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Items: 1 to 50 of 81

1.

From discoveries in ageing research to therapeutics for healthy ageing.

Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E.

Nature. 2019 Jul;571(7764):183-192. doi: 10.1038/s41586-019-1365-2. Epub 2019 Jul 10. Review.

PMID:
31292558
2.

Dietary restriction induces posttranscriptional regulation of longevity genes.

Rollins JA, Shaffer D, Snow SS, Kapahi P, Rogers AN.

Life Sci Alliance. 2019 Jun 28;2(4). pii: e201800281. doi: 10.26508/lsa.201800281. Print 2019 Aug.

3.

RiboTag translatomic profiling of Drosophila oenocytes under aging and induced oxidative stress.

Huang K, Chen W, Zhu F, Li PW, Kapahi P, Bai H.

BMC Genomics. 2019 Jan 16;20(1):50. doi: 10.1186/s12864-018-5404-4.

4.

Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster.

Akagi K, Wilson KA, Katewa SD, Ortega M, Simons J, Hilsabeck TA, Kapuria S, Sharma A, Jasper H, Kapahi P.

PLoS Genet. 2018 Nov 1;14(11):e1007777. doi: 10.1371/journal.pgen.1007777. eCollection 2018 Nov.

5.

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality.

Chaudhuri J, Bains Y, Guha S, Kahn A, Hall D, Bose N, Gugliucci A, Kapahi P.

Cell Metab. 2018 Sep 4;28(3):337-352. doi: 10.1016/j.cmet.2018.08.014. Review.

PMID:
30184484
6.

Correction to: The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.

Kim H, Calatayud C, Guha S, Fernández-Carasa I, Berkowitz L, Carballo-Carbajal I, Ezquerra M, Fernández-Santiago R, Kapahi P, Raya Á, Miranda-Vizuete A, Lizcano JM, Vila M, Caldwell KA, Caldwell GA, Consiglio A, Dalfo E.

Mol Neurobiol. 2018 Sep;55(9):7553-7554. doi: 10.1007/s12035-018-1010-3.

7.

The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.

Kim H, Calatayud C, Guha S, Fernández-Carasa I, Berkowitz L, Carballo-Carbajal I, Ezquerra M, Fernández-Santiago R, Kapahi P, Raya Á, Miranda-Vizuete A, Lizcano JM, Vila M, Caldwell KA, Caldwell GA, Consiglio A, Dalfo E.

Mol Neurobiol. 2018 Sep;55(9):7533-7552. doi: 10.1007/s12035-018-0881-7. Epub 2018 Feb 10. Erratum in: Mol Neurobiol. 2018 Apr 2;:.

8.

Exonuclease EXD2 in mitochondrial translation.

Zid BM, Kapahi P.

Nat Cell Biol. 2018 Feb;20(2):120-122. doi: 10.1038/s41556-017-0031-x. No abstract available.

PMID:
29371705
9.

Mass Spectrometry-based in vitro Assay to Identify Drugs that Influence Cystine Solubility.

Bose N, Zee T, Kapahi P, Stoller ML.

Bio Protoc. 2017 Jul 20;7(14). pii: e2417. doi: 10.21769/BioProtoc.2417.

10.

Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study.

Tomiyama AJ, Milush JM, Lin J, Flynn JM, Kapahi P, Verdin E, Sinclair E, Melov S, Epel ES.

Nutr Healthy Aging. 2017 Mar 31;4(2):147-156. doi: 10.3233/NHA-160017.

11.

α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.

Zee T, Bose N, Zee J, Beck JN, Yang S, Parihar J, Yang M, Damodar S, Hall D, O'Leary MN, Ramanathan A, Gerona RR, Killilea DW, Chi T, Tischfield J, Sahota A, Kahn A, Stoller ML, Kapahi P.

Nat Med. 2017 Mar;23(3):288-290. doi: 10.1038/nm.4280. Epub 2017 Feb 6.

12.

Dietary restriction and lifespan: Lessons from invertebrate models.

Kapahi P, Kaeberlein M, Hansen M.

Ageing Res Rev. 2017 Oct;39:3-14. doi: 10.1016/j.arr.2016.12.005. Epub 2016 Dec 19. Review.

13.

A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans.

Khanna A, Kumar J, Vargas MA, Barrett L, Katewa S, Li P, McCloskey T, Sharma A, Naudé N, Nelson C, Brem R, Killilea DW, Mooney SD, Gill M, Kapahi P.

Sci Rep. 2016 Dec 13;6:38764. doi: 10.1038/srep38764.

14.

Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila.

Nelson CS, Beck JN, Wilson KA, Pilcher ER, Kapahi P, Brem RB.

BMC Genomics. 2016 Nov 4;17(1):867.

15.

Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction.

Luis NM, Wang L, Ortega M, Deng H, Katewa SD, Li PW, Karpac J, Jasper H, Kapahi P.

Cell Rep. 2016 Oct 25;17(5):1207-1216. doi: 10.1016/j.celrep.2016.10.003.

16.

A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.

Chaudhuri J, Bose N, Gong J, Hall D, Rifkind A, Bhaumik D, Peiris TH, Chamoli M, Le CH, Liu J, Lithgow GJ, Ramanathan A, Xu XZS, Kapahi P.

Curr Biol. 2016 Nov 21;26(22):3014-3025. doi: 10.1016/j.cub.2016.09.024. Epub 2016 Oct 20.

17.

Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.

Kumar J, Barhydt T, Awasthi A, Lithgow GJ, Killilea DW, Kapahi P.

PLoS One. 2016 Apr 14;11(4):e0153513. doi: 10.1371/journal.pone.0153513. eCollection 2016.

18.

Alzheimer's Model Develops Early ADHD Syndrome.

Zhang Q, Du G, John V, Kapahi P, Bredesen DE.

J Neurol Neurophysiol. 2015;6(6):1-6.

19.

Simvastatin suppresses breast cancer cell proliferation induced by senescent cells.

Liu S, Uppal H, Demaria M, Desprez PY, Campisi J, Kapahi P.

Sci Rep. 2015 Dec 14;5:17895. doi: 10.1038/srep17895.

20.

Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila.

Katewa SD, Akagi K, Bose N, Rakshit K, Camarella T, Zheng X, Hall D, Davis S, Nelson CS, Brem RB, Ramanathan A, Sehgal A, Giebultowicz JM, Kapahi P.

Cell Metab. 2016 Jan 12;23(1):143-54. doi: 10.1016/j.cmet.2015.10.014. Epub 2015 Nov 25.

21.

The elementome of calcium-based urinary stones and its role in urolithiasis.

Ramaswamy K, Killilea DW, Kapahi P, Kahn AJ, Chi T, Stoller ML.

Nat Rev Urol. 2015 Oct;12(10):543-57. doi: 10.1038/nrurol.2015.208. Epub 2015 Sep 1. Review.

22.

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.

Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Curran SC, Davalos AR, Wilson-Edell KA, Liu S, Limbad C, Demaria M, Li P, Hubbard GB, Ikeno Y, Javors M, Desprez PY, Benz CC, Kapahi P, Nelson PS, Campisi J.

Nat Cell Biol. 2015 Aug;17(8):1049-61. doi: 10.1038/ncb3195. Epub 2015 Jul 6.

23.

The effects of age and dietary restriction on the tissue-specific metabolome of Drosophila.

Laye MJ, Tran V, Jones DP, Kapahi P, Promislow DE.

Aging Cell. 2015 Oct;14(5):797-808. doi: 10.1111/acel.12358. Epub 2015 Jun 18.

24.

Elemental Content of Calcium Oxalate Stones from a Canine Model of Urinary Stone Disease.

Killilea DW, Westropp JL, Shiraki R, Mellema M, Larsen J, Kahn AJ, Kapahi P, Chi T, Stoller ML.

PLoS One. 2015 Jun 11;10(6):e0128374. doi: 10.1371/journal.pone.0128374. eCollection 2015.

25.

A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease.

Chi T, Kim MS, Lang S, Bose N, Kahn A, Flechner L, Blaschko SD, Zee T, Muteliefu G, Bond N, Kolipinski M, Fakra SC, Mandel N, Miller J, Ramanathan A, Killilea DW, Brückner K, Kapahi P, Stoller ML.

PLoS One. 2015 May 13;10(5):e0124150. doi: 10.1371/journal.pone.0124150. eCollection 2015.

26.

Iron promotes protein insolubility and aging in C. elegans.

Klang IM, Schilling B, Sorensen DJ, Sahu AK, Kapahi P, Andersen JK, Swoboda P, Killilea DW, Gibson BW, Lithgow GJ.

Aging (Albany NY). 2014 Nov;6(11):975-91.

27.

Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes.

Chatterjee D, Katewa SD, Qi Y, Jackson SA, Kapahi P, Jasper H.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17959-64. doi: 10.1073/pnas.1409241111. Epub 2014 Dec 3.

28.

Mitobolites: the elixir of life.

Katewa SD, Khanna A, Kapahi P.

Cell Metab. 2014 Jul 1;20(1):8-9. doi: 10.1016/j.cmet.2014.06.013.

29.

Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans.

Lin YH, Chen YC, Kao TY, Lin YC, Hsu TE, Wu YC, Ja WW, Brummel TJ, Kapahi P, Yuh CH, Yu LK, Lin ZH, You RJ, Jhong YT, Wang HD.

Aging Cell. 2014 Aug;13(4):755-64. doi: 10.1111/acel.12232. Epub 2014 May 30.

30.

Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans.

Kaul TK, Reis Rodrigues P, Ogungbe IV, Kapahi P, Gill MS.

PLoS One. 2014 Jan 24;9(1):e86979. doi: 10.1371/journal.pone.0086979. eCollection 2014.

31.

Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans.

Chen D, Li PW, Goldstein BA, Cai W, Thomas EL, Chen F, Hubbard AE, Melov S, Kapahi P.

Cell Rep. 2013 Dec 26;5(6):1600-10. doi: 10.1016/j.celrep.2013.11.018. Epub 2013 Dec 12.

32.

SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.

Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D.

Cell Rep. 2013 Nov 14;5(3):654-665. doi: 10.1016/j.celrep.2013.10.007. Epub 2013 Nov 7. Erratum in: Cell Rep. 2013 Dec 12;5(5):1479.

33.

Late-life rapamycin treatment reverses age-related heart dysfunction.

Flynn JM, O'Leary MN, Zambataro CA, Academia EC, Presley MP, Garrett BJ, Zykovich A, Mooney SD, Strong R, Rosen CJ, Kapahi P, Nelson MD, Kennedy BK, Melov S.

Aging Cell. 2013 Oct;12(5):851-62. doi: 10.1111/acel.12109. Epub 2013 Jul 7.

34.

Drosophila melanogaster as an emerging translational model of human nephrolithiasis.

Miller J, Chi T, Kapahi P, Kahn AJ, Kim MS, Hirata T, Romero MF, Dow JA, Stoller ML.

J Urol. 2013 Nov;190(5):1648-56. doi: 10.1016/j.juro.2013.03.010. Epub 2013 Mar 7. Review.

35.

High carbohydrate-low protein consumption maximizes Drosophila lifespan.

Bruce KD, Hoxha S, Carvalho GB, Yamada R, Wang HD, Karayan P, He S, Brummel T, Kapahi P, Ja WW.

Exp Gerontol. 2013 Oct;48(10):1129-35. doi: 10.1016/j.exger.2013.02.003. Epub 2013 Feb 10.

36.

Strontium substitution for calcium in lithogenesis.

Blaschko SD, Chi T, Miller J, Flechner L, Fakra S, Kapahi P, Kahn A, Stoller ML.

J Urol. 2013 Feb;189(2):735-9. doi: 10.1016/j.juro.2012.08.199. Epub 2012 Dec 20.

37.

Microcomposition of human urinary calculi using advanced imaging techniques.

Blaschko SD, Miller J, Chi T, Flechner L, Fakra S, Kahn A, Kapahi P, Stoller ML.

J Urol. 2013 Feb;189(2):726-34. doi: 10.1016/j.juro.2012.09.098. Epub 2012 Sep 25.

38.

Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster.

Katewa SD, Demontis F, Kolipinski M, Hubbard A, Gill MS, Perrimon N, Melov S, Kapahi P.

Cell Metab. 2012 Jul 3;16(1):97-103. doi: 10.1016/j.cmet.2012.06.005.

39.

Glucocorticoids suppress selected components of the senescence-associated secretory phenotype.

Laberge RM, Zhou L, Sarantos MR, Rodier F, Freund A, de Keizer PL, Liu S, Demaria M, Cong YS, Kapahi P, Desprez PY, Hughes RE, Campisi J.

Aging Cell. 2012 Aug;11(4):569-78. doi: 10.1111/j.1474-9726.2012.00818.x. Epub 2012 Apr 17.

40.

Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.

Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, Shen ZY.

PLoS One. 2011;6(12):e28835. doi: 10.1371/journal.pone.0028835. Epub 2011 Dec 21.

41.

Rapamycin: killing two birds with one stone.

Khanna A, Kapahi P.

Aging (Albany NY). 2011 Nov;3(11):1043-4. No abstract available.

42.

Cellular senescence: a link between cancer and age-related degenerative disease?

Campisi J, Andersen JK, Kapahi P, Melov S.

Semin Cancer Biol. 2011 Dec;21(6):354-9. doi: 10.1016/j.semcancer.2011.09.001. Epub 2011 Sep 10. Review.

43.

Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans.

Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P.

Cell Metab. 2011 Jul 6;14(1):55-66. doi: 10.1016/j.cmet.2011.05.010.

44.

Role of TOR signaling in aging and related biological processes in Drosophila melanogaster.

Katewa SD, Kapahi P.

Exp Gerontol. 2011 May;46(5):382-90. doi: 10.1016/j.exger.2010.11.036. Epub 2010 Dec 2. Review.

45.

Protein synthesis and the antagonistic pleiotropy hypothesis of aging.

Kapahi P.

Adv Exp Med Biol. 2010;694:30-7. Review.

PMID:
20886754
46.

Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans.

McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ.

Cell Metab. 2010 Sep 8;12(3):260-72. doi: 10.1016/j.cmet.2010.08.004.

47.

Circadian clocks and metabolism: the nutrient-sensing AKT and TOR pathways make the link.

Giebultowicz J, Kapahi P.

Curr Biol. 2010 Jul 27;20(14):R608-9. doi: 10.1016/j.cub.2010.05.052.

48.

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.

Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, Kockel L.

Cell Metab. 2010 Jun 9;11(6):453-65. doi: 10.1016/j.cmet.2010.05.001. Review.

49.

Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster.

Garcia AM, Calder RB, Dollé ME, Lundell M, Kapahi P, Vijg J.

PLoS Genet. 2010 May 13;6(5):e1000950. doi: 10.1371/journal.pgen.1000950.

50.

A role for S6 kinase and serotonin in postmating dietary switch and balance of nutrients in D. melanogaster.

Vargas MA, Luo N, Yamaguchi A, Kapahi P.

Curr Biol. 2010 Jun 8;20(11):1006-11. doi: 10.1016/j.cub.2010.04.009. Epub 2010 May 13.

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