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Items: 9

1.

Preclinical metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor.

Pasha MK, Jayaraman R, Reddy VP, Yeo P, Goh E, Williams A, Goh KC, Kantharaj E.

Drug Metab Lett. 2012 Mar;6(1):33-42.

PMID:
22372550
2.

Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.

Wang H, Yu N, Chen D, Lee KC, Lye PL, Chang JW, Deng W, Ng MC, Lu T, Khoo ML, Poulsen A, Sangthongpitag K, Wu X, Hu C, Goh KC, Wang X, Fang L, Goh KL, Khng HH, Goh SK, Yeo P, Liu X, Bonday Z, Wood JM, Dymock BW, Kantharaj E, Sun ET.

J Med Chem. 2011 Jul 14;54(13):4694-720. doi: 10.1021/jm2003552. Epub 2011 Jun 16.

PMID:
21634430
3.

In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species.

Venkatesh PR, Goh E, Zeng P, New LS, Xin L, Pasha MK, Sangthongpitag K, Yeo P, Kantharaj E.

Biol Pharm Bull. 2007 May;30(5):1021-4.

5.
6.

The use of liquid chromatography-atmospheric pressure chemical ionization mass spectrometry to explore the in vitro metabolism of cyanoalkyl piperidine derivatives.

Kantharaj E, Ehmer PB, De Wagter K, Tuytelaars A, Proost PE, Mackie C, Gilissen RA.

Biomed Chromatogr. 2005 Apr;19(3):245-9.

PMID:
15627277
7.

Isoniazid pharmacokinetics-pharmacodynamics in an aerosol infection model of tuberculosis.

Jayaram R, Shandil RK, Gaonkar S, Kaur P, Suresh BL, Mahesh BN, Jayashree R, Nandi V, Bharath S, Kantharaj E, Balasubramanian V.

Antimicrob Agents Chemother. 2004 Aug;48(8):2951-7.

8.

Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry.

Kantharaj E, Tuytelaars A, Proost PE, Ongel Z, Van Assouw HP, Gilissen RA.

Rapid Commun Mass Spectrom. 2003;17(23):2661-8.

PMID:
14648905
9.

Pharmacokinetics-pharmacodynamics of rifampin in an aerosol infection model of tuberculosis.

Jayaram R, Gaonkar S, Kaur P, Suresh BL, Mahesh BN, Jayashree R, Nandi V, Bharat S, Shandil RK, Kantharaj E, Balasubramanian V.

Antimicrob Agents Chemother. 2003 Jul;47(7):2118-24.

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