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Therapeutic efficacy of mesenchymal stem cells for the treatment of congenital and acquired corneal opacity.

Call M, Elzarka M, Kunesh M, Hura N, Birk DE, Kao WW.

Mol Vis. 2019 Aug 7;25:415-426. eCollection 2019.


Repressed Wnt Signaling Accelerates the Aging Process in Mouse Eyes.

Zhang Y, Jeffrey J, Dong F, Zhang J, Kao WW, Liu CY, Yuan Y.

J Ophthalmol. 2019 Jun 17;2019:7604396. doi: 10.1155/2019/7604396. eCollection 2019.


Transient expression of Wnt5a elicits ocular features of pseudoexfoliation syndrome in mice.

Yuan Y, Schlötzer-Schrehardt U, Ritch R, Call M, Chu FB, Dong F, Rice T, Zhang J, Kao WW.

PLoS One. 2019 Mar 6;14(3):e0212569. doi: 10.1371/journal.pone.0212569. eCollection 2019.


Sensory nerve supports epithelial stem cell function in healing of corneal epithelium in mice: the role of trigeminal nerve transient receptor potential vanilloid 4.

Okada Y, Sumioka T, Ichikawa K, Sano H, Nambu A, Kobayashi K, Uchida K, Suzuki Y, Tominaga M, Reinach PS, Hirai SI, Jester JV, Miyajima M, Shirai K, Iwanishi H, Kao WW, Liu CY, Saika S.

Lab Invest. 2019 Feb;99(2):210-230. doi: 10.1038/s41374-018-0118-4. Epub 2018 Nov 9.


Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis.

Wolff G, Taranko AE, Meln I, Weinmann J, Sijmonsma T, Lerch S, Heide D, Billeter AT, Tews D, Krunic D, Fischer-Posovszky P, Müller-Stich BP, Herzig S, Grimm D, Heikenwälder M, Kao WW, Vegiopoulos A.

Mol Metab. 2019 Jan;19:97-106. doi: 10.1016/j.molmet.2018.10.007. Epub 2018 Oct 23.


A Mouse Model of Schnyder Corneal Dystrophy with the N100S Point Mutation.

Dong F, Jin X, Boettler MA, Sciulli H, Abu-Asab M, Del Greco C, Wang S, Hu YC, Campos MM, Jackson SN, Muller L, Woods AS, Combs CA, Zhang J, Nickerson ML, Kruth HS, Weiss JS, Kao WW.

Sci Rep. 2018 Jul 5;8(1):10219. doi: 10.1038/s41598-018-28545-0.


Impaired healing of cornea incision injury in a TRPV1-deficient mouse.

Nidegawa-Saitoh Y, Sumioka T, Okada Y, Reinach PS, Flanders KC, Liu CY, Yamanaka O, Kao WW, Saika S.

Cell Tissue Res. 2018 Nov;374(2):329-338. doi: 10.1007/s00441-018-2878-y. Epub 2018 Jul 4.


Hair Follicle Stem Cell Isolation and Expansion.

Call M, Meyer EA, Kao WW, Kruse FE, Schlötzer-Schrehardt U.

Bio Protoc. 2018 May 20;8(10). pii: e2848. doi: 10.21769/BioProtoc.2848.


Lack of plakoglobin impairs integrity and wound healing in corneal epithelium in mice.

Kokado M, Miyajima M, Okada Y, Ichikawa K, Yamanaka O, Liu CY, Kao WW, Shou W, Saika S.

Lab Invest. 2018 Nov;98(11):1375-1383. doi: 10.1038/s41374-018-0082-z. Epub 2018 May 25.


Impact of Hyaluronic Acid-Containing Artificial Tear Products on Reepithelialization in an In Vivo Corneal Wound Model.

Carlson E, Kao WWY, Ogundele A.

J Ocul Pharmacol Ther. 2018 May;34(4):360-364. doi: 10.1089/jop.2017.0080. Epub 2018 Feb 2.


Generation and Characterization of a Novel Mouse Line, Keratocan-rtTA (KeraRT), for Corneal Stroma and Tendon Research.

Zhang Y, Kao WW, Hayashi Y, Zhang L, Call M, Dong F, Yuan Y, Zhang J, Wang YC, Yuka O, Shiraishi A, Liu CY.

Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4800-4808. doi: 10.1167/iovs.17-22661.


Role of EGF receptor signaling on morphogenesis of eyelid and meibomian glands.

Dong F, Call M, Xia Y, Kao WW.

Exp Eye Res. 2017 Oct;163:58-63. doi: 10.1016/j.exer.2017.04.006. Review.


Loss of SLC25A46 causes neurodegeneration by affecting mitochondrial dynamics and energy production in mice.

Li Z, Peng Y, Hufnagel RB, Hu YC, Zhao C, Queme LF, Khuchua Z, Driver AM, Dong F, Lu QR, Lindquist DM, Jankowski MP, Stottmann RW, Kao WWY, Huang T.

Hum Mol Genet. 2017 Oct 1;26(19):3776-3791. doi: 10.1093/hmg/ddx262.


Meibomian gland morphogenesis requires developmental eyelid closure and lid fusion.

Wang J, Call M, Mongan M, Kao WW, Xia Y.

Ocul Surf. 2017 Oct;15(4):704-712. doi: 10.1016/j.jtos.2017.03.002. Epub 2017 Mar 8.


Lumican Peptides: Rational Design Targeting ALK5/TGFBRI.

Gesteira TF, Coulson-Thomas VJ, Yuan Y, Zhang J, Nader HB, Kao WW.

Sci Rep. 2017 Feb 9;7:42057. doi: 10.1038/srep42057.


Lumican-null mice are susceptible to aging and isoproterenol-induced myocardial fibrosis.

Chen SW, Tung YC, Jung SM, Chu Y, Lin PJ, Kao WW, Chu PH.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1304-1311. doi: 10.1016/j.bbrc.2016.12.033. Epub 2016 Dec 7.


Lumican negatively controls the pathogenicity of murine encephalitic TH17 cells.

Castillo EF, Zheng H, Van Cabanlong C, Dong F, Luo Y, Yang Y, Liu M, Kao WW, Yang XO.

Eur J Immunol. 2016 Dec;46(12):2852-2861. doi: 10.1002/eji.201646507. Epub 2016 Oct 24.


Cell Therapy of Corneal Diseases.

Kao WW, Coulson-Thomas VJ.

Cornea. 2016 Nov;35 Suppl 1:S9-S19. Review.


Study of corneal epithelial progenitor origin and the Yap1 requirement using keratin 12 lineage tracing transgenic mice.

Kasetti RB, Gaddipati S, Tian S, Xue L, Kao WW, Lu Q, Li Q.

Sci Rep. 2016 Oct 13;6:35202. doi: 10.1038/srep35202.


A Case of Solitary Nonvascularized Corneal Epithelial Dysplasia.

Morii T, Sumioka T, Izutani-Kitano A, Takada Y, Okada Y, Kao WW, Saika S.

Case Rep Ophthalmol Med. 2016;2016:5687285. doi: 10.1155/2016/5687285. Epub 2016 Mar 3.


A unique lineage gives rise to the meibomian gland.

Call M, Fischesser K, Lunn MO, Kao WW.

Mol Vis. 2016 Feb 21;22:168-76. eCollection 2016.


Mesenchymal stem cells for treating ocular surface diseases.

Zhang L, Coulson-Thomas VJ, Ferreira TG, Kao WW.

BMC Ophthalmol. 2015 Dec 17;15 Suppl 1:155. doi: 10.1186/s12886-015-0138-4. Review.


Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System.

Coulson-Thomas VJ, Coulson-Thomas YM, Gesteira TF, Kao WW.

Ocul Surf. 2016 Apr;14(2):121-34. doi: 10.1016/j.jtos.2015.11.004. Epub 2016 Jan 12. Review.


Wnt/β-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development.

Zhang Y, Yeh LK, Zhang S, Call M, Yuan Y, Yasunaga M, Kao WW, Liu CY.

Development. 2015 Oct 1;142(19):3383-93. doi: 10.1242/dev.125393.


Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma.

Dong F, Liu CY, Yuan Y, Zhang Y, Li W, Call M, Zhang L, Chen Y, Liu Z, Kao WW.

Dev Biol. 2015 Oct 15;406(2):147-57. doi: 10.1016/j.ydbio.2015.09.003. Epub 2015 Sep 10.


Corneal Epithelial Wound Healing.

Liu CY, Kao WW.

Prog Mol Biol Transl Sci. 2015;134:61-71. doi: 10.1016/bs.pmbts.2015.05.002. Epub 2015 Jun 12. Review.


Disruption of eyelid and cornea morphogenesis by epithelial β-catenin gain-of-function.

Mizoguchi S, Suzuki K, Zhang J, Yamanaka O, Liu CY, Okada Y, Miyajima M, Kokado M, Kao WW, Yamada G, Saika S.

Mol Vis. 2015 Jul 31;21:793-803. eCollection 2015.


Gene-Environment Interactions Target Mitogen-activated Protein 3 Kinase 1 (MAP3K1) Signaling in Eyelid Morphogenesis.

Mongan M, Meng Q, Wang J, Kao WW, Puga A, Xia Y.

J Biol Chem. 2015 Aug 7;290(32):19770-9. doi: 10.1074/jbc.M115.665729. Epub 2015 Jun 24.


Spatiotemporally Regulated Ablation of Klf4 in Adult Mouse Corneal Epithelial Cells Results in Altered Epithelial Cell Identity and Disrupted Homeostasis.

Delp EE, Swamynathan S, Kao WW, Swamynathan SK.

Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3549-58. doi: 10.1167/iovs.15-16463.


Eyelid closure in embryogenesis is required for ocular adnexa development.

Meng Q, Mongan M, Carreira V, Kurita H, Liu CY, Kao WW, Xia Y.

Invest Ophthalmol Vis Sci. 2014 Nov 6;55(11):7652-61. doi: 10.1167/iovs.14-15155.


ABCB5 is a limbal stem cell gene required for corneal development and repair.

Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY.

Nature. 2014 Jul 17;511(7509):353-7. doi: 10.1038/nature13426. Epub 2014 Jul 2.


The role of proteoglycans in the reactive stroma on tumor growth and progression.

Coulson-Thomas YM, Gesteira TF, Norton AL, Kao WW, Nader HB, Coulson-Thomas VJ.

Histol Histopathol. 2015 Jan;30(1):33-41. doi: 10.14670/HH-30.33. Epub 2014 Jun 16. Review.


Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea.

Kawakami-Schulz SV, Verdoni AM, Sattler SG, Jessen E, Kao WW, Ikeda A, Ikeda S.

Physiol Genomics. 2014 Apr 15;46(8):277-89. doi: 10.1152/physiolgenomics.00126.2013. Epub 2014 Feb 18.


Lumican binds ALK5 to promote epithelium wound healing.

Yamanaka O, Yuan Y, Coulson-Thomas VJ, Gesteira TF, Call MK, Zhang Y, Zhang J, Chang SH, Xie C, Liu CY, Saika S, Jester JV, Kao WW.

PLoS One. 2013 Dec 18;8(12):e82730. doi: 10.1371/journal.pone.0082730. eCollection 2013.


Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification.

Ng GY, Yeh LK, Zhang Y, Liu H, Feng GS, Kao WW, Liu CY.

Invest Ophthalmol Vis Sci. 2013 Dec 3;54(13):7933-42. doi: 10.1167/iovs.13-12646.


Dexamethasone induces cross-linked actin networks in trabecular meshwork cells through noncanonical wnt signaling.

Yuan Y, Call MK, Yuan Y, Zhang Y, Fischesser K, Liu CY, Kao WW.

Invest Ophthalmol Vis Sci. 2013 Oct 3;54(10):6502-9. doi: 10.1167/iovs.13-12447.


Transplantation of human umbilical mesenchymal stem cells cures the corneal defects of mucopolysaccharidosis VII mice.

Coulson-Thomas VJ, Caterson B, Kao WW.

Stem Cells. 2013 Oct;31(10):2116-26. doi: 10.1002/stem.1481.


Lumican exhibits anti-angiogenic activity in a context specific manner.

Sharma B, Ramus MD, Kirkwood CT, Sperry EE, Chu PH, Kao WW, Albig AR.

Cancer Microenviron. 2013 Dec;6(3):263-71. doi: 10.1007/s12307-013-0134-2. Epub 2013 Jun 18.


Intracellularly-retained decorin lacking the C-terminal ear repeat causes ER stress: a cell-based etiological mechanism for congenital stromal corneal dystrophy.

Chen S, Sun M, Iozzo RV, Kao WW, Birk DE.

Am J Pathol. 2013 Jul;183(1):247-56. doi: 10.1016/j.ajpath.2013.04.001. Epub 2013 May 15.


Targeted overexpression of TGF-α in the corneal epithelium of adult transgenic mice induces changes in anterior segment morphology and activates noncanonical Wnt signaling.

Yuan Y, Yeh LK, Liu H, Yamanaka O, Hardie WD, Kao WW, Liu CY.

Invest Ophthalmol Vis Sci. 2013 Mar 11;54(3):1829-37. doi: 10.1167/iovs.12-11477.


Lumican expression, localization and antitumor activity in prostate cancer.

Coulson-Thomas VJ, Coulson-Thomas YM, Gesteira TF, Andrade de Paula CA, Carneiro CR, Ortiz V, Toma L, Kao WW, Nader HB.

Exp Cell Res. 2013 Apr 15;319(7):967-81. doi: 10.1016/j.yexcr.2013.01.023. Epub 2013 Feb 8.


Wakayama symposium: challenges of future research in ocular surface cell biology.

Kao WW, Liu H, Zhang J.

Ocul Surf. 2013 Jan;11(1):19-24. doi: 10.1016/j.jtos.2012.07.002. Epub 2012 Jul 25. Review.


Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity.

Zhang Y, Lam O, Nguyen MT, Ng G, Pear WS, Ai W, Wang IJ, Kao WW, Liu CY.

Development. 2013 Feb 1;140(3):594-605. doi: 10.1242/dev.082842.


Impaired cornea wound healing in a tenascin C-deficient mouse model.

Sumioka T, Kitano A, Flanders KC, Okada Y, Yamanaka O, Fujita N, Iwanishi H, Kao WW, Saika S.

Lab Invest. 2013 Feb;93(2):207-17. doi: 10.1038/labinvest.2012.157. Epub 2012 Dec 3.


Lumican regulates ventilation-induced epithelial-mesenchymal transition through extracelluar signal-regulated kinase pathway.

Li LF, Chu PH, Hung CY, Kao WW, Lin MC, Liu YY, Yang CT.

Chest. 2013 May;143(5):1252-1260. doi: 10.1378/chest.12-2058.


Lumican promotes corneal epithelial wound healing.

Liu CY, Kao WW.

Methods Mol Biol. 2012;836:285-90. doi: 10.1007/978-1-61779-498-8_18.


Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specific Col5a1-null mouse model.

Sun M, Chen S, Adams SM, Florer JB, Liu H, Kao WW, Wenstrup RJ, Birk DE.

J Cell Sci. 2011 Dec 1;124(Pt 23):4096-105. doi: 10.1242/jcs.091363. Epub 2011 Dec 8.


Lumican expression in diaphragm induced by mechanical ventilation.

Li LF, Chen BX, Tsai YH, Kao WW, Yang CT, Chu PH.

PLoS One. 2011;6(9):e24692. doi: 10.1371/journal.pone.0024692. Epub 2011 Sep 9.


Crosstalk between TGF-beta and MAPK signaling during corneal wound healing.

Terai K, Call MK, Liu H, Saika S, Liu CY, Hayashi Y, Chikama T, Zhang J, Terai N, Kao CW, Kao WW.

Invest Ophthalmol Vis Sci. 2011 Oct 17;52(11):8208-15. doi: 10.1167/iovs.11-8017.


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