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Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments.

Shen Y, Grisdale CJ, Islam SA, Bose P, Lever J, Zhao EY, Grinshtein N, Ma Y, Mungall AJ, Moore RA, Lun X, Senger DL, Robbins SM, Wang AY, MacIsaac JL, Kobor MS, Luchman HA, Weiss S, Chan JA, Blough MD, Kaplan DR, Cairncross JG, Marra MA, Jones SJM.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19098-19108. doi: 10.1073/pnas.1813495116. Epub 2019 Aug 30.


First-in-Human Brain Imaging of [18F]TRACK, a PET tracer for Tropomyosin Receptor Kinases.

Bailey JJ, Kaiser L, Lindner S, Wüst M, Thiel A, Soucy JP, Rosa-Neto P, Scott PJH, Unterrainer M, Kaplan DR, Wängler C, Wängler B, Bartenstein P, Bernard-Gauthier V, Schirrmacher R.

ACS Chem Neurosci. 2019 Jun 19;10(6):2697-2702. doi: 10.1021/acschemneuro.9b00144. Epub 2019 Apr 29.


Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging.

Schirrmacher R, Bailey JJ, Mossine AV, Scott PJH, Kaiser L, Bartenstein P, Lindner S, Kaplan DR, Kostikov A, Fricker G, Mahringer A, Rosa-Neto P, Schirrmacher E, Wängler C, Wängler B, Thiel A, Soucy JP, Bernard-Gauthier V.

Pharmaceuticals (Basel). 2019 Jan 3;12(1). pii: E7. doi: 10.3390/ph12010007. Review.


Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration.

Carr MJ, Toma JS, Johnston APW, Steadman PE, Yuzwa SA, Mahmud N, Frankland PW, Kaplan DR, Miller FD.

Cell Stem Cell. 2019 Feb 7;24(2):240-256.e9. doi: 10.1016/j.stem.2018.10.024. Epub 2018 Nov 29.


ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts.

Yuan AL, Ricks CB, Bohm AK, Lun X, Maxwell L, Safdar S, Bukhari S, Gerber A, Sayeed W, Bering EA, Pedersen H, Chan JA, Shen Y, Marra M, Kaplan DR, Mason W, Goodman LD, Ezhilarasan R, Kaufmann AB, Cabral M, Robbins SM, Senger DL, Cahill DP, Sulman EP, Cairncross JG, Blough MD.

PLoS One. 2018 Aug 28;13(8):e0202860. doi: 10.1371/journal.pone.0202860. eCollection 2018.


Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development.

Storer MA, Gallagher D, Fatt MP, Simonetta JV, Kaplan DR, Miller FD.

Stem Cell Reports. 2018 May 8;10(5):1464-1480. doi: 10.1016/j.stemcr.2018.03.008. Epub 2018 Apr 5.


A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification.

Zahr SK, Yang G, Kazan H, Borrett MJ, Yuzwa SA, Voronova A, Kaplan DR, Miller FD.

Neuron. 2018 Feb 7;97(3):520-537.e6. doi: 10.1016/j.neuron.2017.12.045. Epub 2018 Jan 27.


Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling.

Yuzwa SA, Borrett MJ, Innes BT, Voronova A, Ketela T, Kaplan DR, Bader GD, Miller FD.

Cell Rep. 2017 Dec 26;21(13):3970-3986. doi: 10.1016/j.celrep.2017.12.017.


Identification of [18F]TRACK, a Fluorine-18-Labeled Tropomyosin Receptor Kinase (Trk) Inhibitor for PET Imaging.

Bernard-Gauthier V, Mossine AV, Mahringer A, Aliaga A, Bailey JJ, Shao X, Stauff J, Arteaga J, Sherman P, Grand'Maison M, Rochon PL, Wängler B, Wängler C, Bartenstein P, Kostikov A, Kaplan DR, Fricker G, Rosa-Neto P, Scott PJH, Schirrmacher R.

J Med Chem. 2018 Feb 22;61(4):1737-1743. doi: 10.1021/acs.jmedchem.7b01607. Epub 2018 Jan 5.


A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.

Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger JR, Moran MF, Rubin LL, Miller FD, Kaplan DR.

J Cell Biol. 2017 Nov 6;216(11):3655-3675. doi: 10.1083/jcb.201705085. Epub 2017 Sep 6.


RNAi screen identifies essential regulators of human brain metastasis-initiating cells.

Singh M, Venugopal C, Tokar T, Brown KR, McFarlane N, Bakhshinyan D, Vijayakumar T, Manoranjan B, Mahendram S, Vora P, Qazi M, Dhillon M, Tong A, Durrer K, Murty N, Hallet R, Hassell JA, Kaplan DR, Cutz JC, Jurisica I, Moffat J, Singh SK.

Acta Neuropathol. 2017 Dec;134(6):923-940. doi: 10.1007/s00401-017-1757-z. Epub 2017 Aug 1.


A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human.

Bernard-Gauthier V, Bailey JJ, Mossine AV, Lindner S, Vomacka L, Aliaga A, Shao X, Quesada CA, Sherman P, Mahringer A, Kostikov A, Grand'Maison M, Rosa-Neto P, Soucy JP, Thiel A, Kaplan DR, Fricker G, Wängler B, Bartenstein P, Schirrmacher R, Scott PJH.

J Med Chem. 2017 Aug 24;60(16):6897-6910. doi: 10.1021/acs.jmedchem.7b00396. Epub 2017 Jul 21.


Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain.

Voronova A, Yuzwa SA, Wang BS, Zahr S, Syal C, Wang J, Kaplan DR, Miller FD.

Neuron. 2017 May 3;94(3):500-516.e9. doi: 10.1016/j.neuron.2017.04.018.


A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.

Seong BK, Fathers KE, Hallett R, Yung CK, Stein LD, Mouaaz S, Kee L, Hawkins CE, Irwin MS, Kaplan DR.

Cancer Res. 2017 Feb 1;77(3):696-706. doi: 10.1158/0008-5472.CAN-16-1502. Epub 2016 Nov 29.


A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring.

Yang G, Cancino GI, Zahr SK, Guskjolen A, Voronova A, Gallagher D, Frankland PW, Kaplan DR, Miller FD.

Cell Rep. 2016 Oct 18;17(4):1022-1036. doi: 10.1016/j.celrep.2016.09.067.


Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma.

Hallett RM, Seong AB, Kaplan DR, Irwin MS.

Mol Oncol. 2016 Nov;10(9):1461-1472. doi: 10.1016/j.molonc.2016.07.012. Epub 2016 Aug 18.


Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks.

Yuzwa SA, Yang G, Borrett MJ, Clarke G, Cancino GI, Zahr SK, Zandstra PW, Kaplan DR, Miller FD.

Neuron. 2016 Sep 7;91(5):988-1004. doi: 10.1016/j.neuron.2016.07.037. Epub 2016 Aug 18.


Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells.

Grinshtein N, Rioseco CC, Marcellus R, Uehling D, Aman A, Lun X, Muto O, Podmore L, Lever J, Shen Y, Blough MD, Cairncross GJ, Robbins SM, Jones SJ, Marra MA, Al-Awar R, Senger DL, Kaplan DR.

Oncotarget. 2016 Sep 13;7(37):59360-59376. doi: 10.18632/oncotarget.10661.


Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip.

Johnston AP, Yuzwa SA, Carr MJ, Mahmud N, Storer MA, Krause MP, Jones K, Paul S, Kaplan DR, Miller FD.

Cell Stem Cell. 2016 Oct 6;19(4):433-448. doi: 10.1016/j.stem.2016.06.002. Epub 2016 Jul 1.


Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma.

Lun X, Wells JC, Grinshtein N, King JC, Hao X, Dang NH, Wang X, Aman A, Uehling D, Datti A, Wrana JL, Easaw JC, Luchman A, Weiss S, Cairncross JG, Kaplan DR, Robbins SM, Senger DL.

Clin Cancer Res. 2016 Aug 1;22(15):3860-75. doi: 10.1158/1078-0432.CCR-15-1798. Epub 2016 Mar 22.


Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair.

Naska S, Yuzwa SA, Johnston AP, Paul S, Smith KM, Paris M, Sefton MV, Datti A, Miller FD, Kaplan DR.

Stem Cell Reports. 2016 Jan 12;6(1):74-84. doi: 10.1016/j.stemcr.2015.12.002. Epub 2015 Dec 24.


Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation.

Fatt M, Hsu K, He L, Wondisford F, Miller FD, Kaplan DR, Wang J.

Stem Cell Reports. 2015 Dec 8;5(6):988-995. doi: 10.1016/j.stemcr.2015.10.014. Epub 2015 Nov 19.


A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.

Amadei G, Zander MA, Yang G, Dumelie JG, Vessey JP, Lipshitz HD, Smibert CA, Kaplan DR, Miller FD.

J Neurosci. 2015 Nov 25;35(47):15666-81. doi: 10.1523/JNEUROSCI.2172-15.2015.


Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system.

Cancino GI, Fatt MP, Miller FD, Kaplan DR.

Cell Cycle. 2015;14(20):3270-81. doi: 10.1080/15384101.2015.1087618.


Axon diameter and axonal transport: In vivo and in vitro effects of androgens.

Pesaresi M, Soon-Shiong R, French L, Kaplan DR, Miller FD, Paus T.

Neuroimage. 2015 Jul 15;115:191-201. doi: 10.1016/j.neuroimage.2015.04.048. Epub 2015 May 6.


Ankrd11 is a chromatin regulator involved in autism that is essential for neural development.

Gallagher D, Voronova A, Zander MA, Cancino GI, Bramall A, Krause MP, Abad C, Tekin M, Neilsen PM, Callen DF, Scherer SW, Keller GM, Kaplan DR, Walz K, Miller FD.

Dev Cell. 2015 Jan 12;32(1):31-42. doi: 10.1016/j.devcel.2014.11.031. Epub 2014 Dec 31.


Ankrd11 is a chromatin regulator involved in autism that is essential for neural development.

Voronova A, Gallagher D, Zander M, Cancino G, Bramall A, Krause MP, Abad C, Tekin M, Neilsen PM, Callen DF, Scherer SW, Keller GM, Kaplan DR, Walz K, Miller FD.

Springerplus. 2015 Jun 12;4(Suppl 1):L28. doi: 10.1186/2193-1801-4-S1-L28. eCollection 2015. No abstract available.


An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.

Yang G, Smibert CA, Kaplan DR, Miller FD.

Neuron. 2014 Nov 19;84(4):723-39. doi: 10.1016/j.neuron.2014.10.022. Epub 2014 Nov 6.


TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival.

Chavali PL, Saini RK, Zhai Q, Vizlin-Hodzic D, Venkatabalasubramanian S, Hayashi A, Johansson E, Zeng ZJ, Mohlin S, Påhlman S, Hansford L, Kaplan DR, Funa K.

Cell Death Dis. 2014 Oct 30;5:e1502. doi: 10.1038/cddis.2014.449.


The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life.

Zander MA, Cancino GI, Gridley T, Kaplan DR, Miller FD.

PLoS One. 2014 Aug 19;9(8):e104767. doi: 10.1371/journal.pone.0104767. eCollection 2014.


Direct genesis of functional rodent and human schwann cells from skin mesenchymal precursors.

Krause MP, Dworski S, Feinberg K, Jones K, Johnston AP, Paul S, Paris M, Peles E, Bagli D, Forrest CR, Kaplan DR, Miller FD.

Stem Cell Reports. 2014 Jun 19;3(1):85-100. doi: 10.1016/j.stemcr.2014.05.011. eCollection 2014 Jul 8.


Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma.

Haftchenary S, Luchman HA, Jouk AO, Veloso AJ, Page BD, Cheng XR, Dawson SS, Grinshtein N, Shahani VM, Kerman K, Kaplan DR, Griffin C, Aman AM, Al-Awar R, Weiss S, Gunning PT.

ACS Med Chem Lett. 2013 Sep 8;4(11):1102-7. doi: 10.1021/ml4003138. eCollection 2013 Nov 14.


p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells.

Fatt MP, Cancino GI, Miller FD, Kaplan DR.

Cell Death Differ. 2014 Oct;21(10):1546-59. doi: 10.1038/cdd.2014.61. Epub 2014 May 9.


Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development.

Zander MA, Burns SE, Yang G, Kaplan DR, Miller FD.

J Neurosci. 2014 Apr 9;34(15):5164-75. doi: 10.1523/JNEUROSCI.0370-14.2014.


Prokineticin signaling is required for the maintenance of a de novo population of c-KIT⁺ cells to sustain neuroblastoma progression.

Lau ST, Hansford LM, Chan WK, Chan GC, Wan TS, Wong KK, Kaplan DR, Tam PK, Ngan ES.

Oncogene. 2015 Feb 19;34(8):1019-34. doi: 10.1038/onc.2014.24. Epub 2014 Mar 17.


Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex.

Dixit R, Wilkinson G, Cancino GI, Shaker T, Adnani L, Li S, Dennis D, Kurrasch D, Chan JA, Olson EC, Kaplan DR, Zimmer C, Schuurmans C.

J Neurosci. 2014 Jan 8;34(2):539-53. doi: 10.1523/JNEUROSCI.0614-13.2014.


Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma.

Wolter JK, Wolter NE, Blanch A, Partridge T, Cheng L, Morgenstern DA, Podkowa M, Kaplan DR, Irwin MS.

Oncotarget. 2014 Jan 15;5(1):161-72.


Strong performance on the Progressive Evaluation of Competency fellowship final examination predicts American Board of Pathology Certification.

Davey DD, Kaplan DR, Michael CW.

J Am Soc Cytopathol. 2014 Sep - Oct;3(5):269-273. doi: 10.1016/j.jasc.2014.05.004. Epub 2014 Jun 4.


CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development.

Tsui D, Voronova A, Gallagher D, Kaplan DR, Miller FD, Wang J.

Dev Biol. 2014 Jan 15;385(2):230-41. doi: 10.1016/j.ydbio.2013.11.005. Epub 2013 Nov 15.


Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway.

Gallagher D, Norman AA, Woodard CL, Yang G, Gauthier-Fisher A, Fujitani M, Vessey JP, Cancino GI, Sachewsky N, Woltjen K, Fatt MP, Morshead CM, Kaplan DR, Miller FD.

Cell Stem Cell. 2013 Nov 7;13(5):564-76. doi: 10.1016/j.stem.2013.10.002.


Sox2-mediated regulation of adult neural crest precursors and skin repair.

Johnston AP, Naska S, Jones K, Jinno H, Kaplan DR, Miller FD.

Stem Cell Reports. 2013 Jun 4;1(1):38-45. doi: 10.1016/j.stemcr.2013.04.004. eCollection 2013.


p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior.

Cancino GI, Yiu AP, Fatt MP, Dugani CB, Flores ER, Frankland PW, Josselyn SA, Miller FD, Kaplan DR.

J Neurosci. 2013 Jul 31;33(31):12569-85. doi: 10.1523/JNEUROSCI.1251-13.2013.


A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines.

Vojvodic M, Hansford LM, Morozova O, Blakely KM, Taylor P, Fathers KE, Moffat J, Marra M, Smith KM, Moran MF, Kaplan DR.

Curr Drug Discov Technol. 2013 Dec;10(4):283-304.


Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes.

Arun V, Worrell L, Wiley JC, Kaplan DR, Guha A.

FEBS Lett. 2013 May 21;587(10):1466-73. doi: 10.1016/j.febslet.2013.03.035. Epub 2013 Apr 10.


FoxP2 regulates neurogenesis during embryonic cortical development.

Tsui D, Vessey JP, Tomita H, Kaplan DR, Miller FD.

J Neurosci. 2013 Jan 2;33(1):244-58. doi: 10.1523/JNEUROSCI.1665-12.2013.


An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells.

Vessey JP, Amadei G, Burns SE, Kiebler MA, Kaplan DR, Miller FD.

Cell Stem Cell. 2012 Oct 5;11(4):517-28. doi: 10.1016/j.stem.2012.06.010. Epub 2012 Aug 16.


Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.

Wang J, Gallagher D, DeVito LM, Cancino GI, Tsui D, He L, Keller GM, Frankland PW, Kaplan DR, Miller FD.

Cell Stem Cell. 2012 Jul 6;11(1):23-35. doi: 10.1016/j.stem.2012.03.016.


Mobilizing endogenous stem cells for repair and regeneration: are we there yet?

Miller FD, Kaplan DR.

Cell Stem Cell. 2012 Jun 14;10(6):650-652. doi: 10.1016/j.stem.2012.05.004.


p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.

Cancino GI, Miller FD, Kaplan DR.

Neurobiol Aging. 2013 Feb;34(2):387-99. doi: 10.1016/j.neurobiolaging.2012.04.010. Epub 2012 May 15.


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