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Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model.

Anthony-Gonda K, Bardhi A, Ray A, Flerin N, Li M, Chen W, Ochsenbauer C, Kappes JC, Krueger W, Worden A, Schneider D, Zhu Z, Orentas R, Dimitrov DS, Goldstein H, Dropulić B.

Sci Transl Med. 2019 Aug 7;11(504). pii: eaav5685. doi: 10.1126/scitranslmed.aav5685.


Primary HIV-1 strains use Nef to downmodulate HLA-E surface expression.

Thans TVS, Akko JI, Niehrs A, Garcia-Beltran WF, Richert L, Stürzel CM, Ford CT, Li H, Ochsenbauer C, Kappes JC, Hahn BH, Kirchhoff F, Martrus G, Sauter D, Altfeld M, Hölzemer A.

J Virol. 2019 Aug 2. pii: JVI.00719-19. doi: 10.1128/JVI.00719-19. [Epub ahead of print]


Growth hormone (GH) receptor (GHR)-specific inhibition of GH-Induced signaling by soluble IGF-1 receptor (sol IGF-1R).

Zhang Y, Gc S, Patel SB, Liu Y, Paterson AJ, Kappes JC, Jiang J, Frank SJ.

Mol Cell Endocrinol. 2019 Jul 15;492:110445. doi: 10.1016/j.mce.2019.05.004. Epub 2019 May 14.


Re-irradiation in locally recurrent lung cancer patients.

Schlampp I, Rieber J, Adeberg S, Bozorgmehr F, Heußel CP, Steins M, Kappes J, Hoffmann H, Welzel T, Debus J, Rieken S.

Strahlenther Onkol. 2019 Aug;195(8):725-733. doi: 10.1007/s00066-019-01457-2. Epub 2019 Apr 1.


Impact of inflammatory markers on survival in patients with limited disease small-cell lung cancer undergoing chemoradiotherapy.

Bernhardt D, Aufderstrasse S, König L, Adeberg S, Bozorgmehr F, Christopoulos P, Shafie RAE, Hörner-Rieber J, Kappes J, Thomas M, Herth F, Steins M, Debus J, Rieken S.

Cancer Manag Res. 2018 Nov 30;10:6563-6569. doi: 10.2147/CMAR.S180990. eCollection 2018.


Nutrients, but not genetic diversity, affect Gracilaria chilensis (Rhodophyta) farming productivity and physiological responses.

Usandizaga S, Camus C, Kappes JL, Guillemin ML, Buschmann AH.

J Phycol. 2018 Dec;54(6):860-869. doi: 10.1111/jpy.12785. Epub 2018 Oct 15.


Whole brain radiation therapy alone versus radiosurgery for patients with 1-10 brain metastases from small cell lung cancer (ENCEPHALON Trial): study protocol for a randomized controlled trial.

Bernhardt D, Hommertgen A, Schmitt D, El Shafie R, Paul A, König L, Mair-Walther J, Krisam J, Klose C, Welzel T, Hörner-Rieber J, Kappes J, Thomas M, Heußel CP, Steins M, Kieser M, Debus J, Rieken S.

Trials. 2018 Jul 16;19(1):388. doi: 10.1186/s13063-018-2745-x.


Incomplete Downregulation of CD4 Expression Affects HIV-1 Env Conformation and Antibody-Dependent Cellular Cytotoxicity Responses.

Prévost J, Richard J, Medjahed H, Alexander A, Jones J, Kappes JC, Ochsenbauer C, Finzi A.

J Virol. 2018 Jun 13;92(13). pii: e00484-18. doi: 10.1128/JVI.00484-18. Print 2018 Jul 1.


Cyclic vomiting syndrome: diagnostic approach and current management strategies.

Hayes WJ, VanGilder D, Berendse J, Lemon MD, Kappes JA.

Clin Exp Gastroenterol. 2018 Feb 26;11:77-84. doi: 10.2147/CEG.S136420. eCollection 2018. Review.


Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1.

Yang Z, Hildebrandt E, Jiang F, Aleksandrov AA, Khazanov N, Zhou Q, An J, Mezzell AT, Xavier BM, Ding H, Riordan JR, Senderowitz H, Kappes JC, Brouillette CG, Urbatsch IL.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):1193-1204. doi: 10.1016/j.bbamem.2018.02.006. Epub 2018 Feb 7.


Generation of a New Disease-specific Prognostic Score for Patients With Brain Metastases From Small-cell Lung Cancer Treated With Whole Brain Radiotherapy (BMS-Score) and Validation of Two Other Indices.

Bernhardt D, König L, Aufderstrasse S, Krisam J, Hoerner-Rieber J, Adeberg S, Bozorgmehr F, El Shafie R, Lang K, Kappes J, Thomas M, Herth F, Heußel CP, Warth A, Marcrom S, Debus J, Steins M, Rieken S.

Clin Lung Cancer. 2018 Jul;19(4):340-345. doi: 10.1016/j.cllc.2017.12.004. Epub 2017 Dec 15.


Treating C3 glomerulopathy with eculizumab.

Welte T, Arnold F, Kappes J, Seidl M, Häffner K, Bergmann C, Walz G, Neumann-Haefelin E.

BMC Nephrol. 2018 Jan 12;19(1):7. doi: 10.1186/s12882-017-0802-4.


[What could the pancreas have to do with shoulder pain?]

Caf P, Kunz J, Flechsig P, Ullrich E, Reimer P, Barreto MM, Kappes J, Herth FJ, Warth A, Kauczor HU, Heußel CP.

Med Klin Intensivmed Notfmed. 2018 Mar;113(2):135-138. doi: 10.1007/s00063-017-0374-x. Epub 2017 Nov 8. German. No abstract available.


Outcome and prognostic factors in single brain metastases from small-cell lung cancer.

Bernhardt D, Adeberg S, Bozorgmehr F, Opfermann N, Hörner-Rieber J, König L, Kappes J, Thomas M, Unterberg A, Herth F, Heußel CP, Warth A, Debus J, Steins M, Rieken S.

Strahlenther Onkol. 2018 Feb;194(2):98-106. doi: 10.1007/s00066-017-1228-4. Epub 2017 Oct 30.


Substitution of Yor1p NBD1 residues improves the thermal stability of Human Cystic Fibrosis Transmembrane Conductance Regulator.

Xavier BM, Hildebrandt E, Jiang F, Ding H, Kappes JC, Urbatsch IL.

Protein Eng Des Sel. 2017 Oct 1;30(10):729-741. doi: 10.1093/protein/gzx054.


Parenchymal and Functional Lung Changes after Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer-Experiences from a Single Institution.

Hörner-Rieber J, Dern J, Bernhardt D, König L, Adeberg S, Verma V, Paul A, Kappes J, Hoffmann H, Debus J, Heussel CP, Rieken S.

Front Oncol. 2017 Sep 19;7:215. doi: 10.3389/fonc.2017.00215. eCollection 2017.


Histology of non-small cell lung cancer predicts the response to stereotactic body radiotherapy.

Hörner-Rieber J, Bernhardt D, Dern J, König L, Adeberg S, Paul A, Heussel CP, Kappes J, Hoffmann H, Herth FJP, Debus J, Warth A, Rieken S.

Radiother Oncol. 2017 Nov;125(2):317-324. doi: 10.1016/j.radonc.2017.08.029. Epub 2017 Sep 14.


Pharmacotherapy Review of Ceftazidime-Avibactam.

Yaeger A, Kappes J.

S D Med. 2017 May;70(5):229-231. Review. No abstract available.


Potent In Vivo NK Cell-Mediated Elimination of HIV-1-Infected Cells Mobilized by a gp120-Bispecific and Hexavalent Broadly Neutralizing Fusion Protein.

Bardhi A, Wu Y, Chen W, Li W, Zhu Z, Zheng JH, Wong H, Jeng E, Jones J, Ochsenbauer C, Kappes JC, Dimitrov DS, Ying T, Goldstein H.

J Virol. 2017 Sep 27;91(20). pii: e00937-17. doi: 10.1128/JVI.00937-17. Print 2017 Oct 15.


Outcome and prognostic factors in patients with brain metastases from small-cell lung cancer treated with whole brain radiotherapy.

Bernhardt D, Adeberg S, Bozorgmehr F, Opfermann N, Hoerner-Rieber J, König L, Kappes J, Thomas M, Herth F, Heußel CP, Warth A, Debus J, Steins M, Rieken S.

J Neurooncol. 2017 Aug;134(1):205-212. doi: 10.1007/s11060-017-2510-0. Epub 2017 May 30.


Brivaracetam: An Adjunctive Treatment for Partial-Onset Seizures.

Kappes JA, Hayes WJ, Strain JD, Farver DK.

J Clin Pharmacol. 2017 Jul;57(7):811-817. doi: 10.1002/jcph.900. Epub 2017 Apr 10. Review.


Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

Bonsignori M, Kreider EF, Fera D, Meyerhoff RR, Bradley T, Wiehe K, Alam SM, Aussedat B, Walkowicz WE, Hwang KK, Saunders KO, Zhang R, Gladden MA, Monroe A, Kumar A, Xia SM, Cooper M, Louder MK, McKee K, Bailer RT, Pier BW, Jette CA, Kelsoe G, Williams WB, Morris L, Kappes J, Wagh K, Kamanga G, Cohen MS, Hraber PT, Montefiori DC, Trama A, Liao HX, Kepler TB, Moody MA, Gao F, Danishefsky SJ, Mascola JR, Shaw GM, Hahn BH, Harrison SC, Korber BT, Haynes BF.

Sci Transl Med. 2017 Mar 15;9(381). pii: eaai7514. doi: 10.1126/scitranslmed.aai7514.


The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria.

Yoder AC, Guo K, Dillon SM, Phang T, Lee EJ, Harper MS, Helm K, Kappes JC, Ochsenbauer C, McCarter MD, Wilson CC, Santiago ML.

PLoS Pathog. 2017 Feb 27;13(2):e1006226. doi: 10.1371/journal.ppat.1006226. eCollection 2017 Feb.


Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein.

Nguyen HT, Madani N, Ding H, Elder E, Princiotto A, Gu C, Darby P, Alin J, Herschhorn A, Kappes JC, Mao Y, Sodroski JG.

Virol J. 2017 Feb 16;14(1):33. doi: 10.1186/s12985-017-0704-x.


Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers.

Go EP, Ding H, Zhang S, Ringe RP, Nicely N, Hua D, Steinbock RT, Golabek M, Alin J, Alam SM, Cupo A, Haynes BF, Kappes JC, Moore JP, Sodroski JG, Desaire H.

J Virol. 2017 Apr 13;91(9). pii: e02428-16. doi: 10.1128/JVI.02428-16. Print 2017 May 1.


Antigenic characterization of the human immunodeficiency virus (HIV-1) envelope glycoprotein precursor incorporated into nanodiscs.

Witt KC, Castillo-Menendez L, Ding H, Espy N, Zhang S, Kappes JC, Sodroski J.

PLoS One. 2017 Feb 2;12(2):e0170672. doi: 10.1371/journal.pone.0170672. eCollection 2017.


Nine-year Experience: Prophylactic Cranial Irradiation in Extensive Disease Small-cell Lung Cancer.

Bernhardt D, Adeberg S, Bozorgmehr F, Opfermann N, Hoerner-Rieber J, Repka MC, Kappes J, Thomas M, Bischoff H, Herth F, Heußel CP, Debus J, Steins M, Rieken S.

Clin Lung Cancer. 2017 Jul;18(4):e267-e271. doi: 10.1016/j.cllc.2016.11.012. Epub 2016 Dec 2.


Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects.

Huang Y, Ferrari G, Alter G, Forthal DN, Kappes JC, Lewis GK, Love JC, Borate B, Harris L, Greene K, Gao H, Phan TB, Landucci G, Goods BA, Dowell KG, Cheng HD, Bailey-Kellogg C, Montefiori DC, Ackerman ME.

J Immunol. 2016 Dec 15;197(12):4603-4612. Epub 2016 Nov 9.


Specific stabilization of CFTR by phosphatidylserine.

Hildebrandt E, Khazanov N, Kappes JC, Dai Q, Senderowitz H, Urbatsch IL.

Biochim Biophys Acta Biomembr. 2017 Feb;1859(2):289-293. doi: 10.1016/j.bbamem.2016.11.013. Epub 2016 Nov 30.


Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain.

Gumiero A, Conz C, Gesé GV, Zhang Y, Weyer FA, Lapouge K, Kappes J, von Plehwe U, Schermann G, Fitzke E, Wölfle T, Fischer T, Rospert S, Sinning I.

Nat Commun. 2016 Nov 24;7:13563. doi: 10.1038/ncomms13563.


Outcome in patients with small cell lung cancer re-irradiated for brain metastases after prior prophylactic cranial irradiation.

Bernhardt D, Bozorgmehr F, Adeberg S, Opfermann N, von Eiff D, Rieber J, Kappes J, Foerster R, König L, Thomas M, Debus J, Steins M, Rieken S.

Lung Cancer. 2016 Nov;101:76-81. doi: 10.1016/j.lungcan.2016.09.010. Epub 2016 Sep 14.


Radiosurgery with flattening-filter-free techniques in the treatment of brain metastases : Plan comparison and early clinical evaluation.

Rieber J, Tonndorf-Martini E, Schramm O, Rhein B, Stefanowicz S, Kappes J, Hoffmann H, Lindel K, Debus J, Rieken S.

Strahlenther Onkol. 2016 Nov;192(11):789-796. Epub 2016 Jul 4.


The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke.

Raju SV, Lin VY, Liu L, McNicholas CM, Karki S, Sloane PA, Tang L, Jackson PL, Wang W, Wilson L, Macon KJ, Mazur M, Kappes JC, DeLucas LJ, Barnes S, Kirk K, Tearney GJ, Rowe SM.

Am J Respir Cell Mol Biol. 2017 Jan;56(1):99-108. doi: 10.1165/rcmb.2016-0226OC.


Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV.

Rodriguez-Garcia M, Shen Z, Barr FD, Boesch AW, Ackerman ME, Kappes JC, Ochsenbauer C, Wira CR.

Mucosal Immunol. 2017 Mar;10(2):531-544. doi: 10.1038/mi.2016.72. Epub 2016 Aug 31.


Establishing stereotactic body radiotherapy with flattening filter free techniques in the treatment of pulmonary lesions - initial experiences from a single institution.

Rieber J, Tonndorf-Martini E, Schramm O, Rhein B, König L, Adeberg S, Meyerhof E, Mohr A, Kappes J, Hoffmann H, Debus J, Rieken S.

Radiat Oncol. 2016 Jun 8;11:80. doi: 10.1186/s13014-016-0648-0.


High-Throughput Humanized Mouse Models for Evaluation of HIV-1 Therapeutics and Pathogenesis.

Thomas T, Seay K, Zheng JH, Zhang C, Ochsenbauer C, Kappes JC, Goldstein H.

Methods Mol Biol. 2016;1354:221-35. doi: 10.1007/978-1-4939-3046-3_15.


Outcome and prognostic factors of postoperative radiation therapy (PORT) after incomplete resection of non-small cell lung cancer (NSCLC).

Rieber J, Deeg A, Ullrich E, Foerster R, Bischof M, Warth A, Schnabel PA, Muley T, Kappes J, Heussel CP, Welzel T, Thomas M, Steins M, Dienemann H, Debus J, Hoffmann H, Rieken S.

Lung Cancer. 2016 Jan;91:41-7. doi: 10.1016/j.lungcan.2015.11.014. Epub 2015 Nov 25.


Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma.

Pal HC, Diamond AC, Strickland LR, Kappes JC, Katiyar SK, Elmets CA, Athar M, Afaq F.

Oncotarget. 2016 Jan 12;7(2):1227-41. doi: 10.18632/oncotarget.6237.


Partial Optimality by Pruning for MAP-Inference with General Graphical Models.

Swoboda P, Shekhovtsov A, Kappes JH, Schnorr C, Savchynskyy B.

IEEE Trans Pattern Anal Mach Intell. 2016 Jul;38(7):1370-82. doi: 10.1109/TPAMI.2015.2484327. Epub 2015 Oct 13.


The dynamic pattern of recurrence in curatively resected non-small cell lung cancer patients: Experiences at a single institution.

Yamauchi Y, Muley T, Safi S, Rieken S, Bischoff H, Kappes J, Warth A, Herth FJ, Dienemann H, Hoffmann H.

Lung Cancer. 2015 Nov;90(2):224-9. doi: 10.1016/j.lungcan.2015.09.010. Epub 2015 Sep 15.


Expression and purification of the alpha subunit of the epithelial sodium channel, ENaC.

Reddy BG, Dai Q, McNicholas CM, Fuller CM, Kappes JC, DeLucas LJ.

Protein Expr Purif. 2016 Jan;117:67-75. doi: 10.1016/j.pep.2015.09.014. Epub 2015 Sep 21.


Outcome and prognostic factors of multimodal therapy for pulmonary large-cell neuroendocrine carcinomas.

Rieber J, Schmitt J, Warth A, Muley T, Kappes J, Eichhorn F, Hoffmann H, Heussel CP, Welzel T, Debus J, Thomas M, Steins M, Rieken S.

Eur J Med Res. 2015 Aug 14;20:64. doi: 10.1186/s40001-015-0158-9.


The Vaginal Acquisition and Dissemination of HIV-1 Infection in a Novel Transgenic Mouse Model Is Facilitated by Coinfection with Herpes Simplex Virus 2 and Is Inhibited by Microbicide Treatment.

Seay K, Khajoueinejad N, Zheng JH, Kiser P, Ochsenbauer C, Kappes JC, Herold B, Goldstein H.

J Virol. 2015 Sep;89(18):9559-70. doi: 10.1128/JVI.01326-15. Epub 2015 Jul 8.


Optimized Replicating Renilla Luciferase Reporter HIV-1 Utilizing Novel Internal Ribosome Entry Site Elements for Native Nef Expression and Function.

Alberti MO, Jones JJ, Miglietta R, Ding H, Bakshi RK, Edmonds TG, Kappes JC, Ochsenbauer C.

AIDS Res Hum Retroviruses. 2015 Dec;31(12):1278-96. doi: 10.1089/aid.2015.0074. Epub 2015 Jun 23.


Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140.

Go EP, Herschhorn A, Gu C, Castillo-Menendez L, Zhang S, Mao Y, Chen H, Ding H, Wakefield JK, Hua D, Liao HX, Kappes JC, Sodroski J, Desaire H.

J Virol. 2015 Aug;89(16):8245-57. doi: 10.1128/JVI.00628-15. Epub 2015 May 27.


In Vivo Activation of Human NK Cells by Treatment with an Interleukin-15 Superagonist Potently Inhibits Acute In Vivo HIV-1 Infection in Humanized Mice.

Seay K, Church C, Zheng JH, Deneroff K, Ochsenbauer C, Kappes JC, Liu B, Jeng EK, Wong HC, Goldstein H.

J Virol. 2015 Jun;89(12):6264-74. doi: 10.1128/JVI.00563-15. Epub 2015 Apr 1.


OnabotulinumtoxinA Injections for the Treatment of Cyclic Vomiting Syndrome.

Hayes WJ, Weisensee LA, Kappes JA, Dalton SM, Lemon MD.

Pharmacotherapy. 2015 May;35(5):e51-5. doi: 10.1002/phar.1570. Epub 2015 Mar 30.


Erratum to: A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface.

Hildebrandt E, Ding H, Mulky A, Dai Q, Aleksandrov AA, Bajrami B, Diego PA, Wu X, Ray M, Naren AP, Riordan JR, Yao X, DeLucas LJ, Urbatsch IL, Kappes JC.

Mol Biotechnol. 2015 May;57(5):406. doi: 10.1007/s12033-015-9857-2. No abstract available.


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