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Items: 1 to 50 of 153

1.

A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages.

Schafer C, Dambrauskas N, Steel RW, Carbonetti S, Chuenchob V, Flannery EL, Vigdorovich V, Oliver BG, Roobsoong W, Maher SP, Kyle D, Sattabongkot J, Kappe SHI, Mikolajczak SA, Sather DN.

Malar J. 2018 Oct 17;17(1):370. doi: 10.1186/s12936-018-2519-7.

2.

Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood.

Murphy SC, Ishizuka AS, Billman ZP, Olsen TM, Seilie AM, Chang M, Smith N, Chuenchob V, Chakravarty S, Sim BKL, Kappe SHI, Hoffman SL, Seder RA.

Malar J. 2018 Jul 27;17(1):275. doi: 10.1186/s12936-018-2422-2.

3.

Characterization of Plasmodium vivax Proteins in Plasma-Derived Exosomes From Malaria-Infected Liver-Chimeric Humanized Mice.

Gualdrón-López M, Flannery EL, Kangwanrangsan N, Chuenchob V, Fernandez-Orth D, Segui-Barber J, Royo F, Falcón-Pérez JM, Fernandez-Becerra C, Lacerda MVG, Kappe SHI, Sattabongkot J, Gonzalez JR, Mikolajczak SA, Del Portillo HA.

Front Microbiol. 2018 Jun 25;9:1271. doi: 10.3389/fmicb.2018.01271. eCollection 2018.

4.

Author Correction: A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum.

Roth A, Maher SP, Conway AJ, Ubalee R, Chaumeau V, Andolina C, Kaba SA, Vantaux A, Bakowski MA, Thomson-Luque R, Adapa SR, Singh N, Barnes SJ, Cooper CA, Rouillier M, McNamara CW, Mikolajczak SA, Sather N, Witkowski B, Campo B, Kappe SHI, Lanar DE, Nosten F, Davidson S, Jiang RHY, Kyle DE, Adams JH.

Nat Commun. 2018 Jun 8;9(1):2317. doi: 10.1038/s41467-018-04817-1.

5.

A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum.

Roth A, Maher SP, Conway AJ, Ubalee R, Chaumeau V, Andolina C, Kaba SA, Vantaux A, Bakowski MA, Luque RT, Adapa SR, Singh N, Barnes SJ, Cooper CA, Rouillier M, McNamara CW, Mikolajczak SA, Sather N, Witkowski B, Campo B, Kappe SHI, Lanar DE, Nosten F, Davidson S, Jiang RHY, Kyle DE, Adams JH.

Nat Commun. 2018 May 9;9(1):1837. doi: 10.1038/s41467-018-04221-9. Erratum in: Nat Commun. 2018 Jun 8;9(1):2317.

6.

Humanized Mouse Models for the Study of Human Malaria Parasite Biology, Pathogenesis, and Immunity.

Minkah NK, Schafer C, Kappe SHI.

Front Immunol. 2018 Apr 19;9:807. doi: 10.3389/fimmu.2018.00807. eCollection 2018. Review.

7.

Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.

Zander RA, Vijay R, Pack AD, Guthmiller JJ, Graham AC, Lindner SE, Vaughan AM, Kappe SHI, Butler NS.

Cell Rep. 2018 Apr 24;23(4):1230-1237. doi: 10.1016/j.celrep.2018.04.048. No abstract available.

8.

PfCap380 as a marker for Plasmodium falciparum oocyst development in vivo and in vitro.

Itsara LS, Zhou Y, Do J, Dungel S, Fishbaugher ME, Betz WW, Nguyen T, Navarro MJ, Flannery EL, Vaughan AM, Kappe SHI, Ghosh AK.

Malar J. 2018 Apr 2;17(1):135. doi: 10.1186/s12936-018-2277-6.

9.

Plasmodium falciparum Liver Stage Infection and Transition to Stable Blood Stage Infection in Liver-Humanized and Blood-Humanized FRGN KO Mice Enables Testing of Blood Stage Inhibitory Antibodies (Reticulocyte-Binding Protein Homolog 5) In Vivo.

Foquet L, Schafer C, Minkah NK, Alanine DGW, Flannery EL, Steel RWJ, Sack BK, Camargo N, Fishbaugher M, Betz W, Nguyen T, Billman ZP, Wilson EM, Bial J, Murphy SC, Draper SJ, Mikolajczak SA, Kappe SHI.

Front Immunol. 2018 Mar 14;9:524. doi: 10.3389/fimmu.2018.00524. eCollection 2018.

10.

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.

Tan J, Sack BK, Oyen D, Zenklusen I, Piccoli L, Barbieri S, Foglierini M, Fregni CS, Marcandalli J, Jongo S, Abdulla S, Perez L, Corradin G, Varani L, Sallusto F, Sim BKL, Hoffman SL, Kappe SHI, Daubenberger C, Wilson IA, Lanzavecchia A.

Nat Med. 2018 May;24(4):401-407. doi: 10.1038/nm.4513. Epub 2018 Mar 19.

11.

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA.

Nat Med. 2018 May;24(4):408-416. doi: 10.1038/nm.4512. Epub 2018 Mar 19.

12.

In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites.

Gural N, Mancio-Silva L, Miller AB, Galstian A, Butty VL, Levine SS, Patrapuvich R, Desai SP, Mikolajczak SA, Kappe SHI, Fleming HE, March S, Sattabongkot J, Bhatia SN.

Cell Host Microbe. 2018 Mar 14;23(3):395-406.e4. doi: 10.1016/j.chom.2018.01.002. Epub 2018 Feb 22.

PMID:
29478773
13.

A Plasmodium Parasite with Complete Late Liver Stage Arrest Protects against Preerythrocytic and Erythrocytic Stage Infection in Mice.

Vaughan AM, Sack BK, Dankwa D, Minkah N, Nguyen T, Cardamone H, Kappe SHI.

Infect Immun. 2018 Apr 23;86(5). pii: e00088-18. doi: 10.1128/IAI.00088-18. Print 2018 May.

14.

Immunization of Malaria-Preexposed Volunteers With PfSPZ Vaccine Elicits Long-Lived IgM Invasion-Inhibitory and Complement-Fixing Antibodies.

Zenklusen I, Jongo S, Abdulla S, Ramadhani K, Lee Sim BK, Cardamone H, Flannery EL, Nguyen T, Fishbaugher M, Steel RWJ, Betz W, Carmago N, Mikolajczak S, Kappe SHI, Hoffman SL, Sack BK, Daubenberger C.

J Infect Dis. 2018 Apr 23;217(10):1569-1578. doi: 10.1093/infdis/jiy080.

PMID:
29438525
15.

cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.

Hahn WO, Butler NS, Lindner SE, Akilesh HM, Sather DN, Kappe SH, Hamerman JA, Gale M Jr, Liles WC, Pepper M.

JCI Insight. 2018 Jan 25;3(2). pii: 94142. doi: 10.1172/jci.insight.94142. [Epub ahead of print]

16.

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo.

Flannery EL, Foquet L, Chuenchob V, Fishbaugher M, Billman Z, Navarro MJ, Betz W, Olsen TM, Lee J, Camargo N, Nguyen T, Schafer C, Sack BK, Wilson EM, Saunders J, Bial J, Campo B, Charman SA, Murphy SC, Phillips MA, Kappe SH, Mikolajczak SA.

JCI Insight. 2018 Jan 11;3(1). pii: 92587. doi: 10.1172/jci.insight.92587. [Epub ahead of print]

17.

Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice.

Sack BK, Mikolajczak SA, Fishbaugher M, Vaughan AM, Flannery EL, Nguyen T, Betz W, Jane Navarro M, Foquet L, Steel RWJ, Billman ZP, Murphy SC, Hoffman SL, Chakravarty S, Sim BKL, Behet M, Reuling IJ, Walk J, Scholzen A, Sauerwein RW, Ishizuka AS, Flynn B, Seder RA, Kappe SHI.

NPJ Vaccines. 2017 Oct 9;2:27. doi: 10.1038/s41541-017-0028-2. eCollection 2017.

18.

Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversal.

Steel RWJ, Pei Y, Camargo N, Kaushansky A, Dankwa DA, Martinson T, Nguyen T, Betz W, Cardamone H, Vigdorovich V, Dambrauskas N, Carbonetti S, Vaughan AM, Sather DN, Kappe SHI.

Cell Microbiol. 2018 Apr;20(4). doi: 10.1111/cmi.12817. Epub 2018 Jan 12.

PMID:
29253313
19.

A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation.

Murphy SC, Duke ER, Shipman KJ, Jensen RL, Fong Y, Ferguson S, Janes HE, Gillespie K, Seilie AM, Hanron AE, Rinn L, Fishbaugher M, VonGoedert T, Fritzen E, Kappe SH, Chang M, Sousa JC, Marcsisin SR, Chalon S, Duparc S, Kerr N, Möhrle JJ, Andenmatten N, Rueckle T, Kublin JG.

J Infect Dis. 2018 Feb 14;217(5):693-702. doi: 10.1093/infdis/jix613.

PMID:
29216395
20.

Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.

Triller G, Scally SW, Costa G, Pissarev M, Kreschel C, Bosch A, Marois E, Sack BK, Murugan R, Salman AM, Janse CJ, Khan SM, Kappe SHI, Adegnika AA, Mordmüller B, Levashina EA, Julien JP, Wardemann H.

Immunity. 2017 Dec 19;47(6):1197-1209.e10. doi: 10.1016/j.immuni.2017.11.007. Epub 2017 Nov 29.

PMID:
29195810
21.

Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.

Zander RA, Vijay R, Pack AD, Guthmiller JJ, Graham AC, Lindner SE, Vaughan AM, Kappe SHI, Butler NS.

Cell Rep. 2017 Nov 14;21(7):1839-1852. doi: 10.1016/j.celrep.2017.10.077. Erratum in: Cell Rep. 2018 Apr 24;23 (4):1230-1237.

22.

A Global Survey of ATPase Activity in Plasmodium falciparum Asexual Blood Stages and Gametocytes.

Ortega C, Frando A, Webb-Robertson BJ, Anderson LN, Fleck N, Flannery EL, Fishbaugher M, Murphree TA, Hansen JR, Smith RD, Kappe SHI, Wright AT, Grundner C.

Mol Cell Proteomics. 2018 Jan;17(1):111-120. doi: 10.1074/mcp.RA117.000088. Epub 2017 Oct 27.

PMID:
29079720
23.

Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites.

Swearingen KE, Lindner SE, Flannery EL, Vaughan AM, Morrison RD, Patrapuvich R, Koepfli C, Muller I, Jex A, Moritz RL, Kappe SHI, Sattabongkot J, Mikolajczak SA.

PLoS Negl Trop Dis. 2017 Jul 31;11(7):e0005791. doi: 10.1371/journal.pntd.0005791. eCollection 2017 Jul.

24.

Genetically attenuated malaria parasites as vaccines.

Vaughan AM, Kappe SHI.

Expert Rev Vaccines. 2017 Aug;16(8):765-767. doi: 10.1080/14760584.2017.1341835. Epub 2017 Jun 16. No abstract available.

PMID:
28612631
25.

A method for the isolation and characterization of functional murine monoclonal antibodies by single B cell cloning.

Carbonetti S, Oliver BG, Vigdorovich V, Dambrauskas N, Sack B, Bergl E, Kappe SHI, Sather DN.

J Immunol Methods. 2017 Sep;448:66-73. doi: 10.1016/j.jim.2017.05.010. Epub 2017 May 26.

26.

Multiplex, DNase-free one-step reverse transcription PCR for Plasmodium 18S rRNA and spliced gametocyte-specific mRNAs.

Hanron AE, Billman ZP, Seilie AM, Olsen TM, Fishbaugher M, Chang M, Rueckle T, Andenmatten N, Greenhouse B, Arinaitwe E, Rek J, Das S, Domingo GJ, Shipman K, Kappe SH, Kublin JG, Murphy SC.

Malar J. 2017 May 19;16(1):208. doi: 10.1186/s12936-017-1863-3.

27.

Towards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection.

Sack B, Kappe SH, Sather DN.

Expert Rev Vaccines. 2017 May;16(5):403-414. doi: 10.1080/14760584.2017.1295853. Epub 2017 Mar 1. Review.

PMID:
28277097
28.

Malaria Parasite Liver Infection and Exoerythrocytic Biology.

Vaughan AM, Kappe SHI.

Cold Spring Harb Perspect Med. 2017 Jun 1;7(6). pii: a025486. doi: 10.1101/cshperspect.a025486. Review.

PMID:
28242785
29.

Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects.

Kublin JG, Mikolajczak SA, Sack BK, Fishbaugher ME, Seilie A, Shelton L, VonGoedert T, Firat M, Magee S, Fritzen E, Betz W, Kain HS, Dankwa DA, Steel RW, Vaughan AM, Noah Sather D, Murphy SC, Kappe SH.

Sci Transl Med. 2017 Jan 4;9(371). pii: eaad9099. doi: 10.1126/scitranslmed.aad9099.

PMID:
28053159
30.

Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein.

Keitany GJ, Kim KS, Krishnamurty AT, Hondowicz BD, Hahn WO, Dambrauskas N, Sather DN, Vaughan AM, Kappe SHI, Pepper M.

Cell Rep. 2016 Dec 20;17(12):3193-3205. doi: 10.1016/j.celrep.2016.11.060.

31.

The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle.

Arredondo SA, Kappe SHI.

Int J Parasitol. 2017 Jun;47(7):409-423. doi: 10.1016/j.ijpara.2016.10.002. Epub 2016 Nov 27. Review.

32.

An Opsonic Phagocytosis Assay for Plasmodium falciparum Sporozoites.

Steel RW, Sack BK, Tsuji M, Navarro MJ, Betz W, Fishbaugher ME, Flannery EL, Kappe SH.

Clin Vaccine Immunol. 2017 Feb 6;24(2). pii: e00445-16. doi: 10.1128/CVI.00445-16. Print 2017 Feb.

33.
34.

Correction: Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein.

Speake C, Pichugin A, Sahu T, Malkov V, Morrison R, Pei Y, Juompan L, Milman N, Zarling S, Anderson C, MacDonald NJ, Wong-Madden S, Wendler J, Ishizuka A, MacMillen ZW, Garcia V, Kappe SH, Krzych U, Duffy PE.

PLoS One. 2016 Oct 20;11(10):e0165489. doi: 10.1371/journal.pone.0165489. eCollection 2016.

35.

Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein.

Speake C, Pichugin A, Sahu T, Malkov V, Morrison R, Pei Y, Juompan L, Milman N, Zarling S, Anderson C, Wong-Madden S, Wendler J, Ishizuka A, MacMillen ZW, Garcia V, Kappe SH, Krzych U, Duffy PE.

PLoS One. 2016 Jul 19;11(7):e0159449. doi: 10.1371/journal.pone.0159449. eCollection 2016. Erratum in: PLoS One. 2016 Oct 20;11(10 ):e0165489.

36.

Corrigendum: Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.

Ishizuka AS, Lyke KE, DeZure A, Berry AA, Richie TL, Mendoza FH, Enama ME, Gordon IJ, Chang LJ, Sarwar UN, Zephir KL, Holman LA, James ER, Billingsley PF, Gunasekera A, Chakravarty S, Manoj A, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, K C N, Murshedkar T, DeCederfelt H, Plummer SH, Hendel CS, Novik L, Costner PJ, Saunders JG, Laurens MB, Plowe CV, Flynn B, Whalen WR, Todd JP, Noor J, Rao S, Sierra-Davidson K, Lynn GM, Epstein JE, Kemp MA, Fahle GA, Mikolajczak SA, Fishbaugher M, Sack BK, Kappe SH, Davidson SA, Garver LS, Björkström NK, Nason MC, Graham BS, Roederer M, Sim BK, Hoffman SL, Ledgerwood JE, Seder RA; VRC 312 and VRC 314 Study Teams.

Nat Med. 2016 Jun 7;22(6):692. doi: 10.1038/nm0616-692c. No abstract available.

PMID:
27270781
37.

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.

Ishizuka AS, Lyke KE, DeZure A, Berry AA, Richie TL, Mendoza FH, Enama ME, Gordon IJ, Chang LJ, Sarwar UN, Zephir KL, Holman LA, James ER, Billingsley PF, Gunasekera A, Chakravarty S, Manoj A, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, K C N, Murshedkar T, DeCederfelt H, Plummer SH, Hendel CS, Novik L, Costner PJ, Saunders JG, Laurens MB, Plowe CV, Flynn B, Whalen WR, Todd JP, Noor J, Rao S, Sierra-Davidson K, Lynn GM, Epstein JE, Kemp MA, Fahle GA, Mikolajczak SA, Fishbaugher M, Sack BK, Kappe SH, Davidson SA, Garver LS, Björkström NK, Nason MC, Graham BS, Roederer M, Sim BK, Hoffman SL, Ledgerwood JE, Seder RA.

Nat Med. 2016 Jun;22(6):614-23. doi: 10.1038/nm.4110. Epub 2016 May 9. Erratum in: Nat Med. 2016 Jun 7;22(6):692.

PMID:
27158907
38.

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics.

Swearingen KE, Lindner SE, Shi L, Shears MJ, Harupa A, Hopp CS, Vaughan AM, Springer TA, Moritz RL, Kappe SH, Sinnis P.

PLoS Pathog. 2016 Apr 29;12(4):e1005606. doi: 10.1371/journal.ppat.1005606. eCollection 2016 Apr.

39.

A Plasmodium yoelii Mei2-Like RNA Binding Protein Is Essential for Completion of Liver Stage Schizogony.

Dankwa DA, Davis MJ, Kappe SHI, Vaughan AM.

Infect Immun. 2016 Apr 22;84(5):1336-1345. doi: 10.1128/IAI.01417-15. Print 2016 May.

40.

Malaria parasites target the hepatocyte receptor EphA2 for successful host infection.

Kaushansky A, Douglass AN, Arang N, Vigdorovich V, Dambrauskas N, Kain HS, Austin LS, Sather DN, Kappe SH.

Science. 2015 Nov 27;350(6264):1089-92. doi: 10.1126/science.aad3318.

41.

Novel approaches to whole sporozoite vaccination against malaria.

Bijker EM, Borrmann S, Kappe SH, Mordmüller B, Sack BK, Khan SM.

Vaccine. 2015 Dec 22;33(52):7462-8. doi: 10.1016/j.vaccine.2015.09.095. Epub 2015 Oct 23. Review.

42.

Measurement of Antibody-Mediated Reduction of Plasmodium yoelii Liver Burden by Bioluminescent Imaging.

Sack BK, Miller JL, Vaughan AM, Kappe SH.

Methods Mol Biol. 2015;1325:69-80. doi: 10.1007/978-1-4939-2815-6_6.

PMID:
26450380
43.

Flow Cytometry-Based Assessment of Antibody Function Against Malaria Pre-erythrocytic Infection.

Douglass AN, Metzger PG, Kappe SH, Kaushansky A.

Methods Mol Biol. 2015;1325:49-58. doi: 10.1007/978-1-4939-2815-6_4.

PMID:
26450378
44.

Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect.

Li X, Kawamura A, Andrews CD, Miller JL, Wu D, Tsao T, Zhang M, Oren D, Padte NN, Porcelli SA, Wong CH, Kappe SH, Ho DD, Tsuji M.

J Immunol. 2015 Sep 15;195(6):2710-21. doi: 10.4049/jimmunol.1403017. Epub 2015 Aug 7.

45.

Host ER stress during malaria parasite infection.

Kaushansky A, Kappe SH.

EMBO Rep. 2015 Aug;16(8):883-4. doi: 10.15252/embr.201540792. Epub 2015 Jul 2. No abstract available.

46.

A Plasmodium α/β-hydrolase modulates the development of invasive stages.

Groat-Carmona AM, Kain H, Brownell J, Douglass AN, Aly AS, Kappe SH.

Cell Microbiol. 2015 Dec;17(12):1848-67. doi: 10.1111/cmi.12477. Epub 2015 Jul 24.

PMID:
26118838
47.

Selection and refinement: the malaria parasite's infection and exploitation of host hepatocytes.

Kaushansky A, Kappe SH.

Curr Opin Microbiol. 2015 Aug;26:71-8. doi: 10.1016/j.mib.2015.05.013. Epub 2015 Jun 21. Review.

48.

Plasmodium falciparum genetic crosses in a humanized mouse model.

Vaughan AM, Pinapati RS, Cheeseman IH, Camargo N, Fishbaugher M, Checkley LA, Nair S, Hutyra CA, Nosten FH, Anderson TJ, Ferdig MT, Kappe SH.

Nat Methods. 2015 Jul;12(7):631-3. doi: 10.1038/nmeth.3432. Epub 2015 Jun 1.

49.

Mechanisms of stage-transcending protection following immunization of mice with late liver stage-arresting genetically attenuated malaria parasites.

Sack BK, Keitany GJ, Vaughan AM, Miller JL, Wang R, Kappe SH.

PLoS Pathog. 2015 May 14;11(5):e1004855. doi: 10.1371/journal.ppat.1004855. eCollection 2015 May.

50.

Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice.

Mikolajczak SA, Vaughan AM, Kangwanrangsan N, Roobsoong W, Fishbaugher M, Yimamnuaychok N, Rezakhani N, Lakshmanan V, Singh N, Kaushansky A, Camargo N, Baldwin M, Lindner SE, Adams JH, Sattabongkot J, Kappe SH.

Cell Host Microbe. 2015 Apr 8;17(4):526-35. doi: 10.1016/j.chom.2015.02.011. Epub 2015 Mar 19.

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