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Items: 1 to 50 of 63

1.

Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity.

Kalpage HA, Vaishnav A, Liu J, Varughese A, Wan J, Turner AA, Ji Q, Zurek MP, Kapralov AA, Kagan VE, Brunzelle JS, Recanati MA, Grossman LI, Sanderson TH, Lee I, Salomon AR, Edwards BFP, Hüttemann M.

FASEB J. 2019 Dec;33(12):13503-13514. doi: 10.1096/fj.201901120R. Epub 2019 Sep 28.

PMID:
31570002
2.

Redox (phospho)lipidomics of signaling in inflammation and programmed cell death.

Tyurina YY, St Croix CM, Watkins SC, Watson AM, Epperly MW, Anthonymuthu TS, Kisin ER, Vlasova II, Krysko O, Krysko DV, Kapralov AA, Dar HH, Tyurin VA, Amoscato AA, Popova EN, Bolevich SB, Timashev PS, Kellum JA, Wenzel SE, Mallampalli RK, Greenberger JS, Bayir H, Shvedova AA, Kagan VE.

J Leukoc Biol. 2019 Jul;106(1):57-81. doi: 10.1002/JLB.3MIR0119-004RR. Epub 2019 May 9. Review.

3.

Targeting myeloid regulators by paclitaxel-loaded enzymatically degradable nanocups.

Burkert SC, Shurin GV, White DL, He X, Kapralov AA, Kagan VE, Shurin MR, Star A.

Nanoscale. 2018 Sep 27;10(37):17990-18000. doi: 10.1039/c8nr04437f.

4.

Structural characterization of cardiolipin-driven activation of cytochrome c into a peroxidase and membrane perturbation.

Mohammadyani D, Yanamala N, Samhan-Arias AK, Kapralov AA, Stepanov G, Nuar N, Planas-Iglesias J, Sanghera N, Kagan VE, Klein-Seetharaman J.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):1057-1068. doi: 10.1016/j.bbamem.2018.01.009. Epub 2018 Jan 6.

5.

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.

Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE.

Cell. 2017 Oct 19;171(3):628-641.e26. doi: 10.1016/j.cell.2017.09.044.

6.

Nanoemitters and innate immunity: the role of surfactants and bio-coronas in myeloperoxidase-catalyzed oxidation of pristine single-walled carbon nanotubes.

Chiu CF, Dar HH, Kapralov AA, Robinson RAS, Kagan VE, Star A.

Nanoscale. 2017 May 11;9(18):5948-5956. doi: 10.1039/c6nr07706d.

7.

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.

Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayır H.

Nat Chem Biol. 2017 Jan;13(1):81-90. doi: 10.1038/nchembio.2238. Epub 2016 Nov 14.

8.

Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE.

Mahapatra G, Varughese A, Ji Q, Lee I, Liu J, Vaishnav A, Sinkler C, Kapralov AA, Moraes CT, Sanderson TH, Stemmler TL, Grossman LI, Kagan VE, Brunzelle JS, Salomon AR, Edwards BF, Hüttemann M.

J Biol Chem. 2017 Jan 6;292(1):64-79. doi: 10.1074/jbc.M116.744664. Epub 2016 Oct 7.

9.

Known unknowns of cardiolipin signaling: The best is yet to come.

Maguire JJ, Tyurina YY, Mohammadyani D, Kapralov AA, Anthonymuthu TS, Qu F, Amoscato AA, Sparvero LJ, Tyurin VA, Planas-Iglesias J, He RR, Klein-Seetharaman J, Bayır H, Kagan VE.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jan;1862(1):8-24. doi: 10.1016/j.bbalip.2016.08.001. Epub 2016 Aug 4. Review.

10.

Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences.

Tejero J, Kapralov AA, Baumgartner MP, Sparacino-Watkins CE, Anthonymutu TS, Vlasova II, Camacho CJ, Gladwin MT, Bayir H, Kagan VE.

Biochim Biophys Acta. 2016 May;1861(5):391-401. doi: 10.1016/j.bbalip.2016.02.022. Epub 2016 Feb 27.

11.

Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications.

Vlasova II, Kapralov AA, Michael ZP, Burkert SC, Shurin MR, Star A, Shvedova AA, Kagan VE.

Toxicol Appl Pharmacol. 2016 May 15;299:58-69. doi: 10.1016/j.taap.2016.01.002. Epub 2016 Jan 6. Review.

12.

NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy.

Kagan VE, Jiang J, Huang Z, Tyurina YY, Desbourdes C, Cottet-Rousselle C, Dar HH, Verma M, Tyurin VA, Kapralov AA, Cheikhi A, Mao G, Stolz D, St Croix CM, Watkins S, Shen Z, Li Y, Greenberg ML, Tokarska-Schlattner M, Boissan M, Lacombe ML, Epand RM, Chu CT, Mallampalli RK, Bayır H, Schlattner U.

Cell Death Differ. 2016 Jul;23(7):1140-51. doi: 10.1038/cdd.2015.160. Epub 2016 Jan 8.

13.

Mitochondrial Redox Opto-Lipidomics Reveals Mono-Oxygenated Cardiolipins as Pro-Apoptotic Death Signals.

Mao G, Qu F, St Croix CM, Tyurina YY, Planas-Iglesias J, Jiang J, Huang Z, Amoscato AA, Tyurin VA, Kapralov AA, Cheikhi A, Maguire J, Klein-Seetharaman J, Bayır H, Kagan VE.

ACS Chem Biol. 2016 Feb 19;11(2):530-40. doi: 10.1021/acschembio.5b00737. Epub 2016 Jan 5.

14.

Inhibition of Peroxidase Activity of Cytochrome c: De Novo Compound Discovery and Validation.

Bakan A, Kapralov AA, Bayir H, Hu F, Kagan VE, Bahar I.

Mol Pharmacol. 2015 Sep;88(3):421-7. doi: 10.1124/mol.115.097816. Epub 2015 Jun 15.

15.

Payload drug vs. nanocarrier biodegradation by myeloperoxidase- and peroxynitrite-mediated oxidations: pharmacokinetic implications.

Seo W, Kapralov AA, Shurin GV, Shurin MR, Kagan VE, Star A.

Nanoscale. 2015 May 21;7(19):8689-94. doi: 10.1039/c5nr00251f.

16.

Nano-gold corking and enzymatic uncorking of carbon nanotube cups.

Zhao Y, Burkert SC, Tang Y, Sorescu DC, Kapralov AA, Shurin GV, Shurin MR, Kagan VE, Star A.

J Am Chem Soc. 2015 Jan 21;137(2):675-84. doi: 10.1021/ja511843w. Epub 2015 Jan 7.

17.

Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate.

Yanamala N, Kapralov AA, Djukic M, Peterson J, Mao G, Klein-Seetharaman J, Stoyanovsky DA, Stursa J, Neuzil J, Kagan VE.

J Biol Chem. 2014 Nov 21;289(47):32488-98. doi: 10.1074/jbc.M114.601377. Epub 2014 Oct 2.

18.

Lung macrophages "digest" carbon nanotubes using a superoxide/peroxynitrite oxidative pathway.

Kagan VE, Kapralov AA, St Croix CM, Watkins SC, Kisin ER, Kotchey GP, Balasubramanian K, Vlasova II, Yu J, Kim K, Seo W, Mallampalli RK, Star A, Shvedova AA.

ACS Nano. 2014 Jun 24;8(6):5610-21. doi: 10.1021/nn406484b. Epub 2014 Jun 4.

19.

A mitochondrial pathway for biosynthesis of lipid mediators.

Tyurina YY, Poloyac SM, Tyurin VA, Kapralov AA, Jiang J, Anthonymuthu TS, Kapralova VI, Vikulina AS, Jung MY, Epperly MW, Mohammadyani D, Klein-Seetharaman J, Jackson TC, Kochanek PM, Pitt BR, Greenberger JS, Vladimirov YA, Bayır H, Kagan VE.

Nat Chem. 2014 Jun;6(6):542-52. doi: 10.1038/nchem.1924. Epub 2014 Apr 20.

20.

Designing inhibitors of cytochrome c/cardiolipin peroxidase complexes: mitochondria-targeted imidazole-substituted fatty acids.

Jiang J, Bakan A, Kapralov AA, Silva KI, Huang Z, Amoscato AA, Peterson J, Garapati VK, Saxena S, Bayir H, Atkinson J, Bahar I, Kagan VE.

Free Radic Biol Med. 2014 Jun;71:221-30. doi: 10.1016/j.freeradbiomed.2014.02.029. Epub 2014 Mar 12.

21.

Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic 'eat-me' signals: cleavage and inhibition of phagocytosis by Lp-PLA2.

Tyurin VA, Balasubramanian K, Winnica D, Tyurina YY, Vikulina AS, He RR, Kapralov AA, Macphee CH, Kagan VE.

Cell Death Differ. 2014 May;21(5):825-35. doi: 10.1038/cdd.2014.1. Epub 2014 Jan 24.

22.

The hydrogen-peroxide-induced radical behaviour in human cytochrome c-phospholipid complexes: implications for the enhanced pro-apoptotic activity of the G41S mutant.

Rajagopal BS, Edzuma AN, Hough MA, Blundell KL, Kagan VE, Kapralov AA, Fraser LA, Butt JN, Silkstone GG, Wilson MT, Svistunenko DA, Worrall JA.

Biochem J. 2013 Dec 15;456(3):441-52. doi: 10.1042/BJ20130758.

PMID:
24099549
23.

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells.

Chu CT, Ji J, Dagda RK, Jiang JF, Tyurina YY, Kapralov AA, Tyurin VA, Yanamala N, Shrivastava IH, Mohammadyani D, Wang KZQ, Zhu J, Klein-Seetharaman J, Balasubramanian K, Amoscato AA, Borisenko G, Huang Z, Gusdon AM, Cheikhi A, Steer EK, Wang R, Baty C, Watkins S, Bahar I, Bayir H, Kagan VE.

Nat Cell Biol. 2013 Oct;15(10):1197-1205. doi: 10.1038/ncb2837. Epub 2013 Sep 15.

24.

LC/MS characterization of rotenone induced cardiolipin oxidation in human lymphocytes: implications for mitochondrial dysfunction associated with Parkinson's disease.

Tyurina YY, Winnica DE, Kapralova VI, Kapralov AA, Tyurin VA, Kagan VE.

Mol Nutr Food Res. 2013 Aug;57(8):1410-22. doi: 10.1002/mnfr.201200801. Epub 2013 May 3.

25.

Effect of antioxidants on enzyme-catalysed biodegradation of carbon nanotubes.

Kotchey GP, Gaugler JA, Kapralov AA, Kagan VE, Star A.

J Mater Chem B. 2013;1(3):302-309.

26.

Biodegradation of single-walled carbon nanotubes by eosinophil peroxidase.

Andón FT, Kapralov AA, Yanamala N, Feng W, Baygan A, Chambers BJ, Hultenby K, Ye F, Toprak MS, Brandner BD, Fornara A, Klein-Seetharaman J, Kotchey GP, Star A, Shvedova AA, Fadeel B, Kagan VE.

Small. 2013 Aug 26;9(16):2721-9, 2720. doi: 10.1002/smll.201202508. Epub 2013 Feb 27.

27.

A natural vanishing act: the enzyme-catalyzed degradation of carbon nanomaterials.

Kotchey GP, Hasan SA, Kapralov AA, Ha SH, Kim K, Shvedova AA, Kagan VE, Star A.

Acc Chem Res. 2012 Oct 16;45(10):1770-81. doi: 10.1021/ar300106h. Epub 2012 Jul 23.

28.

Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice.

Shvedova AA, Kapralov AA, Feng WH, Kisin ER, Murray AR, Mercer RR, St Croix CM, Lang MA, Watkins SC, Konduru NV, Allen BL, Conroy J, Kotchey GP, Mohamed BM, Meade AD, Volkov Y, Star A, Fadeel B, Kagan VE.

PLoS One. 2012;7(3):e30923. doi: 10.1371/journal.pone.0030923. Epub 2012 Mar 30.

29.

Adsorption of surfactant lipids by single-walled carbon nanotubes in mouse lung upon pharyngeal aspiration.

Kapralov AA, Feng WH, Amoscato AA, Yanamala N, Balasubramanian K, Winnica DE, Kisin ER, Kotchey GP, Gou P, Sparvero LJ, Ray P, Mallampalli RK, Klein-Seetharaman J, Fadeel B, Star A, Shvedova AA, Kagan VE.

ACS Nano. 2012 May 22;6(5):4147-56. doi: 10.1021/nn300626q. Epub 2012 Apr 6.

30.

Succinobucol induces apoptosis in vascular smooth muscle cells.

Midwinter RG, Maghzal GJ, Dennis JM, Wu BJ, Cai H, Kapralov AA, Belikova NA, Tyurina YY, Dong LF, Khachigian L, Neuzil J, Kagan VE, Stocker R.

Free Radic Biol Med. 2012 Mar 1;52(5):871-9. doi: 10.1016/j.freeradbiomed.2011.11.029. Epub 2011 Dec 21.

PMID:
22203369
31.

A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death.

Atkinson J, Kapralov AA, Yanamala N, Tyurina YY, Amoscato AA, Pearce L, Peterson J, Huang Z, Jiang J, Samhan-Arias AK, Maeda A, Feng W, Wasserloos K, Belikova NA, Tyurin VA, Wang H, Fletcher J, Wang Y, Vlasova II, Klein-Seetharaman J, Stoyanovsky DA, Bayîr H, Pitt BR, Epperly MW, Greenberger JS, Kagan VE.

Nat Commun. 2011 Oct 11;2:497. doi: 10.1038/ncomms1499.

32.

Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes.

Kapralov AA, Yanamala N, Tyurina YY, Castro L, Samhan-Arias A, Vladimirov YA, Maeda A, Weitz AA, Peterson J, Mylnikov D, Demicheli V, Tortora V, Klein-Seetharaman J, Radi R, Kagan VE.

Biochim Biophys Acta. 2011 Sep;1808(9):2147-55. doi: 10.1016/j.bbamem.2011.04.009. Epub 2011 Apr 29.

33.

The enzymatic oxidation of graphene oxide.

Kotchey GP, Allen BL, Vedala H, Yanamala N, Kapralov AA, Tyurina YY, Klein-Seetharaman J, Kagan VE, Star A.

ACS Nano. 2011 Mar 22;5(3):2098-108. doi: 10.1021/nn103265h. Epub 2011 Feb 23.

34.

Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease.

Bayir H, Kapralov AA, Jiang J, Huang Z, Tyurina YY, Tyurin VA, Zhao Q, Belikova NA, Vlasova II, Maeda A, Zhu J, Na HM, Mastroberardino PG, Sparvero LJ, Amoscato AA, Chu CT, Greenamyre JT, Kagan VE.

J Biol Chem. 2009 Jun 5;284(23):15951-69. doi: 10.1074/jbc.M900418200. Epub 2009 Apr 7.

35.

Molecular design of new inhibitors of peroxidase activity of cytochrome c/cardiolipin complexes: fluorescent oxadiazole-derivatized cardiolipin.

Borisenko GG, Kapralov AA, Tyurin VA, Maeda A, Stoyanovsky DA, Kagan VE.

Biochemistry. 2008 Dec 23;47(51):13699-710. doi: 10.1021/bi801507s.

36.

Biodegradation of single-walled carbon nanotubes through enzymatic catalysis.

Allen BL, Kichambare PD, Gou P, Vlasova II, Kapralov AA, Konduru N, Kagan VE, Star A.

Nano Lett. 2008 Nov;8(11):3899-903. doi: 10.1021/nl802315h. Epub 2008 Oct 28.

PMID:
18954125
37.

The hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells.

Kapralov AA, Kurnikov IV, Vlasova II, Belikova NA, Tyurin VA, Basova LV, Zhao Q, Tyurina YY, Jiang J, Bayir H, Vladimirov YA, Kagan VE.

Biochemistry. 2007 Dec 11;46(49):14232-44. Epub 2007 Nov 16.

PMID:
18004876
38.

Interactions of cardiolipin and lyso-cardiolipins with cytochrome c and tBid: conflict or assistance in apoptosis.

Tyurin VA, Tyurina YY, Osipov AN, Belikova NA, Basova LV, Kapralov AA, Bayir H, Kagan VE.

Cell Death Differ. 2007 Apr;14(4):872-5. Epub 2006 Dec 15. No abstract available.

39.

The "pro-apoptotic genies" get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes.

Kagan VE, Tyurina YY, Bayir H, Chu CT, Kapralov AA, Vlasova II, Belikova NA, Tyurin VA, Amoscato A, Epperly M, Greenberger J, Dekosky S, Shvedova AA, Jiang J.

Chem Biol Interact. 2006 Oct 27;163(1-2):15-28. Epub 2006 May 12. Review.

PMID:
16797512
40.

Oxidation and cytotoxicity of 6-OHDA are mediated by reactive intermediates of COX-2 overexpressed in PC12 cells.

Tyurina YY, Kapralov AA, Jiang J, Borisenko GG, Potapovich AI, Sorokin A, Kochanek PM, Graham SH, Schor NF, Kagan VE.

Brain Res. 2006 Jun 6;1093(1):71-82. Epub 2006 May 18.

PMID:
16712820
41.

Mechanisms of cardiolipin oxidation by cytochrome c: relevance to pro- and antiapoptotic functions of etoposide.

Tyurina YY, Kini V, Tyurin VA, Vlasova II, Jiang J, Kapralov AA, Belikova NA, Yalowich JC, Kurnikov IV, Kagan VE.

Mol Pharmacol. 2006 Aug;70(2):706-17. Epub 2006 May 11.

PMID:
16690782
42.

Peroxidase activity and structural transitions of cytochrome c bound to cardiolipin-containing membranes.

Belikova NA, Vladimirov YA, Osipov AN, Kapralov AA, Tyurin VA, Potapovich MV, Basova LV, Peterson J, Kurnikov IV, Kagan VE.

Biochemistry. 2006 Apr 18;45(15):4998-5009.

43.

Nitric oxide inhibits peroxidase activity of cytochrome c.cardiolipin complex and blocks cardiolipin oxidation.

Vlasova II, Tyurin VA, Kapralov AA, Kurnikov IV, Osipov AN, Potapovich MV, Stoyanovsky DA, Kagan VE.

J Biol Chem. 2006 May 26;281(21):14554-62. Epub 2006 Mar 16.

44.

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors.

Kagan VE, Tyurin VA, Jiang J, Tyurina YY, Ritov VB, Amoscato AA, Osipov AN, Belikova NA, Kapralov AA, Kini V, Vlasova II, Zhao Q, Zou M, Di P, Svistunenko DA, Kurnikov IV, Borisenko GG.

Nat Chem Biol. 2005 Sep;1(4):223-32. Epub 2005 Aug 14.

PMID:
16408039
45.

[Vitamin E and apoptosis].

Petrova GV, Kapralov AA, Donchenko GV.

Ukr Biokhim Zh (1999). 2003 Nov-Dec;75(6):25-34. Review. Russian.

PMID:
15143514
46.

[Comparative study of the effect of alpha-tocopherol, its synthetic metabolite and ionol on dexamethasone-induced apoptosis in rat thymocytes].

Petrova GV, Kapralov AA, Donchenko GV.

Ukr Biokhim Zh (1999). 2003 Jan-Feb;75(1):78-84. Russian.

PMID:
14574742
47.
49.

[Effect of ionophore A23187 and verapamil on RNA and DNA polymerase activity in rat liver nuclei].

Kapralov AA.

Ukr Biokhim Zh (1978). 1997 Jul-Aug;69(4):25-9. Russian.

PMID:
9583118
50.

Tocopherol modulates the effects of A23187, verapamil, and phorbol myristate acetate on RNA-polymerase activity of isolated rat liver nuclei.

Kapralov AA, Petrova GV, Vasilieva SM, Donchenko GV.

Biochemistry (Mosc). 1997 Jul;62(7):694-6.

PMID:
9331960

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