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Items: 1 to 50 of 104

1.

Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.

Pisa R, Cupido T, Steinman JB, Jones NH, Kapoor TM.

Cell Chem Biol. 2019 Sep 19;26(9):1263-1273.e5. doi: 10.1016/j.chembiol.2019.06.001. Epub 2019 Jun 27.

PMID:
31257183
2.

High-resolution imaging reveals how the spindle midzone impacts chromosome movement.

Pamula MC, Carlini L, Forth S, Verma P, Suresh S, Legant WR, Khodjakov A, Betzig E, Kapoor TM.

J Cell Biol. 2019 Aug 5;218(8):2529-2544. doi: 10.1083/jcb.201904169. Epub 2019 Jun 27.

PMID:
31248912
3.

Using chemical inhibitors to probe AAA protein conformational dynamics and cellular functions.

Steinman JB, Kapoor TM.

Curr Opin Chem Biol. 2019 Jun;50:45-54. doi: 10.1016/j.cbpa.2019.02.019. Epub 2019 Mar 23. Review.

PMID:
30913482
4.

Designing Allele-Specific Inhibitors of Spastin, a Microtubule-Severing AAA Protein.

Pisa R, Cupido T, Kapoor TM.

J Am Chem Soc. 2019 Apr 10;141(14):5602-5606. doi: 10.1021/jacs.8b13257. Epub 2019 Mar 27.

PMID:
30875216
5.

Designing a chemical inhibitor for the AAA protein spastin using active site mutations.

Cupido T, Pisa R, Kelley ME, Kapoor TM.

Nat Chem Biol. 2019 May;15(5):444-452. doi: 10.1038/s41589-019-0225-6. Epub 2019 Feb 18.

6.

Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis.

Chen Z, Suzuki H, Kobayashi Y, Wang AC, DiMaio F, Kawashima SA, Walz T, Kapoor TM.

Cell. 2018 Oct 18;175(3):822-834.e18. doi: 10.1016/j.cell.2018.09.015. Epub 2018 Oct 11.

7.

Human β-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability.

Ti SC, Alushin GM, Kapoor TM.

Dev Cell. 2018 Oct 22;47(2):175-190.e5. doi: 10.1016/j.devcel.2018.08.014. Epub 2018 Sep 20.

8.

Analyzing the micromechanics of the cell division apparatus.

Shimamoto Y, Kapoor TM.

Methods Cell Biol. 2018;145:173-190. doi: 10.1016/bs.mcb.2018.03.022. Epub 2018 May 1.

9.

A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells.

Kleiner RE, Hang LE, Molloy KR, Chait BT, Kapoor TM.

Cell Chem Biol. 2018 Jan 18;25(1):110-120.e3. doi: 10.1016/j.chembiol.2017.10.001. Epub 2017 Nov 5.

10.

Leveraging Chemotype-Specific Resistance for Drug Target Identification and Chemical Biology.

Kapoor TM, Miller RM.

Trends Pharmacol Sci. 2017 Dec;38(12):1100-1109. doi: 10.1016/j.tips.2017.09.003. Epub 2017 Oct 13. Review.

11.

Comparison of the Lupus Foundation of America-Rapid Evaluation of Activity in Lupus to More Complex Disease Activity Instruments As Evaluated by Clinical Investigators or Real-World Clinicians.

Askanase AD, Nguyen SC, Costenbader K, Lim SS, Kamen D, Aranow C, Grossman J, Kapoor TM, Baker-Frost D, Aberle T, Thanou-Stavraki A, Hanrahan LM, Kim M, Merrill JT.

Arthritis Care Res (Hoboken). 2018 Jul;70(7):1058-1063. doi: 10.1002/acr.23445. Epub 2018 May 21.

12.

Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action.

Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM.

Elife. 2017 May 19;6. pii: e25174. doi: 10.7554/eLife.25174.

13.

The mechanics of microtubule networks in cell division.

Forth S, Kapoor TM.

J Cell Biol. 2017 Jun 5;216(6):1525-1531. doi: 10.1083/jcb.201612064. Epub 2017 May 10. Review.

14.

Low prevalence of Pneumocystis pneumonia in hospitalized patients with systemic lupus erythematosus: review of a clinical data warehouse.

Kapoor TM, Mahadeshwar P, Nguyen S, Li J, Kapoor S, Bathon J, Giles J, Askanase A.

Lupus. 2017 Dec;26(14):1473-1482. doi: 10.1177/0961203317703494. Epub 2017 Apr 11.

PMID:
28399687
15.

Metaphase Spindle Assembly.

Kapoor TM.

Biology (Basel). 2017 Feb 3;6(1). pii: E8. doi: 10.3390/biology6010008. Review.

16.

Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis.

Kawashima SA, Chen Z, Aoi Y, Patgiri A, Kobayashi Y, Nurse P, Kapoor TM.

Cell. 2016 Oct 6;167(2):512-524.e14. doi: 10.1016/j.cell.2016.08.070. Epub 2016 Sep 22.

17.

Near-atomic cryo-EM structure of PRC1 bound to the microtubule.

Kellogg EH, Howes S, Ti SC, Ramírez-Aportela E, Kapoor TM, Chacón P, Nogales E.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9430-9. doi: 10.1073/pnas.1609903113. Epub 2016 Aug 4.

18.

The structured core of human β tubulin confers isotype-specific polymerization properties.

Pamula MC, Ti SC, Kapoor TM.

J Cell Biol. 2016 May 23;213(4):425-33. doi: 10.1083/jcb.201603050. Epub 2016 May 16.

19.

Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.

Ti SC, Pamula MC, Howes SC, Duellberg C, Cade NI, Kleiner RE, Forth S, Surrey T, Nogales E, Kapoor TM.

Dev Cell. 2016 Apr 4;37(1):72-84. doi: 10.1016/j.devcel.2016.03.003.

20.

Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity.

See SK, Hoogendoorn S, Chung AH, Ye F, Steinman JB, Sakata-Kato T, Miller RM, Cupido T, Zalyte R, Carter AP, Nachury MV, Kapoor TM, Chen JK.

ACS Chem Biol. 2016 Jan 15;11(1):53-60. doi: 10.1021/acschembio.5b00895. Epub 2015 Nov 11.

21.

Measuring Pushing and Braking Forces Generated by Ensembles of Kinesin-5 Crosslinking Two Microtubules.

Shimamoto Y, Forth S, Kapoor TM.

Dev Cell. 2015 Sep 28;34(6):669-81. doi: 10.1016/j.devcel.2015.08.017.

22.

Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response.

Kleiner RE, Verma P, Molloy KR, Chait BT, Kapoor TM.

Nat Chem Biol. 2015 Oct;11(10):807-14. doi: 10.1038/nchembio.1908. Epub 2015 Sep 7.

23.

Reconstitution of the augmin complex provides insights into its architecture and function.

Hsia KC, Wilson-Kubalek EM, Dottore A, Hao Q, Tsai KL, Forth S, Shimamoto Y, Milligan RA, Kapoor TM.

Nat Cell Biol. 2014 Sep;16(9):852-63. doi: 10.1038/ncb3030. Epub 2014 Aug 31.

24.

Direct kinetochore-spindle pole connections are not required for chromosome segregation.

Sikirzhytski V, Magidson V, Steinman JB, He J, Le Berre M, Tikhonenko I, Ault JG, McEwen BF, Chen JK, Sui H, Piel M, Kapoor TM, Khodjakov A.

J Cell Biol. 2014 Jul 21;206(2):231-43. doi: 10.1083/jcb.201401090. Epub 2014 Jul 14.

25.

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.

He M, Subramanian R, Bangs F, Omelchenko T, Liem KF Jr, Kapoor TM, Anderson KV.

Nat Cell Biol. 2014 Jul;16(7):663-72. doi: 10.1038/ncb2988. Epub 2014 Jun 22.

26.

DrugTargetSeqR: a genomics- and CRISPR-Cas9-based method to analyze drug targets.

Kasap C, Elemento O, Kapoor TM.

Nat Chem Biol. 2014 Aug;10(8):626-8. doi: 10.1038/nchembio.1551. Epub 2014 Jun 15.

27.

Asymmetric friction of nonmotor MAPs can lead to their directional motion in active microtubule networks.

Forth S, Hsia KC, Shimamoto Y, Kapoor TM.

Cell. 2014 Apr 10;157(2):420-432. doi: 10.1016/j.cell.2014.02.018.

28.

Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors.

Kashyap S, Sandler J, Peters U, Martinez EJ, Kapoor TM.

Bioorg Med Chem. 2014 Apr 1;22(7):2253-60. doi: 10.1016/j.bmc.2014.02.024. Epub 2014 Feb 28.

29.

Dissecting the first and the second meiotic divisions using a marker-less drug-hypersensitive fission yeast.

Aoi Y, Sato M, Sutani T, Shirahige K, Kapoor TM, Kawashima SA.

Cell Cycle. 2014;13(8):1327-34. doi: 10.4161/cc.28294. Epub 2014 Mar 3.

30.

Micromechanics of the vertebrate meiotic spindle examined by stretching along the pole-to-pole axis.

Takagi J, Itabashi T, Suzuki K, Shimamoto Y, Kapoor TM, Ishiwata S.

Biophys J. 2014 Feb 4;106(3):735-40. doi: 10.1016/j.bpj.2013.12.033.

31.

Slipping past the spindle assembly checkpoint.

Subramanian R, Kapoor TM.

Nat Cell Biol. 2013 Nov;15(11):1261-3. doi: 10.1038/ncb2876.

PMID:
24189515
32.

Using micromanipulation to analyze control of vertebrate meiotic spindle size.

Takagi J, Itabashi T, Suzuki K, Kapoor TM, Shimamoto Y, Ishiwata S.

Cell Rep. 2013 Oct 17;5(1):44-50. doi: 10.1016/j.celrep.2013.09.021. Epub 2013 Oct 10.

33.

Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage.

Yi J, Wu X, Chung AH, Chen JK, Kapoor TM, Hammer JA.

J Cell Biol. 2013 Sep 2;202(5):779-92. doi: 10.1083/jcb.201301004. Epub 2013 Aug 26.

34.

Bumping up kinase activity with an ATP-derived neo-substrate.

Kleiner RE, Kapoor TM.

Cell. 2013 Aug 15;154(4):716-8. doi: 10.1016/j.cell.2013.07.043.

35.

Site-specific chemistry on the microtubule polymer.

Kleiner RE, Ti SC, Kapoor TM.

J Am Chem Soc. 2013 Aug 28;135(34):12520-3. doi: 10.1021/ja405199h. Epub 2013 Aug 15.

36.

Marking and measuring single microtubules by PRC1 and kinesin-4.

Subramanian R, Ti SC, Tan L, Darst SA, Kapoor TM.

Cell. 2013 Jul 18;154(2):377-90. doi: 10.1016/j.cell.2013.06.021. Erratum in: Cell. 2013 Nov 21;155(5):1188.

37.

Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II.

Liu X, Kapoor TM, Chen JK, Huse M.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11976-81. doi: 10.1073/pnas.1306180110. Epub 2013 Jul 1.

38.

A chemical biology strategy to analyze rheostat-like protein kinase-dependent regulation.

Kawashima SA, Takemoto A, Nurse P, Kapoor TM.

Chem Biol. 2013 Feb 21;20(2):262-71. doi: 10.1016/j.chembiol.2013.01.003.

39.

Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach.

Li X, Foley EA, Kawashima SA, Molloy KR, Li Y, Chait BT, Kapoor TM.

Protein Sci. 2013 Mar;22(3):287-95. doi: 10.1002/pro.2210. Epub 2013 Jan 27.

40.

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore.

Foley EA, Kapoor TM.

Nat Rev Mol Cell Biol. 2013 Jan;14(1):25-37. doi: 10.1038/nrm3494. Review.

41.

Building complexity: insights into self-organized assembly of microtubule-based architectures.

Subramanian R, Kapoor TM.

Dev Cell. 2012 Nov 13;23(5):874-85. doi: 10.1016/j.devcel.2012.10.011. Review.

42.

An optical switch for a motor protein.

Li X, Kapoor TM.

Chembiochem. 2011 Oct 17;12(15):2265-6.

43.

Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Kawashima SA, Takemoto A, Nurse P, Kapoor TM.

Chem Biol. 2012 Jul 27;19(7):893-901. doi: 10.1016/j.chembiol.2012.06.008.

44.

Microneedle-based analysis of the micromechanics of the metaphase spindle assembled in Xenopus laevis egg extracts.

Shimamoto Y, Kapoor TM.

Nat Protoc. 2012 Apr 26;7(5):959-69. doi: 10.1038/nprot.2012.033.

45.

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.

Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK.

Nature. 2012 Mar 18;484(7392):125-9. doi: 10.1038/nature10936.

46.

Using transcriptome sequencing to identify mechanisms of drug action and resistance.

Wacker SA, Houghtaling BR, Elemento O, Kapoor TM.

Nat Chem Biol. 2012 Feb 12;8(3):235-7. doi: 10.1038/nchembio.779.

47.

Quantitative chemical proteomics approach to identify post-translational modification-mediated protein-protein interactions.

Li X, Foley EA, Molloy KR, Li Y, Chait BT, Kapoor TM.

J Am Chem Soc. 2012 Feb 1;134(4):1982-5. doi: 10.1021/ja210528v. Epub 2012 Jan 24.

48.

Examining the dynamics of chromosomal passenger complex (CPC)-dependent phosphorylation during cell division.

Tan L, Kapoor TM.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16675-80. doi: 10.1073/pnas.1106748108. Epub 2011 Sep 26.

49.

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase.

Foley EA, Maldonado M, Kapoor TM.

Nat Cell Biol. 2011 Aug 28;13(10):1265-71. doi: 10.1038/ncb2327.

50.

Examining the mechanism of action of a kinesin inhibitor using stable isotope labeled inhibitors for cross-linking (SILIC).

Wacker SA, Kashyap S, Li X, Kapoor TM.

J Am Chem Soc. 2011 Aug 17;133(32):12386-9. doi: 10.1021/ja204561q. Epub 2011 Jul 21.

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