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Functions of Smad Transcription Factors in TGF-β1-Induced Selectin Ligand Expression on Murine CD4 Th Cells.

Ebel ME, Kansas GS.

J Immunol. 2016 Oct 1;197(7):2627-34. doi: 10.4049/jimmunol.1600723. Epub 2016 Aug 19.


Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK.

Ebel ME, Awe O, Kaplan MH, Kansas GS.

J Immunol. 2015 Jun 15;194(12):5781-8. doi: 10.4049/jimmunol.1500485. Epub 2015 May 4.


Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection.

Sarraj B, Ye J, Akl AI, Chen G, Wang JJ, Zhang Z, Abadja F, Abecassis M, Miller SD, Kansas GS, Ansari MJ.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12145-50. doi: 10.1073/pnas.1303676111. Epub 2014 Aug 4.


Defining the functional boundaries of the murine α1,3-fucosyltransferase Fut7 reveals a remarkably compact locus.

Ebel ME, Kansas GS.

J Biol Chem. 2014 Mar 7;289(10):6341-9. doi: 10.1074/jbc.M113.511790. Epub 2014 Jan 23.


Therapeutic inflammatory monocyte modulation using immune-modifying microparticles.

Getts DR, Terry RL, Getts MT, Deffrasnes C, Müller M, van Vreden C, Ashhurst TM, Chami B, McCarthy D, Wu H, Ma J, Martin A, Shae LD, Witting P, Kansas GS, Kühn J, Hafezi W, Campbell IL, Reilly D, Say J, Brown L, White MY, Cordwell SJ, Chadban SJ, Thorp EB, Bao S, Miller SD, King NJ.

Sci Transl Med. 2014 Jan 15;6(219):219ra7. doi: 10.1126/scitranslmed.3007563.


Overlapping roles for endothelial selectins in murine hematopoietic stem/progenitor cell homing to bone marrow.

Nabors LK, Wang LD, Wagers AJ, Kansas GS.

Exp Hematol. 2013 Jul;41(7):588-96. doi: 10.1016/j.exphem.2013.02.014. Epub 2013 Mar 14.


IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation.

Sehra S, Yao Y, Howell MD, Nguyen ET, Kansas GS, Leung DY, Travers JB, Kaplan MH.

J Immunol. 2010 Mar 15;184(6):3186-90. doi: 10.4049/jimmunol.0901860. Epub 2010 Feb 10.


A transgenic mouse model of plasma cell malignancy shows phenotypic, cytogenetic, and gene expression heterogeneity similar to human multiple myeloma.

Boylan KL, Gosse MA, Staggs SE, Janz S, Grindle S, Kansas GS, Van Ness BG.

Cancer Res. 2007 May 1;67(9):4069-78.


Stat3 and Stat4 direct development of IL-17-secreting Th cells.

Mathur AN, Chang HC, Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT, Kapur R, Levy DE, Kansas GS, Kaplan MH.

J Immunol. 2007 Apr 15;178(8):4901-7.


T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.

Mathur AN, Chang HC, Zisoulis DG, Kapur R, Belladonna ML, Kansas GS, Kaplan MH.

Blood. 2006 Sep 1;108(5):1595-601. Epub 2006 May 2.


Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells.

Fornek JL, Tygrett LT, Waldschmidt TJ, Poli V, Rickert RC, Kansas GS.

Blood. 2006 Feb 1;107(3):1085-91. Epub 2005 Oct 13.


A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells.

Underhill GH, Zisoulis DG, Kolli KP, Ellies LG, Marth JD, Kansas GS.

Blood. 2005 Dec 1;106(12):3867-73. Epub 2005 Aug 11.


H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells.

Zisoulis DG, Kansas GS.

J Biol Chem. 2004 Sep 17;279(38):39495-504. Epub 2004 Jul 19.


Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation.

Ley K, Kansas GS.

Nat Rev Immunol. 2004 May;4(5):325-35. Review. No abstract available.


Platelet-monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting.

Fernandes LS, Conde ID, Wayne Smith C, Kansas GS, Snapp KR, Bennet N, Ballantyne C, McIntire LV, O'Brian Smith E, Klem JA, Mathew S, Frangogiannis N, Turner NA, Maresh KJ, Kleiman NS.

Thromb Res. 2003;111(3):171-7.


Avidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers.

Dwir O, Solomon A, Mangan S, Kansas GS, Schwarz US, Alon R.

J Cell Biol. 2003 Nov 10;163(3):649-59. Epub 2003 Nov 3.


Control of FucT-VII expression in CD4+ T cells.

Kansas GS.

Ernst Schering Res Found Workshop. 2004;(44):95-107. Review. No abstract available.


P-selectin and P-selectin glycoprotein ligand 1 are major determinants for Th1 cell recruitment to nonlymphoid effector sites in the intestinal lamina propria.

Haddad W, Cooper CJ, Zhang Z, Brown JB, Zhu Y, Issekutz A, Fuss I, Lee HO, Kansas GS, Barrett TA.

J Exp Med. 2003 Aug 4;198(3):369-77. Epub 2003 Jul 28.


Complexity within the plasma cell compartment of mice deficient in both E- and P-selectin: implications for plasma cell differentiation.

Underhill GH, Kolli KP, Kansas GS.

Blood. 2003 Dec 1;102(12):4076-83. Epub 2003 Jul 24.


Induction of FucT-VII by the Ras/MAP kinase cascade in Jurkat T cells.

Barry SM, Zisoulis DG, Neal JW, Clipstone NA, Kansas GS.

Blood. 2003 Sep 1;102(5):1771-8. Epub 2003 May 8.


Gene expression profiling reveals a highly specialized genetic program of plasma cells.

Underhill GH, George D, Bremer EG, Kansas GS.

Blood. 2003 May 15;101(10):4013-21. Epub 2003 Jan 23.


Sialyltransferase specificity in selectin ligand formation.

Ellies LG, Sperandio M, Underhill GH, Yousif J, Smith M, Priatel JJ, Kansas GS, Ley K, Marth JD.

Blood. 2002 Nov 15;100(10):3618-25. Epub 2002 Jul 25.


The role of bone marrow-derived stromal cells in the maintenance of plasma cell longevity.

Minges Wols HA, Underhill GH, Kansas GS, Witte PL.

J Immunol. 2002 Oct 15;169(8):4213-21.


IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules.

Underhill GH, Minges Wols HA, Fornek JL, Witte PL, Kansas GS.

Blood. 2002 Apr 15;99(8):2905-12. Erratum in: Blood 2002 Dec 15;100(13):4265. Minges-Wols Heather A [corrected to Minges Wols Heather A].


L-selectin dimerization enhances tether formation to properly spaced ligand.

Dwir O, Steeber DA, Schwarz US, Camphausen RT, Kansas GS, Tedder TF, Alon R.

J Biol Chem. 2002 Jun 14;277(24):21130-9. Epub 2002 Mar 20.


Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression.

Uchimura K, El-Fasakhany FM, Hori M, Hemmerich S, Blink SE, Kansas GS, Kanamori A, Kumamoto K, Kannagi R, Muramatsu T.

J Biol Chem. 2002 Feb 8;277(6):3979-84. Epub 2001 Nov 28.


Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.

Herron MJ, Nelson CM, Larson J, Snapp KR, Kansas GS, Goodman JL.

Science. 2000 Jun 2;288(5471):1653-6.


Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1.

Hentzen ER, Neelamegham S, Kansas GS, Benanti JA, McIntire LV, Smith CW, Simon SI.

Blood. 2000 Feb 1;95(3):911-20.


PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in suppression of hematopoiesis.

Lévesque JP, Zannettino AC, Pudney M, Niutta S, Haylock DN, Snapp KR, Kansas GS, Berndt MC, Simmons PJ.

Immunity. 1999 Sep;11(3):369-78.


The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin.

Romo GM, Dong JF, Schade AJ, Gardiner EE, Kansas GS, Li CQ, McIntire LV, Berndt MC, López JA.

J Exp Med. 1999 Sep 20;190(6):803-14.


Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-->3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotransferase cDNA.

Kimura N, Mitsuoka C, Kanamori A, Hiraiwa N, Uchimura K, Muramatsu T, Tamatani T, Kansas GS, Kannagi R.

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4530-5.


Dynamic association of L-selectin with the lymphocyte cytoskeletal matrix.

Evans SS, Schleider DM, Bowman LA, Francis ML, Kansas GS, Black JD.

J Immunol. 1999 Mar 15;162(6):3615-24.


Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4.

Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH.

J Immunol. 1999 Mar 15;162(6):3193-201.


Venous levels of shear support neutrophil-platelet adhesion and neutrophil aggregation in blood via P-selectin and beta2-integrin.

Konstantopoulos K, Neelamegham S, Burns AR, Hentzen E, Kansas GS, Snapp KR, Berg EL, Hellums JD, Smith CW, McIntire LV, Simon SI.

Circulation. 1998 Sep 1;98(9):873-82.


Dimerization of P-selectin glycoprotein ligand-1 (PSGL-1) required for optimal recognition of P-selectin.

Snapp KR, Craig R, Herron M, Nelson RD, Stoolman LM, Kansas GS.

J Cell Biol. 1998 Jul 13;142(1):263-70.


Expression of leukocyte fucosyltransferases regulates binding to E-selectin: relationship to previously implicated carbohydrate epitopes.

Wagers AJ, Stoolman LM, Kannagi R, Craig R, Kansas GS.

J Immunol. 1997 Aug 15;159(4):1917-29.


Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin.

Goetz DJ, Greif DM, Ding H, Camphausen RT, Howes S, Comess KM, Snapp KR, Kansas GS, Luscinskas FW.

J Cell Biol. 1997 Apr 21;137(2):509-19.


Threshold levels of fluid shear promote leukocyte adhesion through selectins (CD62L,P,E)

Lawrence MB, Kansas GS, Kunkel EJ, Ley K.

J Cell Biol. 1997 Feb 10;136(3):717-27. Erratum in: J Cell Biol 1997 Apr 7;137(1):261.

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