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Items: 1 to 50 of 176

1.

HCN on Tap: On-Demand Continuous Production of Anhydrous HCN for Organic Synthesis.

Köckinger M, Hone CA, Kappe CO.

Org Lett. 2019 Jul 5;21(13):5326-5330. doi: 10.1021/acs.orglett.9b01941. Epub 2019 Jun 19.

PMID:
31247792
2.

Visible-Light-Mediated Iodoperfluoroalkylation of Alkenes in Flow and Its Application to the Synthesis of a Key Fulvestrant Intermediate.

Rosso C, Williams JD, Filippini G, Prato M, Kappe CO.

Org Lett. 2019 Jul 5;21(13):5341-5345. doi: 10.1021/acs.orglett.9b01992. Epub 2019 Jun 21.

PMID:
31247766
3.

On the reactivity of anodically generated trifluoromethyl radicals toward aryl alkynes in organic/aqueous media.

Jud W, Kappe CO, Cantillo D.

Org Biomol Chem. 2019 Apr 3;17(14):3529-3537. doi: 10.1039/c9ob00456d.

PMID:
30896005
4.

Correction to: The Use of Molecular Oxygen for Liquid Phase Aerobic Oxidations in Continuous Flow.

Hone CA, Kappe CO.

Top Curr Chem (Cham). 2019 Feb 7;377(2):7. doi: 10.1007/s41061-019-0233-8.

PMID:
30729395
5.

Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients.

Aguiar RM, Leão RAC, Mata A, Cantillo D, Kappe CO, Miranda LSM, de Souza ROMA.

Org Biomol Chem. 2019 Feb 6;17(6):1552-1557. doi: 10.1039/c8ob03088j.

PMID:
30693360
6.

Photochemical benzylic bromination in continuous flow using BrCCl3 and its application to telescoped p-methoxybenzyl protection.

Otake Y, Williams JD, Rincón JA, de Frutos O, Mateos C, Kappe CO.

Org Biomol Chem. 2019 Feb 6;17(6):1384-1388. doi: 10.1039/c9ob00044e.

PMID:
30676602
7.

The Use of Molecular Oxygen for Liquid Phase Aerobic Oxidations in Continuous Flow.

Hone CA, Kappe CO.

Top Curr Chem (Cham). 2018 Dec 11;377(1):2. doi: 10.1007/s41061-018-0226-z. Review. Erratum in: Top Curr Chem (Cham). 2019 Feb 7;377(2):7.

8.

Continuous-flow Synthesis of Aryl Aldehydes by Pd-catalyzed Formylation of Aryl Bromides Using Carbon Monoxide and Hydrogen.

Hone CA, Lopatka P, Munday R, O'Kearney-McMullan A, Kappe CO.

ChemSusChem. 2019 Jan 10;12(1):326-337. doi: 10.1002/cssc.201802261. Epub 2018 Nov 13.

9.

Catalyst-Free Oxytrifluoromethylation of Alkenes through Paired Electrolysis in Organic-Aqueous Media.

Jud W, Kappe CO, Cantillo D.

Chemistry. 2018 Nov 22;24(65):17234-17238. doi: 10.1002/chem.201804708. Epub 2018 Oct 30.

PMID:
30285302
10.

My Twenty Years in Microwave Chemistry: From Kitchen Ovens to Microwaves that aren't Microwaves.

Kappe CO.

Chem Rec. 2019 Jan;19(1):15-39. doi: 10.1002/tcr.201800045. Epub 2018 Jun 15. Review.

11.

Continuous multistep synthesis of 2-(azidomethyl)oxazoles.

Rossa TA, Suveges NS, Sá MM, Cantillo D, Kappe CO.

Beilstein J Org Chem. 2018 Feb 23;14:506-514. doi: 10.3762/bjoc.14.36. eCollection 2018.

12.

Lab-scale production of anhydrous diazomethane using membrane separation technology.

Dallinger D, Kappe CO.

Nat Protoc. 2017 Oct;12(10):2138-2147. doi: 10.1038/nprot.2017.046. Epub 2017 Sep 14.

PMID:
28906494
13.

Integration of Bromine and Cyanogen Bromide Generators for the Continuous-Flow Synthesis of Cyclic Guanidines.

Glotz G, Lebl R, Dallinger D, Kappe CO.

Angew Chem Int Ed Engl. 2017 Oct 23;56(44):13786-13789. doi: 10.1002/anie.201708533. Epub 2017 Oct 2.

PMID:
28877406
14.

Design and Performance Validation of a Conductively Heated Sealed-Vessel Reactor for Organic Synthesis.

Obermayer D, Znidar D, Glotz G, Stadler A, Dallinger D, Kappe CO.

J Org Chem. 2016 Dec 2;81(23):11788-11801. Epub 2016 Nov 18.

PMID:
27934447
15.

The Use of Molecular Oxygen in Pharmaceutical Manufacturing: Is Flow the Way to Go?

Hone CA, Roberge DM, Kappe CO.

ChemSusChem. 2017 Jan 10;10(1):32-41. doi: 10.1002/cssc.201601321. Epub 2016 Nov 16.

PMID:
27863103
16.

Continuous Flow Homolytic Aromatic Substitution with Electrophilic Radicals: A Fast and Scalable Protocol for Trifluoromethylation.

Monteiro JL, Carneiro PF, Elsner P, Roberge DM, Wuts PG, Kurjan KC, Gutmann B, Kappe CO.

Chemistry. 2017 Jan 1;23(1):176-186. doi: 10.1002/chem.201604579. Epub 2016 Dec 2.

PMID:
27775849
17.
18.

Laboratory-Scale Membrane Reactor for the Generation of Anhydrous Diazomethane.

Dallinger D, Pinho VD, Gutmann B, Kappe CO.

J Org Chem. 2016 Jul 15;81(14):5814-23. doi: 10.1021/acs.joc.6b01190. Epub 2016 Jul 5.

PMID:
27359257
19.

Batch- and Continuous-Flow Aerobic Oxidation of 14-Hydroxy Opioids to 1,3-Oxazolidines-A Concise Synthesis of Noroxymorphone.

Gutmann B, Weigl U, Cox DP, Kappe CO.

Chemistry. 2016 Jul 18;22(30):10393-8. doi: 10.1002/chem.201601902. Epub 2016 Jun 21.

PMID:
27172347
20.

Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies.

Pieber B, Kappe CO.

Org Lett. 2016 Mar 4;18(5):1076-9. doi: 10.1021/acs.orglett.6b00194. Epub 2016 Feb 23.

PMID:
26902154
21.

Diazo Strategy for the Synthesis of Pyridazines: Pivotal Impact of the Configuration of the Diazo Precursor on the Process.

Nikolaev VA, Cantillo D, Kappe CO, Medvedev JJ, Prakash GK, Supurgibekov MB.

Chemistry. 2016 Jan 4;22(1):174-84. doi: 10.1002/chem.201503448. Epub 2015 Nov 25.

PMID:
26603264
22.

Light-Induced C-H Arylation of (Hetero)arenes by In Situ Generated Diazo Anhydrides.

Cantillo D, Mateos C, Rincon JA, de Frutos O, Kappe CO.

Chemistry. 2015 Sep 7;21(37):12894-8. doi: 10.1002/chem.201502357. Epub 2015 Aug 3.

PMID:
26239967
23.

Continuous-flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients.

Gutmann B, Cantillo D, Kappe CO.

Angew Chem Int Ed Engl. 2015 Jun 1;54(23):6688-728. doi: 10.1002/anie.201409318. Epub 2015 May 18. Review.

PMID:
25989203
24.

A sequential Ugi multicomponent/Cu-catalyzed azide-alkyne cycloaddition approach for the continuous flow generation of cyclic peptoids.

Salvador CE, Pieber B, Neu PM, Torvisco A, Kleber Z Andrade C, Kappe CO.

J Org Chem. 2015 May 1;80(9):4590-602. doi: 10.1021/acs.joc.5b00445. Epub 2015 Apr 13.

PMID:
25842982
25.

Continuous flow reduction of artemisinic acid utilizing multi-injection strategies-closing the gap towards a fully continuous synthesis of antimalarial drugs.

Pieber B, Glasnov T, Kappe CO.

Chemistry. 2015 Mar 9;21(11):4368-76. doi: 10.1002/chem.201406439. Epub 2015 Feb 5.

PMID:
25655090
26.

TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1.

Doleschal B, Primessnig U, Wölkart G, Wolf S, Schernthaner M, Lichtenegger M, Glasnov TN, Kappe CO, Mayer B, Antoons G, Heinzel F, Poteser M, Groschner K.

Cardiovasc Res. 2015 Apr 1;106(1):163-73. doi: 10.1093/cvr/cvv022. Epub 2015 Jan 28.

27.

Singlet-oxygen oxidation of 5-hydroxymethylfurfural in continuous flow.

Heugebaert TS, Stevens CV, Kappe CO.

ChemSusChem. 2015 May 22;8(10):1648-51. doi: 10.1002/cssc.201403182. Epub 2014 Dec 11.

PMID:
25505009
28.

Immobilized iron oxide nanoparticles as stable and reusable catalysts for hydrazine-mediated nitro reductions in continuous flow.

Moghaddam MM, Pieber B, Glasnov T, Kappe CO.

ChemSusChem. 2014 Nov;7(11):3122-31. doi: 10.1002/cssc.201402455. Epub 2014 Sep 10.

PMID:
25209099
29.

Shifting chemical equilibria in flow--efficient decarbonylation driven by annular flow regimes.

Gutmann B, Elsner P, Glasnov T, Roberge DM, Kappe CO.

Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11557-61. doi: 10.1002/anie.201407219. Epub 2014 Sep 4.

PMID:
25196172
30.

A continuous-flow protocol for light-induced benzylic fluorinations.

Cantillo D, de Frutos O, Rincón JA, Mateos C, Kappe CO.

J Org Chem. 2014 Sep 5;79(17):8486-90. doi: 10.1021/jo5016757. Epub 2014 Aug 26.

PMID:
25144336
31.

Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids.

Hofbauer HF, Schopf FH, Schleifer H, Knittelfelder OL, Pieber B, Rechberger GN, Wolinski H, Gaspar ML, Kappe CO, Stadlmann J, Mechtler K, Zenz A, Lohner K, Tehlivets O, Henry SA, Kohlwein SD.

Dev Cell. 2014 Jun 23;29(6):729-39. doi: 10.1016/j.devcel.2014.04.025.

32.

Anthropogenic reaction parameters--the missing link between chemical intuition and the available chemical space.

Keserű GM, Soós T, Kappe CO.

Chem Soc Rev. 2014 Aug 7;43(15):5387-99. doi: 10.1039/c3cs60423c.

PMID:
24877159
33.

Continuous flow synthesis of α-halo ketones: essential building blocks of antiretroviral agents.

Pinho VD, Gutmann B, Miranda LS, de Souza RO, Kappe CO.

J Org Chem. 2014 Feb 21;79(4):1555-62. doi: 10.1021/jo402849z. Epub 2014 Feb 4.

34.

Continuous flow α-trifluoromethylation of ketones by metal-free visible light photoredox catalysis.

Cantillo D, de Frutos O, Rincón JA, Mateos C, Kappe CO.

Org Lett. 2014 Feb 7;16(3):896-9. doi: 10.1021/ol403650y. Epub 2014 Jan 16.

PMID:
24432711
35.

Effect of configuration of 2-vinyldiazocarbonyl compounds on their reactivity: experimental and computational study.

Supurgibekov MB, Cantillo D, Kappe CO, Prakash GK, Nikolaev VA.

Org Biomol Chem. 2014 Jan 28;12(4):682-9. doi: 10.1039/c3ob42102c.

PMID:
24302300
36.

A scalable procedure for light-induced benzylic brominations in continuous flow.

Cantillo D, de Frutos O, Rincon JA, Mateos C, Kappe CO.

J Org Chem. 2014 Jan 3;79(1):223-9. doi: 10.1021/jo402409k. Epub 2013 Nov 27.

PMID:
24261546
37.

A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir.

Dalla-Vechia L, Reichart B, Glasnov T, Miranda LS, Kappe CO, de Souza RO.

Org Biomol Chem. 2013 Oct 21;11(39):6806-13. doi: 10.1039/c3ob41464g.

PMID:
24175328
38.

Simulating microwave chemistry in a resistance-heated autoclave made of semiconducting silicon carbide ceramic.

Obermayer D, Damm M, Kappe CO.

Chemistry. 2013 Nov 18;19(47):15827-30. doi: 10.1002/chem.201303638. Epub 2013 Oct 15. No abstract available.

PMID:
24130085
39.

Continuous flow generation and reactions of anhydrous diazomethane using a Teflon AF-2400 tube-in-tube reactor.

Mastronardi F, Gutmann B, Kappe CO.

Org Lett. 2013 Nov 1;15(21):5590-3. doi: 10.1021/ol4027914. Epub 2013 Oct 15.

PMID:
24128181
40.

Direct preparation of nitriles from carboxylic acids in continuous flow.

Cantillo D, Kappe CO.

J Org Chem. 2013 Oct 18;78(20):10567-71. doi: 10.1021/jo401945r. Epub 2013 Oct 8.

PMID:
24066706
41.

In situ generation of diimide from hydrazine and oxygen: continuous-flow transfer hydrogenation of olefins.

Pieber B, Martinez ST, Cantillo D, Kappe CO.

Angew Chem Int Ed Engl. 2013 Sep 23;52(39):10241-4. doi: 10.1002/anie.201303528. Epub 2013 Aug 14. No abstract available.

PMID:
23946202
42.

Continuous-flow synthesis of CdSe quantum dots: a size-tunable and scalable approach.

Mirhosseini Moghaddam M, Baghbanzadeh M, Sadeghpour A, Glatter O, Kappe CO.

Chemistry. 2013 Aug 26;19(35):11629-36. doi: 10.1002/chem.201301117. Epub 2013 Jul 15.

PMID:
23857757
43.

Reply to the Correspondence on microwave effects in organic synthesis.

Kappe CO.

Angew Chem Int Ed Engl. 2013 Jul 29;52(31):7924-8. doi: 10.1002/anie.201304368. Epub 2013 Jul 3. No abstract available.

PMID:
23825030
44.

Design and evaluation of improved magnetic stir bars for single-mode microwave reactors.

Obermayer D, Damm M, Kappe CO.

Org Biomol Chem. 2013 Aug 14;11(30):4949-56. doi: 10.1039/c3ob40790j. Epub 2013 Jun 25.

PMID:
23797332
45.

Continuous-flow synthesis of adipic acid from cyclohexene using hydrogen peroxide in high-temperature explosive regimes.

Damm M, Gutmann B, Kappe CO.

ChemSusChem. 2013 Jun;6(6):978-82. doi: 10.1002/cssc.201300197. Epub 2013 Apr 16.

PMID:
23592635
46.

Hydrazine-mediated reduction of nitro and azide functionalities catalyzed by highly active and reusable magnetic iron oxide nanocrystals.

Cantillo D, Moghaddam MM, Kappe CO.

J Org Chem. 2013 May 3;78(9):4530-42. doi: 10.1021/jo400556g. Epub 2013 Apr 15.

PMID:
23560824
47.

In situ preparation of silver nanocomposites on cellulosic fibers--microwave vs. conventional heating.

Breitwieser D, Moghaddam MM, Spirk S, Baghbanzadeh M, Pivec T, Fasl H, Ribitsch V, Kappe CO.

Carbohydr Polym. 2013 Apr 15;94(1):677-86. doi: 10.1016/j.carbpol.2013.01.077. Epub 2013 Feb 7.

PMID:
23544590
48.

Unraveling the mysteries of microwave chemistry using silicon carbide reactor technology.

Kappe CO.

Acc Chem Res. 2013 Jul 16;46(7):1579-87. doi: 10.1021/ar300318c. Epub 2013 Mar 6. Review.

PMID:
23463987
49.

How to measure reaction temperature in microwave-heated transformations.

Kappe CO.

Chem Soc Rev. 2013 Jun 21;42(12):4977-90. doi: 10.1039/c3cs00010a.

PMID:
23443140
50.

Microwave effects in organic synthesis: myth or reality?

Kappe CO, Pieber B, Dallinger D.

Angew Chem Int Ed Engl. 2013 Jan 21;52(4):1088-94. doi: 10.1002/anie.201204103. Epub 2012 Dec 7. No abstract available.

PMID:
23225754

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