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Items: 10

1.

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice.

Kapelyukh Y, Henderson CJ, Scheer N, Rode A, Wolf CR.

Drug Metab Dispos. 2019 Aug;47(8):907-918. doi: 10.1124/dmd.119.087718. Epub 2019 May 30.

2.

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.

Henderson CJ, Kapelyukh Y, Scheer N, Rode A, McLaren AW, MacLeod AK, Lin D, Wright J, Stanley LA, Wolf CR.

Drug Metab Dispos. 2019 Jun;47(6):601-615. doi: 10.1124/dmd.119.086397. Epub 2019 Mar 25.

3.

The usage of a three-compartment model to investigate the metabolic differences between hepatic reductase null and wild-type mice.

Hill L, Chaplain MAJ, Wolf R, Kapelyukh Y.

Math Med Biol. 2017 Mar 1;34(1):1-13. doi: 10.1093/imammb/dqv029.

PMID:
26443812
4.

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model.

Scheer N, Kapelyukh Y, Rode A, Oswald S, Busch D, McLaughlin LA, Lin D, Henderson CJ, Wolf CR.

Drug Metab Dispos. 2015 Nov;43(11):1679-90. doi: 10.1124/dmd.115.065656. Epub 2015 Aug 11.

PMID:
26265742
5.

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice.

Henderson CJ, McLaughlin LA, Finn RD, Ronseaux S, Kapelyukh Y, Wolf CR.

Drug Metab Dispos. 2014 Jan;42(1):70-7. doi: 10.1124/dmd.113.055277. Epub 2013 Oct 10.

6.

Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines.

Scheer N, Kapelyukh Y, Chatham L, Rode A, Buechel S, Wolf CR.

Mol Pharmacol. 2012 Dec;82(6):1022-9. doi: 10.1124/mol.112.080036. Epub 2012 Aug 23.

PMID:
22918969
7.

Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines.

Scheer N, Kapelyukh Y, McEwan J, Beuger V, Stanley LA, Rode A, Wolf CR.

Mol Pharmacol. 2012 Jan;81(1):63-72. doi: 10.1124/mol.111.075192. Epub 2011 Oct 11.

PMID:
21989258
8.

Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line.

Hasegawa M, Kapelyukh Y, Tahara H, Seibler J, Rode A, Krueger S, Lee DN, Wolf CR, Scheer N.

Mol Pharmacol. 2011 Sep;80(3):518-28. doi: 10.1124/mol.111.071845. Epub 2011 May 31.

PMID:
21628639
9.

In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice.

Scheer N, Ross J, Kapelyukh Y, Rode A, Wolf CR.

Drug Metab Dispos. 2010 Jul;38(7):1046-53. doi: 10.1124/dmd.109.031872. Epub 2010 Mar 30.

PMID:
20354104
10.

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

Kapelyukh Y, Paine MJ, Maréchal JD, Sutcliffe MJ, Wolf CR, Roberts GC.

Drug Metab Dispos. 2008 Oct;36(10):2136-44. doi: 10.1124/dmd.108.021733. Epub 2008 Jul 21.

PMID:
18645035

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