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Items: 1 to 50 of 229

1.

Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules.

Krovi SH, Kappler JW, Marrack P, Gapin L.

Proc Natl Acad Sci U S A. 2019 Sep 30. pii: 201909504. doi: 10.1073/pnas.1909504116. [Epub ahead of print]

2.

Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6.

Clayton GM, White J, Lee S, Kappler JW, Chan SK.

PLoS One. 2019 Sep 16;14(9):e0213052. doi: 10.1371/journal.pone.0213052. eCollection 2019.

3.

How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.

Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S.

Sci Immunol. 2019 Apr 5;4(34). pii: eaav7517. doi: 10.1126/sciimmunol.aav7517.

PMID:
30952805
4.

Development of T cell lines sensitive to antigen stimulation.

Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M.

J Immunol Methods. 2018 Nov;462:65-73. doi: 10.1016/j.jim.2018.08.011. Epub 2018 Aug 28.

PMID:
30165064
5.

MHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection.

Rozanov DV, Rozanov ND, Chiotti KE, Reddy A, Wilmarth PA, David LL, Cha SW, Woo S, Pevzner P, Bafna V, Burrows GG, Rantala JK, Levin T, Anur P, Johnson-Camacho K, Tabatabaei S, Munson DJ, Bruno TC, Slansky JE, Kappler JW, Hirano N, Boegel S, Fox BA, Egelston C, Simons DL, Jimenez G, Lee PP, Gray JW, Spellman PT.

J Proteomics. 2018 Mar 30;176:13-23. doi: 10.1016/j.jprot.2018.01.004. Epub 2018 Jan 10.

6.

C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.

Wang Y, Sosinowski T, Novikov A, Crawford F, Neau DB, Yang J, Kwok WW, Marrack P, Kappler JW, Dai S.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):162-167. doi: 10.1073/pnas.1716527115. Epub 2017 Dec 18.

7.

Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.

Liu H, Wang C, Lee S, Deng Y, Wither M, Oh S, Ning F, Dege C, Zhang Q, Liu X, Johnson AM, Zang J, Chen Z, Janknecht R, Hansen K, Marrack P, Li CY, Kappler JW, Hagman J, Zhang G.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7717-E7726. doi: 10.1073/pnas.1706831114. Epub 2017 Aug 28.

8.

The domestic cat antibody response to feline herpesvirus-1 increases with age.

Munks MW, Montoya AM, Pywell CM, Talmage G, Forssen A, Campbell TL, Dodge DD, Kappler JW, Marrack P.

Vet Immunol Immunopathol. 2017 Jun;188:65-70. doi: 10.1016/j.vetimm.2017.05.002. Epub 2017 May 4.

PMID:
28615129
9.

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity.

Rubtsova K, Rubtsov AV, Thurman JM, Mennona JM, Kappler JW, Marrack P.

J Clin Invest. 2017 Apr 3;127(4):1392-1404. doi: 10.1172/JCI91250. Epub 2017 Feb 27.

10.

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.

Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M.

Diabetes. 2017 Mar;66(3):722-734. doi: 10.2337/db16-1025. Epub 2016 Dec 5.

11.

T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses.

Rubtsova K, Rubtsov AV, Halemano K, Li SX, Kappler JW, Santiago ML, Marrack P.

PLoS One. 2016 Nov 23;11(11):e0166322. doi: 10.1371/journal.pone.0166322. eCollection 2016.

12.

Pillars Article: Characterization of a Monoclonal Antibody Which Detects All Murine αβ T Cell Receptors. J. Immunol. 1989. 142: 2736-2742.

Kubo RT, Born W, Kappler JW, Marrack P, Pigeon M.

J Immunol. 2016 Nov 1;197(9):3437-3443. No abstract available.

13.

Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.

Ranasinghe S, Lamothe PA, Soghoian DZ, Kazer SW, Cole MB, Shalek AK, Yosef N, Jones RB, Donaghey F, Nwonu C, Jani P, Clayton GM, Crawford F, White J, Montoya A, Power K, Allen TM, Streeck H, Kaufmann DE, Picker LJ, Kappler JW, Walker BD.

Immunity. 2016 Oct 18;45(4):917-930. doi: 10.1016/j.immuni.2016.09.015.

14.

Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors.

Silberman D, Krovi SH, Tuttle KD, Crooks J, Reisdorph R, White J, Gross J, Matsuda JL, Gapin L, Marrack P, Kappler JW.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5608-17. doi: 10.1073/pnas.1609717113. Epub 2016 Sep 1.

15.

Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines.

Noges LE, White J, Cambier JC, Kappler JW, Marrack P.

J Immunol. 2016 Aug 15;197(4):1221-30. doi: 10.4049/jimmunol.1501565. Epub 2016 Jun 29.

16.

Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR.

Munson DJ, Egelston CA, Chiotti KE, Parra ZE, Bruno TC, Moore BL, Nakano TA, Simons DL, Jimenez G, Yim JH, Rozanov DV, Falta MT, Fontenot AP, Reynolds PR, Leach SM, Borges VF, Kappler JW, Spellman PT, Lee PP, Slansky JE.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8272-7. doi: 10.1073/pnas.1606994113. Epub 2016 Jun 15.

17.

Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation.

Fontenot AP, Falta MT, Kappler JW, Dai S, McKee AS.

J Immunol. 2016 Jan 1;196(1):22-7. doi: 10.4049/jimmunol.1502011. Review.

18.

N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.

Jin N, Wang Y, Crawford F, White J, Marrack P, Dai S, Kappler JW.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13318-23. doi: 10.1073/pnas.1517862112. Epub 2015 Oct 9.

19.

A Rapid Method to Characterize Mouse IgG Antibodies and Isolate Native Antigen Binding IgG B Cell Hybridomas.

Liu H, White J, Crawford F, Jin N, Ju X, Liu K, Jiang C, Marrack P, Zhang G, Kappler JW.

PLoS One. 2015 Aug 28;10(8):e0136613. doi: 10.1371/journal.pone.0136613. eCollection 2015.

20.

Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice.

Falta MT, Tinega AN, Mack DG, Bowerman NA, Crawford F, Kappler JW, Pinilla C, Fontenot AP.

Mucosal Immunol. 2016 Jan;9(1):218-28. doi: 10.1038/mi.2015.54. Epub 2015 Jul 1.

21.

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs.

Rubtsov AV, Rubtsova K, Kappler JW, Jacobelli J, Friedman RS, Marrack P.

J Immunol. 2015 Jul 1;195(1):71-9. doi: 10.4049/jimmunol.1500055. Epub 2015 Jun 1.

22.

Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects.

Nakayama M, McDaniel K, Fitzgerald-Miller L, Kiekhaefer C, Snell-Bergeon JK, Davidson HW, Rewers M, Yu L, Gottlieb P, Kappler JW, Michels A.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4429-34. doi: 10.1073/pnas.1502967112. Epub 2015 Mar 23.

23.

Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease.

Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S.

Science. 2014 Oct 17;346(6207):363-8. doi: 10.1126/science.1259077.

24.

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes.

Yang J, Chow IT, Sosinowski T, Torres-Chinn N, Greenbaum CJ, James EA, Kappler JW, Davidson HW, Kwok WW.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14840-5. doi: 10.1073/pnas.1416864111. Epub 2014 Sep 29.

25.

Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.

Clayton GM, Wang Y, Crawford F, Novikov A, Wimberly BT, Kieft JS, Falta MT, Bowerman NA, Marrack P, Fontenot AP, Dai S, Kappler JW.

Cell. 2014 Jul 3;158(1):132-42. doi: 10.1016/j.cell.2014.04.048.

26.

Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease.

Mack DG, Falta MT, McKee AS, Martin AK, Simonian PL, Crawford F, Gordon T, Mercer RR, Hoover MD, Marrack P, Kappler JW, Tuder RM, Fontenot AP.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8553-8. doi: 10.1073/pnas.1408048111. Epub 2014 May 27.

27.

Molecules in medicine mini review: the αβ T cell receptor.

Clambey ET, Davenport B, Kappler JW, Marrack P, Homann D.

J Mol Med (Berl). 2014 Jul;92(7):735-41. doi: 10.1007/s00109-014-1145-2. Epub 2014 May 22. Review.

28.

Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation.

David A, Crawford F, Garside P, Kappler JW, Marrack P, MacLeod M.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7735-40. doi: 10.1073/pnas.1406218111. Epub 2014 May 12.

29.

Identification of multiple public TCR repertoires in chronic beryllium disease.

Bowerman NA, Falta MT, Mack DG, Wehrmann F, Crawford F, Mroz MM, Maier LA, Kappler JW, Fontenot AP.

J Immunol. 2014 May 15;192(10):4571-80. doi: 10.4049/jimmunol.1400007. Epub 2014 Apr 9.

30.

Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes.

Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2656-61. doi: 10.1073/pnas.1323436111. Epub 2014 Feb 3.

31.

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity.

Bedel R, Berry R, Mallevaey T, Matsuda JL, Zhang J, Godfrey DI, Rossjohn J, Kappler JW, Marrack P, Gapin L.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E119-28. doi: 10.1073/pnas.1320777110. Epub 2013 Dec 16.

32.

Improving antigenic peptide vaccines for cancer immunotherapy using a dominant tumor-specific T cell receptor.

Buhrman JD, Jordan KR, Munson DJ, Moore BL, Kappler JW, Slansky JE.

J Biol Chem. 2013 Nov 15;288(46):33213-25. doi: 10.1074/jbc.M113.509554. Epub 2013 Oct 8.

33.

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance.

Rubtsova K, Rubtsov AV, van Dyk LF, Kappler JW, Marrack P.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3216-24. doi: 10.1073/pnas.1312348110. Epub 2013 Aug 6.

34.

Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease.

Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP.

J Exp Med. 2013 Jul 1;210(7):1403-18.

35.

Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence.

Macleod MK, David A, Jin N, Noges L, Wang J, Kappler JW, Marrack P.

PLoS One. 2013 Apr 16;8(4):e61775. doi: 10.1371/journal.pone.0061775. Print 2013.

36.

The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.

Clambey ET, Collins B, Young MH, Eberlein J, David A, Kappler JW, Marrack P.

PLoS One. 2013;8(2):e57435. doi: 10.1371/journal.pone.0057435. Epub 2013 Feb 26.

37.

Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.

McKee AS, Burchill MA, Munks MW, Jin L, Kappler JW, Friedman RS, Jacobelli J, Marrack P.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1122-31. doi: 10.1073/pnas.1300392110. Epub 2013 Feb 27.

38.

Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line.

Collins B, Clambey ET, Scott-Browne J, White J, Marrack P, Hagman J, Kappler JW.

Eur J Immunol. 2013 Feb;43(2):521-32. doi: 10.1002/eji.201242757. Epub 2012 Dec 27.

39.

T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.

Yin L, Crawford F, Marrack P, Kappler JW, Dai S.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18517-22. doi: 10.1073/pnas.1215928109. Epub 2012 Oct 22.

40.

T cells and their eons-old obsession with MHC.

Yin L, Scott-Browne J, Kappler JW, Gapin L, Marrack P.

Immunol Rev. 2012 Nov;250(1):49-60. doi: 10.1111/imr.12004. Review.

41.

Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases?

Marrack P, Kappler JW.

Cold Spring Harb Perspect Med. 2012 Sep 1;2(9):a007765. doi: 10.1101/cshperspect.a007765. Review.

42.

TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice.

Rubtsov AV, Rubtsova K, Kappler JW, Marrack P.

Immunol Res. 2013 Mar;55(1-3):210-6. doi: 10.1007/s12026-012-8365-8.

43.

A closer look at TCR germline recognition.

Garcia KC, Gapin L, Adams JJ, Birnbaum ME, Scott-Browne JP, Kappler JW, Marrack P.

Immunity. 2012 Jun 29;36(6):887-8. doi: 10.1016/j.immuni.2012.05.018. Epub 2012 Jun 14. No abstract available.

44.

TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines.

Jordan KR, Buhrman JD, Sprague J, Moore BL, Gao D, Kappler JW, Slansky JE.

Cancer Immunol Immunother. 2012 Oct;61(10):1627-38. Epub 2012 Feb 21.

45.

Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice.

Zhang L, Stadinski BD, Michels A, Kappler JW, Eisenbarth GS.

Diabetes Metab Res Rev. 2011 Nov;27(8):784-9. doi: 10.1002/dmrr.1252.

PMID:
22069260
46.

Evolutionarily conserved features contribute to αβ T cell receptor specificity.

Scott-Browne JP, Crawford F, Young MH, Kappler JW, Marrack P, Gapin L.

Immunity. 2011 Oct 28;35(4):526-35. doi: 10.1016/j.immuni.2011.09.005. Epub 2011 Sep 29.

47.

Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse.

Crawford F, Stadinski B, Jin N, Michels A, Nakayama M, Pratt P, Marrack P, Eisenbarth G, Kappler JW.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16729-34. doi: 10.1073/pnas.1113954108. Epub 2011 Sep 26.

48.

Mutagenesis of beryllium-specific TCRs suggests an unusual binding topology for antigen recognition.

Bowerman NA, Falta MT, Mack DG, Kappler JW, Fontenot AP.

J Immunol. 2011 Oct 1;187(7):3694-703. doi: 10.4049/jimmunol.1101872. Epub 2011 Aug 26.

49.

IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity.

Kenyon KD, Cole C, Crawford F, Kappler JW, Thurman JM, Bratton DL, Boackle SA, Henson PM.

J Immunol. 2011 Sep 1;187(5):2101-11. doi: 10.4049/jimmunol.1003468. Epub 2011 Aug 3.

50.

A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers.

Yin L, Huseby E, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S, Kappler JW.

Immunity. 2011 Jul 22;35(1):23-33. doi: 10.1016/j.immuni.2011.04.017. Epub 2011 Jun 16.

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