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Place of death trends among patients with dementia in Japan: a population-based observational study.

Koyama T, Sasaki M, Hagiya H, Zamami Y, Funahashi T, Ohshima A, Tatebe Y, Mikami N, Shinomiya K, Kitamura Y, Sendo T, Hinotsu S, Kano MR.

Sci Rep. 2019 Dec 27;9(1):20235. doi: 10.1038/s41598-019-56388-w.


Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study.

Hagiya H, Koyama T, Zamami Y, Tatebe Y, Funahashi T, Shinomiya K, Kitamura Y, Hinotsu S, Sendo T, Rakugi H, Kano MR.

BMJ Open. 2019 Dec 11;9(12):e033462. doi: 10.1136/bmjopen-2019-033462.


Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database.

Zamami Y, Niimura T, Koyama T, Shigemi Y, Izawa-Ishizawa Y, Morita M, Ohshima A, Harada K, Imai T, Hagiwara H, Okada N, Goda M, Takechi K, Chuma M, Kondo Y, Tsuchiya K, Hinotsu S, Kano MR, Ishizawa K.

Front Pharmacol. 2019 Nov 8;10:1257. doi: 10.3389/fphar.2019.01257. eCollection 2019.


Oral anticoagulants usage in Japanese patients aged 18-74 years with non-valvular atrial fibrillation: a retrospective analysis based on insurance claims data.

Ohshima A, Koyama T, Ogawa A, Zamami Y, Tanaka HY, Kitamura Y, Sendo T, Hinotsu S, Miller MW, Kano MR.

Fam Pract. 2019 Nov 18;36(6):685-692. doi: 10.1093/fampra/cmz016.


In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers.

Watanabe S, Hayashi K, Toh K, Kim HJ, Liu X, Chaya H, Fukushima S, Katsushima K, Kondo Y, Uchida S, Ogura S, Nomoto T, Takemoto H, Cabral H, Kinoh H, Tanaka HY, Kano MR, Matsumoto Y, Fukuhara H, Uchida S, Nangaku M, Osada K, Nishiyama N, Miyata K, Kataoka K.

Nat Commun. 2019 Apr 24;10(1):1894. doi: 10.1038/s41467-019-09856-w.


Association between rapid antigen detection tests and antibiotics for acute pharyngitis in Japan: A retrospective observational study.

Teratani Y, Hagiya H, Koyama T, Ohshima A, Zamami Y, Tatebe Y, Tasaka K, Shinomiya K, Kitamura Y, Sendo T, Hinotsu S, Kano MR.

J Infect Chemother. 2019 Apr;25(4):267-272. doi: 10.1016/j.jiac.2018.12.005. Epub 2019 Jan 12.


Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness.

Tanaka HY, Kitahara K, Sasaki N, Nakao N, Sato K, Narita H, Shimoda H, Matsusaki M, Nishihara H, Masamune A, Kano MR.

Biomaterials. 2019 Feb;192:355-367. doi: 10.1016/j.biomaterials.2018.11.023. Epub 2018 Nov 17.


Trends in incidence and mortality of tuberculosis in Japan: a population-based study, 1997-2016.

Hagiya H, Koyama T, Zamami Y, Minato Y, Tatebe Y, Mikami N, Teratani Y, Ohshima A, Shinomiya K, Kitamura Y, Sendo T, Hinotsu S, Tomono K, Kano MR.

Epidemiol Infect. 2018 Nov 9:1-10. doi: 10.1017/S095026881800290X. [Epub ahead of print]


Trends in Polypharmacy in Japan: A Nationwide Retrospective Study.

Onoue H, Koyama T, Zamami Y, Hagiya H, Tatebe Y, Mikami N, Shinomiya K, Kitamura Y, Hinotsu S, Sendo T, Ouchi Y, Kano MR.

J Am Geriatr Soc. 2018 Dec;66(12):2267-2273. doi: 10.1111/jgs.15569. Epub 2018 Oct 6.


Pattern of antibiotic prescriptions for outpatients with acute respiratory tract infections in Japan, 2013-15: a retrospective observational study.

Teratani Y, Hagiya H, Koyama T, Adachi M, Ohshima A, Zamami Y, Tanaka HY, Tatebe Y, Tasaka K, Mikami N, Shinomiya K, Kitamura Y, Kano MR, Hinotsu S, Sendo T.

Fam Pract. 2019 Jul 31;36(4):402-409. doi: 10.1093/fampra/cmy094.


In vitro 3D blood/lymph-vascularized human stromal tissues for preclinical assays of cancer metastasis.

Nishiguchi A, Matsusaki M, Kano MR, Nishihara H, Okano D, Asano Y, Shimoda H, Kishimoto S, Iwai S, Akashi M.

Biomaterials. 2018 Oct;179:144-155. doi: 10.1016/j.biomaterials.2018.06.019. Epub 2018 Jul 2.


Stromal barriers to nanomedicine penetration in the pancreatic tumor microenvironment.

Tanaka HY, Kano MR.

Cancer Sci. 2018 Jul;109(7):2085-2092. doi: 10.1111/cas.13630. Epub 2018 Jun 9. Review.


Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest.

Niimura T, Zamami Y, Koyama T, Izawa-Ishizawa Y, Miyake M, Koga T, Harada K, Ohshima A, Imai T, Kondo Y, Imanishi M, Takechi K, Fukushima K, Horinouchi Y, Ikeda Y, Fujino H, Tsuchiya K, Tamaki T, Hinotsu S, Kano MR, Ishizawa K.

Sci Rep. 2017 Dec 20;7(1):17919. doi: 10.1038/s41598-017-17686-3.


Desmoplastic Reaction in 3D-Pancreatic Cancer Tissues Suppresses Molecular Permeability.

Matsusaki M, Komeda M, Mura S, Tanaka HY, Kano MR, Couvreur P, Akashi M.

Adv Healthc Mater. 2017 Aug;6(15). doi: 10.1002/adhm.201700057. Epub 2017 Apr 27.


Regulation of endothelial Fas expression as a mechanism of promotion of vascular integrity by mural cells in tumors.

Kamei R, Tanaka HY, Kawano T, Morii C, Tanaka S, Nishihara H, Iwata C, Kano MR.

Cancer Sci. 2017 May;108(5):1080-1088. doi: 10.1111/cas.13216. Epub 2017 May 24.


Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2.

Sakai S, Iwata C, Tanaka HY, Cabral H, Morishita Y, Miyazono K, Kano MR.

J Control Release. 2016 May 28;230:109-15. doi: 10.1016/j.jconrel.2016.04.007. Epub 2016 Apr 12.


Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery.

Matsumoto Y, Nichols JW, Toh K, Nomoto T, Cabral H, Miura Y, Christie RJ, Yamada N, Ogura T, Kano MR, Matsumura Y, Nishiyama N, Yamasoba T, Bae YH, Kataoka K.

Nat Nanotechnol. 2016 Jun;11(6):533-538. doi: 10.1038/nnano.2015.342. Epub 2016 Feb 15.


Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors.

Anraku Y, Kishimura A, Kamiya M, Tanaka S, Nomoto T, Toh K, Matsumoto Y, Fukushima S, Sueyoshi D, Kano MR, Urano Y, Nishiyama N, Kataoka K.

Angew Chem Int Ed Engl. 2016 Jan 11;55(2):560-5. doi: 10.1002/anie.201508339. Epub 2015 Dec 2.


Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas.

Kawamura W, Miura Y, Kokuryo D, Toh K, Yamada N, Nomoto T, Matsumoto Y, Sueyoshi D, Liu X, Aoki I, Kano MR, Nishiyama N, Saga T, Kishimura A, Kataoka K.

Sci Technol Adv Mater. 2015 May 20;16(3):035004. eCollection 2015 Jun.


Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers.

Cabral H, Makino J, Matsumoto Y, Mi P, Wu H, Nomoto T, Toh K, Yamada N, Higuchi Y, Konishi S, Kano MR, Nishihara H, Miura Y, Nishiyama N, Kataoka K.

ACS Nano. 2015 May 26;9(5):4957-67. doi: 10.1021/nn5070259. Epub 2015 Apr 20.


Nano-pathophysiology: a novel integrated approach to disease through application of nanotechnology.

Kano MR.

Adv Drug Deliv Rev. 2014 Jul;74:1. doi: 10.1016/j.addr.2014.07.014. Epub 2014 Aug 2. No abstract available.


Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation.

Wu H, Cabral H, Toh K, Mi P, Chen YC, Matsumoto Y, Yamada N, Liu X, Kinoh H, Miura Y, Kano MR, Nishihara H, Nishiyama N, Kataoka K.

J Control Release. 2014 Sep 10;189:1-10. doi: 10.1016/j.jconrel.2014.06.018. Epub 2014 Jun 20.


Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors.

Ge Z, Chen Q, Osada K, Liu X, Tockary TA, Uchida S, Dirisala A, Ishii T, Nomoto T, Toh K, Matsumoto Y, Oba M, Kano MR, Itaka K, Kataoka K.

Biomaterials. 2014 Mar;35(10):3416-26. doi: 10.1016/j.biomaterials.2013.12.086. Epub 2014 Jan 15.


Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier.

Miura Y, Takenaka T, Toh K, Wu S, Nishihara H, Kano MR, Ino Y, Nomoto T, Matsumoto Y, Koyama H, Cabral H, Nishiyama N, Kataoka K.

ACS Nano. 2013 Oct 22;7(10):8583-92. doi: 10.1021/nn402662d. Epub 2013 Sep 18.


Nanotechnology and tumor microcirculation.

Kano MR.

Adv Drug Deliv Rev. 2014 Jul;74:2-11. doi: 10.1016/j.addr.2013.08.010. Epub 2013 Aug 30. Review.


Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis.

Cabral H, Murakami M, Hojo H, Terada Y, Kano MR, Chung UI, Nishiyama N, Kataoka K.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11397-402. doi: 10.1073/pnas.1301348110. Epub 2013 Jun 25.


SPIO-PICsome: development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes).

Kokuryo D, Anraku Y, Kishimura A, Tanaka S, Kano MR, Kershaw J, Nishiyama N, Saga T, Aoki I, Kataoka K.

J Control Release. 2013 Aug 10;169(3):220-7. doi: 10.1016/j.jconrel.2013.03.016. Epub 2013 Mar 29. Erratum in: J Control Release. 2014 Mar 28;178:125.


Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.

Wu S, Kasim V, Kano MR, Tanaka S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung UI, Yang L, Kataoka K, Nishiyama N, Miyagishi M.

Cancer Res. 2013 Mar 15;73(6):1787-99. doi: 10.1158/0008-5472.CAN-12-0366. Epub 2013 Jan 17.


NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo.

Harada M, Iwata C, Saito H, Ishii K, Hayashi T, Yashiro M, Hirakawa K, Miyazono K, Kato Y, Kano MR.

Int J Nanomedicine. 2012;7:2713-27. doi: 10.2147/IJN.S31247. Epub 2012 May 31.


Pericyte-coverage of human tumor vasculature and nanoparticle permeability.

Zhang L, Nishihara H, Kano MR.

Biol Pharm Bull. 2012;35(5):761-6.


Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.

Chen Q, Osada K, Ishii T, Oba M, Uchida S, Tockary TA, Endo T, Ge Z, Kinoh H, Kano MR, Itaka K, Kataoka K.

Biomaterials. 2012 Jun;33(18):4722-30. doi: 10.1016/j.biomaterials.2012.03.017. Epub 2012 Mar 22.


PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker.

Yuzawa S, Kano MR, Einama T, Nishihara H.

Med Oncol. 2012 Dec;29(4):2824-30. doi: 10.1007/s12032-012-0193-0. Epub 2012 Mar 9.


Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis.

Rafi M, Cabral H, Kano MR, Mi P, Iwata C, Yashiro M, Hirakawa K, Miyazono K, Nishiyama N, Kataoka K.

J Control Release. 2012 Apr 30;159(2):189-96. doi: 10.1016/j.jconrel.2012.01.038. Epub 2012 Feb 3.


Engineering fibrotic tissue in pancreatic cancer: a novel three-dimensional model to investigate nanoparticle delivery.

Hosoya H, Kadowaki K, Matsusaki M, Cabral H, Nishihara H, Ijichi H, Koike K, Kataoka K, Miyazono K, Akashi M, Kano MR.

Biochem Biophys Res Commun. 2012 Mar 2;419(1):32-7. doi: 10.1016/j.bbrc.2012.01.117. Epub 2012 Jan 30.


Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size.

Cabral H, Matsumoto Y, Mizuno K, Chen Q, Murakami M, Kimura M, Terada Y, Kano MR, Miyazono K, Uesaka M, Nishiyama N, Kataoka K.

Nat Nanotechnol. 2011 Oct 23;6(12):815-23. doi: 10.1038/nnano.2011.166.


High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism.

Nakagome K, Imamura M, Kawahata K, Harada H, Okunishi K, Matsumoto T, Sasaki O, Tanaka R, Kano MR, Chang H, Hanawa H, Miyazaki J, Yamamoto K, Dohi M.

J Immunol. 2011 Nov 15;187(10):5077-89. doi: 10.4049/jimmunol.1001560. Epub 2011 Oct 12.


Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties.

Kumagai M, Sarma TK, Cabral H, Kaida S, Sekino M, Herlambang N, Osada K, Kano MR, Nishiyama N, Kataoka K.

Macromol Rapid Commun. 2010 Sep 1;31(17):1521-8. doi: 10.1002/marc.201000341.


Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting.

Murakami M, Cabral H, Matsumoto Y, Wu S, Kano MR, Yamori T, Nishiyama N, Kataoka K.

Sci Transl Med. 2011 Jan 5;3(64):64ra2. doi: 10.1126/scitranslmed.3001385.


Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.

Ehata S, Johansson E, Katayama R, Koike S, Watanabe A, Hoshino Y, Katsuno Y, Komuro A, Koinuma D, Kano MR, Yashiro M, Hirakawa K, Aburatani H, Fujita N, Miyazono K.

Oncogene. 2011 Apr 7;30(14):1693-705. doi: 10.1038/onc.2010.546. Epub 2010 Dec 6.


Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.

Oba M, Miyata K, Osada K, Christie RJ, Sanjoh M, Li W, Fukushima S, Ishii T, Kano MR, Nishiyama N, Koyama H, Kataoka K.

Biomaterials. 2011 Jan;32(2):652-63. doi: 10.1016/j.biomaterials.2010.09.022. Epub 2010 Oct 6.


Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-β-disrupted diffuse-type gastric carcinoma.

Johansson E, Komuro A, Iwata C, Hagiwara A, Fuse Y, Watanabe A, Morishita Y, Aburatani H, Funa K, Kano MR, Miyazono K.

Cancer Sci. 2010 Nov;101(11):2398-403. doi: 10.1111/j.1349-7006.2010.01688.x.


LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.

Sumida H, Noguchi K, Kihara Y, Abe M, Yanagida K, Hamano F, Sato S, Tamaki K, Morishita Y, Kano MR, Iwata C, Miyazono K, Sakimura K, Shimizu T, Ishii S.

Blood. 2010 Dec 2;116(23):5060-70. doi: 10.1182/blood-2010-03-272443. Epub 2010 Aug 16.


Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway.

Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y.

Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2205-11. doi: 10.1161/ATVBAHA.110.210500. Epub 2010 Aug 12.


Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-1.

Oba M, Vachutinsky Y, Miyata K, Kano MR, Ikeda S, Nishiyama N, Itaka K, Miyazono K, Koyama H, Kataoka K.

Mol Pharm. 2010 Apr 5;7(2):501-9. doi: 10.1021/mp9002317.


Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles.

Vachutinsky Y, Oba M, Miyata K, Hiki S, Kano MR, Nishiyama N, Koyama H, Miyazono K, Kataoka K.

J Control Release. 2011 Jan 5;149(1):51-7. doi: 10.1016/j.jconrel.2010.02.002. Epub 2010 Feb 6.


Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells.

Kiyono K, Suzuki HI, Matsuyama H, Morishita Y, Komuro A, Kano MR, Sugimoto K, Miyazono K.

Cancer Res. 2009 Dec 1;69(23):8844-52. doi: 10.1158/0008-5472.CAN-08-4401. Epub 2009 Nov 10.


c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.

Kiyono K, Suzuki HI, Morishita Y, Komuro A, Iwata C, Yashiro M, Hirakawa K, Kano MR, Miyazono K.

Cancer Sci. 2009 Oct;100(10):1809-16. doi: 10.1111/j.1349-7006.2009.01248.x. Epub 2009 Jun 17.


Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block copolymer-coated magnetite nanoparticles with TGF-beta inhibitor.

Kumagai M, Kano MR, Morishita Y, Ota M, Imai Y, Nishiyama N, Sekino M, Ueno S, Miyazono K, Kataoka K.

J Control Release. 2009 Dec 16;140(3):306-11. doi: 10.1016/j.jconrel.2009.06.002. Epub 2009 Jun 12.


Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles.

Han M, Oba M, Nishiyama N, Kano MR, Kizaka-Kondoh S, Kataoka K.

Mol Ther. 2009 Aug;17(8):1404-10. doi: 10.1038/mt.2009.119. Epub 2009 May 26.


Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling.

Komuro A, Yashiro M, Iwata C, Morishita Y, Johansson E, Matsumoto Y, Watanabe A, Aburatani H, Miyoshi H, Kiyono K, Shirai YT, Suzuki HI, Hirakawa K, Kano MR, Miyazono K.

J Natl Cancer Inst. 2009 Apr 15;101(8):592-604. doi: 10.1093/jnci/djp058. Epub 2009 Apr 7.

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