 2019 Oct 25:1-3. doi: 10.1159/000503904. [Epub ahead of print] No abstract available.


Placebo Response in Chronic Idiopathic Constipation: A Systematic Review and Meta-Analysis.

Nee J, Sugarman MA, Ballou S, Katon J, Rangan V, Singh P, Zubiago J, Kaptchuk TJ, Lembo A.

Am J Gastroenterol. 2019 Oct 3. doi: 10.14309/ajg.0000000000000399. [Epub ahead of print]


Are Conditioned Open Placebos Feasible as an Adjunctive Treatment to Opioids? Results from a Single-Group Dose-Extender Pilot Study with Acute Pain Patients.

Bernstein MH, Magill M, Weiss AP, Kaptchuk TJ, Blease C, Kirsch I, Rich JD, Becker SJ, Mach S, Beaudoin FL.

Psychother Psychosom. 2019 Sep 27:1-3. doi: 10.1159/000503038. [Epub ahead of print] No abstract available.


Non-concealed placebo treatment for menopausal hot flushes: Study protocol of a randomized-controlled trial.

Pan Y, Meister R, Löwe B, Winkelmann A, Kaptchuk TJ, Buhling KJ, Nestoriuc Y.

Trials. 2019 Aug 16;20(1):508. doi: 10.1186/s13063-019-3575-1.


Nocebo Effects in Concussion: Is All That is Told Beneficial?

Polich G, Iaccarino MA, Kaptchuk TJ, Morales-Quezada L, Zafonte R.

Am J Phys Med Rehabil. 2019 Aug 6. doi: 10.1097/PHM.0000000000001290. [Epub ahead of print]


Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment.

Belcher AM, Cole TO, Greenblatt AD, Hoag SW, Epstein DH, Wagner M, Billing AS, Massey E, Hamilton KR, Kozak ZK, Welsh CJ, Weintraub E, Wickwire EM, Wish ED, Kaptchuk TJ, Colloca L.

BMJ Open. 2019 Jun 21;9(6):e026604. doi: 10.1136/bmjopen-2018-026604.


Multivariate resting-state functional connectivity predicts responses to real and sham acupuncture treatment in chronic low back pain.

Tu Y, Ortiz A, Gollub RL, Cao J, Gerber J, Lang C, Park J, Wilson G, Shen W, Chan ST, Wasan AD, Edwards RR, Napadow V, Kaptchuk TJ, Rosen B, Kong J.

Neuroimage Clin. 2019;23:101885. doi: 10.1016/j.nicl.2019.101885. Epub 2019 May 28.


Systems pharmacogenomics - gene, disease, drug and placebo interactions: a case study in COMT.

Hall KT, Loscalzo J, Kaptchuk TJ.

Pharmacogenomics. 2019 May;20(7):529-551. doi: 10.2217/pgs-2019-0001.


Abnormal medial prefrontal cortex functional connectivity and its association with clinical symptoms in chronic low back pain.

Tu Y, Jung M, Gollub RL, Napadow V, Gerber J, Ortiz A, Lang C, Mawla I, Shen W, Chan ST, Wasan AD, Edwards RR, Kaptchuk TJ, Rosen B, Kong J.

Pain. 2019 Jun;160(6):1308-1318. doi: 10.1097/j.pain.0000000000001507.


Correction: Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition.

Crum AJ, Akinola M, Turnwald BP, Kaptchuk TJ, Hall KT.

PLoS One. 2019 May 2;14(5):e0216305. doi: 10.1371/journal.pone.0216305. eCollection 2019.


Artificial Intelligence and the Future of Primary Care: Exploratory Qualitative Study of UK General Practitioners' Views.

Blease C, Kaptchuk TJ, Bernstein MH, Mandl KD, Halamka JD, DesRoches CM.

J Med Internet Res. 2019 Mar 20;21(3):e12802. doi: 10.2196/12802.


Changing Patient Mindsets about Non-Life-Threatening Symptoms During Oral Immunotherapy: A Randomized Clinical Trial.

Howe LC, Leibowitz KA, Perry MA, Bitler JM, Block W, Kaptchuk TJ, Nadeau KC, Crum AJ.

J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1550-1559. doi: 10.1016/j.jaip.2019.01.022. Epub 2019 Jan 23.


COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials.

Hall KT, Buring JE, Mukamal KJ, Vinayaga Moorthy M, Wayne PM, Kaptchuk TJ, Battinelli EM, Ridker PM, Sesso HD, Weinstein SJ, Albanes D, Cook NR, Chasman DI.

J Natl Cancer Inst. 2019 Jan 8. doi: 10.1093/jnci/djy204. [Epub ahead of print]


A test of positive suggestions about side effects as a way of enhancing the analgesic response to NSAIDs.

Fernandez A, Kirsch I, Noël L, Rodondi PY, Kaptchuk TJ, Suter MR, Décosterd I, Berna C.

PLoS One. 2019 Jan 3;14(1):e0209851. doi: 10.1371/journal.pone.0209851. eCollection 2019.


Computerization and the future of primary care: A survey of general practitioners in the UK.

Blease C, Bernstein MH, Gaab J, Kaptchuk TJ, Kossowsky J, Mandl KD, Davis RB, DesRoches CM.

PLoS One. 2018 Dec 12;13(12):e0207418. doi: 10.1371/journal.pone.0207418. eCollection 2018.


Machine learning-based prediction of clinical pain using multimodal neuroimaging and autonomic metrics.

Lee J, Mawla I, Kim J, Loggia ML, Ortiz A, Jung C, Chan ST, Gerber J, Schmithorst VJ, Edwards RR, Wasan AD, Berna C, Kong J, Kaptchuk TJ, Gollub RL, Rosen BR, Napadow V.

Pain. 2019 Mar;160(3):550-560. doi: 10.1097/j.pain.0000000000001417.


The relationship between catastrophizing and altered pain sensitivity in patients with chronic low-back pain.

Meints SM, Mawla I, Napadow V, Kong J, Gerber J, Chan ST, Wasan AD, Kaptchuk TJ, McDonnell C, Carriere J, Rosen B, Gollub RL, Edwards RR.

Pain. 2019 Apr;160(4):833-843. doi: 10.1097/j.pain.0000000000001461.


Challenges of differential placebo effects in contemporary medicine: The example of brain stimulation.

Burke MJ, Kaptchuk TJ, Pascual-Leone A.

Ann Neurol. 2019 Jan;85(1):12-20. doi: 10.1002/ana.25387. Epub 2019 Jan 8. No abstract available.


Parent management training for conduct problems in children: Enhancing treatment to improve therapeutic change.

Kazdin AE, Glick A, Pope J, Kaptchuk TJ, Lecza B, Carrubba E, McWhinney E, Hamilton N.

Int J Clin Health Psychol. 2018 May-Aug;18(2):91-101. doi: 10.1016/j.ijchp.2017.12.002. Epub 2018 Feb 7.


Open-Label Placebo: Reflections on a Research Agenda.

Kaptchuk TJ.

Perspect Biol Med. 2018;61(3):311-334. doi: 10.1353/pbm.2018.0045.


Open label placebo: can honestly prescribed placebos evoke meaningful therapeutic benefits?

Kaptchuk TJ, Miller FG.

BMJ. 2018 Oct 2;363:k3889. doi: 10.1136/bmj.k3889. No abstract available.


Symptom perception, placebo effects, and the Bayesian brain.

Ongaro G, Kaptchuk TJ.

Pain. 2019 Jan;160(1):1-4. doi: 10.1097/j.pain.0000000000001367. Review. No abstract available.


Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus.

Evers AWM, Colloca L, Blease C, Annoni M, Atlas LY, Benedetti F, Bingel U, Büchel C, Carvalho C, Colagiuri B, Crum AJ, Enck P, Gaab J, Geers AL, Howick J, Jensen KB, Kirsch I, Meissner K, Napadow V, Peerdeman KJ, Raz A, Rief W, Vase L, Wager TD, Wampold BE, Weimer K, Wiech K, Kaptchuk TJ, Klinger R, Kelley JM.

Psychother Psychosom. 2018;87(4):204-210. doi: 10.1159/000490354. Epub 2018 Jun 12.


Enhancing treatment of osteoarthritis knee pain by boosting expectancy: A functional neuroimaging study.

Kong J, Wang Z, Leiser J, Minicucci D, Edwards R, Kirsch I, Wasan AD, Lang C, Gerber J, Yu S, Napadow V, Kaptchuk TJ, Gollub RL.

Neuroimage Clin. 2018 Feb 28;18:325-334. doi: 10.1016/j.nicl.2018.01.021. eCollection 2018.


Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition.

Crum AJ, Akinola M, Turnwald BP, Kaptchuk TJ, Hall KT.

PLoS One. 2018 Apr 20;13(4):e0195883. doi: 10.1371/journal.pone.0195883. eCollection 2018. Erratum in: PLoS One. 2019 May 2;14(5):e0216305.


Factors Associated With Response to Placebo in Patients With Irritable Bowel Syndrome and Constipation.

Ballou S, Beath A, Kaptchuk TJ, Hirsch W, Sommers T, Nee J, Iturrino J, Rangan V, Singh P, Jones M, Lembo A.

Clin Gastroenterol Hepatol. 2018 Nov;16(11):1738-1744.e1. doi: 10.1016/j.cgh.2018.04.009. Epub 2018 Apr 12.


Learned immunosuppressive placebo responses in renal transplant patients.

Kirchhof J, Petrakova L, Brinkhoff A, Benson S, Schmidt J, Unteroberdörster M, Wilde B, Kaptchuk TJ, Witzke O, Schedlowski M.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4223-4227. doi: 10.1073/pnas.1720548115. Epub 2018 Apr 2.


Open-Label Placebo Treatment for Cancer-Related Fatigue: A Randomized-Controlled Clinical Trial.

Hoenemeyer TW, Kaptchuk TJ, Mehta TS, Fontaine KR.

Sci Rep. 2018 Feb 9;8(1):2784. doi: 10.1038/s41598-018-20993-y.


Placebo Effects in Traumatic Brain Injury.

Polich G, Iaccarino MA, Kaptchuk TJ, Morales-Quezada L, Zafonte R.

J Neurotrauma. 2018 Jun 1;35(11):1205-1212. doi: 10.1089/neu.2017.5506. Epub 2018 Apr 5. Review.


A Functional Neuroimaging Study of Expectancy Effects on Pain Response in Patients With Knee Osteoarthritis.

Gollub RL, Kirsch I, Maleki N, Wasan AD, Edwards RR, Tu Y, Kaptchuk TJ, Kong J.

J Pain. 2018 May;19(5):515-527. doi: 10.1016/j.jpain.2017.12.260. Epub 2018 Jan 8.


The National Cancer Institute's Conference on Acupuncture for Symptom Management in Oncology: State of the Science, Evidence, and Research Gaps.

Zia FZ, Olaku O, Bao T, Berger A, Deng G, Fan AY, Garcia MK, Herman PM, Kaptchuk TJ, Ladas EJ, Langevin HM, Lao L, Lu W, Napadow V, Niemtzow RC, Vickers AJ, Shelley Wang X, Witt CM, Mao JJ.

J Natl Cancer Inst Monogr. 2017 Nov 1;2017(52). doi: 10.1093/jncimonographs/lgx005.


Dopaminergic tone does not influence pain levels during placebo interventions in patients with chronic neuropathic pain.

Skyt I, Moslemi K, Baastrup C, Grosen K, Benedetti F, Petersen GL, Price DD, Hall KT, Kaptchuk TJ, Svensson P, Jensen TS, Vase L.

Pain. 2018 Feb;159(2):261-272. doi: 10.1097/j.pain.0000000000001089.


Influence of the patient-practitioner interaction context on acupuncture outcomes in functional dyspepsia: study protocol for a multicenter randomized controlled trial.

Ko SJ, Park JW, Leem J, Kaptchuk TJ, Napadow V, Kuo B, Gerber J, Dimisko L, Yeo I, Lee J, Kim J.

BMC Complement Altern Med. 2017 Jul 14;17(1):363. doi: 10.1186/s12906-017-1869-y.


Network analysis of the genomic basis of the placebo effect.

Wang RS, Hall KT, Giulianini F, Passow D, Kaptchuk TJ, Loscalzo J.

JCI Insight. 2017 Jun 2;2(11). pii: 93911. doi: 10.1172/jci.insight.93911. eCollection 2017 Jun 2.


Open-label versus double-blind placebo treatment in irritable bowel syndrome: study protocol for a randomized controlled trial.

Ballou S, Kaptchuk TJ, Hirsch W, Nee J, Iturrino J, Hall KT, Kelley JM, Cheng V, Kirsch I, Jacobson E, Conboy L, Lembo A, Davis RB.

Trials. 2017 May 25;18(1):234. doi: 10.1186/s13063-017-1964-x.


Certainty of genuine treatment increases drug responses among intellectually disabled patients.

Jensen KB, Kirsch I, Pontén M, Rosén A, Yang K, Gollub RL, des Portes V, Kaptchuk TJ, Curie A.

Neurology. 2017 May 16;88(20):1912-1918. doi: 10.1212/WNL.0000000000003934. Epub 2017 Apr 19.


Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture.

Maeda Y, Kim H, Kettner N, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Ong-Sutherland R, Mezzacappa P, Libby A, Mawla I, Morse LR, Kaptchuk TJ, Audette J, Napadow V.

Brain. 2017 Apr 1;140(4):914-927. doi: 10.1093/brain/awx015.



Carvalho C, Kirsch I, Kaptchuk TJ.

Pain. 2017 Mar;158(3):536-537. doi: 10.1097/j.pain.0000000000000795. No abstract available.


Side effects can enhance treatment response through expectancy effects: an experimental analgesic randomized controlled trial.

Berna C, Kirsch I, Zion SR, Lee YC, Jensen KB, Sadler P, Kaptchuk TJ, Edwards RR.

Pain. 2017 Jun;158(6):1014-1020. doi: 10.1097/j.pain.0000000000000870.


Informed consent and clinical trials: where is the placebo effect?

Blease CR, Bishop FL, Kaptchuk TJ.

BMJ. 2017 Feb 3;356:j463. doi: 10.1136/bmj.j463. No abstract available.


Parental Attitudes About Placebo Use in Children.

Faria V, Kossowsky J, Petkov MP, Kaptchuk TJ, Kirsch I, Lebel A, Borsook D.

J Pediatr. 2017 Feb;181:272-278.e10. doi: 10.1016/j.jpeds.2016.10.018. Epub 2016 Nov 15.


Open-label placebo treatment in chronic low back pain: a randomized controlled trial.

Carvalho C, Caetano JM, Cunha L, Rebouta P, Kaptchuk TJ, Kirsch I.

Pain. 2016 Dec;157(12):2766-2772. Erratum in: Pain. 2017 Feb;158(2):365.


Effects of subtle cognitive manipulations on placebo analgesia - An implicit priming study.

Rosén A, Yi J, Kirsch I, Kaptchuk TJ, Ingvar M, Jensen KB.

Eur J Pain. 2017 Apr;21(4):594-604. doi: 10.1002/ejp.961. Epub 2016 Oct 17.


Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome.

Hall KT, Kossowsky J, Oberlander TF, Kaptchuk TJ, Saul JP, Wyller VB, Fagermoen E, Sulheim D, Gjerstad J, Winger A, Mukamal KJ.

Pharmacogenomics J. 2016 Oct;16(5):454-60. doi: 10.1038/tpj.2016.53. Epub 2016 Jul 26.


Effect of EphB4/EphrinB2 reverse signal on angiogenesis induced by Xuefu Zhuyu Capsule () containing serum in human microvascular endothelial cell 1.

Zhang JS, Wang YZ, Hu YQ, Lin F, Gao D, Song J, Kaptchuk TJ, Chen KJ.

Chin J Integr Med. 2016 Aug;22(8):605-10. doi: 10.1007/s11655-016-2470-9. Epub 2016 Jun 14.


Catechol-O-methyltransferase association with hemoglobin A1c.

Hall KT, Jablonski KA, Chen L, Harden M, Tolkin BR, Kaptchuk TJ, Bray GA, Ridker PM, Florez JC; Diabetes Prevention Program Research Group, Mukamal KJ, Chasman DI.

Metabolism. 2016 Jul;65(7):961-967. doi: 10.1016/j.metabol.2016.04.001. Epub 2016 Apr 14.


Placebo effects in obesity research.

Fontaine KR, Williams MS, Hoenemeyer TW, Kaptchuk TJ, Dutton GR.

Obesity (Silver Spring). 2016 Apr;24(4):769-71. doi: 10.1002/oby.21456. No abstract available.


Establishing an Integrative Medicine Program Within an Academic Health Center: Essential Considerations.

Eisenberg DM, Kaptchuk TJ, Post DE, Hrbek AL, O'Connor BB, Osypiuk K, Wayne PM, Buring JE, Levy DB.

Acad Med. 2016 Sep;91(9):1223-30. doi: 10.1097/ACM.0000000000001173.

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