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Items: 1 to 50 of 61

1.

Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens.

Deng J, Wang X, Zhang BZ, Gao P, Lin Q, Kao RY, Gustafsson K, Yuen KY, Huang JD.

mSphere. 2019 Sep 4;4(5). pii: e00362-19. doi: 10.1128/mSphere.00362-19.

2.

Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts.

Lam WH, Sze KH, Ke Y, Tse MK, Zhang H, Woo PCY, Lau SKP, Lau CCY, Xu S, Lai PM, Zhou T, Antonyuk SV, Kao RYT, Yuen KY, Hao Q.

Infect Immun. 2019 Mar 25;87(4). pii: e00679-18. doi: 10.1128/IAI.00679-18. Print 2019 Apr.

PMID:
30670555
3.

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication.

Yan B, Chu H, Yang D, Sze KH, Lai PM, Yuan S, Shuai H, Wang Y, Kao RY, Chan JF, Yuen KY.

Viruses. 2019 Jan 16;11(1). pii: E73. doi: 10.3390/v11010073.

4.

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.

Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY.

Nat Commun. 2019 Jan 10;10(1):120. doi: 10.1038/s41467-018-08015-x.

5.

A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating.

Ni YX, Zhou N, Xue WQ, Rong L, Yung WH, Lin RZ, Kao RY, Duan ZG, Sun HT, Gong HR, Tang XM, Liu MF, Zhang W, Qi S, Chung S, Song YQ, Huang JD.

Cell Discov. 2018 Dec 25;4:65. doi: 10.1038/s41421-018-0067-5. eCollection 2018.

6.

Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein⁻Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers.

Yiu SPT, Hui KF, Choi CK, Kao RYT, Ma CW, Yang D, Chiang AKS.

Cancers (Basel). 2018 Dec 11;10(12). pii: E505. doi: 10.3390/cancers10120505.

7.

The ribosomal maturation factor P from Mycobacterium smegmatis facilitates the ribosomal biogenesis by binding to the small ribosomal protein S12.

Chu T, Weng X, Law COK, Kong HK, Lau J, Li S, Pham HQ, Wang R, Zhang L, Kao RYT, Lau KF, Ngo JCK, Lau TCK.

J Biol Chem. 2019 Jan 4;294(1):372-378. doi: 10.1074/jbc.RA118.002298. Epub 2018 Nov 8.

PMID:
30409901
8.

Suppression of Staphylococcus aureus virulence by a small-molecule compound.

Gao P, Ho PL, Yan B, Sze KH, Davies J, Kao RYT.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):8003-8008. doi: 10.1073/pnas.1720520115. Epub 2018 Jul 16.

9.

Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice.

Lee ACY, To KKW, Zhang AJX, Zhu H, Li C, Zhang RR, Hung IFN, Kao RYT, Chan KH, Yuen KY.

Arch Virol. 2018 Sep;163(9):2349-2358. doi: 10.1007/s00705-018-3852-4. Epub 2018 May 7.

PMID:
29736671
10.

Identification of catabolite control protein A from Staphylococcus aureus as a target of silver ions.

Liao X, Yang F, Wang R, He X, Li H, Kao RYT, Xia W, Sun H.

Chem Sci. 2017 Dec 1;8(12):8061-8066. doi: 10.1039/c7sc02251d. Epub 2017 Oct 2.

11.

Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors.

Wang R, Lai TP, Gao P, Zhang H, Ho PL, Woo PC, Ma G, Kao RY, Li H, Sun H.

Nat Commun. 2018 Jan 30;9(1):439. doi: 10.1038/s41467-018-02828-6.

12.

Mp1p homologues as virulence factors in Aspergillus fumigatus.

Woo PCY, Lau SKP, Lau CCY, Tung ETK, Au-Yeung RKH, Cai JP, Chong KTK, Sze KH, Kao RY, Hao Q, Yuen KY.

Med Mycol. 2018 Apr 1;56(3):350-360. doi: 10.1093/mmy/myx052.

PMID:
28992243
13.

A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis.

Tse H, Gu Q, Sze KH, Chu IK, Kao RY, Lee KC, Lam CW, Yang D, Tai SS, Ke Y, Chan E, Chan WM, Dai J, Leung SP, Leung SY, Yuen KY.

J Biol Chem. 2017 Nov 24;292(47):19503-19520. doi: 10.1074/jbc.M117.791558. Epub 2017 Sep 26.

14.

Dehydrosqualene Desaturase as a Novel Target for Anti-Virulence Therapy against Staphylococcus aureus.

Gao P, Davies J, Kao RYT.

MBio. 2017 Sep 5;8(5). pii: e01224-17. doi: 10.1128/mBio.01224-17.

15.

Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model.

Zhang BZ, Cai J, Yu B, Xiong L, Lin Q, Yang XY, Xu C, Zheng S, Kao RY, Sze K, Yuen KY, Huang JD.

J Infect Dis. 2017 Jul 15;216(2):245-253. doi: 10.1093/infdis/jix290.

16.

Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response.

Cheung NN, Lai KK, Dai J, Kok KH, Chen H, Chan KH, Yuen KY, Kao RYT.

J Gen Virol. 2017 May;98(5):946-954. doi: 10.1099/jgv.0.000758. Epub 2017 May 30.

PMID:
28555543
17.

Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor.

Chan JF, Chik KK, Yuan S, Yip CC, Zhu Z, Tee KM, Tsang JO, Chan CC, Poon VK, Lu G, Zhang AJ, Lai KK, Chan KH, Kao RY, Yuen KY.

Antiviral Res. 2017 May;141:29-37. doi: 10.1016/j.antiviral.2017.02.002. Epub 2017 Feb 7.

PMID:
28185815
18.

Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response.

Sze KH, Lam WH, Zhang H, Ke YH, Tse MK, Woo PCY, Lau SKP, Lau CCY, Cai JP, Tung ETK, Lo RKC, Xu S, Kao RYT, Hao Q, Yuen KY.

Cell Chem Biol. 2017 Feb 16;24(2):182-194. doi: 10.1016/j.chembiol.2016.12.014. Epub 2017 Jan 19.

19.

Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface.

Yuan S, Chu H, Ye J, Singh K, Ye Z, Zhao H, Kao RY, Chow BK, Zhou J, Zheng BJ.

Antiviral Res. 2017 Jan;137:58-66. doi: 10.1016/j.antiviral.2016.11.005. Epub 2016 Nov 10.

PMID:
27840201
20.

A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile.

Zhang BZ, Cai J, Yu B, Hua Y, Lau CC, Kao RY, Sze KH, Yuen KY, Huang JD.

BMC Infect Dis. 2016 Oct 22;16(1):596.

21.

Construction of a Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression and the Identification of Usnic Acid as a Potent Suppressor of psm Gene Expression.

Gao P, Wang Y, Villanueva I, Ho PL, Davies J, Kao RY.

Front Microbiol. 2016 Aug 30;7:1344. doi: 10.3389/fmicb.2016.01344. eCollection 2016.

22.

Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei.

Woo PC, Lau SK, Lau CC, Tung ET, Chong KT, Yang F, Zhang H, Lo RK, Cai JP, Au-Yeung RK, Ng WF, Tse H, Wong SS, Xu S, Lam WH, Tse MK, Sze KH, Kao RY, Reiner NE, Hao Q, Yuen KY.

PLoS Negl Trop Dis. 2016 Aug 25;10(8):e0004907. doi: 10.1371/journal.pntd.0004907. eCollection 2016 Aug.

23.

Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites.

Pang B, Cheung NN, Zhang W, Dai J, Kao RY, Zhang H, Hao Q.

Sci Rep. 2016 Jul 11;6:29684. doi: 10.1038/srep29684.

24.

A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication.

Yuan S, Chu H, Zhang K, Ye J, Singh K, Kao RY, Chow BK, Zhou J, Zheng BJ.

J Antimicrob Chemother. 2016 Sep;71(9):2489-97. doi: 10.1093/jac/dkw194. Epub 2016 Jun 5.

PMID:
27272726
25.

Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans.

To KK, Mok KY, Chan AS, Cheung NN, Wang P, Lui YM, Chan JF, Chen H, Chan KH, Kao RY, Yuen KY.

J Gen Virol. 2016 Aug;97(8):1807-17. doi: 10.1099/jgv.0.000512. Epub 2016 Jun 2.

PMID:
27259985
26.

Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization.

Chan CM, Chu H, Zhang AJ, Leung LH, Sze KH, Kao RY, Chik KK, To KK, Chan JF, Chen H, Jin DY, Liu L, Yuen KY.

Virology. 2016 Jul;494:78-88. doi: 10.1016/j.virol.2016.04.008. Epub 2016 Apr 14.

27.

A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase.

Yuan S, Chu H, Singh K, Zhao H, Zhang K, Kao RY, Chow BK, Zhou J, Zheng BJ.

Sci Rep. 2016 Mar 9;6:22880. doi: 10.1038/srep22880.

28.

Development of novel implants with self-antibacterial performance through in-situ growth of 1D ZnO nanowire.

Wang W, Li TL, Wong HM, Chu PK, Kao RYT, Wu S, Leung FKL, Wong TM, To MKT, Cheung KMC, Yeung KWK.

Colloids Surf B Biointerfaces. 2016 May 1;141:623-633. doi: 10.1016/j.colsurfb.2016.02.036. Epub 2016 Feb 18.

PMID:
26918511
29.

Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies.

Choi CK, Ho DN, Hui KF, Kao RY, Chiang AK.

PLoS One. 2015 Dec 30;10(12):e0145994. doi: 10.1371/journal.pone.0145994. eCollection 2015.

30.

Identification of Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics.

Lai KK, Cheung NN, Yang F, Dai J, Liu L, Chen Z, Sze KH, Chen H, Yuen KY, Kao RY.

J Virol. 2015 Dec 16;90(5):2690-701. doi: 10.1128/JVI.02326-15.

31.

Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase.

Yuan S, Chu H, Zhao H, Zhang K, Singh K, Chow BK, Kao RY, Zhou J, Zheng BJ.

Antiviral Res. 2016 Jan;125:34-42. doi: 10.1016/j.antiviral.2015.11.005. Epub 2015 Nov 22.

PMID:
26593979
32.

Recombinant ESAT-6-like proteins provoke protective immune responses against invasive Staphylococcus aureus disease in a murine model.

Zhang BZ, Hua YH, Yu B, Lau CC, Cai JP, Zheng SY, Yam WC, Kao RY, Sze KH, Zheng BJ, Yuen KY, Huang JD.

Infect Immun. 2015 Jan;83(1):339-45. doi: 10.1128/IAI.02498-14. Epub 2014 Nov 3.

33.

An upstream truncation of the furA-katG operon confers high-level isoniazid resistance in a Mycobacterium tuberculosis clinical isolate with no known resistance-associated mutations.

Siu GK, Yam WC, Zhang Y, Kao RY.

Antimicrob Agents Chemother. 2014 Oct;58(10):6093-100. doi: 10.1128/AAC.03277-14. Epub 2014 Aug 4.

34.

In vitro and in vivo activity of a novel antifungal small molecule against Candida infections.

Wong SS, Kao RY, Yuen KY, Wang Y, Yang D, Samaranayake LP, Seneviratne CJ.

PLoS One. 2014 Jan 22;9(1):e85836. doi: 10.1371/journal.pone.0085836. eCollection 2014.

35.

Surfactant protein B gene polymorphism is associated with severe influenza.

To KKW, Zhou J, Song YQ, Hung IFN, Ip WCT, Cheng ZS, Chan ASF, Kao RYT, Wu AKL, Chau S, Luk WK, Ip MSM, Chan KH, Yuen KY.

Chest. 2014 Jun;145(6):1237-1243. doi: 10.1378/chest.13-1651.

PMID:
24337193
36.

Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus.

Chan JF, Chan KH, Kao RY, To KK, Zheng BJ, Li CP, Li PT, Dai J, Mok FK, Chen H, Hayden FG, Yuen KY.

J Infect. 2013 Dec;67(6):606-16. doi: 10.1016/j.jinf.2013.09.029. Epub 2013 Oct 3.

PMID:
24096239
37.

Unraveling the molecular basis of temperature-dependent genetic regulation in Penicillium marneffei.

Yang E, Wang G, Woo PC, Lau SK, Chow WN, Chong KT, Tse H, Kao RY, Chan CM, Che X, Yuen KY, Cai JJ.

Eukaryot Cell. 2013 Sep;12(9):1214-24. doi: 10.1128/EC.00159-13. Epub 2013 Jul 12.

38.

Nucleozin targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection.

Amorim MJ, Kao RY, Digard P.

J Virol. 2013 Apr;87(8):4694-703. doi: 10.1128/JVI.03123-12. Epub 2013 Feb 13.

39.

Low prevalence of vancomycin heteroresistance among meticillin-resistant Staphylococcus aureus causing bacteraemia in Hong Kong.

Ho PL, Siu JT, Law PY, Lai EL, Tse CW, Lee R, Kao RY, Cheng VC, Que TL.

Int J Antimicrob Agents. 2012 Dec;40(6):564-6. doi: 10.1016/j.ijantimicag.2012.07.008. Epub 2012 Oct 4. No abstract available.

PMID:
23040009
40.

Draft genome sequence of Penicillium marneffei strain PM1.

Woo PC, Lau SK, Liu B, Cai JJ, Chong KT, Tse H, Kao RY, Chan CM, Chow WN, Yuen KY.

Eukaryot Cell. 2011 Dec;10(12):1740-1. doi: 10.1128/EC.05255-11.

41.

Structural basis and sequence co-evolution analysis of the hemagglutinin protein of pandemic influenza A/H1N1 (2009) virus.

Tse H, Kao RY, Wu WL, Lim WW, Chen H, Yeung MY, Woo PC, Sze KH, Yuen KY.

Exp Biol Med (Maywood). 2011 Aug;236(8):915-25. doi: 10.1258/ebm.2011.010264. Epub 2011 Jul 4.

PMID:
21727184
42.

Plasma-modified biomaterials for self-antimicrobial applications.

Wu S, Liu X, Yeung A, Yeung KW, Kao RY, Wu G, Hu T, Xu Z, Chu PK.

ACS Appl Mater Interfaces. 2011 Aug;3(8):2851-60. doi: 10.1021/am2003944. Epub 2011 Jun 14. Review.

PMID:
21668027
43.

Methionine aminopeptidase as a novel target for antibiotic therapy against Staphylococcus aureus: a proteomic approach.

Kao RY, Yuen KY, Che CM, Siu FM.

Hong Kong Med J. 2011 Feb;17 Suppl 2:29-31. No abstract available.

44.

Molecular characterization of fluoroquinolone resistance in Mycobacterium tuberculosis: functional analysis of gyrA mutation at position 74.

Lau RW, Ho PL, Kao RY, Yew WW, Lau TC, Cheng VC, Yuen KY, Tsui SK, Chen X, Yam WC.

Antimicrob Agents Chemother. 2011 Feb;55(2):608-14. doi: 10.1128/AAC.00920-10. Epub 2010 Oct 18.

45.

Gentamicin-loaded strontium-containing hydroxyapatite bioactive bone cement--an efficient bioactive antibiotic drug delivery system.

Liu WC, Wong CT, Fong MK, Cheung WS, Kao RY, Luk KD, Lu WW.

J Biomed Mater Res B Appl Biomater. 2010 Nov;95(2):397-406. doi: 10.1002/jbm.b.31730.

PMID:
20878924
46.

Identification of influenza A nucleoprotein as an antiviral target.

Kao RY, Yang D, Lau LS, Tsui WH, Hu L, Dai J, Chan MP, Chan CM, Wang P, Zheng BJ, Sun J, Huang JD, Madar J, Chen G, Chen H, Guan Y, Yuen KY.

Nat Biotechnol. 2010 Jun;28(6):600-5. doi: 10.1038/nbt.1638. Epub 2010 May 30.

PMID:
20512121
47.

Vancomycin MIC creep in MRSA isolates from 1997 to 2008 in a healthcare region in Hong Kong.

Ho PL, Lo PY, Chow KH, Lau EH, Lai EL, Cheng VC, Kao RY.

J Infect. 2010 Feb;60(2):140-5. doi: 10.1016/j.jinf.2009.11.011. Epub 2009 Dec 2.

PMID:
19961873
48.

Rapid diagnosis of multidrug-resistant smear-positive pulmonary tuberculosis.

Lau RW, Ho PL, Kao RY, Siu GK, Cheng VC, Yuen KY, Yam WC.

Int J Antimicrob Agents. 2010 Feb;35(2):202-3. doi: 10.1016/j.ijantimicag.2009.09.022. Epub 2009 Nov 24. No abstract available.

PMID:
19939635
49.

Cleavage of spike protein of SARS coronavirus by protease factor Xa is associated with viral infectivity.

Du L, Kao RY, Zhou Y, He Y, Zhao G, Wong C, Jiang S, Yuen KY, Jin DY, Zheng BJ.

Biochem Biophys Res Commun. 2007 Jul 20;359(1):174-9. Epub 2007 May 22.

50.

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