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Identification of chronic brain protein changes and protein targets of serum auto-antibodies after blast-mediated traumatic brain injury.

Harper MM, Rudd D, Meyer KJ, Kanthasamy AG, Anantharam V, Pieper AA, Vázquez-Rosa E, Shin MK, Chaubey K, Koh Y, Evans LP, Bassuk AG, Anderson MG, Dutca L, Kudva IT, John M.

Heliyon. 2020 Feb 17;6(2):e03374. doi: 10.1016/j.heliyon.2020.e03374. eCollection 2020 Feb.


Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.

Sarkar S, Dammer EB, Malovic E, Olsen AL, Raza SA, Gao T, Xiao H, Oliver DL, Duong D, Joers V, Seyfried N, Huang M, Kukar T, Tansey MG, Kanthasamy AG, Rangaraju S.

Front Immunol. 2020 Jan 31;11:33. doi: 10.3389/fimmu.2020.00033. eCollection 2020.


Nouveaux e-outils médicaux pour le self-monitoring ; les patients enfin acteurs de leur propre santé ?

Chapot A, Kanthasamy A, Le Gavrian G, Nussbaumer C, Sultan R.

Rev Med Suisse. 2019 Nov 27;15(673):2214-2215. French. No abstract available.


α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients.

Manne S, Kondru N, Jin H, Anantharam V, Huang X, Kanthasamy A, Kanthasamy AG.

Mov Disord. 2020 Feb;35(2):268-278. doi: 10.1002/mds.27907. Epub 2019 Nov 23.


MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome changes of Parkinson's disease.

Ghaisas S, Langley MR, Palanisamy BN, Dutta S, Narayanaswamy K, Plummer PJ, Sarkar S, Ay M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Neurotoxicology. 2019 Dec;75:186-199. doi: 10.1016/j.neuro.2019.09.004. Epub 2019 Sep 7.


Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease.

Panicker N, Kanthasamy A, Kanthasamy AG.

Aging (Albany NY). 2019 Aug 27;11(16):5871-5873. doi: 10.18632/aging.102210. Epub 2019 Aug 27. No abstract available.


Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease.

Harischandra DS, Rokad D, Ghaisas S, Verma S, Robertson A, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Biochim Biophys Acta Mol Basis Dis. 2020 Apr 1;1866(4):165533. doi: 10.1016/j.bbadis.2019.165533. Epub 2019 Aug 20.


Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation.

Harischandra DS, Ghaisas S, Zenitsky G, Jin H, Kanthasamy A, Anantharam V, Kanthasamy AG.

Front Neurosci. 2019 Jun 26;13:654. doi: 10.3389/fnins.2019.00654. eCollection 2019. Review.


The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review.

Ambrosini YM, Borcherding D, Kanthasamy A, Kim HJ, Willette AA, Jergens A, Allenspach K, Mochel JP.

Front Aging Neurosci. 2019 Jun 18;11:130. doi: 10.3389/fnagi.2019.00130. eCollection 2019. Review.


Neurotoxicity of pesticides.

Richardson JR, Fitsanakis V, Westerink RHS, Kanthasamy AG.

Acta Neuropathol. 2019 Sep;138(3):343-362. doi: 10.1007/s00401-019-02033-9. Epub 2019 Jun 13. Review.


Exosomes as Mediators of Chemical-Induced Toxicity.

Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Curr Environ Health Rep. 2019 Sep;6(3):73-79. doi: 10.1007/s40572-019-00233-9. Review.


Is Cerebrospinal Fluid Superoxide Dismutase 1 a Biomarker of Tau But Not Amyloid-Induced Neurodegeneration in Alzheimer's Disease?

McLimans KE, Clark BE, Plagman A, Pappas C, Klinedinst B, Anatharam V, Kanthasamy A, Willette AA.

Antioxid Redox Signal. 2019 Sep 10;31(8):572-578. doi: 10.1089/ars.2019.7762. Epub 2019 Jun 26.


Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.

Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A.

J Exp Med. 2019 Jun 3;216(6):1411-1430. doi: 10.1084/jem.20182191. Epub 2019 Apr 29.


Epigallocatechin Gallate Protects against TNFα- or H2O2- Induced Apoptosis by Modulating Iron Related Proteins in a Cell Culture Model.

Xu Q, Kanthasamy AG, Reddy MB.

Int J Vitam Nutr Res. 2018 Jun;88(3-4):158-165. doi: 10.1024/0300-9831/a000493. Epub 2019 Apr 8.


Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson's Disease.

Luo J, Padhi P, Jin H, Anantharam V, Zenitsky G, Wang Q, Willette AA, Kanthasamy A, Kanthasamy AG.

J Neuroimmune Pharmacol. 2019 Dec;14(4):595-607. doi: 10.1007/s11481-019-09844-3. Epub 2019 Mar 16. Review.


Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.

Harischandra DS, Rokad D, Neal ML, Ghaisas S, Manne S, Sarkar S, Panicker N, Zenitsky G, Jin H, Lewis M, Huang X, Anantharam V, Kanthasamy A, Kanthasamy AG.

Sci Signal. 2019 Mar 12;12(572). pii: eaau4543. doi: 10.1126/scisignal.aau4543.


HMGB1-RAGE Signaling Plays a Role in Organic Dust-Induced Microglial Activation and Neuroinflammation.

Massey N, Puttachary S, Bhat SM, Kanthasamy AG, Charavaryamath C.

Toxicol Sci. 2019 Jun 1;169(2):579-592. doi: 10.1093/toxsci/kfz071.


Mechanistic Interplay Between Autophagy and Apoptotic Signaling in Endosulfan-Induced Dopaminergic Neurotoxicity: Relevance to the Adverse Outcome Pathway in Pesticide Neurotoxicity.

Song C, Charli A, Luo J, Riaz Z, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Toxicol Sci. 2019 Jun 1;169(2):333-352. doi: 10.1093/toxsci/kfz049.


Cholecystokinin and Alzheimer's disease: a biomarker of metabolic function, neural integrity, and cognitive performance.

Plagman A, Hoscheidt S, McLimans KE, Klinedinst B, Pappas C, Anantharam V, Kanthasamy A, Willette AA; Alzheimer's Disease Neuroimaging Initiative.

Neurobiol Aging. 2019 Apr;76:201-207. doi: 10.1016/j.neurobiolaging.2019.01.002. Epub 2019 Jan 9.


Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders.

Manne S, Kondru N, Hepker M, Jin H, Anantharam V, Lewis M, Huang X, Kanthasamy A, Kanthasamy AG.

J Neuroimmune Pharmacol. 2019 Sep;14(3):423-435. doi: 10.1007/s11481-019-09835-4. Epub 2019 Jan 31.


Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neuroinflammatory mechanisms.

Kanthasamy A, Jin H, Charli A, Vellareddy A, Kanthasamy A.

Pharmacol Ther. 2019 May;197:61-82. doi: 10.1016/j.pharmthera.2019.01.001. Epub 2019 Jan 22. Review.


Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells.

Sarkar S, Rokad D, Malovic E, Luo J, Harischandra DS, Jin H, Anantharam V, Huang X, Lewis M, Kanthasamy A, Kanthasamy AG.

Sci Signal. 2019 Jan 8;12(563). pii: eaat9900. doi: 10.1126/scisignal.aat9900.


Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes.

Frederick NM, Shah PV, Didonna A, Langley MR, Kanthasamy AG, Opal P.

Hum Mol Genet. 2019 Apr 15;28(8):1343-1356. doi: 10.1093/hmg/ddy433.


Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.

Gordon R, Albornoz EA, Christie DC, Langley MR, Kumar V, Mantovani S, Robertson AAB, Butler MS, Rowe DB, O'Neill LA, Kanthasamy AG, Schroder K, Cooper MA, Woodruff TM.

Sci Transl Med. 2018 Oct 31;10(465). pii: eaah4066. doi: 10.1126/scitranslmed.aah4066.


Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery.

Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD.

J Biomed Mater Res A. 2018 Nov;106(11):2881-2890. doi: 10.1002/jbm.a.36477. Epub 2018 Oct 26.


Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes.

Neal M, Luo J, Harischandra DS, Gordon R, Sarkar S, Jin H, Anantharam V, Désaubry L, Kanthasamy A, Kanthasamy A.

Glia. 2018 Oct;66(10):2137-2157. doi: 10.1002/glia.23467. Epub 2018 Sep 12.


Accelerated accumulation of retinal α-synuclein (pSer129) and tau, neuroinflammation, and autophagic dysregulation in a seeded mouse model of Parkinson's disease.

Mammadova N, Summers CM, Kokemuller RD, He Q, Ding S, Baron T, Yu C, Valentine RJ, Sakaguchi DS, Kanthasamy AG, Greenlee JJ, Heather West Greenlee M.

Neurobiol Dis. 2019 Jan;121:1-16. doi: 10.1016/j.nbd.2018.09.013. Epub 2018 Sep 12.


Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events.

Singh N, Lawana V, Luo J, Phong P, Abdalla A, Palanisamy B, Rokad D, Sarkar S, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A.

Neurobiol Dis. 2018 Sep;117:82-113. doi: 10.1016/j.nbd.2018.05.019. Epub 2018 May 31.


Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults.

Sarkar S, Malovic E, Sarda D, Lawana V, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Neurotoxicology. 2018 Jul;67:129-140. doi: 10.1016/j.neuro.2018.05.002. Epub 2018 May 30.


Status Epilepticus: Behavioral and Electroencephalography Seizure Correlates in Kainate Experimental Models.

Sharma S, Puttachary S, Thippeswamy A, Kanthasamy AG, Thippeswamy T.

Front Neurol. 2018 Jan 23;9:7. doi: 10.3389/fneur.2018.00007. eCollection 2018. Review.


Mechanism of intranasal drug delivery directly to the brain.

Crowe TP, Greenlee MHW, Kanthasamy AG, Hsu WH.

Life Sci. 2018 Feb 15;195:44-52. doi: 10.1016/j.lfs.2017.12.025. Epub 2017 Dec 22. Review.


Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model.

Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK.

Ann N Y Acad Sci. 2017 Nov;1408(1):61-78. doi: 10.1111/nyas.13559.


Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy.

Sharma S, Carlson S, Puttachary S, Sarkar S, Showman L, Putra M, Kanthasamy AG, Thippeswamy T.

Neurobiol Dis. 2018 Feb;110:102-121. doi: 10.1016/j.nbd.2017.11.008. Epub 2017 Nov 29.


Ante-mortem detection of chronic wasting disease in recto-anal mucosa-associated lymphoid tissues from elk (Cervus elaphus nelsoni) using real-time quaking-induced conversion (RT-QuIC) assay: A blinded collaborative study.

Manne S, Kondru N, Nichols T, Lehmkuhl A, Thomsen B, Main R, Halbur P, Dutta S, Kanthasamy AG.

Prion. 2017 Nov 2;11(6):415-430. doi: 10.1080/19336896.2017.1368936. Epub 2017 Nov 3.


Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.

Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

NPJ Parkinsons Dis. 2017 Oct 17;3:30. doi: 10.1038/s41531-017-0032-2. eCollection 2017.


Peripheral versus Central Index of Metabolic Dysfunction and Associations with Clinical and Pathological Outcomes in Alzheimer's Disease.

McLimans KE, Webb JL, Anantharam V, Kanthasamy A, Willette AA; Alzheimer’s Disease Neuroimaging Initiative.

J Alzheimers Dis. 2017;60(4):1313-1324. doi: 10.3233/JAD-170263.


Neurotoxicity of Vanadium.

Ngwa HA, Ay M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Adv Neurobiol. 2017;18:287-301. doi: 10.1007/978-3-319-60189-2_14. Review.


Epigallocatechin Gallate Has a Neurorescue Effect in a Mouse Model of Parkinson Disease.

Xu Q, Langley M, Kanthasamy AG, Reddy MB.

J Nutr. 2017 Oct;147(10):1926-1931. doi: 10.3945/jn.117.255034. Epub 2017 Aug 23.


Characterizing a mouse model for evaluation of countermeasures against hydrogen sulfide-induced neurotoxicity and neurological sequelae.

Anantharam P, Whitley EM, Mahama B, Kim DS, Imerman PM, Shao D, Langley MR, Kanthasamy A, Rumbeiha WK.

Ann N Y Acad Sci. 2017 Jul;1400(1):46-64. doi: 10.1111/nyas.13419. Epub 2017 Jul 18.


Experimental Transmission of the Chronic Wasting Disease Agent to Swine after Oral or Intracranial Inoculation.

Moore SJ, West Greenlee MH, Kondru N, Manne S, Smith JD, Kunkle RA, Kanthasamy A, Greenlee JJ.

J Virol. 2017 Sep 12;91(19). pii: e00926-17. doi: 10.1128/JVI.00926-17. Print 2017 Oct 1.


Lasting Retinal Injury in a Mouse Model of Blast-Induced Trauma.

Mammadova N, Ghaisas S, Zenitsky G, Sakaguchi DS, Kanthasamy AG, Greenlee JJ, West Greenlee MH.

Am J Pathol. 2017 Jul;187(7):1459-1472. doi: 10.1016/j.ajpath.2017.03.005. Epub 2017 Jun 9.


Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and environment interactions in metal neurotoxicity.

Langley MR, Ghaisas S, Ay M, Luo J, Palanisamy BN, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Neurotoxicology. 2018 Jan;64:240-255. doi: 10.1016/j.neuro.2017.06.002. Epub 2017 Jun 20.


Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes.

Sarkar S, Malovic E, Harischandra DS, Ngwa HA, Ghosh A, Hogan C, Rokad D, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A.

Neurotoxicology. 2018 Jan;64:204-218. doi: 10.1016/j.neuro.2017.05.009. Epub 2017 May 21.


Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Diseases.

Harischandra DS, Ghaisas S, Rokad D, Kanthasamy AG.

Toxicol Sci. 2017 Jul 1;158(1):3-13. doi: 10.1093/toxsci/kfx074. Review.


Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System.

Lawana V, Singh N, Sarkar S, Charli A, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A.

J Neuroimmune Pharmacol. 2017 Dec;12(4):624-660. doi: 10.1007/s11481-017-9746-5. Epub 2017 May 2.


Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity.

Harischandra DS, Ghaisas S, Rokad D, Zamanian M, Jin H, Anantharam V, Kimber M, Kanthasamy A, Kanthasamy AG.

Neurotoxicology. 2018 Jan;64:267-277. doi: 10.1016/j.neuro.2017.04.007. Epub 2017 Apr 24.


Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility.

Sarkar S, Malovic E, Plante B, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

J Vis Exp. 2017 Apr 13;(122). doi: 10.3791/55364.


Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.

Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, Narasimhan B, Kalyanaraman B, Kanthasamy AG.

Antioxid Redox Signal. 2017 Nov 10;27(14):1048-1066. doi: 10.1089/ars.2016.6905. Epub 2017 Apr 4.


Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases.

Kondru N, Manne S, Greenlee J, West Greenlee H, Anantharam V, Halbur P, Kanthasamy A, Kanthasamy A.

Sci Rep. 2017 Feb 24;7:43155. doi: 10.1038/srep43155.

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