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Longitudinal patterns of cortical thinning in multiple sclerosis.

Tsagkas C, Chakravarty MM, Gaetano L, Naegelin Y, Amann M, Parmar K, Papadopoulou A, Wuerfel J, Kappos L, Sprenger T, Magon S.

Hum Brain Mapp. 2020 Feb 17. doi: 10.1002/hbm.24940. [Epub ahead of print]


Advances in oral immunomodulating therapies in relapsing multiple sclerosis.

Derfuss T, Mehling M, Papadopoulou A, Bar-Or A, Cohen JA, Kappos L.

Lancet Neurol. 2020 Feb 11. pii: S1474-4422(19)30391-6. doi: 10.1016/S1474-4422(19)30391-6. [Epub ahead of print] Review.


Blood neurofilament light levels segregate treatment effects in multiple sclerosis.

Delcoigne B, Manouchehrinia A, Barro C, Benkert P, Michalak Z, Kappos L, Leppert D, Tsai JA, Plavina T, Kieseier BC, Lycke J, Alfredsson L, Kockum I, Kuhle J, Olsson T, Piehl F.

Neurology. 2020 Feb 11. pii: 10.1212/WNL.0000000000009097. doi: 10.1212/WNL.0000000000009097. [Epub ahead of print]


Volume loss in the deep gray matter and thalamic subnuclei: a longitudinal study on disability progression in multiple sclerosis.

Magon S, Tsagkas C, Gaetano L, Patel R, Naegelin Y, Amann M, Parmar K, Papadopoulou A, Wuerfel J, Stippich C, Kappos L, Chakravarty MM, Sprenger T.

J Neurol. 2020 Feb 10. doi: 10.1007/s00415-020-09740-4. [Epub ahead of print]


Growth differentiation factor 15 is increased in stable MS.

Amstad A, Coray M, Frick C, Barro C, Oechtering J, Amann M, Wischhusen J, Kappos L, Naegelin Y, Kuhle J, Mehling M.

Neurol Neuroimmunol Neuroinflamm. 2020 Feb 5;7(2). pii: e675. doi: 10.1212/NXI.0000000000000675. Print 2020 Mar 5.


Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS.

Boligan KF, Oechtering J, Keller CW, Peschke B, Rieben R, Bovin N, Kappos L, Cummings RD, Kuhle J, von Gunten S, Lünemann JD.

Neurol Neuroimmunol Neuroinflamm. 2020 Feb 3;7(2). pii: e676. doi: 10.1212/NXI.0000000000000676. Print 2020 Mar.


PARP-1 deregulation in multiple sclerosis.

Meira M, Sievers C, Hoffmann F, Bodmer H, Derfuss T, Kuhle J, Haghikia A, Kappos L, Lindberg RL.

Mult Scler J Exp Transl Clin. 2019 Dec 16;5(4):2055217319894604. doi: 10.1177/2055217319894604. eCollection 2019 Oct-Dec.


No evidence of disease activity status in patients treated with early vs. delayed subcutaneous interferon β-1a.

Freedman MS, Comi G, Coyle PK, Aldridge J, Chen L, Marhardt K, Kappos L.

Mult Scler Relat Disord. 2019 Dec 9;39:101891. doi: 10.1016/j.msard.2019.101891. [Epub ahead of print]


Impact of informative censoring on the treatment effect estimate of disability worsening in multiple sclerosis clinical trials.

Riester K, Kappos L, Selmaj K, Lindborg S, Lipkovich I, Elkins J.

Mult Scler Relat Disord. 2019 Nov 23;39:101865. doi: 10.1016/j.msard.2019.101865. [Epub ahead of print]


Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods.

de Sitter A, Visser M, Brouwer I, Cover KS, van Schijndel RA, Eijgelaar RS, Müller DMJ, Ropele S, Kappos L, Rovira Á, Filippi M, Enzinger C, Frederiksen J, Ciccarelli O, Guttmann CRG, Wattjes MP, Witte MG, de Witt Hamer PC, Barkhof F, Vrenken H; MAGNIMS Study Group and Alzheimer’s Disease Neuroimaging Initiative.

Eur Radiol. 2020 Feb;30(2):1062-1074. doi: 10.1007/s00330-019-06459-3. Epub 2019 Nov 5.


Neurofilament light levels are associated with long-term outcomes in multiple sclerosis.

Kuhle J, Plavina T, Barro C, Disanto G, Sangurdekar D, Singh CM, de Moor C, Engle B, Kieseier BC, Fisher E, Kappos L, Rudick RA, Goyal J.

Mult Scler. 2019 Nov 4:1352458519885613. doi: 10.1177/1352458519885613. [Epub ahead of print]


New and enlarging white matter lesions adjacent to the ventricle system and thalamic atrophy are independently associated with lateral ventricular enlargement in multiple sclerosis.

Sinnecker T, Ruberte E, Schädelin S, Canova V, Amann M, Naegelin Y, Penner IK, Müller J, Kuhle J, Décard B, Derfuss T, Kappos L, Granziera C, Wuerfel J, Magon S, Yaldizli Ö.

J Neurol. 2020 Jan;267(1):192-202. doi: 10.1007/s00415-019-09565-w. Epub 2019 Oct 14.


Extended treatment with fingolimod for relapsing multiple sclerosis: the 14-year LONGTERMS study results.

Cohen JA, Tenenbaum N, Bhatt A, Zhang Y, Kappos L.

Ther Adv Neurol Disord. 2019 Sep 25;12:1756286419878324. doi: 10.1177/1756286419878324. eCollection 2019.


Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis.

Elliott C, Belachew S, Wolinsky JS, Hauser SL, Kappos L, Barkhof F, Bernasconi C, Fecker J, Model F, Wei W, Arnold DL.

Brain. 2019 Sep 1;142(9):2787-2799. doi: 10.1093/brain/awz212.


Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (RADIANCE): a multicentre, randomised, 24-month, phase 3 trial.

Cohen JA, Comi G, Selmaj KW, Bar-Or A, Arnold DL, Steinman L, Hartung HP, Montalban X, Kubala Havrdová E, Cree BAC, Sheffield JK, Minton N, Raghupathi K, Huang V, Kappos L; RADIANCE Trial Investigators.

Lancet Neurol. 2019 Nov;18(11):1021-1033. doi: 10.1016/S1474-4422(19)30238-8. Epub 2019 Sep 3.


Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (SUNBEAM): a multicentre, randomised, minimum 12-month, phase 3 trial.

Comi G, Kappos L, Selmaj KW, Bar-Or A, Arnold DL, Steinman L, Hartung HP, Montalban X, Kubala Havrdová E, Cree BAC, Sheffield JK, Minton N, Raghupathi K, Ding N, Cohen JA; SUNBEAM Study Investigators.

Lancet Neurol. 2019 Nov;18(11):1009-1020. doi: 10.1016/S1474-4422(19)30239-X. Epub 2019 Sep 3.


Hereditary defect of cobalamin metabolism with adolescence onset resembling multiple sclerosis: 41-year follow up in two cases.

Motte J, Kneiphof J, Straßburger-Krogias K, Pitarokoili K, Fisse AL, Kappos L, Gold R.

Ther Adv Neurol Disord. 2019 Aug 24;12:1756286419872115. doi: 10.1177/1756286419872115. eCollection 2019.


Onset of clinical and MRI efficacy of ocrelizumab in relapsing multiple sclerosis.

Barkhof F, Kappos L, Wolinsky JS, Li DKB, Bar-Or A, Hartung HP, Belachew S, Han J, Julian L, Sauter A, Napieralski J, Koendgen H, Hauser SL.

Neurology. 2019 Nov 5;93(19):e1778-e1786. doi: 10.1212/WNL.0000000000008189. Epub 2019 Sep 4.


Video-Based Pairwise Comparison: Enabling the Development of Automated Rating of Motor Dysfunction in Multiple Sclerosis.

Burggraaff J, Dorn J, D'Souza M, Morrison C, Kamm CP, Kontschieder P, Tewarie P, Steinheimer S, Sellen A, Dahlke F, Kappos L, Uitdehaag B.

Arch Phys Med Rehabil. 2020 Feb;101(2):234-241. doi: 10.1016/j.apmr.2019.07.016. Epub 2019 Aug 30.


Hepatitis E virus infections in patients with MS on oral disease-modifying treatment.

Diebold M, Fischer-Barnicol B, Tsagkas C, Kuhle J, Kappos L, Derfuss T, Décard BF.

Neurol Neuroimmunol Neuroinflamm. 2019 Jul 11;6(5). pii: e594. doi: 10.1212/NXI.0000000000000594. Print 2019 Sep.


Automatic Spinal Cord Gray Matter Quantification: A Novel Approach.

Tsagkas C, Horvath A, Altermatt A, Pezold S, Weigel M, Haas T, Amann M, Kappos L, Sprenger T, Bieri O, Cattin P, Parmar K.

AJNR Am J Neuroradiol. 2019 Sep;40(9):1592-1600. doi: 10.3174/ajnr.A6157. Epub 2019 Aug 22.


PML with dimethyl fumarate-No convincing case against natalizumab.

Diebold M, Altersberger V, Décard BF, Kappos L, Derfuss T, Lorscheider J.

Mult Scler. 2019 Oct;25(12):1687-1688. doi: 10.1177/1352458519872894. Epub 2019 Aug 22. No abstract available.


Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis.

Sinnecker T, Clarke MA, Meier D, Enzinger C, Calabrese M, De Stefano N, Pitiot A, Giorgio A, Schoonheim MM, Paul F, Pawlak MA, Schmidt R, Kappos L, Montalban X, Rovira À, Evangelou N, Wuerfel J; MAGNIMS Study Group.

JAMA Neurol. 2019 Aug 19. doi: 10.1001/jamaneurol.2019.2478. [Epub ahead of print]


Association Between Serum Neurofilament Light Chain Levels and Long-term Disease Course Among Patients With Multiple Sclerosis Followed up for 12 Years.

Cantó E, Barro C, Zhao C, Caillier SJ, Michalak Z, Bove R, Tomic D, Santaniello A, Häring DA, Hollenbach J, Henry RG, Cree BAC, Kappos L, Leppert D, Hauser SL, Benkert P, Oksenberg JR, Kuhle J.

JAMA Neurol. 2019 Aug 12. doi: 10.1001/jamaneurol.2019.2137. [Epub ahead of print]


Short timescale modulation of cortical and cerebellar activity in the early phase of motor sequence learning: an fMRI study.

Magon S, Pfister A, Laura G, Lüthi M, Papadopoulou A, Kappos L, Sprenger T.

Brain Imaging Behav. 2019 Jul 27. doi: 10.1007/s11682-019-00167-8. [Epub ahead of print]


Blood neurofilament light as a potential endpoint in Phase 2 studies in MS.

Sormani MP, Haering DA, Kropshofer H, Leppert D, Kundu U, Barro C, Kappos L, Tomic D, Kuhle J.

Ann Clin Transl Neurol. 2019 May 28;6(6):1081-1089. doi: 10.1002/acn3.795. eCollection 2019 Jun.


A case of progressive multifocal leukoencephalopathy under dimethyl fumarate treatment without severe lymphopenia or immunosenescence.

Diebold M, Altersberger V, Décard BF, Kappos L, Derfuss T, Lorscheider J.

Mult Scler. 2019 Oct;25(12):1682-1685. doi: 10.1177/1352458519852100. Epub 2019 Jun 18.


Accurate, rapid and reliable, fully automated MRI brainstem segmentation for application in multiple sclerosis and neurodegenerative diseases.

Sander L, Pezold S, Andermatt S, Amann M, Meier D, Wendebourg MJ, Sinnecker T, Radue EW, Naegelin Y, Granziera C, Kappos L, Wuerfel J, Cattin P, Schlaeger R; Alzheimer's Disease Neuroimaging Initiative.

Hum Brain Mapp. 2019 Oct 1;40(14):4091-4104. doi: 10.1002/hbm.24687. Epub 2019 Jun 17.


Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

Bridel C, van Wieringen WN, Zetterberg H, Tijms BM, Teunissen CE; and the NFL Group, Alvarez-Cermeño JC, Andreasson U, Axelsson M, Bäckström DC, Bartos A, Bjerke M, Blennow K, Boxer A, Brundin L, Burman J, Christensen T, Fialová L, Forsgren L, Frederiksen JL, Gisslén M, Gray E, Gunnarsson M, Hall S, Hansson O, Herbert MK, Jakobsson J, Jessen-Krut J, Janelidze S, Johannsson G, Jonsson M, Kappos L, Khademi M, Khalil M, Kuhle J, Landén M, Leinonen V, Logroscino G, Lu CH, Lycke J, Magdalinou NK, Malaspina A, Mattsson N, Meeter LH, Mehta SR, Modvig S, Olsson T, Paterson RW, Pérez-Santiago J, Piehl F, Pijnenburg YAL, Pyykkö OT, Ragnarsson O, Rojas JC, Romme Christensen J, Sandberg L, Scherling CS, Schott JM, Sellebjerg FT, Simone IL, Skillbäck T, Stilund M, Sundström P, Svenningsson A, Tortelli R, Tortorella C, Trentini A, Troiano M, Turner MR, van Swieten JC, Vågberg M, Verbeek MM, Villar LM, Visser PJ, Wallin A, Weiss A, Wikkelsø C, Wild EJ.

JAMA Neurol. 2019 Jun 17. doi: 10.1001/jamaneurol.2019.1534. [Epub ahead of print]


Association of brain volume loss and long-term disability outcomes in patients with multiple sclerosis treated with teriflunomide.

Sprenger T, Kappos L, Radue EW, Gaetano L, Mueller-Lenke N, Wuerfel J, Poole EM, Cavalier S.

Mult Scler. 2019 Jun 14:1352458519855722. doi: 10.1177/1352458519855722. [Epub ahead of print]


Long-term outcomes with teriflunomide in patients with clinically isolated syndrome: Results of the TOPIC extension study★★.

Miller AE, Vermersch P, Kappos L, Comi G, Freedman MS, Oh J, de Seze J, Truffinet P, Benamor M, Purvis A, Wolinsky JS; TOPIC study group.

Mult Scler Relat Disord. 2019 Aug;33:131-138. doi: 10.1016/j.msard.2019.05.014. Epub 2019 May 24.


Electronic Neurostatus-EDSS increases the quality of expanded disability status scale assessments: Experience from two phase 3 clinical trials.

D'Souza M, Heikkilä A, Lorscheider J, Haller V, Kravalis K, Gysin S, Fuertes NAC, Fricker E, Lam E, Higgins P, Tomic D, Papadopoulou A, Kappos L.

Mult Scler. 2019 May 7:1352458519845108. doi: 10.1177/1352458519845108. [Epub ahead of print]


Antigen Extraction and B Cell Activation Enable Identification of Rare Membrane Antigen Specific Human B Cells.

Zimmermann M, Rose N, Lindner JM, Kim H, Gonçalves AR, Callegari I, Syedbasha M, Kaufmann L, Egli A, Lindberg RLP, Kappos L, Traggiai E, Sanderson NSR, Derfuss T.

Front Immunol. 2019 Apr 16;10:829. doi: 10.3389/fimmu.2019.00829. eCollection 2019.


Damage of the lateral geniculate nucleus in MS: Assessing the missing node of the visual pathway.

Papadopoulou A, Gaetano L, Pfister A, Altermatt A, Tsagkas C, Morency F, Brandt AU, Hardmeier M, Chakravarty MM, Descoteaux M, Kappos L, Sprenger T, Magon S.

Neurology. 2019 May 7;92(19):e2240-e2249. doi: 10.1212/WNL.0000000000007450. Epub 2019 Apr 10.


Effect of dimethyl fumarate on lymphocytes in RRMS: Implications for clinical practice.

Mehta D, Miller C, Arnold DL, Bame E, Bar-Or A, Gold R, Hanna J, Kappos L, Liu S, Matta A, Phillips JT, Robertson D, von Hehn CA, Campbell J, Spach K, Yang L, Fox RJ.

Neurology. 2019 Apr 9;92(15):e1724-e1738. doi: 10.1212/WNL.0000000000007262. Epub 2019 Mar 27.


Ocrelizumab infusion experience in patients with relapsing and primary progressive multiple sclerosis: Results from the phase 3 randomized OPERA I, OPERA II, and ORATORIO studies.

Mayer L, Kappos L, Racke MK, Rammohan K, Traboulsee A, Hauser SL, Julian L, Köndgen H, Li C, Napieralski J, Zheng H, Wolinsky JS.

Mult Scler Relat Disord. 2019 May;30:236-243. doi: 10.1016/j.msard.2019.01.044. Epub 2019 Jan 28.


Ocrelizumab efficacy in subgroups of patients with relapsing multiple sclerosis.

Turner B, Cree BAC, Kappos L, Montalban X, Papeix C, Wolinsky JS, Buffels R, Fiore D, Garren H, Han J, Hauser SL.

J Neurol. 2019 May;266(5):1182-1193. doi: 10.1007/s00415-019-09248-6. Epub 2019 Feb 28.


Setwise comparison: efficient fine-grained rating of movement videos using algorithmic support - a proof of concept study.

Steinheimer S, Dorn JF, Morrison C, Sarkar A, D'Souza M, Boisvert J, Bedi R, Burggraaff J, Kontschieder P, Dahlke F, Sellen A, Uitdehaag BMJ, Kappos L, Kamm CP.

Disabil Rehabil. 2019 Feb 20:1-7. doi: 10.1080/09638288.2018.1563832. [Epub ahead of print]


Blood neurofilament light chain as a biomarker of MS disease activity and treatment response.

Kuhle J, Kropshofer H, Haering DA, Kundu U, Meinert R, Barro C, Dahlke F, Tomic D, Leppert D, Kappos L.

Neurology. 2019 Mar 5;92(10):e1007-e1015. doi: 10.1212/WNL.0000000000007032. Epub 2019 Feb 8.


Clinical associations of T2-weighted lesion load and lesion location in small vessel disease: Insights from a large prospective cohort study.

Altermatt A, Gaetano L, Magon S, Bauer L, Feurer R, Gnahn H, Hartmann J, Seifert CL, Poppert H, Wuerfel J, Radue EW, Kappos L, Sprenger T.

Neuroimage. 2019 Apr 1;189:727-733. doi: 10.1016/j.neuroimage.2019.01.052. Epub 2019 Jan 24.


Comparison of fingolimod, dimethyl fumarate and teriflunomide for multiple sclerosis.

Kalincik T, Kubala Havrdova E, Horakova D, Izquierdo G, Prat A, Girard M, Duquette P, Grammond P, Onofrj M, Lugaresi A, Ozakbas S, Kappos L, Kuhle J, Terzi M, Lechner-Scott J, Boz C, Grand'Maison F, Prevost J, Sola P, Ferraro D, Granella F, Trojano M, Bergamaschi R, Pucci E, Turkoglu R, McCombe PA, Pesch VV, Van Wijmeersch B, Solaro C, Ramo-Tello C, Slee M, Alroughani R, Yamout B, Shaygannejad V, Spitaleri D, Sánchez-Menoyo JL, Ampapa R, Hodgkinson S, Karabudak R, Butler E, Vucic S, Jokubaitis V, Spelman T, Butzkueven H.

J Neurol Neurosurg Psychiatry. 2019 Apr;90(4):458-468. doi: 10.1136/jnnp-2018-319831. Epub 2019 Jan 13.


Association of Rituximab Treatment With Disability Progression Among Patients With Secondary Progressive Multiple Sclerosis.

Naegelin Y, Naegelin P, von Felten S, Lorscheider J, Sonder J, Uitdehaag BMJ, Scotti B, Zecca C, Gobbi C, Kappos L, Derfuss T.

JAMA Neurol. 2019 Mar 1;76(3):274-281. doi: 10.1001/jamaneurol.2018.4239.


Central Slab versus Whole Brain to Measure Brain Atrophy in Multiple Sclerosis.

Ruberte E, Sinnecker T, Amann M, Gaetano L, Naegelin Y, Penner IK, Kuhle J, Derfuss T, Kappos L, Granziera C, Wuerfel J, Yaldizli Ö.

Eur Neurol. 2018;80(3-4):207-214. doi: 10.1159/000495798. Epub 2019 Jan 3.


Unraveling treatment response in multiple sclerosis: A clinical and MRI challenge.

Gasperini C, Prosperini L, Tintoré M, Sormani MP, Filippi M, Rio J, Palace J, Rocca MA, Ciccarelli O, Barkhof F, Sastre-Garriga J, Vrenken H, Frederiksen JL, Yousry TA, Enzinger C, Rovira A, Kappos L, Pozzilli C, Montalban X, De Stefano N; the MAGNIMS Study Group.

Neurology. 2019 Jan 22;92(4):180-192. doi: 10.1212/WNL.0000000000006810. Epub 2018 Dec 26. Review.


Slowly expanding/evolving lesions as a magnetic resonance imaging marker of chronic active multiple sclerosis lesions.

Elliott C, Wolinsky JS, Hauser SL, Kappos L, Barkhof F, Bernasconi C, Wei W, Belachew S, Arnold DL.

Mult Scler. 2019 Dec;25(14):1915-1925. doi: 10.1177/1352458518814117. Epub 2018 Dec 19.


Neurofilament light chain serum levels correlate with 10-year MRI outcomes in multiple sclerosis.

Chitnis T, Gonzalez C, Healy BC, Saxena S, Rosso M, Barro C, Michalak Z, Paul A, Kivisakk P, Diaz-Cruz C, Sattarnezhad N, Pierre IV, Glanz BI, Tomic D, Kropshofer H, Häring D, Leppert D, Kappos L, Bakshi R, Weiner HL, Kuhle J.

Ann Clin Transl Neurol. 2018 Oct 16;5(12):1478-1491. doi: 10.1002/acn3.638. eCollection 2018 Dec.


Learning ability correlates with brain atrophy and disability progression in RRMS.

Sormani MP, De Stefano N, Giovannoni G, Langdon D, Piani-Meier D, Haering DA, Kappos L, Tomic D.

J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):38-43. doi: 10.1136/jnnp-2018-319129. Epub 2018 Oct 15.


Anti-inflammatory disease-modifying treatment and disability progression in primary progressive multiple sclerosis: a cohort study.

Lorscheider J, Kuhle J, Izquierdo G, Lugaresi A, Havrdova E, Horakova D, Hupperts R, Duquette P, Girard M, Prat A, Grand'Maison F, Grammond P, Sola P, Ferraro D, Trojano M, Ramo-Tello C, Lechner-Scott J, Pucci E, Solaro C, Slee M, Van Pesch V, Sanchez Menoyo JL, van der Walt A, Butzkueven H, Kappos L, Kalincik T; MSBase Study Group.

Eur J Neurol. 2019 Feb;26(2):363-370. doi: 10.1111/ene.13824. Epub 2018 Nov 2.


Association of antibodies against myelin and neuronal antigens with neuroinflammation in systemic lupus erythematosus.

Pröbstel AK, Thanei M, Erni B, Lecourt AC, Branco L, André R, Roux-Lombard P, Koenig KF, Huynh-Do U, Ribi C, Chizzolini C, Kappos L, Trendelenburg M, Derfuss T; Swiss Systemic Lupus Erythematosus Cohort Study Group.

Rheumatology (Oxford). 2019 May 1;58(5):908-913. doi: 10.1093/rheumatology/key282.


Design and construction of an innovative brain phantom prototype for MRI.

Altermatt A, Santini F, Deligianni X, Magon S, Sprenger T, Kappos L, Cattin P, Wuerfel J, Gaetano L.

Magn Reson Med. 2019 Feb;81(2):1165-1171. doi: 10.1002/mrm.27464. Epub 2018 Sep 17.


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