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Withdrawal: Isolation and functional analysis of mouse UbA52 gene and its relevance to diabetic nephropathy.

Sun L, Pan X, Wada J, Haas CS, Wuthrich RP, Danesh FR, Chugh SS, Kanwar YS.

J Biol Chem. 2019 Jun 28;294(26):10382. doi: 10.1074/jbc.W119.009588. No abstract available.


Withdrawal: High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway.

Lin S, Sahai A, Chugh SS, Pan X, Wallner EI, Danesh FR, Lomasney JW, Kanwar YS.

J Biol Chem. 2019 Jun 28;294(26):10381. doi: 10.1074/jbc.W119.009587. No abstract available.


Corrigendum to 'Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis' [Redox Biology 16 (2018) 32-46].

Han Y, Xu X, Tang C, Gao P, Chen X, Xiong X, Yang M, Yang S, Zhu X, Yuan S, Liu F, Xiao L, Kanwar YS, Sun L.

Redox Biol. 2019 Jun;24:101216. doi: 10.1016/j.redox.2019.101216. Epub 2019 May 22. No abstract available.


DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity.

Yang M, Zhao L, Gao P, Zhu X, Han Y, Chen X, Li L, Xiao Y, Wei L, Li C, Xiao L, Yuan S, Liu F, Dong LQ, Kanwar YS, Sun L.

EBioMedicine. 2019 May;43:607-619. doi: 10.1016/j.ebiom.2019.04.044. Epub 2019 May 3.


A clinically relevant murine model unmasks a "two-hit" mechanism for reactivation and dissemination of cytomegalovirus after kidney transplant.

Zhang Z, Qiu L, Yan S, Wang JJ, Thomas PM, Kandpal M, Zhao L, Iovane A, Liu XF, Thorp EB, Chen Q, Hummel M, Kanwar YS, Abecassis MM.

Am J Transplant. 2019 Apr 4. doi: 10.1111/ajt.15376. [Epub ahead of print]


Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy.

Chen X, Han Y, Gao P, Yang M, Xiao L, Xiong X, Zhao H, Tang C, Chen G, Zhu X, Yuan S, Liu F, Dong LQ, Liu F, Kanwar YS, Sun L.

Kidney Int. 2019 Apr;95(4):880-895. doi: 10.1016/j.kint.2018.10.038. Epub 2019 Feb 18.


Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress.

Tominaga T, Sharma I, Fujita Y, Doi T, Wallner AK, Kanwar YS.

Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F301-F315. doi: 10.1152/ajprenal.00534.2018. Epub 2018 Dec 12.


The Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker for Diabetic Nephropathy.

Gao P, Xu B, Song P, Zhu X, Yuan S, Kanwar YS, Sun L.

Kidney Blood Press Res. 2018;43(6):1772-1785. doi: 10.1159/000495635. Epub 2018 Nov 30.


An adjustment in BMP4 function represents a treatment for diabetic nephropathy and podocyte injury.

Fujita Y, Tominaga T, Abe H, Kangawa Y, Fukushima N, Ueda O, Jishage KI, Kishi S, Murakami T, Saga Y, Kanwar YS, Nagai K, Doi T.

Sci Rep. 2018 Aug 29;8(1):13011. doi: 10.1038/s41598-018-31464-9.


PIMT/NCOA6IP Deletion in the Mouse Heart Causes Delayed Cardiomyopathy Attributable to Perturbation in Energy Metabolism.

Jia Y, Liu N, Viswakarma N, Sun R, Schipma MJ, Shang M, Thorp EB, Kanwar YS, Thimmapaya B, Reddy JK.

Int J Mol Sci. 2018 May 16;19(5). pii: E1485. doi: 10.3390/ijms19051485.


Perturbations in mitochondrial dynamics by p66Shc lead to renal tubular oxidative injury in human diabetic nephropathy.

Zhan M, Usman I, Yu J, Ruan L, Bian X, Yang J, Yang S, Sun L, Kanwar YS.

Clin Sci (Lond). 2018 Jun 26;132(12):1297-1314. doi: 10.1042/CS20180005. Print 2018 Jun 29.


Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis.

Han Y, Xu X, Tang C, Gao P, Chen X, Xiong X, Yang M, Yang S, Zhu X, Yuan S, Liu F, Xiao L, Kanwar YS, Sun L.

Redox Biol. 2018 Jun;16:32-46. doi: 10.1016/j.redox.2018.02.013. Epub 2018 Feb 15. Erratum in: Redox Biol. 2019 Jun;24:101216.


Effects of Omega-3 Fatty Acids on Markers of Inflammation in Patients With Chronic Kidney Disease: A Controversial Issue.

Hu C, Yang M, Zhu X, Gao P, Yang S, Han Y, Chen X, Xiao L, Yuan S, Liu F, Kanwar YS, Sun L.

Ther Apher Dial. 2018 Apr;22(2):124-132. doi: 10.1111/1744-9987.12611. Epub 2017 Dec 22.


Contribution of myo-inositol oxygenase in AGE:RAGE-mediated renal tubulointerstitial injury in the context of diabetic nephropathy.

Sharma I, Tupe RS, Wallner AK, Kanwar YS.

Am J Physiol Renal Physiol. 2018 Jan 1;314(1):F107-F121. doi: 10.1152/ajprenal.00434.2017. Epub 2017 Sep 20.


Glomerular mesangial cell recruitment and function require the co-receptor neuropilin-1.

Bartlett CS, Scott RP, Carota IA, Wnuk ML, Kanwar YS, Miner JH, Quaggin SE.

Am J Physiol Renal Physiol. 2017 Dec 1;313(6):F1232-F1242. doi: 10.1152/ajprenal.00311.2017. Epub 2017 Aug 23.


Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc.

Yang S, Zhao L, Han Y, Liu Y, Chen C, Zhan M, Xiong X, Zhu X, Xiao L, Hu C, Liu F, Zhou Z, Kanwar YS, Sun L.

Redox Biol. 2017 Oct;13:482-497. doi: 10.1016/j.redox.2017.07.002. Epub 2017 Jul 4.


A case of atypical hemolytic uremic syndrome in a second renal transplant.

Zwang NA, Ho B, Kanwar YS, Lewis B, Cusick M, Friedewald JJ, Gallon L.

J Nephrol. 2018 Feb;31(1):165-172. doi: 10.1007/s40620-016-0373-7. Epub 2017 Feb 21.


High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.

Sharma I, Dutta RK, Singh NK, Kanwar YS.

Am J Pathol. 2017 Apr;187(4):724-739. doi: 10.1016/j.ajpath.2016.12.011. Epub 2017 Feb 14.


Beneficial Effects of Myo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI.

Dutta RK, Kondeti VK, Sharma I, Chandel NS, Quaggin SE, Kanwar YS.

J Am Soc Nephrol. 2017 May;28(5):1421-1436. doi: 10.1681/ASN.2016070744. Epub 2016 Nov 28.


Correction: Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice.

Jia Y, Chang HC, Schipma MJ, Liu J, Shete V, Liu N, Sato T, Thorp EB, Barger PM, Zhu YJ, Viswakarma N, Kanwar YS, Ardehali H, Thimmapaya B, Reddy JK.

PLoS One. 2016 Sep 30;11(9):e0164316. doi: 10.1371/journal.pone.0164316. eCollection 2016.


Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.

Kavanagh D, McGlasson S, Jury A, Williams J, Scolding N, Bellamy C, Gunther C, Ritchie D, Gale DP, Kanwar YS, Challis R, Buist H, Overell J, Weller B, Flossmann O, Blunden M, Meyer EP, Krucker T, Evans SJ, Campbell IL, Jackson AP, Chandran S, Hunt DP.

Blood. 2016 Dec 15;128(24):2824-2833. Epub 2016 Sep 23.


Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice.

Jia Y, Chang HC, Schipma MJ, Liu J, Shete V, Liu N, Sato T, Thorp EB, Barger PM, Zhu YJ, Viswakarma N, Kanwar YS, Ardehali H, Thimmapaya B, Reddy JK.

PLoS One. 2016 Aug 22;11(8):e0160755. doi: 10.1371/journal.pone.0160755. eCollection 2016. Erratum in: PLoS One. 2016 Sep 30;11(9):e0164316.


p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy.

Xu X, Zhu X, Ma M, Han Y, Hu C, Yuan S, Yang Y, Xiao L, Liu F, Kanwar YS, Sun L.

Sci Rep. 2016 Jul 5;6:29302. doi: 10.1038/srep29302.


miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy.

Badal SS, Wang Y, Long J, Corcoran DL, Chang BH, Truong LD, Kanwar YS, Overbeek PA, Danesh FR.

Nat Commun. 2016 Jun 28;7:12076. doi: 10.1038/ncomms12076.


Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.

Tominaga T, Dutta RK, Joladarashi D, Doi T, Reddy JK, Kanwar YS.

J Biol Chem. 2016 Jan 15;291(3):1348-67. doi: 10.1074/jbc.M115.698191. Epub 2015 Nov 17.


Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice.

Nagasu H, Satoh M, Kiyokage E, Kidokoro K, Toida K, Channon KM, Kanwar YS, Sasaki T, Kashihara N.

Lab Invest. 2016 Jan;96(1):25-36. doi: 10.1038/labinvest.2015.128. Epub 2015 Nov 9.


Nonchimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers.

Leventhal JR, Mathew JM, Salomon DR, Kurian SM, Friedewald JJ, Gallon L, Konieczna I, Tambur AR, Charette J, Levitsky J, Jie C, Kanwar YS, Abecassis MM, Miller J.

Am J Transplant. 2016 Jan;16(1):221-34. doi: 10.1111/ajt.13416. Epub 2015 Jul 30.


Insights into the Mechanisms Involved in the Expression and Regulation of Extracellular Matrix Proteins in Diabetic Nephropathy.

Hu C, Sun L, Xiao L, Han Y, Fu X, Xiong X, Xu X, Liu Y, Yang S, Liu F, Kanwar YS.

Curr Med Chem. 2015;22(24):2858-70. Review.


MicroRNA-129-5p modulates epithelial-to-mesenchymal transition by targeting SIP1 and SOX4 during peritoneal dialysis.

Xiao L, Zhou X, Liu F, Hu C, Zhu X, Luo Y, Wang M, Xu X, Yang S, Kanwar YS, Sun L.

Lab Invest. 2015 Jul;95(7):817-832. doi: 10.1038/labinvest.2015.57. Epub 2015 May 11.


AKT regulation of mesothelial-to-mesenchymal transition in peritoneal dialysis is modulated by Smurf2 and deubiquitinating enzyme USP4.

Xiao L, Peng X, Liu F, Tang C, Hu C, Xu X, Wang M, Luo Y, Yang S, Song P, Xiao P, Kanwar YS, Sun L.

BMC Cell Biol. 2015 Mar 6;16:7. doi: 10.1186/s12860-015-0055-7.


Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection.

Lerret NM, Li T, Wang JJ, Kang HK, Wang S, Wang X, Jie C, Kanwar YS, Abecassis MM, Luo X, Zhang Z.

J Am Soc Nephrol. 2015 Nov;26(11):2753-64. doi: 10.1681/ASN.2014080813. Epub 2015 Mar 18.


PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation.

Gao Q, Jia Y, Yang G, Zhang X, Boddu PC, Petersen B, Narsingam S, Zhu YJ, Thimmapaya B, Kanwar YS, Reddy JK.

Am J Pathol. 2015 May;185(5):1396-408. doi: 10.1016/j.ajpath.2015.01.018. Epub 2015 Mar 12.


Continuum of historical controversies regarding the structural-functional relationship of the glomerular ultrafiltration unit.

Kanwar YS.

Am J Physiol Renal Physiol. 2015 Mar 1;308(5):F420-4. doi: 10.1152/ajprenal.00640.2014. Epub 2014 Dec 10. No abstract available.


Spontaneous calf hematoma in a patient with diabetic nephropathy receiving maintenance hemodialysis: A case report and review of the literature.

Xiao L, Ling F, Tan L, Li H, Hu C, Luo Y, Tang D, Liu F, Kanwar YS, Sun L.

Hemodial Int. 2015 Oct;19(4):E49-53. doi: 10.1111/hdi.12246. Epub 2014 Nov 18. Review.


Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease.

Zhan M, Usman IM, Sun L, Kanwar YS.

J Am Soc Nephrol. 2015 Jun;26(6):1304-21. doi: 10.1681/ASN.2014050457. Epub 2014 Sep 30.


A glimpse of matrix metalloproteinases in diabetic nephropathy.

Xu X, Xiao L, Xiao P, Yang S, Chen G, Liu F, Kanwar YS, Sun L.

Curr Med Chem. 2014;21(28):3244-60. Review.


Hierarchy of molecules in TGF-β1 signaling relevant to myofibroblast activation and renal fibrosis.

Zhan M, Kanwar YS.

Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F385-7. doi: 10.1152/ajprenal.00338.2014. Epub 2014 Jun 25. No abstract available.


Modulation of angiotensin II-induced inflammatory cytokines by the Epac1-Rap1A-NHE3 pathway: implications in renal tubular pathobiology.

Xie P, Joladarashi D, Dudeja P, Sun L, Kanwar YS.

Am J Physiol Renal Physiol. 2014 Jun 1;306(11):F1260-74. doi: 10.1152/ajprenal.00069.2014. Epub 2014 Feb 19.


Rap1 ameliorates renal tubular injury in diabetic nephropathy.

Xiao L, Zhu X, Yang S, Liu F, Zhou Z, Zhan M, Xie P, Zhang D, Li J, Song P, Kanwar YS, Sun L.

Diabetes. 2014 Apr;63(4):1366-80. doi: 10.2337/db13-1412. Epub 2013 Dec 18.


Urine miRNAs: potential biomarkers for monitoring progression of early stages of diabetic nephropathy.

Yang Y, Xiao L, Li J, Kanwar YS, Liu F, Sun L.

Med Hypotheses. 2013 Aug;81(2):274-8. doi: 10.1016/j.mehy.2013.04.031. Epub 2013 May 14.


Renal morphologic lesions reminiscent of diabetic nephropathy.

Raparia K, Usman I, Kanwar YS.

Arch Pathol Lab Med. 2013 Mar;137(3):351-9. doi: 10.5858/arpa.2012-0243-RA. Review.


Role of guanine-nucleotide exchange factor Epac in renal physiology and pathophysiology.

Yang SK, Xiao L, Li J, Liu F, Sun L, Kanwar YS.

Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F831-9. doi: 10.1152/ajprenal.00711.2012. Epub 2013 Jan 30. Review. Retraction in: Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F612.


Aging and hemoglobin-induced acute kidney injury.

Kanwar YS.

Am J Physiol Renal Physiol. 2013 May 1;304(9):F1167-8. doi: 10.1152/ajprenal.00032.2013. Epub 2013 Jan 30. No abstract available.


Review and discussion of tubular biomarkers in the diagnosis and management of diabetic nephropathy.

Tramonti G, Kanwar YS.

Endocrine. 2013 Jun;43(3):494-503. doi: 10.1007/s12020-012-9820-y. Epub 2012 Oct 20. Review.


Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling.

Satoh M, Nagasu H, Morita Y, Yamaguchi TP, Kanwar YS, Kashihara N.

Am J Physiol Renal Physiol. 2012 Dec 15;303(12):F1641-51. doi: 10.1152/ajprenal.00460.2012. Epub 2012 Oct 3.


Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.

Jia Y, Viswakarma N, Crawford SE, Sarkar J, Sambasiva Rao M, Karpus WJ, Kanwar YS, Zhu YJ, Reddy JK.

Mech Dev. 2012 Sep-Dec;129(9-12):193-207. doi: 10.1016/j.mod.2012.08.002. Epub 2012 Sep 7.

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