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Items: 1 to 50 of 55

1.

mAKAPβ signalosomes - A nodal regulator of gene transcription associated with pathological cardiac remodeling.

Dodge-Kafka K, Gildart M, Tokarski K, Kapiloff MS.

Cell Signal. 2019 Jul 9;63:109357. doi: 10.1016/j.cellsig.2019.109357. [Epub ahead of print] Review.

PMID:
31299211
2.

Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment.

Boczek T, Cameron EG, Yu W, Xia X, Shah SH, Castillo Chabeco B, Galvao J, Nahmou M, Li J, Thakur H, Goldberg JL, Kapiloff MS.

J Neurosci. 2019 Jul 10;39(28):5466-5480. doi: 10.1523/JNEUROSCI.2752-18.2019. Epub 2019 May 16.

PMID:
31097623
3.

Muscle A-kinase-anchoring protein-β-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D.

Li J, Aponte Paris S, Thakur H, Kapiloff MS, Dodge-Kafka KL.

J Biol Chem. 2019 Feb 15;294(7):2543-2554. doi: 10.1074/jbc.RA118.005465. Epub 2018 Dec 6.

PMID:
30523159
4.

Calcineurin-AKAP interactions: therapeutic targeting of a pleiotropic enzyme with a little help from its friends.

Gildart M, Kapiloff MS, Dodge-Kafka KL.

J Physiol. 2018 Nov 29. doi: 10.1113/JP276756. [Epub ahead of print]

PMID:
30488951
5.

PDE4 and mAKAPβ are nodal organizers of β2-ARs nuclear PKA signalling in cardiac myocytes.

Bedioune I, Lefebvre F, Lechêne P, Varin A, Domergue V, Kapiloff MS, Fischmeister R, Vandecasteele G.

Cardiovasc Res. 2018 Sep 1;114(11):1499-1511. doi: 10.1093/cvr/cvy110.

PMID:
29733383
6.

Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes.

Dodge-Kafka KL, Gildart M, Li J, Thakur H, Kapiloff MS.

J Mol Cell Cardiol. 2018 May;118:13-25. doi: 10.1016/j.yjmcc.2018.03.001. Epub 2018 Mar 6.

7.

Intracellular compartmentation of cAMP promotes neuroprotection and regeneration of CNS neurons.

Cameron EG, Kapiloff MS.

Neural Regen Res. 2017 Feb;12(2):201-202. doi: 10.4103/1673-5374.200797. No abstract available.

8.

Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation.

Shaw PX, Fang J, Sang A, Wang Y, Kapiloff MS, Goldberg JL.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):5083-5092. doi: 10.1167/iovs.16-19465.

9.

RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome.

Passariello CL, Martinez EC, Thakur H, Cesareo M, Li J, Kapiloff MS.

J Mol Cell Cardiol. 2016 Apr;93:98-105. doi: 10.1016/j.yjmcc.2016.02.020. Epub 2016 Mar 3.

10.

The cardiac enigma: current conundrums in heart failure research.

Kapiloff MS, Emter CA.

F1000Res. 2016 Jan 18;5. pii: F1000 Faculty Rev-72. doi: 10.12688/f1000research.7278.1. eCollection 2016. Review.

11.

Muscle A-Kinase Anchoring Protein-α is an Injury-Specific Signaling Scaffold Required for Neurotrophic- and Cyclic Adenosine Monophosphate-Mediated Survival.

Wang Y, Cameron EG, Li J, Stiles TL, Kritzer MD, Lodhavia R, Hertz J, Nguyen T, Kapiloff MS, Goldberg JL.

EBioMedicine. 2015 Oct 28;2(12):1880-7. doi: 10.1016/j.ebiom.2015.10.025. eCollection 2015 Dec.

12.

RSK3: A regulator of pathological cardiac remodeling.

Martinez EC, Passariello CL, Li J, Matheson CJ, Dodge-Kafka K, Reigan P, Kapiloff MS.

IUBMB Life. 2015 May;67(5):331-7. doi: 10.1002/iub.1383. Epub 2015 May 19. Review.

13.

S-nitrosoglutathione reductase-dependent PPARγ denitrosylation participates in MSC-derived adipogenesis and osteogenesis.

Cao Y, Gomes SA, Rangel EB, Paulino EC, Fonseca TL, Li J, Teixeira MB, Gouveia CH, Bianco AC, Kapiloff MS, Balkan W, Hare JM.

J Clin Invest. 2015 Apr;125(4):1679-91. doi: 10.1172/JCI73780. Epub 2015 Mar 23.

14.

mAKAP-a master scaffold for cardiac remodeling.

Passariello CL, Li J, Dodge-Kafka K, Kapiloff MS.

J Cardiovasc Pharmacol. 2015 Mar;65(3):218-25. doi: 10.1097/FJC.0000000000000206. Review.

15.

The role of soluble adenylyl cyclase in neurite outgrowth.

Stiles TL, Kapiloff MS, Goldberg JL.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt B):2561-8. doi: 10.1016/j.bbadis.2014.07.012. Epub 2014 Jul 23. Review.

16.

The scaffold protein muscle A-kinase anchoring protein β orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure.

Kritzer MD, Li J, Passariello CL, Gayanilo M, Thakur H, Dayan J, Dodge-Kafka K, Kapiloff MS.

Circ Heart Fail. 2014 Jul;7(4):663-72. doi: 10.1161/CIRCHEARTFAILURE.114.001266. Epub 2014 May 8.

17.

Architectural and functional roles of A kinase-anchoring proteins in cAMP microdomains.

Kapiloff MS, Rigatti M, Dodge-Kafka KL.

J Gen Physiol. 2014 Jan;143(1):9-15. doi: 10.1085/jgp.201311020. No abstract available.

18.

CIP4 is required for the hypertrophic growth of neonatal cardiac myocytes.

Rusconi F, Thakur H, Li J, Kapiloff MS.

J Biomed Sci. 2013 Aug 3;20:56. doi: 10.1186/1423-0127-20-56. Erratum in: J Biomed Sci. 2014;21:45.

19.

p90 ribosomal S6 kinase 3 contributes to cardiac insufficiency in α-tropomyosin Glu180Gly transgenic mice.

Passariello CL, Gayanilo M, Kritzer MD, Thakur H, Cozacov Z, Rusconi F, Wieczorek D, Sanders M, Li J, Kapiloff MS.

Am J Physiol Heart Circ Physiol. 2013 Oct 1;305(7):H1010-9. doi: 10.1152/ajpheart.00237.2013. Epub 2013 Aug 2.

20.

Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes.

Li J, Vargas MA, Kapiloff MS, Dodge-Kafka KL.

Exp Cell Res. 2013 Feb 15;319(4):447-54. doi: 10.1016/j.yexcr.2012.12.016. Epub 2012 Dec 21.

21.

Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy.

Li J, Kritzer MD, Michel JJ, Le A, Thakur H, Gayanilo M, Passariello CL, Negro A, Danial JB, Oskouei B, Sanders M, Hare JM, Hanauer A, Dodge-Kafka K, Kapiloff MS.

Circ Res. 2013 Jan 4;112(1):128-39. doi: 10.1161/CIRCRESAHA.112.276162. Epub 2012 Sep 20.

22.

Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation.

Vargas MA, Tirnauer JS, Glidden N, Kapiloff MS, Dodge-Kafka KL.

Cell Signal. 2012 Aug;24(8):1496-503. doi: 10.1016/j.cellsig.2012.03.017. Epub 2012 Mar 30.

23.

A-kinase anchoring proteins: temporal and spatial regulation of intracellular signal transduction in the cardiovascular system.

Kapiloff MS, Chandrasekhar KD.

J Cardiovasc Pharmacol. 2011 Oct;58(4):337-8. doi: 10.1097/FJC.0B013E31822D5C08. No abstract available.

24.

A-kinase anchoring proteins: scaffolding proteins in the heart.

Diviani D, Dodge-Kafka KL, Li J, Kapiloff MS.

Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1742-53. doi: 10.1152/ajpheart.00569.2011. Epub 2011 Aug 19. Review.

25.

AKAPs: the architectural underpinnings of local cAMP signaling.

Kritzer MD, Li J, Dodge-Kafka K, Kapiloff MS.

J Mol Cell Cardiol. 2012 Feb;52(2):351-8. doi: 10.1016/j.yjmcc.2011.05.002. Epub 2011 May 11. Review.

26.

Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes.

Zhang L, Malik S, Kelley GG, Kapiloff MS, Smrcka AV.

J Biol Chem. 2011 Jul 1;286(26):23012-21. doi: 10.1074/jbc.M111.231993. Epub 2011 May 5.

27.

Inflammation, stem cells and atherosclerosis genetics.

Goldschmidt-Clermont PJ, Seo DM, Wang L, Beecham GW, Liu ZJ, Vazquez-Padron RI, Dong C, Hare JM, Kapiloff MS, Bishopric NH, Pericak-Vance M, Vance JM, Velazquez OC.

Curr Opin Mol Ther. 2010 Dec;12(6):712-23. Review.

PMID:
21154163
28.

The large isoforms of A-kinase anchoring protein 18 mediate the phosphorylation of inhibitor-1 by protein kinase A and the inhibition of protein phosphatase 1 activity.

Singh A, Redden JM, Kapiloff MS, Dodge-Kafka KL.

Mol Pharmacol. 2011 Mar;79(3):533-40. doi: 10.1124/mol.110.065425. Epub 2010 Dec 13.

29.

cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3.

Dodge-Kafka KL, Bauman A, Mayer N, Henson E, Heredia L, Ahn J, McAvoy T, Nairn AC, Kapiloff MS.

J Biol Chem. 2010 Apr 9;285(15):11078-86. doi: 10.1074/jbc.M109.034868. Epub 2010 Jan 27.

30.

The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin.

Li J, Negro A, Lopez J, Bauman AL, Henson E, Dodge-Kafka K, Kapiloff MS.

J Mol Cell Cardiol. 2010 Feb;48(2):387-94. doi: 10.1016/j.yjmcc.2009.10.023. Epub 2009 Oct 31.

31.

An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes.

Kapiloff MS, Piggott LA, Sadana R, Li J, Heredia LA, Henson E, Efendiev R, Dessauer CW.

J Biol Chem. 2009 Aug 28;284(35):23540-6. doi: 10.1074/jbc.M109.030072. Epub 2009 Jul 1.

32.

Signalosomes as Therapeutic Targets.

Negro A, Dodge-Kafka K, Kapiloff MS.

Prog Pediatr Cardiol. 2008 Apr;25(1):51-56.

33.

mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha.

Wong W, Goehring AS, Kapiloff MS, Langeberg LK, Scott JD.

Sci Signal. 2008 Dec 23;1(51):ra18. doi: 10.1126/scisignal.2000026.

34.

A-kinase anchoring proteins as the basis for cAMP signaling.

Dodge-Kafka KL, Bauman A, Kapiloff MS.

Handb Exp Pharmacol. 2008;(186):3-14. doi: 10.1007/978-3-540-72843-6_1. Review.

PMID:
18491046
35.

The mAKAP signalosome and cardiac myocyte hypertrophy.

Bauman AL, Michel JJ, Henson E, Dodge-Kafka KL, Kapiloff MS.

IUBMB Life. 2007 Mar;59(3):163-9. Review.

36.

The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways.

Dodge-Kafka KL, Kapiloff MS.

Eur J Cell Biol. 2006 Jul;85(7):593-602. Epub 2006 Feb 7. Review.

PMID:
16460834
37.

Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha.

Michel JJ, Townley IK, Dodge-Kafka KL, Zhang F, Kapiloff MS, Scott JD.

Mol Cell. 2005 Dec 9;20(5):661-72.

38.

The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling.

Pare GC, Bauman AL, McHenry M, Michel JJ, Dodge-Kafka KL, Kapiloff MS.

J Cell Sci. 2005 Dec 1;118(Pt 23):5637-46.

39.

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

Dodge-Kafka KL, Soughayer J, Pare GC, Carlisle Michel JJ, Langeberg LK, Kapiloff MS, Scott JD.

Nature. 2005 Sep 22;437(7058):574-8.

40.

A novel isoform of Cbl-associated protein that binds protein kinase A.

Matson SA, Pare GC, Kapiloff MS.

Biochim Biophys Acta. 2005 Feb 14;1727(2):145-9. Epub 2004 Dec 28.

PMID:
15716063
41.

Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope.

Pare GC, Easlick JL, Mislow JM, McNally EM, Kapiloff MS.

Exp Cell Res. 2005 Feb 15;303(2):388-99.

PMID:
15652351
42.
43.
44.

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.

Dodge KL, Khouangsathiene S, Kapiloff MS, Mouton R, Hill EV, Houslay MD, Langeberg LK, Scott JD.

EMBO J. 2001 Apr 17;20(8):1921-30.

45.

mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes.

Kapiloff MS, Schillace RV, Westphal AM, Scott JD.

J Cell Sci. 1999 Aug;112 ( Pt 16):2725-36.

46.

Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.

Cruzalegui FH, Kapiloff MS, Morfin JP, Kemp BE, Rosenfeld MG, Means AR.

Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12127-31.

47.

Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements.

Kapiloff MS, Farkash Y, Wegner M, Rosenfeld MG.

Science. 1991 Aug 16;253(5021):786-9.

PMID:
1652153
48.

Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation.

Kapiloff MS, Mathis JM, Nelson CA, Lin CR, Rosenfeld MG.

Proc Natl Acad Sci U S A. 1991 May 1;88(9):3710-4.

49.

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.

Ingraham HA, Flynn SE, Voss JW, Albert VR, Kapiloff MS, Wilson L, Rosenfeld MG.

Cell. 1990 Jun 15;61(6):1021-33.

PMID:
2350782
50.

A family of POU-domain and Pit-1 tissue-specific transcription factors in pituitary and neuroendocrine development.

Ingraham HA, Albert VR, Chen RP, Crenshaw 3d EB, Elsholtz HP, He X, Kapiloff MS, Mangalam HJ, Swanson LW, Treacy MN, et al.

Annu Rev Physiol. 1990;52:773-91. Review.

PMID:
2184776

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