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The IARC Monographs: Updated procedures for modern and transparent evidence synthesis in cancer hazard identification.

Samet JM, Chiu WA, Cogliano V, Jinot J, Kriebel D, Lunn RM, Beland FA, Bero L, Browne P, Fritschi L, Kanno J, Lachenmeier DW, Lan Q, Lasfargues G, Curieux FL, Peters S, Shubat P, Sone H, White MC, Williamson J, Yakubovskaya M, Siemiatycki J, White PA, Guyton KZ, Schubauer-Berigan MK, Hall AL, Grosse Y, Bouvard V, Benbrahim-Tallaa L, Ghissassi FE, Lauby-Secretan B, Armstrong B, Saracci R, Zavadil J, Straif K, Wild CP.

J Natl Cancer Inst. 2019 Sep 9. pii: djz169. doi: 10.1093/jnci/djz169. [Epub ahead of print]


Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration.

Abdelgied M, El-Gazzar AM, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Hirose A, Taquahashi Y, Kanno J, Abdelhamid M, Abdou KA, Takahashi S, Alexander DB, Tsuda H.

Part Fibre Toxicol. 2019 Sep 2;16(1):34. doi: 10.1186/s12989-019-0316-2.


CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.

Kobayashi K, Kuze J, Abe S, Takehara S, Minegishi G, Igarashi K, Kitajima S, Kanno J, Yamamoto T, Oshimura M, Kazuki Y.

Mol Pharmacol. 2019 Nov;96(5):600-608. doi: 10.1124/mol.119.117333. Epub 2019 Aug 27.


Automated Measurement of the Foveal Avascular Zone in Swept-Source Optical Coherence Tomography Angiography Images.

Ishii H, Shoji T, Yoshikawa Y, Kanno J, Ibuki H, Shinoda K.

Transl Vis Sci Technol. 2019 May 30;8(3):28. doi: 10.1167/tvst.8.3.28. eCollection 2019 May.


Exosome-mediated horizontal gene transfer occurs in double-strand break repair during genome editing.

Ono R, Yasuhiko Y, Aisaki KI, Kitajima S, Kanno J, Hirabayashi Y.

Commun Biol. 2019 Feb 8;2:57. doi: 10.1038/s42003-019-0300-2. eCollection 2019.


Pulmonary and pleural toxicity of potassium octatitanate fibers, rutile titanium dioxide nanoparticles, and MWCNT-7 in male Fischer 344 rats.

Abdelgied M, El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA, Hirose A, Taquahashi Y, Kanno J, Abdelhamid M, Tsuda H, Takahashi S.

Arch Toxicol. 2019 Apr;93(4):909-920. doi: 10.1007/s00204-019-02410-z. Epub 2019 Feb 13.


A Follow-Up from Infancy to Puberty in a Japanese Male with SRY-Negative 46,XX Testicular Disorder of Sex Development Carrying a p.Arg92Trp Mutation in NR5A1.

Saito-Hakoda A, Kanno J, Suzuki D, Kawashima S, Kamimura M, Hirano K, Sakai K, Igarashi M, Fukami M, Fujiwara I.

Sex Dev. 2019;13(2):60-66. doi: 10.1159/000496777. Epub 2019 Feb 9.


Carcinogenicity of isobutyl nitrite, β-picoline, and some acrylates.

Kromhout H, Friesen M, Marques MM, Sergi CM, Abdallah M, Benke G, Cesta M, Germolec D, Houck K, Ichihara G, Jameson CW, Kanno J, Pogribny I, Svendsen C, Benbrahim-Tallaa L, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Hall A, Jaillet C, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.

Lancet Oncol. 2018 Aug;19(8):1020-1022. doi: 10.1016/S1470-2045(18)30491-1. Epub 2018 Jun 28. No abstract available.


Reproducibility of Macular Vessel Density Calculations Via Imaging With Two Different Swept-Source Optical Coherence Tomography Angiography Systems.

Shoji T, Yoshikawa Y, Kanno J, Ishii H, Ibuki H, Ozaki K, Kimura I, Shinoda K.

Transl Vis Sci Technol. 2018 Dec 21;7(6):31. doi: 10.1167/tvst.7.6.31. eCollection 2018 Nov.


Evaluation of microvascular changes in the macular area of eyes with rhegmatogenous retinal detachment without macular involvement using swept-source optical coherence tomography angiography.

Yoshikawa Y, Shoji T, Kanno J, Ibuki H, Ozaki K, Ishii H, Ichikawa Y, Kimura I, Shinoda K.

Clin Ophthalmol. 2018 Oct 15;12:2059-2067. doi: 10.2147/OPTH.S177933. eCollection 2018.


Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes.

Otsuka K, Yamada K, Taquahashi Y, Arakaki R, Ushio A, Saito M, Yamada A, Tsunematsu T, Kudo Y, Kanno J, Ishimaru N.

PLoS One. 2018 Oct 29;13(10):e0205702. doi: 10.1371/journal.pone.0205702. eCollection 2018.


Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes.

Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H.

Chem Res Toxicol. 2018 Oct 15;31(10):1025-1031. doi: 10.1021/acs.chemrestox.8b00067. Epub 2018 Sep 13.


On the Definiteness of Earth Mover's Distance and Its Relation to Set Intersection.

Gardner A, Duncan CA, Kanno J, Selmic RR.

IEEE Trans Cybern. 2018 Nov;48(11):3184-3196. doi: 10.1109/TCYB.2017.2761798. Epub 2017 Oct 30.


Optic disc vessel density in nonglaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study.

Yoshikawa Y, Shoji T, Kanno J, Kimura I, Hangai M, Shinoda K.

Clin Ophthalmol. 2018 Jun 19;12:1113-1119. doi: 10.2147/OPTH.S167222. eCollection 2018.


Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats.

Abdelgied M, El-Gazzar AM, Alexander DB, Alexander WT, Numano T, Iigou M, Naiki-Ito A, Takase H, Abdou KA, Hirose A, Taquahashi Y, Kanno J, Tsuda H, Takahashi S.

Cancer Sci. 2018 Jul;109(7):2164-2177. doi: 10.1111/cas.13643. Epub 2018 Jun 22.


A follow-up during puberty in a Japanese girl with type A insulin resistance due to a novel mutation in INSR.

Saito-Hakoda A, Nishii A, Uchida T, Kikuchi A, Kanno J, Fujiwara I, Kure S.

Clin Pediatr Endocrinol. 2018;27(1):53-57. doi: 10.1297/cpe.27.53. Epub 2018 Jan 30. No abstract available.


Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.

Buesen R, Chorley BN, da Silva Lima B, Daston G, Deferme L, Ebbels T, Gant TW, Goetz A, Greally J, Gribaldo L, Hackermüller J, Hubesch B, Jennen D, Johnson K, Kanno J, Kauffmann HM, Laffont M, McMullen P, Meehan R, Pemberton M, Perdichizzi S, Piersma AH, Sauer UG, Schmidt K, Seitz H, Sumida K, Tollefsen KE, Tong W, Tralau T, van Ravenzwaay B, Weber RJM, Worth A, Yauk C, Poole A.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S3-S13. doi: 10.1016/j.yrtph.2017.09.002. Epub 2017 Sep 25. Review.


Responsiveness to pamidronate treatment is not related to the genotype of type I collagen in patients with osteogenesis imperfecta.

Kanno J, Saito-Hakoda A, Kure S, Fujiwara I.

J Bone Miner Metab. 2018 May;36(3):344-351. doi: 10.1007/s00774-017-0840-9. Epub 2017 May 20.


Distribution of 1,2-dichloropropane in blood and other tissues of rats after oral administration.

Take M, Takeuchi T, Hirai S, Takanobu K, Matsumoto M, Fukushima S, Kanno J.

J Toxicol Sci. 2017;42(2):121-128. doi: 10.2131/jts.42.121.


Xp22.31 Microdeletion due to Microhomology-Mediated Break-Induced Replication in a Boy with Contiguous Gene Deletion Syndrome.

Nagai K, Shima H, Kamimura M, Kanno J, Suzuki E, Ishiguro A, Narumi S, Kure S, Fujiwara I, Fukami M.

Cytogenet Genome Res. 2017;151(1):1-4. doi: 10.1159/000458469. Epub 2017 Mar 3.


The p.R92W variant of NR5A1/Nr5a1 induces testicular development of 46,XX gonads in humans, but not in mice: phenotypic comparison of human patients and mutation-induced mice.

Miyado M, Inui M, Igarashi M, Katoh-Fukui Y, Takasawa K, Hakoda A, Kanno J, Kashimada K, Miyado K, Tamano M, Ogata T, Takada S, Fukami M.

Biol Sex Differ. 2016 Nov 8;7:56. eCollection 2016.


The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling.

Ohtake F, Saeki Y, Ishido S, Kanno J, Tanaka K.

Mol Cell. 2016 Oct 20;64(2):251-266. doi: 10.1016/j.molcel.2016.09.014. Epub 2016 Oct 13.


Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues.

Igarashi M, Takasawa K, Hakoda A, Kanno J, Takada S, Miyado M, Baba T, Morohashi KI, Tajima T, Hata K, Nakabayashi K, Matsubara Y, Sekido R, Ogata T, Kashimada K, Fukami M.

Hum Mutat. 2017 Jan;38(1):39-42. doi: 10.1002/humu.23116. Epub 2016 Sep 21.


Learning and Memory Deficits in Male Adult Mice Treated with a Benzodiazepine Sleep-Inducing Drug during the Juvenile Period.

Furukawa Y, Tanemura K, Igarashi K, Ideta-Otsuka M, Aisaki K, Kitajima S, Kitagawa M, Kanno J.

Front Neurosci. 2016 Jul 20;10:339. doi: 10.3389/fnins.2016.00339. eCollection 2016.


Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignant mesothelioma and lung tumors.

Suzui M, Futakuchi M, Fukamachi K, Numano T, Abdelgied M, Takahashi S, Ohnishi M, Omori T, Tsuruoka S, Hirose A, Kanno J, Sakamoto Y, Alexander DB, Alexander WT, Jiegou X, Tsuda H.

Cancer Sci. 2016 Jul;107(7):924-35. doi: 10.1111/cas.12954. Epub 2016 Jun 23.


Systematic molecular analyses of SHOX in Japanese patients with idiopathic short stature and Leri-Weill dyschondrosteosis.

Shima H, Tanaka T, Kamimaki T, Dateki S, Muroya K, Horikawa R, Kanno J, Adachi M, Naiki Y, Tanaka H, Mabe H, Yagasaki H, Kure S, Matsubara Y, Tajima T, Kashimada K, Ishii T, Asakura Y, Fujiwara I, Soneda S, Nagasaki K, Hamajima T, Kanzaki S, Jinno T, Ogata T, Fukami M; Japanese SHOX study group.

J Hum Genet. 2016 Jul;61(7):585-91. doi: 10.1038/jhg.2016.18. Epub 2016 Mar 17.


[Biomechanism-based innovation of toxicology by the fundamental concept of "Signal Toxicity"].

Kanno J.

Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2015;(133):21-8. Review. Japanese.


Increase in prostate stem cell antigen expression in prostatic hyperplasia induced by testosterone and 17β-estradiol in C57BL mice.

Fujimoto N, Kanno J.

J Steroid Biochem Mol Biol. 2016 Apr;158:56-62. doi: 10.1016/j.jsbmb.2016.01.011. Epub 2016 Jan 24.


Introduction to the concept of signal toxicity.

Kanno J.

J Toxicol Sci. 2016;41(Special):SP105-SP109. doi: 10.2131/jts.41.SP105. Review.


Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid.

Juliandi B, Tanemura K, Igarashi K, Tominaga T, Furukawa Y, Otsuka M, Moriyama N, Ikegami D, Abematsu M, Sanosaka T, Tsujimura K, Narita M, Kanno J, Nakashima K.

Stem Cell Reports. 2015 Dec 8;5(6):996-1009. doi: 10.1016/j.stemcr.2015.10.012. Epub 2015 Nov 19.


Gene expression response to EWS-FLI1 in mouse embryonic cartilage.

Tanaka M, Aisaki K, Kitajima S, Igarashi K, Kanno J, Nakamura T.

Genom Data. 2014 Sep 16;2:296-8. doi: 10.1016/j.gdata.2014.09.003. eCollection 2014 Dec.



Mori K, Kanno J, Gehlbach PL.

Retina. 2016 Feb;36(2):375-84. doi: 10.1097/IAE.0000000000000703.


Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes.

Ono R, Ishii M, Fujihara Y, Kitazawa M, Usami T, Kaneko-Ishino T, Kanno J, Ikawa M, Ishino F.

Sci Rep. 2015 Jul 28;5:12281. doi: 10.1038/srep12281.


Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study.

Xu J, Alexander DB, Iigo M, Hamano H, Takahashi S, Yokoyama T, Kato M, Usami I, Tokuyama T, Tsutsumi M, Tamura M, Oguri T, Niimi A, Hayashi Y, Yokoyama Y, Tonegawa K, Fukamachi K, Futakuchi M, Sakai Y, Suzui M, Kamijima M, Hisanaga N, Omori T, Nakae D, Hirose A, Kanno J, Tsuda H.

Cancer Sci. 2015 Jul;106(7):825-32. doi: 10.1111/cas.12687. Epub 2015 Jun 5.


[Introduction to the series of Topics from the Joint JSCT-JSOT symposia].

Kanno J.

Chudoku Kenkyu. 2014 Dec;27(4):357. Japanese. No abstract available.


Mutations in PIGL in a patient with Mabry syndrome.

Fujiwara I, Murakami Y, Niihori T, Kanno J, Hakoda A, Sakamoto O, Okamoto N, Funayama R, Nagashima T, Nakayama K, Kinoshita T, Kure S, Matsubara Y, Aoki Y.

Am J Med Genet A. 2015 Apr;167A(4):777-85. doi: 10.1002/ajmg.a.36987. Epub 2015 Feb 23.


Discussion on the boundary of risk assessment and risk management.

Kanno J.

Genes Environ. 2015 Jul 30;37:9. doi: 10.1186/s41021-015-0008-6. eCollection 2015.


Ubiquitin acetylation inhibits polyubiquitin chain elongation.

Ohtake F, Saeki Y, Sakamoto K, Ohtake K, Nishikawa H, Tsuchiya H, Ohta T, Tanaka K, Kanno J.

EMBO Rep. 2015 Feb;16(2):192-201. doi: 10.15252/embr.201439152. Epub 2014 Dec 19.


Association of achondroplasia with Down syndrome: difficulty in prenatal diagnosis by sonographic and 3-D helical computed tomographic analyses.

Kaga A, Murotsuki J, Kamimura M, Kimura M, Saito-Hakoda A, Kanno J, Hoshi K, Kure S, Fujiwara I.

Congenit Anom (Kyoto). 2015 May;55(2):116-20. doi: 10.1111/cga.12097.


Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors.

Tanaka M, Yamazaki Y, Kanno Y, Igarashi K, Aisaki K, Kanno J, Nakamura T.

J Clin Invest. 2014 Jul;124(7):3061-74. doi: 10.1172/JCI72399. Epub 2014 Jun 9.


MWCNT causes extensive damage to the ciliated epithelium of the trachea of rodents.

Ohba T, Xu J, Alexander DB, Yamada A, Kanno J, Hirose A, Tsuda H, Imaizumi Y.

J Toxicol Sci. 2014 Jun;39(3):499-505.


Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.

Yokoyama A, Igarashi K, Sato T, Takagi K, Otsuka I M, Shishido Y, Baba T, Ito R, Kanno J, Ohkawa Y, Morohashi K, Sugawara A.

J Biol Chem. 2014 Jun 27;289(26):18152-62. doi: 10.1074/jbc.M114.566448. Epub 2014 May 14.


Active repression by RARγ signaling is required for vertebrate axial elongation.

Janesick A, Nguyen TT, Aisaki K, Igarashi K, Kitajima S, Chandraratna RA, Kanno J, Blumberg B.

Development. 2014 Jun;141(11):2260-70. doi: 10.1242/dev.103705. Epub 2014 May 12.


Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes.

Xu J, Alexander DB, Futakuchi M, Numano T, Fukamachi K, Suzui M, Omori T, Kanno J, Hirose A, Tsuda H.

Cancer Sci. 2014 Jul;105(7):763-9. doi: 10.1111/cas.12437. Epub 2014 Jul 1.


Comparative study of toxic effects of anatase and rutile type nanosized titanium dioxide particles in vivo and in vitro.

Numano T, Xu J, Futakuchi M, Fukamachi K, Alexander DB, Furukawa F, Kanno J, Hirose A, Tsuda H, Suzui M.

Asian Pac J Cancer Prev. 2014;15(2):929-35.


Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice.

Kondoh S, Inoue K, Igarashi K, Sugizaki H, Shirode-Fukuda Y, Inoue E, Yu T, Takeuchi JK, Kanno J, Bonewald LF, Imai Y.

Bone. 2014 Mar;60:68-77. doi: 10.1016/j.bone.2013.12.005. Epub 2013 Dec 10.


Brain white matter abnormality in a newborn infant with congenital adrenal hyperplasia.

Kaga A, Saito-Hakoda A, Uematsu M, Kamimura M, Kanno J, Kure S, Fujiwara I.

Clin Pediatr Endocrinol. 2013 Oct;22(4):77-81. doi: 10.1292/cpe.22.77. Epub 2013 Oct 26.


Nateglinide is Effective for Diabetes Mellitus with Reactive Hypoglycemia in a Child with a Compound Heterozygous ABCC8 Mutation.

Saito-Hakoda A, Yorifuji T, Kanno J, Kure S, Fujiwara I.

Clin Pediatr Endocrinol. 2012 Jul;21(3):45-52. doi: 10.1297/cpe.21.45. Epub 2012 Jul 25.


Oral administration of pentachlorophenol induces interferon signaling mRNAs in C57BL/6 male mouse liver.

Kanno J, Aisaki K, Igarashi K, Kitajima S, Matsuda N, Morita K, Tsuji M, Moriyama N, Furukawa Y, Otsuka M, Tachihara E, Nakatsu N, Kodama Y.

J Toxicol Sci. 2013;38(4):643-54.

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