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Items: 1 to 50 of 67

1.

Synthesis of Novel Hybrids of Quinazoline and Artemisinin with High Activities against Plasmodium falciparum, Human Cytomegalovirus, and Leukemia Cells.

Fröhlich T, Reiter C, Ibrahim MM, Beutel J, Hutterer C, Zeitträger I, Bahsi H, Leidenberger M, Friedrich O, Kappes B, Efferth T, Marschall M, Tsogoeva SB.

ACS Omega. 2017 Jun 30;2(6):2422-2431. doi: 10.1021/acsomega.7b00310. Epub 2017 Jun 1.

2.

Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents.

Fröhlich T, Reiter C, Saeed MEM, Hutterer C, Hahn F, Leidenberger M, Friedrich O, Kappes B, Marschall M, Efferth T, Tsogoeva SB.

ACS Med Chem Lett. 2017 Dec 21;9(6):534-539. doi: 10.1021/acsmedchemlett.7b00412. eCollection 2018 Jun 14.

PMID:
29937978
3.

Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin.

Çapcı Karagöz A, Reiter C, Seo EJ, Gruber L, Hahn F, Leidenberger M, Klein V, Hampel F, Friedrich O, Marschall M, Kappes B, Efferth T, Tsogoeva SB.

Bioorg Med Chem. 2018 Jul 23;26(12):3610-3618. doi: 10.1016/j.bmc.2018.05.041. Epub 2018 May 24.

PMID:
29887512
4.

Label-free, high-throughput detection of P. falciparum infection in sphered erythrocytes with digital holographic microscopy.

Ugele M, Weniger M, Leidenberger M, Huang Y, Bassler M, Friedrich O, Kappes B, Hayden O, Richter L.

Lab Chip. 2018 Jun 12;18(12):1704-1712. doi: 10.1039/c8lc00350e.

PMID:
29796511
5.

Synthesis of Artemisinin-Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action.

Fröhlich T, Hahn F, Belmudes L, Leidenberger M, Friedrich O, Kappes B, Couté Y, Marschall M, Tsogoeva SB.

Chemistry. 2018 Jun 7;24(32):8103-8113. doi: 10.1002/chem.201800729. Epub 2018 May 14.

PMID:
29570874
6.

Hybrid integration of scalable mechanical and magnetophoretic focusing for magnetic flow cytometry.

Reisbeck M, Richter L, Helou MJ, Arlinghaus S, Anton B, van Dommelen I, Nitzsche M, Baßler M, Kappes B, Friedrich O, Hayden O.

Biosens Bioelectron. 2018 Jun 30;109:98-108. doi: 10.1016/j.bios.2018.02.046. Epub 2018 Mar 15.

7.

Quantification of human complement factor H binding to asexual malaria blood stages by an enzyme-linked immunosorbent assay.

Simon N, Friedrich O, Kappes B.

Vaccine. 2018 Mar 14;36(12):1545-1547. doi: 10.1016/j.vaccine.2018.01.080. Epub 2018 Feb 12.

PMID:
29449098
8.

Deeper Insight into the Six-Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products.

Bock CM, Parameshwarappa G, Bönisch S, Bauer W, Hutterer C, Leidenberger M, Friedrich O, Marschall M, Kappes B, Görling A, Tsogoeva SB.

ChemistryOpen. 2017 Apr 26;6(3):364-374. doi: 10.1002/open.201700005. eCollection 2017 Jun.

9.

SYBR® Green I-Based Fluorescence Assay to Assess Cell Viability of Malaria Parasites for Routine Use in Compound Screening.

Leidenberger M, Voigtländer C, Simon N, Kappes B.

Methods Mol Biol. 2017;1601:97-110. doi: 10.1007/978-1-4939-6960-9_9.

PMID:
28470521
10.

Magnetic fingerprints of rolling cells for quantitative flow cytometry in whole blood.

Reisbeck M, Helou MJ, Richter L, Kappes B, Friedrich O, Hayden O.

Sci Rep. 2016 Sep 6;6:32838. doi: 10.1038/srep32838.

11.

Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities.

Reiter C, Fröhlich T, Gruber L, Hutterer C, Marschall M, Voigtländer C, Friedrich O, Kappes B, Efferth T, Tsogoeva SB.

Bioorg Med Chem. 2015 Sep 1;23(17):5452-8. doi: 10.1016/j.bmc.2015.07.048. Epub 2015 Jul 29.

PMID:
26260339
12.

Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission.

Auernheimer V, Lautscham LA, Leidenberger M, Friedrich O, Kappes B, Fabry B, Goldmann WH.

J Cell Sci. 2015 Sep 15;128(18):3435-43. doi: 10.1242/jcs.172031. Epub 2015 Aug 3.

13.

New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids.

Reiter C, Fröhlich T, Zeino M, Marschall M, Bahsi H, Leidenberger M, Friedrich O, Kappes B, Hampel F, Efferth T, Tsogoeva SB.

Eur J Med Chem. 2015 Jun 5;97:164-72. doi: 10.1016/j.ejmech.2015.04.053. Epub 2015 Apr 28.

PMID:
25965779
14.

Expression, purification and biochemical characterization of recombinant Ca-dependent protein kinase 2 of the malaria parasite Plasmodium falciparum.

Lauciello L, Kappes B, Scapozza L, Perozzo R.

Protein Expr Purif. 2013 Aug;90(2):170-7. doi: 10.1016/j.pep.2013.06.006. Epub 2013 Jun 18.

PMID:
23792132
15.

The shikimate pathway in apicomplexan parasites: implications for drug development.

Derrer B, Macheroux P, Kappes B.

Front Biosci (Landmark Ed). 2013 Jun 1;18:944-69. Review.

PMID:
23747859
16.

Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme.

Guédez G, Hipp K, Windeisen V, Derrer B, Gengenbacher M, Böttcher B, Sinning I, Kappes B, Tews I.

Structure. 2012 Jan 11;20(1):172-84. doi: 10.1016/j.str.2011.11.015.

17.

PLP-dependent enzymes as potential drug targets for protozoan diseases.

Kappes B, Tews I, Binter A, Macheroux P.

Biochim Biophys Acta. 2011 Nov;1814(11):1567-76. doi: 10.1016/j.bbapap.2011.07.018. Epub 2011 Jul 24. Review.

PMID:
21884827
18.

Flavogenomics--a genomic and structural view of flavin-dependent proteins.

Macheroux P, Kappes B, Ealick SE.

FEBS J. 2011 Aug;278(15):2625-34. doi: 10.1111/j.1742-4658.2011.08202.x. Epub 2011 Jul 5. Review.

19.

Moiré superstructures of graphene on faceted nickel islands.

Murata Y, Petrova V, Kappes BB, Ebnonnasir A, Petrov I, Xie YH, Ciobanu CV, Kodambaka S.

ACS Nano. 2010 Nov 23;4(11):6509-14. doi: 10.1021/nn102446y. Epub 2010 Oct 14.

PMID:
20945924
20.

Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase.

Derrer B, Windeisen V, Guédez Rodríguez G, Seidler J, Gengenbacher M, Lehmann WD, Rippe K, Sinning I, Tews I, Kappes B.

FEBS Lett. 2010 Oct 8;584(19):4169-74. doi: 10.1016/j.febslet.2010.09.013. Epub 2010 Sep 17.

21.

Vitamin B6 biosynthesis is essential for survival and virulence of Mycobacterium tuberculosis.

Dick T, Manjunatha U, Kappes B, Gengenbacher M.

Mol Microbiol. 2010 Nov;78(4):980-8. doi: 10.1111/j.1365-2958.2010.07381.x. Epub 2010 Sep 22.

22.

Minimally permutated peptide analogs as internal standards for relative and absolute quantification of peptides and proteins.

Winter D, Seidler J, Kugelstadt D, Derrer B, Kappes B, Lehmann WD.

Proteomics. 2010 Apr;10(7):1510-4. doi: 10.1002/pmic.200900695.

PMID:
20104620
24.

Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1.

Lemercier G, Fernandez-Montalvan A, Shaw JP, Kugelstadt D, Bomke J, Domostoj M, Schwarz MK, Scheer A, Kappes B, Leroy D.

Biochemistry. 2009 Jul 14;48(27):6379-89. doi: 10.1021/bi9005122.

PMID:
19507895
25.

Structural and thermodynamic insights into the assembly of the heteromeric pyridoxal phosphate synthase from Plasmodium falciparum.

Flicker K, Neuwirth M, Strohmeier M, Kappes B, Tews I, Macheroux P.

J Mol Biol. 2007 Nov 30;374(3):732-48. Epub 2007 Sep 20.

PMID:
17950752
26.

Two independent routes of de novo vitamin B6 biosynthesis: not that different after all.

Fitzpatrick TB, Amrhein N, Kappes B, Macheroux P, Tews I, Raschle T.

Biochem J. 2007 Oct 1;407(1):1-13. Review.

PMID:
17822383
27.

Microtubule inhibitors as a potential treatment for malaria.

Kappes B, Rohrbach P.

Future Microbiol. 2007 Aug;2(4):409-23. Review.

PMID:
17683277
28.

Conservation of NADPH utilization by chorismate synthase and its implications for the evolution of the shikimate pathway.

Ehammer H, Rauch G, Prem A, Kappes B, Macheroux P.

Mol Microbiol. 2007 Sep;65(5):1249-57. Epub 2007 Jul 27.

29.

Vitamin and cofactor biosynthesis pathways in Plasmodium and other apicomplexan parasites.

Müller S, Kappes B.

Trends Parasitol. 2007 Mar;23(3):112-21. Epub 2007 Feb 2. Review.

30.

Raf kinase inhibitor protein affects activity of Plasmodium falciparum calcium-dependent protein kinase 1.

Kugelstadt D, Winter D, Plückhahn K, Lehmann WD, Kappes B.

Mol Biochem Parasitol. 2007 Jan;151(1):111-7. Epub 2006 Nov 15.

PMID:
17123645
31.

Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights.

Gengenbacher M, Fitzpatrick TB, Raschle T, Flicker K, Sinning I, Müller S, Macheroux P, Tews I, Kappes B.

J Biol Chem. 2006 Feb 10;281(6):3633-41. Epub 2005 Dec 8.

32.

Export of Plasmodium falciparum calcium-dependent protein kinase 1 to the parasitophorous vacuole is dependent on three N-terminal membrane anchor motifs.

Möskes C, Burghaus PA, Wernli B, Sauder U, Dürrenberger M, Kappes B.

Mol Microbiol. 2004 Nov;54(3):676-91.

33.

Annotating the Plasmodium genome and the enigma of the shikimate pathway.

McConkey GA, Pinney JW, Westhead DR, Plueckhahn K, Fitzpatrick TB, Macheroux P, Kappes B.

Trends Parasitol. 2004 Feb;20(2):60-5. Review.

PMID:
14747018
34.

Hexacyclinol, a new antiproliferative metabolite of Panus rudis HKI 0254.

Schlegel B, Härtl A, Dahse HM, Gollmick FA, Gräfe U, Dörfelt H, Kappes B.

J Antibiot (Tokyo). 2002 Sep;55(9):814-7. No abstract available.

35.

Environmental monitoring of heavy metals and arsenic from Ag-Pb-Zn mining: a case study over two millennia.

Stüben D, Berner Z, Kappes B, Puchelt H.

Environ Monit Assess. 2001 Jul;70(1-2):181-200.

PMID:
11516013
36.

Subcellular localization and characterization of chorismate synthase in the apicomplexan Plasmodium falciparum.

Fitzpatrick T, Ricken S, Lanzer M, Amrhein N, Macheroux P, Kappes B.

Mol Microbiol. 2001 Apr;40(1):65-75.

37.

Effects of neutral posture on muscle tension during computer use.

Dowler E, Kappes B, Fenaughty A, Pemberton G.

Int J Occup Saf Ergon. 2001;7(1):61-78.

PMID:
11276265
38.

The cell cycle in protozoan parasites.

Doerig C, Chakrabarti D, Kappes B, Matthews K.

Prog Cell Cycle Res. 2000;4:163-83. Review.

PMID:
10740824
39.

Activation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 and cyclin H. Functional characterization of a P. falciparum cyclin homologue.

Le Roch K, Sestier C, Dorin D, Waters N, Kappes B, Chakrabarti D, Meijer L, Doerig C.

J Biol Chem. 2000 Mar 24;275(12):8952-8.

40.

An overview of Plasmodium protein kinases.

Kappes B, Doerig CD, Graeser R.

Parasitol Today. 1999 Nov;15(11):449-54. Review.

PMID:
10511687
41.
42.

Molecular cloning and characterization of a second calcium-dependent protein kinase of Plasmodium falciparum.

Färber PM, Graeser R, Franklin RM, Kappes B.

Mol Biochem Parasitol. 1997 Aug;87(2):211-6. No abstract available.

PMID:
9247932
43.

Characterization of a mitogen-activated protein (MAP) kinase from Plasmodium falciparum.

Graeser R, Küry P, Franklin RM, Kappes B.

Mol Microbiol. 1997 Jan;23(1):151-9.

44.

Plasmodium falciparum protein kinase 5 and the malarial nuclear division cycles.

Graeser R, Wernli B, Franklin RM, Kappes B.

Mol Biochem Parasitol. 1996 Nov 12;82(1):37-49.

PMID:
8943149
45.

Mechanisms of activation of the cdc2-related kinase PfPK5 from Plasmodium falciparum.

Graeser R, Franklin RM, Kappes B.

Mol Biochem Parasitol. 1996 Jul;79(1):125-7. No abstract available.

PMID:
8844681
46.

A Plasmodium falciparum protein kinase with two unusually large kinase inserts.

Kappes B, Yang J, Suetterlin BW, Rathgeb-Szabo K, Lindt MJ, Franklin RM.

Mol Biochem Parasitol. 1995 Jun;72(1-2):163-78.

PMID:
8538687
47.

Plasmodium falciparum calcium-dependent protein kinase phosphorylates proteins of the host erythrocytic membrane.

Zhao Y, Franklin RM, Kappes B.

Mol Biochem Parasitol. 1994 Aug;66(2):329-43.

PMID:
7808482
48.
49.

Isolation and expression of a gene specifying a cdc2-like protein kinase from the human malaria parasite Plasmodium falciparum.

Ross-Macdonald PB, Graeser R, Kappes B, Franklin R, Williamson DH.

Eur J Biochem. 1994 Mar 15;220(3):693-701.

50.

Two major phosphoproteins of Plasmodium falciparum are heat shock proteins.

Kappes B, Suetterlin BW, Hofer-Warbinek R, Humar R, Franklin RM.

Mol Biochem Parasitol. 1993 May;59(1):83-94.

PMID:
8515785

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