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Drug Leads from Endophytic Fungi: Lessons Learned via Scaled Production.

Graf TN, Kao D, Rivera-Chávez J, Gallagher JM, Raja HA, Oberlies NH.

Planta Med. 2020 Mar 26. doi: 10.1055/a-1130-4856. [Epub ahead of print]


Analysis of Outcomes in 8304 Patients Undergoing Lead Extraction for Infection.

Aleong RG, Zipse MM, Tompkins C, Aftab M, Varosy P, Sauer W, Kao D.

J Am Heart Assoc. 2020 Apr 7;9(7):e011473. doi: 10.1161/JAHA.118.011473. Epub 2020 Mar 20.


Risk Factors that Predict the Failure of Multiple Fecal Microbiota Transplantations for Clostridioides difficile Infection.

Allegretti JR, Mehta SR, Kassam Z, Kelly CR, Kao D, Xu H, Fischer M.

Dig Dis Sci. 2020 Mar 13. doi: 10.1007/s10620-020-06198-2. [Epub ahead of print]


Variation in clinical and patient-reported outcomes among complex heart failure with preserved ejection fraction phenotypes.

Flint KM, Shah SJ, Lewis EF, Kao DP.

ESC Heart Fail. 2020 Mar 11. doi: 10.1002/ehf2.12660. [Epub ahead of print]


Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in Inflammatory Bowel Disease.

deZoeten EF, Battista KD, Colson SB, Lovell MA, Kessler BE, Isfort RW, Fennimore BP, Onyiah JC, Kao DJ, Yeckes A, Keely S, Murray M, Hoffenberg EJ, Colgan SP, Gerich ME.

Hypoxia (Auckl). 2020 Feb 10;8:1-12. doi: 10.2147/HP.S219049. eCollection 2020.


Peripheral nerve repair throughout the body with processed nerve allografts: Results from a large multicenter study.

Safa B, Jain S, Desai MJ, Greenberg JA, Niacaris TR, Nydick JA, Leversedge FJ, Megee DM, Zoldos J, Rinker BD, McKee DM, MacKay BJ, Ingari JV, Nesti LJ, Cho M, Valerio IL, Kao DS, El-Sheikh Y, Weber RV, Shores JT, Styron JF, Thayer WP, Przylecki WH, Hoyen HA, Buncke GM.

Microsurgery. 2020 Feb 26. doi: 10.1002/micr.30574. [Epub ahead of print]


Evaluating sustainability in the Childhood Obesity Research Demonstration project: the model and process.

Lee RE, Kao D, Parker NH, Hallett AM, Kochi CY, Modelska MJ, Rifai HS, O'Connor DP.

Arch Public Health. 2020 Feb 13;78:13. doi: 10.1186/s13690-020-0397-2. eCollection 2020.


Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience.

Aquilante CL, Kao DP, Trinkley KE, Lin CT, Crooks KR, Hearst EC, Hess SJ, Kudron EL, Lee YM, Liko I, Lowery J, Mathias RA, Monte AA, Rafaels N, Rioth MJ, Roberts ER, Taylor MR, Williamson C, Barnes KC.

Pharmacogenomics. 2020 Feb 20. doi: 10.2217/pgs-2020-0007. [Epub ahead of print]


Comparative safety and efficacy of ozanimod versus fingolimod for relapsing multiple sclerosis.

Swallow E, Patterson-Lomba O, Yin L, Mehta R, Pelletier C, Kao D, Sheffield JK, Stonehouse T, Signorovitch J.

J Comp Eff Res. 2020 Mar;9(4):275-285. doi: 10.2217/cer-2019-0169. Epub 2020 Jan 17.


Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro.

Kosyakova N, Kao DD, Figetakis M, López-Giráldez F, Spindler S, Graham M, James KJ, Won Shin J, Liu X, Tietjen GT, Pober JS, Chang WG.

NPJ Regen Med. 2020 Jan 6;5:1. doi: 10.1038/s41536-019-0086-3. eCollection 2020.


New tricks for old dogs: Two new macrocyclic trichothecene epimers and absolute configuration of 16-hydroxyverrucarin B.

Kao D, Flores-Bocanegra L, Raja HA, Darveaux BA, Pearce CJ, Oberlies NH.

Phytochemistry. 2020 Apr;172:112238. doi: 10.1016/j.phytochem.2019.112238. Epub 2020 Jan 10.


Heart Failure Management Innovation Enabled by Electronic Health Records.

Kao DP, Trinkley KE, Lin CT.

JACC Heart Fail. 2020 Mar;8(3):223-233. doi: 10.1016/j.jchf.2019.09.008. Epub 2020 Jan 8. Review.


The neuropeptide Drosulfakinin regulates social isolation-induced aggression in Drosophila.

Agrawal P, Kao D, Chung P, Looger LL.

J Exp Biol. 2020 Jan 29;223(Pt 2). pii: jeb207407. doi: 10.1242/jeb.207407.


Tracking Pathogen Infections by Time-Resolved Chemical Proteomics.

Zhang Y, Kao DS, Gu B, Bomjan R, Srivastava M, Lu H, Zhou D, Tao WA.

Angew Chem Int Ed Engl. 2020 Feb 3;59(6):2235-2240. doi: 10.1002/anie.201911078. Epub 2020 Jan 9.


Therapeutic futility and phenotypic heterogeneity in heart failure with preserved ejection fraction: what is the role of bionic learning?

Kao D, Purohit S, Jhund P.

Eur J Heart Fail. 2020 Jan;22(1):159-161. doi: 10.1002/ejhf.1658. Epub 2019 Nov 20. No abstract available.


Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance.

Toni LS, Carroll IA, Jones KL, Schwisow JA, Minobe WA, Rodriguez EM, Altman NL, Lowes BD, Gilbert EM, Buttrick PM, Kao DP, Bristow MR.

PLoS One. 2019 Oct 22;14(10):e0224389. doi: 10.1371/journal.pone.0224389. eCollection 2019.


Reliability and Validity of Upper Extremity Patient-Reported Outcome Measures in Assessing Traumatic Finger Amputation Management.

Yoon AP, Kaur S, Chou CH, Chung KC, Malay S, Shauver M, Wang L, Zhong L, Sommers K, Hume K, Sawada H, Hsu CC, Tai-Jung T, Yang G, Zhang Z, Giladi A, Fleming I, Sabapathy SR, Kumaran MS, Ishiko T, Nishizuka T, Kawamura K, Sebastin S, Yong J, Jain S, Colvell K, Lacey M, Hillard C, Fowler J, Neumeister M, Lovel B, Kao D, Arif H, Spiess A, Grybowski D, Michelotti B, Costa B, Drolet B, Bueno RA Jr, Spear M, Woo SH, Kim YW, Moore A, Roth Bettlach C, Linkugel A, Dalton J; FRANCHISE Group.

Plast Reconstr Surg. 2020 Jan;145(1):94e-105e. doi: 10.1097/PRS.0000000000006326.


International consensus conference on stool banking for faecal microbiota transplantation in clinical practice.

Cammarota G, Ianiro G, Kelly CR, Mullish BH, Allegretti JR, Kassam Z, Putignani L, Fischer M, Keller JJ, Costello SP, Sokol H, Kump P, Satokari R, Kahn SA, Kao D, Arkkila P, Kuijper EJ, Vehreschild MJG, Pintus C, Lopetuso L, Masucci L, Scaldaferri F, Terveer EM, Nieuwdorp M, López-Sanromán A, Kupcinskas J, Hart A, Tilg H, Gasbarrini A.

Gut. 2019 Dec;68(12):2111-2121. doi: 10.1136/gutjnl-2019-319548. Epub 2019 Sep 28. Review.


Intelligent Artificial Intelligence: Present Considerations and Future Implications of Machine Learning Applied to Electrocardiogram Interpretation.

Kao DP.

Circ Cardiovasc Qual Outcomes. 2019 Sep;12(9):e006021. doi: 10.1161/CIRCOUTCOMES.119.006021. Epub 2019 Sep 5. No abstract available.


Anterolateral thigh free flaps for the reconstruction of scalp angiosarcoma - 18-year experience in Chang Gung memorial hospital.

Chou PY, Kao D, Denadai R, Huang CY, Lin CH, Lin CH.

J Plast Reconstr Aesthet Surg. 2019 Dec;72(12):1900-1908. doi: 10.1016/j.bjps.2019.07.024. Epub 2019 Aug 8.


Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection.

Monaghan TM, Pučić-Baković M, Vučković F, Lee C, Kao D; Human Glycome Project.

Gastroenterology. 2019 Dec;157(6):1676-1678.e3. doi: 10.1053/j.gastro.2019.08.034. Epub 2019 Aug 30. No abstract available.


Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance.

Toni LS, Carroll IA, Jones KL, Schwisow JA, Minobe WA, Rodriguez EM, Altman NL, Lowes BD, Gilbert EM, Buttrick PM, Kao DP, Bristow MR.

PLoS One. 2019 Aug 30;14(8):e0221519. doi: 10.1371/journal.pone.0221519. eCollection 2019. Erratum in: PLoS One. 2019 Oct 22;14(10):e0224389.


Design of a "Lean" Case Report Form for Heart Failure Therapeutic Development.

Psotka MA, Fiuzat M, Carson PE, Kao DP, Cerkvenik J, Schaber DE, Verta P, Kazmierski RT, Shinnar M, Stockbridge N, Unger EF, Zuckerman B, Butler J, Felker GM, Konstam MA, Lindenfeld J, Solomon SD, Teerlink JR, O'Connor CM, Abraham WT.

JACC Heart Fail. 2019 Nov;7(11):913-921. doi: 10.1016/j.jchf.2019.07.001. Epub 2019 Aug 7. Review.


Evaluation of a Pharmacist-Managed Antidiabetic Deprescribing Program in an Integrated Health Care System.

Hui RL, Chang CC, Niu F, Tang YK, Harano D, Deguzman L, Kao DJ, Awsare S, Draves M.

J Manag Care Spec Pharm. 2019 Aug;25(8):927-934. doi: 10.18553/jmcp.2019.25.8.927.


2019 ACC/AHA/ASE Key Data Elements and Definitions for Transthoracic Echocardiography: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Clinical Data Standards for Transthoracic Echocardiography) and the American Society of Echocardiography.

Writing Committee Members, Douglas PS, Carabello BA, Lang RM, Lopez L, Pellikka PA, Picard MH, Thomas JD, Varghese P, Wang TY, Weissman NJ, Wilgus R; ACC/AHA Task Force on Clinical Data Standards Members, Bozkurt B, Jneid H, Al-Khatib SM, Anderson HV, Gilstrap L, Graham GN, Jones GK, Kao D, Lopez L, Marcus G, Rymer J, Tcheng JE, Weintraub WS.

J Am Soc Echocardiogr. 2019 Sep;32(9):1161-1248. doi: 10.1016/j.echo.2019.05.006. Epub 2019 Jun 24. No abstract available.


The association of material deprivation component measures with injury hospital separations in British Columbia, Canada.

Rajabali F, Zheng A, Turcotte K, Zhang LR, Kao D, Rasali D, Oakey M, Pike I.

Inj Epidemiol. 2019 Jun 10;6:20. doi: 10.1186/s40621-019-0198-7. eCollection 2019.


In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation.

McSweeney B, Allegretti JR, Fischer M, Xu H, Goodman KJ, Monaghan T, McLeod C, Mullish BH, Petrof EO, Phelps EL, Chis R, Edmison A, Juby A, Ennis-Davis R, Roach B, Wong K, Kao D.

Gut Microbes. 2020;11(1):51-62. doi: 10.1080/19490976.2019.1611153. Epub 2019 May 23.


Droplet probe: coupling chromatography to the in situ evaluation of the chemistry of nature.

Oberlies NH, Knowles SL, Amrine CSM, Kao D, Kertesz V, Raja HA.

Nat Prod Rep. 2019 Jul 1;36(7):944-959. doi: 10.1039/c9np00019d. Epub 2019 May 21.


Expanding the Boundaries of RNA Sequencing as a Diagnostic Tool for Rare Mendelian Disease.

Gonorazky HD, Naumenko S, Ramani AK, Nelakuditi V, Mashouri P, Wang P, Kao D, Ohri K, Viththiyapaskaran S, Tarnopolsky MA, Mathews KD, Moore SA, Osorio AN, Villanova D, Kemaladewi DU, Cohn RD, Brudno M, Dowling JJ.

Am J Hum Genet. 2019 May 2;104(5):1007. doi: 10.1016/j.ajhg.2019.04.004. No abstract available.


Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined HF Population: The GENETIC-AF Trial.

Piccini JP, Abraham WT, Dufton C, Carroll IA, Healey JS, van Veldhuisen DJ, Sauer WH, Anand IS, White M, Wilton SB, Aleong R, Rienstra M, Krueger SK, Ayala-Paredes F, Khaykin Y, Merkely B, Miloradović V, Wranicz JK, Ilkhanoff L, Ziegler PD, Davis G, Emery LL, Marshall D, Kao DP, Bristow MR, Connolly SJ; GENETIC-AF Trial Investigators.

JACC Heart Fail. 2019 Jul;7(7):586-598. doi: 10.1016/j.jchf.2019.04.004. Epub 2019 Apr 29.


Clinician preferences for computerised clinical decision support for medications in primary care: a focus group study.

Trinkley KE, Blakeslee WW, Matlock DD, Kao DP, Van Matre AG, Harrison R, Larson CL, Kostman N, Nelson JA, Lin CT, Malone DC.

BMJ Health Care Inform. 2019 Apr;26(1):0. doi: 10.1136/bmjhci-2019-000015.


The success of fecal microbial transplantation in Clostridium difficile infection correlates with bacteriophage relative abundance in the donor: a retrospective cohort study.

Park H, Laffin MR, Jovel J, Millan B, Hyun JE, Hotte N, Kao D, Madsen KL.

Gut Microbes. 2019;10(6):676-687. doi: 10.1080/19490976.2019.1586037. Epub 2019 Mar 13.


Expanding the Boundaries of RNA Sequencing as a Diagnostic Tool for Rare Mendelian Disease.

Gonorazky HD, Naumenko S, Ramani AK, Nelakuditi V, Mashouri P, Wang P, Kao D, Ohri K, Viththiyapaskaran S, Tarnopolsky MA, Mathews KD, Moore SA, Osorio AN, Villanova D, Kemaladewi DU, Cohn RD, Brudno M, Dowling JJ.

Am J Hum Genet. 2019 Mar 7;104(3):466-483. doi: 10.1016/j.ajhg.2019.01.012. Epub 2019 Feb 28. Erratum in: Am J Hum Genet. 2019 May 2;104(5):1007.


Sex Differences in Outcomes and Responses to Spironolactone in Heart Failure With Preserved Ejection Fraction: A Secondary Analysis of TOPCAT Trial.

Merrill M, Sweitzer NK, Lindenfeld J, Kao DP.

JACC Heart Fail. 2019 Mar;7(3):228-238. doi: 10.1016/j.jchf.2019.01.003.


Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection.

Mullish BH, McDonald JAK, Pechlivanis A, Allegretti JR, Kao D, Barker GF, Kapila D, Petrof EO, Joyce SA, Gahan CGM, Glegola-Madejska I, Williams HRT, Holmes E, Clarke TB, Thursz MR, Marchesi JR.

Gut. 2019 Oct;68(10):1791-1800. doi: 10.1136/gutjnl-2018-317842. Epub 2019 Feb 11.


Area-based socioeconomic disparities in mortality due to unintentional injury and youth suicide in British Columbia, 2009-2013.

Zandy M, Zhang LR, Kao D, Rajabali F, Turcotte K, Zheng A, Oakey M, Smolina K, Pike I, Rasali D.

Health Promot Chronic Dis Prev Can. 2019 Feb;39(2):35-44. doi: 10.24095/hpcdp.39.2.01. English, French.


Risk of Clostridium difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant: Should We Recommend Anti-Clostridium difficile Antibiotic Prophylaxis?

Allegretti JR, Kao D, Phelps E, Roach B, Smith J, Ganapini VC, Kassam Z, Xu H, Fischer M.

Dig Dis Sci. 2019 Jun;64(6):1668-1671. doi: 10.1007/s10620-018-5450-4. Epub 2019 Jan 10.


Non-Destructive Chemical Analysis of a Garcinia mangostana L. (Mangosteen) Herbarium Voucher Specimen.

Kao D, Henkin JM, Soejarto DD, Kinghorn AD, Oberlies NH.

Phytochem Lett. 2018 Dec;28:124-129. doi: 10.1016/j.phytol.2018.10.001. Epub 2018 Oct 12.


Analytic atomic gradients in the fermi-löwdin orbital self-interaction correction.

Trepte K, Schwalbe S, Hahn T, Kortus J, Kao DY, Yamamoto Y, Baruah T, Zope RR, Withanage KPK, Peralta JE, Jackson KA.

J Comput Chem. 2019 Mar 5;40(6):820-825. doi: 10.1002/jcc.25767. Epub 2018 Dec 27.


The need to move away from fecal transplant towards targeted, refined microbiome therapy.

Russell L, Monaghan T, Kao D.

J Thorac Dis. 2018 Oct;10(10):E755-E757. doi: 10.21037/jtd.2018.09.80. No abstract available.


Comparative population genomics reveals key barriers to dispersal in Southern Ocean penguins.

Clucas GV, Younger JL, Kao D, Emmerson L, Southwell C, Wienecke B, Rogers AD, Bost CA, Miller GD, Polito MJ, Lelliott P, Handley J, Crofts S, Phillips RA, Dunn MJ, Miller KJ, Hart T.

Mol Ecol. 2018 Dec;27(23):4680-4697. doi: 10.1111/mec.14896. Epub 2018 Nov 22.


Planning Interventions to Treat Brachial Plexopathies.

Bunnell AE, Kao DS.

Phys Med Rehabil Clin N Am. 2018 Nov;29(4):689-700. doi: 10.1016/j.pmr.2018.06.005. Epub 2018 Sep 5. Review.


Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells.

Mihaylova Y, Abnave P, Kao D, Hughes S, Lai A, Jaber-Hijazi F, Kosaka N, Aboobaker AA.

Nat Commun. 2018 Sep 7;9(1):3633. doi: 10.1038/s41467-018-06092-6.


Calothrixamides A and B from the Cultured Cyanobacterium Calothrix sp. UIC 10520.

Crnkovic CM, Krunic A, May DS, Wilson TA, Kao D, Burdette JE, Fuchs JR, Oberlies NH, Orjala J.

J Nat Prod. 2018 Sep 28;81(9):2083-2090. doi: 10.1021/acs.jnatprod.8b00432. Epub 2018 Sep 7.


Neutrophils as sources of dinucleotide polyphosphates and metabolism by epithelial ENPP1 to influence barrier function via adenosine signaling.

Curtis VF, Cartwright IM, Lee JS, Wang RX, Kao DJ, Lanis JM, Burney KM, Welch N, Hall CHT, Goldberg MS, Campbell EL, Colgan SP.

Mol Biol Cell. 2018 Nov 1;29(22):2687-2699. doi: 10.1091/mbc.E18-06-0377. Epub 2018 Sep 6.


Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway.

Monaghan T, Mullish BH, Patterson J, Wong GK, Marchesi JR, Xu H, Jilani T, Kao D.

Gut Microbes. 2019;10(2):142-148. doi: 10.1080/19490976.2018.1506667. Epub 2018 Sep 5.


Epigenetic analyses of planarian stem cells demonstrate conservation of bivalent histone modifications in animal stem cells.

Dattani A, Kao D, Mihaylova Y, Abnave P, Hughes S, Lai A, Sahu S, Aboobaker AA.

Genome Res. 2018 Oct;28(10):1543-1554. doi: 10.1101/gr.239848.118. Epub 2018 Aug 24.


Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience.

Cheng YW, Phelps E, Ganapini V, Khan N, Ouyang F, Xu H, Khanna S, Tariq R, Friedman-Moraco RJ, Woodworth MH, Dhere T, Kraft CS, Kao D, Smith J, Le L, El-Nachef N, Kaur N, Kowsika S, Ehrlich A, Smith M, Safdar N, Misch EA, Allegretti JR, Flynn A, Kassam Z, Sharfuddin A, Vuppalanchi R, Fischer M.

Am J Transplant. 2019 Feb;19(2):501-511. doi: 10.1111/ajt.15058. Epub 2018 Aug 31.


Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota.

McDonald JAK, Mullish BH, Pechlivanis A, Liu Z, Brignardello J, Kao D, Holmes E, Li JV, Clarke TB, Thursz MR, Marchesi JR.

Gastroenterology. 2018 Nov;155(5):1495-1507.e15. doi: 10.1053/j.gastro.2018.07.014. Epub 2018 Jul 17.


Marijuana use and short-term outcomes in patients hospitalized for acute myocardial infarction.

Johnson-Sasso CP, Tompkins C, Kao DP, Walker LA.

PLoS One. 2018 Jul 11;13(7):e0199705. doi: 10.1371/journal.pone.0199705. eCollection 2018.

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