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Items: 10


Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8+ T Cell Survival, Differentiation, and Function.

Cannons JL, Preite S, Kapnick SM, Uzel G, Schwartzberg PL.

Front Immunol. 2018 Aug 2;9:1758. doi: 10.3389/fimmu.2018.01758. eCollection 2018.


The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism.

Kapnick SM, Pacheco SE, McGuire PJ.

Metabolism. 2018 Apr;81:97-112. doi: 10.1016/j.metabol.2017.11.010. Epub 2017 Nov 21. Review.


Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.

Ritter AT, Kapnick SM, Murugesan S, Schwartzberg PL, Griffiths GM, Lippincott-Schwartz J.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6585-E6594. doi: 10.1073/pnas.1710751114. Epub 2017 Jul 17.


Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and Differentiation.

Tarasenko TN, Pacheco SE, Koenig MK, Gomez-Rodriguez J, Kapnick SM, Diaz F, Zerfas PM, Barca E, Sudderth J, DeBerardinis RJ, Covian R, Balaban RS, DiMauro S, McGuire PJ.

Cell Metab. 2017 Jun 6;25(6):1254-1268.e7. doi: 10.1016/j.cmet.2017.05.007.


Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs.

Kapnick SM, Stinchcombe JC, Griffiths GM, Schwartzberg PL.

J Immunol. 2017 Apr 1;198(7):2699-2711. doi: 10.4049/jimmunol.1601202. Epub 2017 Feb 17.


Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.

Ruffo E, Malacarne V, Larsen SE, Das R, Patrussi L, Wülfing C, Biskup C, Kapnick SM, Verbist K, Tedrick P, Schwartzberg PL, Baldari CT, Rubio I, Nichols KE, Snow AL, Baldanzi G, Graziani A.

Sci Transl Med. 2016 Jan 13;8(321):321ra7. doi: 10.1126/scitranslmed.aad1565.


Discoidin domain receptor 2 regulates neutrophil chemotaxis in 3D collagen matrices.

Afonso PV, McCann CP, Kapnick SM, Parent CA.

Blood. 2013 Feb 28;121(9):1644-50. doi: 10.1182/blood-2012-08-451575. Epub 2012 Dec 11.


Passive immunotherapies protect WRvFire and IHD-J-Luc vaccinia virus-infected mice from lethality by reducing viral loads in the upper respiratory tract and internal organs.

Zaitseva M, Kapnick SM, Meseda CA, Shotwell E, King LR, Manischewitz J, Scott J, Kodihalli S, Merchlinsky M, Nielsen H, Lantto J, Weir JP, Golding H.

J Virol. 2011 Sep;85(17):9147-58. doi: 10.1128/JVI.00121-11. Epub 2011 Jun 29.


Application of bioluminescence imaging to the prediction of lethality in vaccinia virus-infected mice.

Zaitseva M, Kapnick SM, Scott J, King LR, Manischewitz J, Sirota L, Kodihalli S, Golding H.

J Virol. 2009 Oct;83(20):10437-47. doi: 10.1128/JVI.01296-09. Epub 2009 Aug 5.


New tuberculosis drug development: targeting the shikimate pathway.

Kapnick SM, Zhang Y.

Expert Opin Drug Discov. 2008 May;3(5):565-77. doi: 10.1517/17460441.3.5.565.


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