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Items: 44

1.

Novel Biomarkers for Change in Renal Function in People With Dysglycemia.

Gerstein HC, Paré G, McQueen MJ, Lee SF, Bangdiwala SI, Kannt A, Hess S; ORIGIN Trial Investigators.

Diabetes Care. 2019 Nov 14. pii: dc191604. doi: 10.2337/dc19-1604. [Epub ahead of print]

PMID:
31727687
2.

Vasodilation of rat skeletal muscle arteries by the novel BK channel opener GoSlo is mediated by the simultaneous activation of BK and Kv7 channels.

Zavaritskaya O, Dudem S, Ma D, Kaneez RE, Albrecht S, Tsvetkov D, Kassmann M, Thornbury K, Mladenov M, Kammermeier C, Sergeant G, Mullins N, Wouappi O, Wurm H, Kannt A, Gollasch M, Hollywood MA, Schubert R.

Br J Pharmacol. 2019 Oct 28. doi: 10.1111/bph.14910. [Epub ahead of print]

PMID:
31658366
3.

Mastiha (Pistacia lentiscus) Improves Gut Microbiota Diversity, Hepatic Steatosis, and Disease Activity in a Biopsy-Confirmed Mouse Model of Advanced Non-Alcoholic Steatohepatitis and Fibrosis.

Kannt A, Papada E, Kammermeier C, D'Auria G, Jiménez-Hernández N, Stephan M, Schwahn U, Madsen AN, Østergaard MV, Dedoussis G, Francino MP; MAST4HEALTH consortium.

Mol Nutr Food Res. 2019 Dec;63(24):e1900927. doi: 10.1002/mnfr.201900927. Epub 2019 Oct 23.

PMID:
31599067
4.

High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).

Policarpo RL, Decultot L, May E, Kuzmič P, Carlson S, Huang D, Chu V, Wright BA, Dhakshinamoorthy S, Kannt A, Rani S, Dittakavi S, Panarese JD, Gaudet R, Shair MD.

J Med Chem. 2019 Nov 14;62(21):9837-9873. doi: 10.1021/acs.jmedchem.9b01238. Epub 2019 Oct 25.

PMID:
31589440
5.

A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice.

Wang X, Sommerfeld MR, Jahn-Hofmann K, Cai B, Filliol A, Remotti HE, Schwabe RF, Kannt A, Tabas I.

Hepatol Commun. 2019 Jul 23;3(9):1221-1234. doi: 10.1002/hep4.1405. eCollection 2019 Sep. Erratum in: Hepatol Commun. 2019 Nov 26;4(1):134.

6.

Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.

Gordin D, Shah H, Shinjo T, St-Louis R, Qi W, Park K, Paniagua SM, Pober DM, Wu IH, Bahnam V, Brissett MJ, Tinsley LJ, Dreyfuss JM, Pan H, Dong Y, Niewczas MA, Amenta P, Sadowski T, Kannt A, Keenan HA, King GL.

Diabetes Care. 2019 Jul;42(7):1263-1273. doi: 10.2337/dc18-2585. Epub 2019 May 10.

PMID:
31076418
7.

Smoking and Other Risk Factors in Type 2 Diabetes.

Kannt A.

N Engl J Med. 2018 Dec 27;379(26):2574. doi: 10.1056/NEJMc1812842. No abstract available.

PMID:
30586514
8.

Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance.

Brachs S, Polack J, Brachs M, Jahn-Hofmann K, Elvert R, Pfenninger A, Bärenz F, Margerie D, Mai K, Spranger J, Kannt A.

Diabetes. 2019 Mar;68(3):527-542. doi: 10.2337/db18-0780. Epub 2018 Dec 14.

9.

Team Players or Opponents: Coadministration of Selective Glucagon and GLP-1 Receptor Agonists in Obese Diabetic Monkeys.

Elvert R, Bossart M, Herling AW, Weiss T, Zhang B, Kannt A, Wagner M, Haack T, Evers A, Dudda A, Keil S, Lorenz M, Lorenz K, Riz M, Hennerici W, Larsen PJ.

Endocrinology. 2018 Aug 1;159(8):3105-3119. doi: 10.1210/en.2018-00399.

PMID:
29992313
10.

Running on mixed fuel-dual agonistic approach of GLP-1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non-human primates.

Elvert R, Herling AW, Bossart M, Weiss T, Zhang B, Wenski P, Wandschneider J, Kleutsch S, Butty U, Kannt A, Wagner M, Haack T, Evers A, Dudda A, Lorenz M, Keil S, Larsen PJ.

Diabetes Obes Metab. 2018 Aug;20(8):1836-1851. doi: 10.1111/dom.13212. Epub 2018 Jun 25.

11.

Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity.

Qiu J, Hauske SJ, Zhang S, Rodriguez-Niño A, Albrecht T, Pastene DO, van den Born J, van Goor H, Ruf S, Kohlmann M, Teufel M, Krämer BK, Hammes HP, Peters V, Yard BA, Kannt A.

Amino Acids. 2019 Jan;51(1):7-16. doi: 10.1007/s00726-018-2601-z. Epub 2018 Jun 20.

PMID:
29922921
12.

A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.

Kannt A, Rajagopal S, Kadnur SV, Suresh J, Bhamidipati RK, Swaminathan S, Hallur MS, Kristam R, Elvert R, Czech J, Pfenninger A, Rudolph C, Schreuder H, Chandrasekar DV, Mane VS, Birudukota S, Shaik S, Zope BR, Burri RR, Anand NN, Thakur MK, Singh M, Parveen R, Kandan S, Mullangi R, Yura T, Gosu R, Ruf S, Dhakshinamoorthy S.

Sci Rep. 2018 Feb 26;8(1):3660. doi: 10.1038/s41598-018-22081-7.

13.

Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.

Ruf S, Hallur MS, Anchan NK, Swamy IN, Murugesan KR, Sarkar S, Narasimhulu LK, Putta VPRK, Shaik S, Chandrasekar DV, Mane VS, Kadnur SV, Suresh J, Bhamidipati RK, Singh M, Burri RR, Kristam R, Schreuder H, Czech J, Rudolph C, Marker A, Langer T, Mullangi R, Yura T, Gosu R, Kannt A, Dhakshinamoorthy S, Rajagopal S.

Bioorg Med Chem Lett. 2018 Mar 1;28(5):922-925. doi: 10.1016/j.bmcl.2018.01.058. Epub 2018 Jan 31.

PMID:
29433927
14.

Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.

Swaminathan S, Birudukota S, Thakur MK, Parveen R, Kandan S, Juluri S, Shaik S, Anand NN, Burri RR, Kristam R, Hallur MS, Rajagopal S, Schreuder H, Langer T, Rudolph C, Ruf S, Dhakshinamoorthy S, Gosu R, Kannt A.

Biochem Biophys Res Commun. 2017 Sep 16;491(2):416-422. doi: 10.1016/j.bbrc.2017.07.087. Epub 2017 Jul 15.

PMID:
28720493
15.

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.

Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman IE, Amenta PS, Feener EP, Vander Heiden MG, Stanton RC, King GL.

Nat Med. 2017 Jun;23(6):753-762. doi: 10.1038/nm.4328. Epub 2017 Apr 24.

16.

Managing risks in drug discovery: reproducibility of published findings.

Kannt A, Wieland T.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Apr;389(4):353-60. doi: 10.1007/s00210-016-1216-8. Epub 2016 Feb 17. Review.

17.

Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.

Winkel AF, Engel CK, Margerie D, Kannt A, Szillat H, Glombik H, Kallus C, Ruf S, Güssregen S, Riedel J, Herling AW, von Knethen A, Weigert A, Brüne B, Schmoll D.

J Biol Chem. 2015 Nov 20;290(47):28446-55. doi: 10.1074/jbc.M115.678136. Epub 2015 Oct 12.

18.

Management of nicotinamide N-methyltransferase overexpression: inhibit the enzyme or reduce nicotinamide intake? Reply to Zhou S, Li D, Zhou Y [letter].

Kannt A, Pfenninger A, Tönjes A, Blüher M.

Diabetologia. 2015 Sep;58(9):2193-4. doi: 10.1007/s00125-015-3678-5. Epub 2015 Jun 26. No abstract available.

PMID:
26113421
19.

Electrochemistry suggests proton access from the exit site to the binuclear center in Paracoccus denitrificans cytochrome c oxidase pathway variants.

Meyer T, Melin F, Richter OM, Ludwig B, Kannt A, Müller H, Michel H, Hellwig P.

FEBS Lett. 2015 Feb 27;589(5):565-8. doi: 10.1016/j.febslet.2015.01.014. Epub 2015 Jan 28.

20.

End-organ protection in hypertension by the novel and selective Rho-kinase inhibitor, SAR407899.

Löhn M, Plettenburg O, Kannt A, Kohlmann M, Hofmeister A, Kadereit D, Monecke P, Schiffer A, Schulte A, Ruetten H, Ivashchenko Y.

World J Cardiol. 2015 Jan 26;7(1):31-42. doi: 10.4330/wjc.v7.i1.31.

21.

GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.

Mastaitis J, Min S, Elvert R, Kannt A, Xin Y, Ochoa F, Gale NW, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1845-9. doi: 10.1073/pnas.1424968112. Epub 2015 Jan 26.

22.

Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance.

Kannt A, Pfenninger A, Teichert L, Tönjes A, Dietrich A, Schön MR, Klöting N, Blüher M.

Diabetologia. 2015 Apr;58(4):799-808. doi: 10.1007/s00125-014-3490-7. Epub 2015 Jan 18.

23.

Systemic treatment with erythropoietin protects the neurovascular unit in a rat model of retinal neurodegeneration.

Busch S, Kannt A, Kolibabka M, Schlotterer A, Wang Q, Lin J, Feng Y, Hoffmann S, Gretz N, Hammes HP.

PLoS One. 2014 Jul 11;9(7):e102013. doi: 10.1371/journal.pone.0102013. eCollection 2014.

24.

Expression patterning reveals retinal inflammation as a minor factor in experimental retinopathy of ZDF rats.

Wohlfart P, Lin J, Dietrich N, Kannt A, Elvert R, Herling AW, Hammes HP.

Acta Diabetol. 2014 Aug;51(4):553-8. doi: 10.1007/s00592-013-0550-2. Epub 2014 Jan 30.

25.

Novel β-amino acid derivatives as inhibitors of cathepsin A.

Ruf S, Buning C, Schreuder H, Horstick G, Linz W, Olpp T, Pernerstorfer J, Hiss K, Kroll K, Kannt A, Kohlmann M, Linz D, Hübschle T, Rütten H, Wirth K, Schmidt T, Sadowski T.

J Med Chem. 2012 Sep 13;55(17):7636-49. doi: 10.1021/jm300663n. Epub 2012 Aug 16.

PMID:
22861813
26.

Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds.

Kannt A, Sicka K, Kroll K, Kadereit D, Gögelein H.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul;385(7):717-27. doi: 10.1007/s00210-012-0750-2. Epub 2012 Apr 19.

27.

Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.

Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, Abellan van Kan G, Andrieu S, Bauer J, Breuille D, Cederholm T, Chandler J, De Meynard C, Donini L, Harris T, Kannt A, Keime Guibert F, Onder G, Papanicolaou D, Rolland Y, Rooks D, Sieber C, Souhami E, Verlaan S, Zamboni M.

J Am Med Dir Assoc. 2011 May;12(4):249-56. doi: 10.1016/j.jamda.2011.01.003. Epub 2011 Mar 4.

28.

Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor.

Löhn M, Plettenburg O, Ivashchenko Y, Kannt A, Hofmeister A, Kadereit D, Schaefer M, Linz W, Kohlmann M, Herbert JM, Janiak P, O'Connor SE, Ruetten H.

Hypertension. 2009 Sep;54(3):676-83. doi: 10.1161/HYPERTENSIONAHA.109.134353. Epub 2009 Jul 13.

PMID:
19597037
29.

Probing the access of protons to the K pathway in the Paracoccus denitrificans cytochrome c oxidase.

Richter OM, Dürr KL, Kannt A, Ludwig B, Scandurra FM, Giuffrè A, Sarti P, Hellwig P.

FEBS J. 2005 Jan;272(2):404-12.

30.

Tyrosine 167: the origin of the radical species observed in the reaction of cytochrome c oxidase with hydrogen peroxide in Paracoccus denitrificans.

Budiman K, Kannt A, Lyubenova S, Richter OM, Ludwig B, Michel H, MacMillan F.

Biochemistry. 2004 Sep 21;43(37):11709-16.

PMID:
15362855
31.
32.

Reduction of cytochrome c oxidase by a second electron leads to proton translocation.

Ruitenberg M, Kannt A, Bamberg E, Fendler K, Michel H.

Nature. 2002 May 2;417(6884):99-102.

PMID:
11986672
33.
34.

Tracing the D-pathway in reconstituted site-directed mutants of cytochrome c oxidase from Paracoccus denitrificans.

Pfitzner U, Hoffmeier K, Harrenga A, Kannt A, Michel H, Bamberg E, Richter OM, Ludwig B.

Biochemistry. 2000 Jun 13;39(23):6756-62.

PMID:
10841754
35.

Single-electron reduction of the oxidized state is coupled to proton uptake via the K pathway in Paracoccus denitrificans cytochrome c oxidase.

Ruitenberg M, Kannt A, Bamberg E, Ludwig B, Michel H, Fendler K.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4632-6.

36.

The symbiotically essential cbb(3)-type oxidase of Bradyrhizobium japonicum is a proton pump.

Arslan E, Kannt A, Thöny-Meyer L, Hennecke H.

FEBS Lett. 2000 Mar 17;470(1):7-10.

37.

Structural investigations of the CuA centre of nitrous oxide reductase from Pseudomonas stutzeri by site-directed mutagenesis and X-ray absorption spectroscopy.

Charnock JM, Dreusch A, Körner H, Neese F, Nelson J, Kannt A, Michel H, Garner CD, Kroneck PM, Zumft WG.

Eur J Biochem. 2000 Mar;267(5):1368-81.

38.

Mutation of Arg-54 strongly influences heme composition and rate and directionality of electron transfer in Paracoccus denitrificans cytochrome c oxidase.

Kannt A, Pfitzner U, Ruitenberg M, Hellwig P, Ludwig B, Mäntele W, Fendler K, Michel H.

J Biol Chem. 1999 Dec 31;274(53):37974-81.

39.

Direct evidence for a tyrosine radical in the reaction of cytochrome c oxidase with hydrogen peroxide.

MacMillan F, Kannt A, Behr J, Prisner T, Michel H.

Biochemistry. 1999 Jul 20;38(29):9179-84.

PMID:
10413492
40.

Electrical current generation and proton pumping catalyzed by the ba3-type cytochrome c oxidase from Thermus thermophilus.

Kannt A, Soulimane T, Buse G, Becker A, Bamberg E, Michel H.

FEBS Lett. 1998 Aug 28;434(1-2):17-22.

41.

Cytochrome c oxidase: structure and spectroscopy.

Michel H, Behr J, Harrenga A, Kannt A.

Annu Rev Biophys Biomol Struct. 1998;27:329-56. Review.

PMID:
9646871
42.

The role of electrostatic interactions for cytochrome c oxidase function.

Kannt A, Lancaster CR, Michel H.

J Bioenerg Biomembr. 1998 Feb;30(1):81-7. Review.

PMID:
9623809
44.

The role of acidic residues of plastocyanin in its interaction with cytochrome ƒ.

Kannt A, Young S, Bendall DS.

Biochim Biophys Acta. 1996 Nov 12;1277(1-2):115-126.

PMID:
30897681

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