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Mol Cancer Ther. 2019 Sep;18(9):1475-1483. doi: 10.1158/1535-7163.MCT-19-0307.

DUBbing Down Translation: The Functional Interaction of Deubiquitinases with the Translational Machinery.

Author information

1
University of Maryland School of Medicine, Baltimore, Maryland. rgartenhaus@som.umaryland.edu BKapadia@som.umaryland.edu.
2
Veterans Administration Medical Center, Baltimore, Maryland.

Abstract

Cancer cells revamp the regulatory processes that control translation to induce tumor-specific translational programs that can adapt to a hostile microenvironment as well as withstand anticancer therapeutics. Translational initiation has been established as a common downstream effector of numerous deregulated signaling pathways that together culminate in prooncogenic expression. Other mechanisms, including ribosomal stalling and stress granule assembly, also appear to be rewired in the malignant phenotype. Therefore, better understanding of the underlying perturbations driving oncogenic translation in the transformed state will provide innovative therapeutic opportunities. This review highlights deubiquitinating enzymes that are activated/dysregulated in hematologic malignancies, thereby altering the translational output and contributing to tumorigenesis.

PMID:
31481479
PMCID:
PMC6727985
[Available on 2020-03-01]
DOI:
10.1158/1535-7163.MCT-19-0307

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