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Items: 33

1.

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.

Lally JSV, Ghoshal S, DePeralta DK, Moaven O, Wei L, Masia R, Erstad DJ, Fujiwara N, Leong V, Houde VP, Anagnostopoulos AE, Wang A, Broadfield LA, Ford RJ, Foster RA, Bates J, Sun H, Wang T, Liu H, Ray AS, Saha AK, Greenwood J, Bhat S, Harriman G, Miao W, Rocnik JL, Westlin WF, Muti P, Tsakiridis T, Harwood HJ Jr, Kapeller R, Hoshida Y, Tanabe KK, Steinberg GR, Fuchs BC.

Cell Metab. 2019 Jan 8;29(1):174-182.e5. doi: 10.1016/j.cmet.2018.08.020. Epub 2018 Sep 20.

PMID:
30244972
2.

Ensuring selectivity using retention time modulation by solvent composition, applied to the analysis of phenol in e-liquids.

Auer A, Kapeller R, Rothberger K, Schütte M.

J Chromatogr A. 2018 Nov 2;1574:122-129. doi: 10.1016/j.chroma.2018.08.062. Epub 2018 Sep 1.

PMID:
30190080
3.

Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double-blind, crossover study.

Stiede K, Miao W, Blanchette HS, Beysen C, Harriman G, Harwood HJ Jr, Kelley H, Kapeller R, Schmalbach T, Westlin WF.

Hepatology. 2017 Aug;66(2):324-334. doi: 10.1002/hep.29246. Epub 2017 Jul 5.

4.

Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.

Akahane K, Li Z, Etchin J, Berezovskaya A, Gjini E, Masse CE, Miao W, Rocnik J, Kapeller R, Greenwood JR, Tiv H, Sanda T, Weinstock DM, Look AT.

Br J Haematol. 2017 Apr;177(2):271-282. doi: 10.1111/bjh.14563. Epub 2017 Mar 14.

5.

Accelerating drug discovery through tight integration of expert molecular design and predictive scoring.

Abel R, Mondal S, Masse C, Greenwood J, Harriman G, Ashwell MA, Bhat S, Wester R, Frye L, Kapeller R, Friesner RA.

Curr Opin Struct Biol. 2017 Apr;43:38-44. doi: 10.1016/j.sbi.2016.10.007. Epub 2016 Nov 9. Review.

PMID:
27816785
6.

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.

Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ Jr, Saghatelian A, Kapeller R, Metallo CM, Shaw RJ.

Nat Med. 2016 Oct;22(10):1108-1119. doi: 10.1038/nm.4181. Epub 2016 Sep 19.

7.

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.

Harriman G, Greenwood J, Bhat S, Huang X, Wang R, Paul D, Tong L, Saha AK, Westlin WF, Kapeller R, Harwood HJ Jr.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1796-805. doi: 10.1073/pnas.1520686113. Epub 2016 Mar 14.

8.

Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy.

Kelly PN, Romero DL, Yang Y, Shaffer AL 3rd, Chaudhary D, Robinson S, Miao W, Rui L, Westlin WF, Kapeller R, Staudt LM.

J Exp Med. 2015 Dec 14;212(13):2189-201. doi: 10.1084/jem.20151074. Epub 2015 Nov 30.

9.

Retention time correction in gas chromatography by modeling concentration related effects, applied to the analysis of fatty acid methyl esters.

Kapeller R.

J Chromatogr A. 2015 May 15;1394:118-27. doi: 10.1016/j.chroma.2015.03.045. Epub 2015 Mar 25.

PMID:
25843421
10.

Correlation of serpin-protease expression by comparative analysis of real-time PCR profiling data.

Badola S, Spurling H, Robison K, Fedyk ER, Silverman GA, Strayle J, Kapeller R, Tsu CA.

Genomics. 2006 Aug;88(2):173-84. Epub 2006 May 18.

11.

Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells.

Xu H, Yang Q, Shen M, Huang X, Dembski M, Gimeno R, Tartaglia LA, Kapeller R, Wu Z.

J Biol Chem. 2005 Oct 28;280(43):36013-8. Epub 2005 Aug 26.

12.

Quantifying selectivity: a statistical approach for chromatography.

Kapeller R.

Anal Bioanal Chem. 2003 Nov;377(6):1060-70. Epub 2003 Sep 11.

PMID:
13680068
13.

Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance.

Xu H, Dembski M, Yang Q, Yang D, Moriarty A, Tayber O, Chen H, Kapeller R, Tartaglia LA.

J Biol Chem. 2003 Aug 8;278(32):30187-92. Epub 2003 May 30.

14.

RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes.

Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR.

Biochem J. 2001 Oct 1;359(Pt 1):109-18.

15.

ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1.

Kas K, Finger E, Grall F, Gu X, Akbarali Y, Boltax J, Weiss A, Oettgen P, Kapeller R, Libermann TA.

J Biol Chem. 2000 Jan 28;275(4):2986-98.

16.

Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation.

Stubdal H, Lynch CA, Moriarty A, Fang Q, Chickering T, Deeds JD, Fairchild-Huntress V, Charlat O, Dunmore JH, Kleyn P, Huszar D, Kapeller R.

Mol Cell Biol. 2000 Feb;20(3):878-82.

17.

Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin.

Kapeller R, Moriarty A, Strauss A, Stubdal H, Theriault K, Siebert E, Chickering T, Morgenstern JP, Tartaglia LA, Lillie J.

J Biol Chem. 1999 Aug 27;274(35):24980-6.

18.

The extracellular signal-regulated kinase pathway is required for activation-induced cell death of T cells.

van den Brink MR, Kapeller R, Pratt JC, Chang JH, Burakoff SJ.

J Biol Chem. 1999 Apr 16;274(16):11178-85.

19.

The small GTP-binding protein Rho potentiates AP-1 transcription in T cells.

Chang JH, Pratt JC, Sawasdikosol S, Kapeller R, Burakoff SJ.

Mol Cell Biol. 1998 Sep;18(9):4986-93.

20.

Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase.

Sen J, Kapeller R, Fragoso R, Sen R, Zon LI, Burakoff SJ.

J Immunol. 1996 Jun 15;156(12):4535-8.

PMID:
8648093
21.

Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.

Kapeller R, Toker A, Cantley LC, Carpenter CL.

J Biol Chem. 1995 Oct 27;270(43):25985-91.

22.

Phosphatidylinositol 3-kinase.

Kapeller R, Cantley LC.

Bioessays. 1994 Aug;16(8):565-76. Review.

PMID:
8086005
23.

Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.

Kapeller R, Prasad KV, Janssen O, Hou W, Schaffhausen BS, Rudd CE, Cantley LC.

J Biol Chem. 1994 Jan 21;269(3):1927-33.

24.

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

Prasad KV, Kapeller R, Janssen O, Repke H, Duke-Cohan JS, Cantley LC, Rudd CE.

Mol Cell Biol. 1993 Dec;13(12):7708-17.

25.

Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase).

Prasad KV, Kapeller R, Janssen O, Duke-Cohan JS, Repke H, Cantley LC, Rudd CE.

Philos Trans R Soc Lond B Biol Sci. 1993 Oct 29;342(1299):35-42.

PMID:
7904344
27.

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

Prasad KV, Janssen O, Kapeller R, Raab M, Cantley LC, Rudd CE.

Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7366-70.

28.

Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of phosphatidylinositol-3-kinase.

Yoakim M, Hou W, Liu Y, Carpenter CL, Kapeller R, Schaffhausen BS.

J Virol. 1992 Sep;66(9):5485-91.

29.

Phosphatidylinositol-3 kinase and growth regulation.

Soltoff SP, Carpenter CL, Auger KR, Kapeller R, Schaffhausen B, Cantley LC.

Cold Spring Harb Symp Quant Biol. 1992;57:75-80. Review. No abstract available.

PMID:
1339706
30.

Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin.

Kapeller R, Chen KS, Yoakim M, Schaffhausen BS, Backer J, White MF, Cantley LC, Ruderman NB.

Mol Endocrinol. 1991 Jun;5(6):769-77.

PMID:
1656240
31.

Oncogenes and signal transduction.

Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S.

Cell. 1991 Jan 25;64(2):281-302. Review. No abstract available. Erratum in: Cell 1991 May 31;65(5):following 914.

PMID:
1846320
32.

Activation of phosphatidylinositol 3-kinase by insulin.

Ruderman NB, Kapeller R, White MF, Cantley LC.

Proc Natl Acad Sci U S A. 1990 Feb;87(4):1411-5.

33.

The post-analytic migratory symptom.

KAPELLER R.

J Clin Exp Psychopathol. 1946 Apr;7:821-3. No abstract available.

PMID:
20999877

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