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Route of Oseltamivir Administration Affects Metabolite Concentrations in Critically Ill Children.

Tang Girdwood SC, Mizuno T, Krallman KA, Benken LA, Stoneman EM, Yunger TM, Wong HR, Vinks AA, Kaplan JM.

Pediatr Infect Dis J. 2019 Dec;38(12):1224-1227. doi: 10.1097/INF.0000000000002473.


A Hyperactive Form of unc-13 Enhances Ca2+ Sensitivity and Synaptic Vesicle Release Probability in C. elegans.

Li L, Liu H, Hall Q, Wang W, Yu Y, Kaplan JM, Hu Z.

Cell Rep. 2019 Sep 10;28(11):2979-2995.e4. doi: 10.1016/j.celrep.2019.08.018.


A Case of Methotrexate Neurotoxicity Presented as Status Epilepticus, Encephalopathy, and High Fever.

Ayalon I, Friedman S, Binenbaum Y, Oppenheimer N, Shiran S, Grisaru-Soen G, Uliel-Sibony S, Glatstein M, Kaplan JM, Sadot E.

J Investig Med High Impact Case Rep. 2019 Jan-Dec;7:2324709619862311. doi: 10.1177/2324709619862311.


A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer's Disease.

Gibbs E, Silverman JM, Zhao B, Peng X, Wang J, Wellington CL, Mackenzie IR, Plotkin SS, Kaplan JM, Cashman NR.

Sci Rep. 2019 Jul 8;9(1):9870. doi: 10.1038/s41598-019-46306-5.


Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans.

Liu H, Li L, Nedelcu D, Hall Q, Zhou L, Wang W, Yu Y, Kaplan JM, Hu Z.

Elife. 2019 Feb 25;8. pii: e40585. doi: 10.7554/eLife.40585.


Clinical and genetic analysis in a large Chinese cohort of patients with X-linked hypophosphatemia.

Zhang C, Zhao Z, Sun Y, Xu L, JiaJue R, Cui L, Pang Q, Jiang Y, Li M, Wang O, He X, He S, Nie M, Xing X, Meng X, Zhou X, Yan L, Kaplan JM, Insogna KL, Xia W.

Bone. 2019 Apr;121:212-220. doi: 10.1016/j.bone.2019.01.021. Epub 2019 Jan 23.


Sepsis Induces Adipose Tissue Browning in Nonobese Mice But Not in Obese Mice.

Ayalon I, Shen H, Williamson L, Stringer K, Zingarelli B, Kaplan JM.

Shock. 2018 Nov;50(5):557-564. doi: 10.1097/SHK.0000000000001076.


Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial.

Kaplan JM, Zingarelli B, Krallman K, Tang Girdwood S, Lagory D, Mizuno T, Fei L, Wong HR, Vinks AA.

Intensive Care Med. 2018 Nov;44(11):2006-2008. doi: 10.1007/s00134-018-5374-7. Epub 2018 Sep 25. No abstract available.


Axonal Mitochondria Modulate Neuropeptide Secretion Through the Hypoxic Stress Response in Caenorhabditis elegans.

Zhao T, Hao Y, Kaplan JM.

Genetics. 2018 Sep;210(1):275-285. doi: 10.1534/genetics.118.301014. Epub 2018 Jul 26.


Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide.

Hao Y, Yang W, Ren J, Hall Q, Zhang Y, Kaplan JM.

Elife. 2018 Jul 17;7. pii: e36833. doi: 10.7554/eLife.36833.


Ethical Guidelines for Genetic Research on Alcohol Addiction and Its Applications.

Chapman AR, Carter A, Kaplan JM, Morphett K, Hall W.

Kennedy Inst Ethics J. 2018;28(1):1-22. doi: 10.1353/ken.2018.0000.


Hypoxia-Inducible Factor and Its Role in the Management of Anemia in Chronic Kidney Disease.

Kaplan JM, Sharma N, Dikdan S.

Int J Mol Sci. 2018 Jan 29;19(2). pii: E389. doi: 10.3390/ijms19020389. Review.


Retrograde Synaptic Inhibition Is Mediated by α-Neurexin Binding to the α2δ Subunits of N-Type Calcium Channels.

Tong XJ, López-Soto EJ, Li L, Liu H, Nedelcu D, Lipscombe D, Hu Z, Kaplan JM.

Neuron. 2017 Jul 19;95(2):326-340.e5. doi: 10.1016/j.neuron.2017.06.018. Epub 2017 Jun 29.


High fat diet-induced obesity increases myocardial injury and alters cardiac STAT3 signaling in mice after polymicrobial sepsis.

DeMartini T, Nowell M, James J, Williamson L, Lahni P, Shen H, Kaplan JM.

Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt B):2654-2660. doi: 10.1016/j.bbadis.2017.06.008. Epub 2017 Jun 15.


Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression.

Pym E, Sasidharan N, Thompson-Peer KL, Simon DJ, Anselmo A, Sadreyev R, Hall Q, Nurrish S, Kaplan JM.

Elife. 2017 May 6;6. pii: e18931. doi: 10.7554/eLife.18931.


What's New in Shock, May 2017?

Zingarelli B, Kaplan JM.

Shock. 2017 May;47(5):533-536. doi: 10.1097/SHK.0000000000000840. No abstract available.


The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion.

Chen D, Taylor KP, Hall Q, Kaplan JM.

Genetics. 2016 Nov;204(3):1151-1159. doi: 10.1534/genetics.116.192898. Epub 2016 Aug 31.


Obesity enhances sepsis-induced liver inflammation and injury in mice.

Kaplan JM, Nowell M, Lahni P, Shen H, Shanmukhappa SK, Zingarelli B.

Obesity (Silver Spring). 2016 Jul;24(7):1480-8. doi: 10.1002/oby.21504. Epub 2016 May 13.


A Case of Salicylate Intoxication Complicated by Coagulopathy, Pulmonary Edema, and Pancreatitis.

Ayalon I, Alder MN, Langner TR, Hafberg ET, Miethke AG, Kaplan JM.

Am J Ther. 2016 Nov/Dec;23(6):e1929-e1932. Review.


A network of autism linked genes stabilizes two pools of synaptic GABA(A) receptors.

Tong XJ, Hu Z, Liu Y, Anderson D, Kaplan JM.

Elife. 2015 Nov 17;4:e09648. doi: 10.7554/eLife.09648.


Higher-volume hypertonic saline and increased thrombotic risk in pediatric traumatic brain injury.

Webster DL, Fei L, Falcone RA, Kaplan JM.

J Crit Care. 2015 Dec;30(6):1267-71. doi: 10.1016/j.jcrc.2015.07.022. Epub 2015 Jul 29.


Reduction of inflammation and preservation of neurological function by anti-CD52 therapy in murine experimental autoimmune encephalomyelitis.

Turner MJ, Pang PT, Chretien N, Havari E, LaMorte MJ, Oliver J, Pande N, Masterjohn E, Carter K, Reczek D, Brondyk W, Roberts BL, Kaplan JM, Siders WM.

J Neuroimmunol. 2015 Aug 15;285:4-12. doi: 10.1016/j.jneuroim.2015.05.018. Epub 2015 May 20.


Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release.

Choi S, Taylor KP, Chatzigeorgiou M, Hu Z, Schafer WR, Kaplan JM.

PLoS Genet. 2015 Jul 8;11(7):e1005359. doi: 10.1371/journal.pgen.1005359. eCollection 2015 Jul.


Late surgical explantation and aortic valve replacement after transcatheter aortic valve implantation.

Wang LW, Granger EK, McCourt JA, Pye R, Kaplan JM, Muller DW.

Ann Thorac Surg. 2015 Apr;99(4):1434-6. doi: 10.1016/j.athoracsur.2014.06.099.


Gould on Morton, Redux: What can the debate reveal about the limits of data?

Kaplan JM, Pigliucci M, Banta JA.

Stud Hist Philos Biol Biomed Sci. 2015 Aug;52:22-31. doi: 10.1016/j.shpsc.2015.01.001. Epub 2015 Feb 7.


NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release.

Hu Z, Vashlishan-Murray AB, Kaplan JM.

J Neurosci. 2015 Jan 21;35(3):1038-42. doi: 10.1523/JNEUROSCI.2825-14.2015.


Insights into the Mechanisms of the Therapeutic Efficacy of Alemtuzumab in Multiple Sclerosis.

Freedman MS, Kaplan JM, Markovic-Plese S.

J Clin Cell Immunol. 2013 Jul 8;4(4). pii: 1000152.


Impact of alemtuzumab treatment on the survival and function of human regulatory T cells in vitro.

Havari E, Turner MJ, Campos-Rivera J, Shankara S, Nguyen TH, Roberts B, Siders W, Kaplan JM.

Immunology. 2014 Jan;141(1):123-31. doi: 10.1111/imm.12178.


Conformationally constrained functional peptide monolayers for the controlled display of bioactive carbohydrate ligands.

Kaplan JM, Shang J, Gobbo P, Antonello S, Armelao L, Chatare V, Ratner DM, Andrade RB, Maran F.

Langmuir. 2013 Jul 2;29(26):8187-92. doi: 10.1021/la4008894. Epub 2013 Jun 21.


Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans.

Choi S, Chatzigeorgiou M, Taylor KP, Schafer WR, Kaplan JM.

Neuron. 2013 Jun 5;78(5):869-80. doi: 10.1016/j.neuron.2013.04.002.


Immune status following alemtuzumab treatment in human CD52 transgenic mice.

Turner MJ, Lamorte MJ, Chretien N, Havari E, Roberts BL, Kaplan JM, Siders WM.

J Neuroimmunol. 2013 Aug 15;261(1-2):29-36. doi: 10.1016/j.jneuroim.2013.04.018. Epub 2013 Jun 4.


Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans.

Hu Z, Hom S, Kudze T, Tong XJ, Choi S, Aramuni G, Zhang W, Kaplan JM.

Science. 2012 Aug 24;337(6097):980-4. doi: 10.1126/science.1224896. Epub 2012 Aug 2.


Human peripheral blood mononuclear cells exhibit heterogeneous CD52 expression levels and show differential sensitivity to alemtuzumab mediated cytolysis.

Rao SP, Sancho J, Campos-Rivera J, Boutin PM, Severy PB, Weeden T, Shankara S, Roberts BL, Kaplan JM.

PLoS One. 2012;7(6):e39416. doi: 10.1371/journal.pone.0039416. Epub 2012 Jun 25.


Biofunctional paper via the covalent modification of cellulose.

Yu A, Shang J, Cheng F, Paik BA, Kaplan JM, Andrade RB, Ratner DM.

Langmuir. 2012 Jul 31;28(30):11265-73. doi: 10.1021/la301661x. Epub 2012 Jul 20.


Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsis.

Kaplan JM, Nowell M, Lahni P, O'Connor MP, Hake PW, Zingarelli B.

Obesity (Silver Spring). 2012 Oct;20(10):1995-2002. doi: 10.1038/oby.2012.40. Epub 2012 Feb 15.


HBL-1 patterns synaptic remodeling in C. elegans.

Thompson-Peer KL, Bai J, Hu Z, Kaplan JM.

Neuron. 2012 Feb 9;73(3):453-65. doi: 10.1016/j.neuron.2011.11.025.


RIC-7 promotes neuropeptide secretion.

Hao Y, Hu Z, Sieburth D, Kaplan JM.

PLoS Genet. 2012 Jan;8(1):e1002464. doi: 10.1371/journal.pgen.1002464. Epub 2012 Jan 19.


Novel Therapeutic Agents in Pediatric Sepsis: Peroxisome Proliferator Receptor γ (PPAR γ) Agonists.

Kaplan JM, Zingarelli B.

Open Inflamm J. 2011 Oct 7;4(Suppl 1-M14):120-124. No abstract available.


An organophosphonate strategy for functionalizing silicon photonic biosensors.

Shang J, Cheng F, Dubey M, Kaplan JM, Rawal M, Jiang X, Newburg DS, Sullivan PA, Andrade RB, Ratner DM.

Langmuir. 2012 Feb 14;28(6):3338-44. doi: 10.1021/la2043153. Epub 2012 Jan 30.


The immunoglobulin super family protein RIG-3 prevents synaptic potentiation and regulates Wnt signaling.

Babu K, Hu Z, Chien SC, Garriga G, Kaplan JM.

Neuron. 2011 Jul 14;71(1):103-16. doi: 10.1016/j.neuron.2011.05.034.


A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release.

Hu Z, Pym EC, Babu K, Vashlishan Murray AB, Kaplan JM.

Neuron. 2011 Jul 14;71(1):92-102. doi: 10.1016/j.neuron.2011.04.021.


Validation of a gene expression-based subclassification strategy for pediatric septic shock.

Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Wheeler DS, Doughty LA, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Varisco BM, Barr FE.

Crit Care Med. 2011 Nov;39(11):2511-7. doi: 10.1097/CCM.0b013e3182257675.


Immunomodulatory activity of mesenchymal stem cells.

Kaplan JM, Youd ME, Lodie TA.

Curr Stem Cell Res Ther. 2011 Dec;6(4):297-316. Review.


Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis.

Bai J, Hu Z, Dittman JS, Pym EC, Kaplan JM.

Cell. 2010 Oct 29;143(3):430-41. doi: 10.1016/j.cell.2010.09.024.


Sucking patterns and behavioral state in 1- and 2-day-old full-term infants.

Medoff-Cooper B, Bilker W, Kaplan JM.

J Obstet Gynecol Neonatal Nurs. 2010 Sep-Oct;39(5):519-24. doi: 10.1111/j.1552-6909.2010.01173.x.


Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-γ during polymicrobial sepsis.

Kaplan JM, Hake PW, Denenberg A, Nowell M, Piraino G, Zingarelli B.

Mol Med. 2010 Nov-Dec;16(11-12):491-7. doi: 10.2119/molmed.2010.00063. Epub 2010 Aug 19.


Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept.

Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA.

Crit Care Med. 2010 Oct;38(10):1955-61. doi: 10.1097/CCM.0b013e3181eb924f.


Biomarker discovery and development in pediatric critical care medicine.

Kaplan JM, Wong HR.

Pediatr Crit Care Med. 2011 Mar;12(2):165-73. doi: 10.1097/PCC.0b013e3181e28876. Review.


Involvement of neutrophils and natural killer cells in the anti-tumor activity of alemtuzumab in xenograft tumor models.

Siders WM, Shields J, Garron C, Hu Y, Boutin P, Shankara S, Weber W, Roberts B, Kaplan JM.

Leuk Lymphoma. 2010 Jul;51(7):1293-304. doi: 10.3109/10428191003777963.


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