Sort by
Items per page

Send to

Choose Destination

Search results

Items: 47


The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network.

Neier SC, Ferrer A, Wilton KM, Smith SEP, Kelcher AMH, Pavelko KD, Canfield JM, Davis TR, Stiles RJ, Chen Z, McCluskey J, Burrows SR, Rossjohn J, Hebrink DM, Carmona EM, Limper AH, Kappes DJ, Wettstein PJ, Johnson AJ, Pease LR, Daniels MA, Neuhauser C, Gil D, Schrum AG.

Sci Immunol. 2019 Feb 15;4(32). pii: eaal2201. doi: 10.1126/sciimmunol.aal2201.


ThPOK, a Key Regulator of T Cell Development and Function.

Mookerjee-Basu J, Chemmannur SV, Qin L, Kappes DJ.

In: Soboloff J, Kappes DJ, editors. Signaling Mechanisms Regulating T Cell Diversity and Function. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 5.


TCR Signaling Circuits in αβ/γδ T Lineage Choice.

Fahl SP, Kappes DJ, Wiest DL.

In: Soboloff J, Kappes DJ, editors. Signaling Mechanisms Regulating T Cell Diversity and Function. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 6.


Functional Conservation of a Developmental Switch in Mammals since the Jurassic Age.

Mookerjee-Basu J, Hua X, Ge L, Nicolas E, Li Q, Czyzewicz P, Zhongping D, Peri S, FuxmanBass JI, Walhout AJM, Kappes DJ.

Mol Biol Evol. 2019 Jan 1;36(1):39-53. doi: 10.1093/molbev/msy191.


Role of a selecting ligand in shaping the murine γδ-TCR repertoire.

Fahl SP, Coffey F, Kain L, Zarin P, Dunbrack RL Jr, Teyton L, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1889-1894. doi: 10.1073/pnas.1718328115. Epub 2018 Feb 5.


Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.

Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, Kappes DJ, Feng Q, Rhodes J, Amieux PS, Morris DR, Kennedy BK, Wiest DL.

Cell Rep. 2017 Jan 10;18(2):545-556. doi: 10.1016/j.celrep.2016.12.034.


iNKT cells do a fat lot of good.

Mookerjee-Basu J, Kappes DJ.

Nat Immunol. 2016 Dec 16;18(1):10-12. doi: 10.1038/ni.3639. No abstract available.


Novel STIM1-dependent control of Ca2+ clearance regulates NFAT activity during T-cell activation.

Samakai E, Hooper R, Martin KA, Shmurak M, Zhang Y, Kappes DJ, Tempera I, Soboloff J.

FASEB J. 2016 Nov;30(11):3878-3886. Epub 2016 Aug 15.


Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish.

Seiler C, Gebhart N, Zhang Y, Shinton SA, Li YS, Ross NL, Liu X, Li Q, Bilbee AN, Varshney GK, LaFave MC, Burgess SM, Balciuniene J, Balciunas D, Hardy RR, Kappes DJ, Wiest DL, Rhodes J.

PLoS One. 2015 Jul 10;10(7):e0131908. doi: 10.1371/journal.pone.0131908. eCollection 2015.


Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas.

Lee HO, He X, Mookerjee-Basu J, Zhongping D, Hua X, Nicolas E, Sulis ML, Ferrando AA, Testa JR, Kappes DJ.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7773-8. doi: 10.1073/pnas.1424104112. Epub 2015 Jun 8.


Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates.

Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick SM, Fehling HJ, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL.

Immunity. 2014 Dec 18;41(6):934-46. doi: 10.1016/j.immuni.2014.10.021. Epub 2014 Nov 28.


New ingredients for brewing CD4(+)T (cells): TCF-1 and LEF-1.

Mookerjee-Basu J, Kappes DJ.

Nat Immunol. 2014 Jul;15(7):593-4. doi: 10.1038/ni.2927. No abstract available.


The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification.

Coffey F, Lee SY, Buus TB, Lauritsen JP, Wong GW, Joachims ML, Thompson LF, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL.

J Exp Med. 2014 Feb 10;211(2):329-43. doi: 10.1084/jem.20131540. Epub 2014 Feb 3.


Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs.

Zhang Y, Duc AC, Rao S, Sun XL, Bilbee AN, Rhodes M, Li Q, Kappes DJ, Rhodes J, Wiest DL.

Dev Cell. 2013 Feb 25;24(4):411-25. doi: 10.1016/j.devcel.2013.01.018.


Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

Qiao Y, Zhu L, Sofi H, Lapinski PE, Horai R, Mueller K, Stritesky GL, He X, Teh HS, Wiest DL, Kappes DJ, King PD, Hogquist KA, Schwartzberg PL, Sant'Angelo DB, Chang CH.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16264-9. doi: 10.1073/pnas.1207528109. Epub 2012 Sep 17.


Developing intestinal fortitude.

Kappes DJ.

Nat Immunol. 2011 Apr;12(4):281-2. doi: 10.1038/ni0411-281. No abstract available.


Expanding roles for ThPOK in thymic development.

Kappes DJ.

Immunol Rev. 2010 Nov;238(1):182-94. doi: 10.1111/j.1600-065X.2010.00958.x. Review.


Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors.

Kim ST, Touma M, Takeuchi K, Sun ZY, Dave VP, Kappes DJ, Wagner G, Reinherz EL.

J Immunol. 2010 Sep 1;185(5):2951-9. doi: 10.4049/jimmunol.1000732. Epub 2010 Jul 26.


TCR-mediated ThPOK induction promotes development of mature (CD24-) gammadelta thymocytes.

Park K, He X, Lee HO, Hua X, Li Y, Wiest D, Kappes DJ.

EMBO J. 2010 Jul 21;29(14):2329-41. doi: 10.1038/emboj.2010.113. Epub 2010 Jun 15.


Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice.

Lee SY, Stadanlick J, Kappes DJ, Wiest DL.

Semin Immunol. 2010 Aug;22(4):237-46. doi: 10.1016/j.smim.2010.04.008. Epub 2010 May 14. Review.


The role of ThPOK in control of CD4/CD8 lineage commitment.

He X, Park K, Kappes DJ.

Annu Rev Immunol. 2010;28:295-320. doi: 10.1146/annurev.immunol.25.022106.141715. Review.


Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.

Lauritsen JP, Wong GW, Lee SY, Lefebvre JM, Ciofani M, Rhodes M, Kappes DJ, Zúñiga-Pflücker JC, Wiest DL.

Immunity. 2009 Oct 16;31(4):565-75. doi: 10.1016/j.immuni.2009.07.010.


CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus.

He X, Park K, Wang H, He X, Zhang Y, Hua X, Li Y, Kappes DJ.

Immunity. 2008 Mar;28(3):346-58. doi: 10.1016/j.immuni.2008.02.006.


CD4 and CD8: hogging all the Lck.

Kappes DJ.

Immunity. 2007 Nov;27(5):691-3. Review.


CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision.

Yin X, Ladi E, Chan SW, Li O, Killeen N, Kappes DJ, Robey EA.

J Immunol. 2007 Dec 1;179(11):7358-64.


CD4/CD8 lineage commitment: light at the end of the tunnel?

He X, Kappes DJ.

Curr Opin Immunol. 2006 Apr;18(2):135-42. Epub 2006 Feb 15. Review.


Role of the transcription factor Th-POK in CD4:CD8 lineage commitment.

Kappes DJ, He X, He X.

Immunol Rev. 2006 Feb;209:237-52. Review.


Recent insights into the signals that control alphabeta/gammadelta-lineage fate.

Lauritsen JP, Haks MC, Lefebvre JM, Kappes DJ, Wiest DL.

Immunol Rev. 2006 Feb;209:176-90. Review.


CD4-CD8 lineage commitment: an inside view.

Kappes DJ, He X, He X.

Nat Immunol. 2005 Aug;6(8):761-6. Review.


Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage.

Haks MC, Lefebvre JM, Lauritsen JP, Carleton M, Rhodes M, Miyazaki T, Kappes DJ, Wiest DL.

Immunity. 2005 May;22(5):595-606.


The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.

He X, He X, Dave VP, Zhang Y, Hua X, Nicolas E, Xu W, Roe BA, Kappes DJ.

Nature. 2005 Feb 24;433(7028):826-33.


Activation-induced modification in the CD3 complex of the gammadelta T cell receptor.

Hayes SM, Laky K, El-Khoury D, Kappes DJ, Fowlkes BJ, Love PE.

J Exp Med. 2002 Nov 18;196(10):1355-61. Erratum in: J Exp Med 2002 Dec 16;196(12):1653.


Protection of CD3 delta knockout mice from lymphocytic choriomeningitis virus-induced immunopathology: implications for viral neuroinvasion.

Kappes DJ, Lawrence DM, Vaughn MM, Davé VP, Belman AR, Rall GF.

Virology. 2000 Apr 10;269(2):248-56.


Regulation of lineage commitment distinct from positive selection.

Keefe R, Dave V, Allman D, Wiest D, Kappes DJ.

Science. 1999 Nov 5;286(5442):1149-53.


Limiting TCR expression leads to quantitative but not qualitative changes in thymic selection.

Dave VP, Allman D, Wiest DL, Kappes DJ.

J Immunol. 1999 May 15;162(10):5764-74.


Altered functional responsiveness of thymocyte subsets from CD3delta-deficient mice to TCR-CD3 engagement.

Dave VP, Keefe R, Berger MA, Drbal K, Punt JA, Wiest DL, Alarcon B, Kappes DJ.

Int Immunol. 1998 Oct;10(10):1481-90.


HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells.

Dave VP, Allman D, Keefe R, Hardy RR, Kappes DJ.

Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8187-92.


Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required.

Berger MA, Davé V, Rhodes MR, Bosma GC, Bosma MJ, Kappes DJ, Wiest DL.

J Exp Med. 1997 Nov 3;186(9):1461-7.


CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage.

Dave VP, Cao Z, Browne C, Alarcon B, Fernandez-Miguel G, Lafaille J, de la Hera A, Tonegawa S, Kappes DJ.

EMBO J. 1997 Mar 17;16(6):1360-70.


T lymphocyte receptor deficiencies.

Kappes DJ, Alarcón B, Regueiro JR.

Curr Opin Immunol. 1995 Aug;7(4):441-7. Review.


Surface expression of alternative forms of the TCR/CD3 complex.

Kappes DJ, Tonegawa S.

Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10619-23.


Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor gamma chain.

Kappes DJ, Browne CP, Tonegawa S.

Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2204-8.


Structure and evolution of the HLA class II SX beta gene.

Kappes DJ, Strominger JL.

Immunogenetics. 1986;24(1):1-7.


Structure and polymorphism of the HLA class II SB light chain genes.

Kappes DJ, Arnot D, Okada K, Strominger JL.

EMBO J. 1984 Dec 1;3(12):2985-93.


Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.

Collins T, Korman AJ, Wake CT, Boss JM, Kappes DJ, Fiers W, Ault KA, Gimbrone MA Jr, Strominger JL, Pober JS.

Proc Natl Acad Sci U S A. 1984 Aug;81(15):4917-21.

Supplemental Content

Loading ...
Support Center